DAPL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DAPL1
Entrez Gene ID	92196
Full Name	death associated protein like 1
General protein information	Preferred Names death associated protein like 1 Names death-associated protein-like 1 early epithelial differentiation-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q24.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017920.2	NP_001017920.2	death-associated protein-like 1
NM_001017920.3	NP_001017920.2	death-associated protein-like 1

Pathways from BioSystems

Homologies

	DAPL1	XP_001092189.1
Canis lupus familiaris (dog)	DAPL1	XP_849683.1
Bos taurus (cattle)	DAPL1	NP_001020517.1
Mus musculus (house mouse)	Dapl1	NP_083999.1
Xenopus tropicalis (tropical clawed frog)	dapl1	NP_001039052.1
Homo sapiens (human)	DAPL1	NP_001017920.2
Rattus norvegicus (Norway rat)	Dapl1	NP_001102052.1
Pan troglodytes (chimpanzee)	DAPL1	XP_001147594.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death-associated protein like-1 DAPL1 by alternative MITF splice forms.
Ma X, Hua J, Zheng G, Li F, Rao C, Li H, Wang J, Pan L, Hou L
Pigment cell & melanoma research(2017 Nov)

DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.
Ma X, Li H, Wang Y, Wang J, Zheng Q, Hua J, Yang J, Pan L, Lu F, Qu J, Hou L
Human molecular genetics26(9)1612-1621(2017 05)

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).
Grassmann F, Friedrich U, Fauser S, Schick T, Milenkovic A, Schulz HL, von Strachwitz CN, Bettecken T, Lichtner P, Meitinger T, Arend N, Wolf A, Haritoglou C, Rudolph G, Chakravarthy U, Silvestri G, McKay GJ, Freitag-Wolf S, Krawczak M, Smith RT, Merriam JC, Merriam JE, Allikmets R, Heid IM, Weber BH
Neuromolecular medicine17(2)111-20(2015 Jun)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanch? H, Schreiber S, Nebel A
Mutation research694(1-2)13-9(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors show that DAPL1 is a novel regulator of RPE cell proliferation that is important for the maintenance of the RPE as a monolayer. The findings suggest that DAPL1 dysregulation may be involved in abnormal RPE-related proliferative diseases and corresponding retinal dysfunctions in humans.
Title: DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.

DAPL1 plays a role in epithelial differentiation and may be involved in apoptotic processes thereby suggesting a possible novel pathway in AMD pathogenesis.
Title: A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

The following DAPL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAPL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31843	NM_001017920.3 Latest version!	Homo sapiens death associated protein like 1 (DAPL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31843	NM_001017920.2	Homo sapiens death associated protein like 1 (DAPL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DAPL1 ( NM_001017920.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017920.2 Homo sapiens death associated protein like 1 (DAPL1), mRNA.

Price & Availability↑

CloneID	OHu31843
Clone ID Related Accession (Same CDS sequence)	NM_001017920.2 , NM_001017920.3
Accession Version	NM_001017920.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	death-associated protein-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY324399.1, BC127683.1, CD675155.1, AC079877.5 and AF086541.1. On Dec 11, 2008 this sequence version replaced NM_001017920.1. ##Evidence-Data-START## Transcript exon combination :: AY324399.1, BQ185417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAATG AAGTGCAAGA CCTGCTCTCC CCTCGGAAAG GGGGACATCC TCCTGCAGTA 
AAAGCTGGAG GAATGAGAAT TTCCAAAAAA CAAGAAATTG GCACCTTGGA AAGACATACC 
AAAAAAACAG GATTCGAGAA AACAAGTGCC ATTGCAAATG TTGCCAAAAT ACAGACACTG 
GATGCCCTGA ATGACGCACT GGAGAAGCTC AACTATAAAT TTCCAGCAAC AGTGCACATG 
GCGCATCAAA AACCCACACC TGCTCTGGAA AAGGTTGTTC CACTGAAAAG GATCTACATT 
ATTCAGCAGC CTCGAAAATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017920.2
CDS	57..380
Translation	MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC

Target ORF information:

RefSeq Version	NM_001017920.2
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein like 1 (DAPL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017920.2

ORF Insert Sequence:

ATGGCAAATG AAGTGCAAGA CCTGCTCTCC CCTCGGAAAG GGGGACATCC TCCTGCAGTA 
AAAGCTGGAG GAATGAGAAT TTCCAAAAAA CAAGAAATTG GCACCTTGGA AAGACATACC 
AAAAAAACAG GATTCGAGAA AACAAGTGCC ATTGCAAATG TTGCCAAAAT ACAGACACTG 
GATGCCCTGA ATGACGCACT GGAGAAGCTC AACTATAAAT TTCCAGCAAC AGTGCACATG 
GCGCATCAAA AACCCACACC TGCTCTGGAA AAGGTTGTTC CACTGAAAAG GATCTACATT 
ATTCAGCAGC CTCGAAAATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAPL1 ( NM_001017920.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017920.2 Homo sapiens death associated protein like 1 (DAPL1), mRNA.

Price & Availability↑

CloneID	OHu31843
Clone ID Related Accession (Same CDS sequence)	NM_001017920.2 , NM_001017920.3
Accession Version	NM_001017920.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	death-associated protein-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY324399.1, BC127683.1, CD675155.1, AC079877.5 and AF086541.1. On Jun 2, 2019 this sequence version replaced NM_001017920.2. ##Evidence-Data-START## Transcript exon combination :: AY324399.1, BX117859.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAAATG AAGTGCAAGA CCTGCTCTCC CCTCGGAAAG GGGGACATCC TCCTGCAGTA 
AAAGCTGGAG GAATGAGAAT TTCCAAAAAA CAAGAAATTG GCACCTTGGA AAGACATACC 
AAAAAAACAG GATTCGAGAA AACAAGTGCC ATTGCAAATG TTGCCAAAAT ACAGACACTG 
GATGCCCTGA ATGACGCACT GGAGAAGCTC AACTATAAAT TTCCAGCAAC AGTGCACATG 
GCGCATCAAA AACCCACACC TGCTCTGGAA AAGGTTGTTC CACTGAAAAG GATCTACATT 
ATTCAGCAGC CTCGAAAATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017920.2
CDS	57..380
Translation	MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC

Target ORF information:

RefSeq Version	NM_001017920.3
Organism	Homo sapiens(human)
Definition	Homo sapiens death associated protein like 1 (DAPL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017920.3

ORF Insert Sequence:

ATGGCAAATG AAGTGCAAGA CCTGCTCTCC CCTCGGAAAG GGGGACATCC TCCTGCAGTA 
AAAGCTGGAG GAATGAGAAT TTCCAAAAAA CAAGAAATTG GCACCTTGGA AAGACATACC 
AAAAAAACAG GATTCGAGAA AACAAGTGCC ATTGCAAATG TTGCCAAAAT ACAGACACTG 
GATGCCCTGA ATGACGCACT GGAGAAGCTC AACTATAAAT TTCCAGCAAC AGTGCACATG 
GCGCATCAAA AACCCACACC TGCTCTGGAA AAGGTTGTTC CACTGAAAAG GATCTACATT 
ATTCAGCAGC CTCGAAAATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death-associated protein like-1 DAPL1 by alternative MITF splice forms.
Pigment cell & melanoma research(2017 Nov)
Ma X,Hua J,Zheng G,Li F,Rao C,Li H,Wang J,Pan L,Hou L

DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.
Human molecular genetics26(9)1612-1621(2017 05)
Ma X,Li H,Wang Y,Wang J,Zheng Q,Hua J,Yang J,Pan L,Lu F,Qu J,Hou L

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).
Neuromolecular medicine17(2)111-20(2015 Jun)
Grassmann F,Friedrich U,Fauser S,Schick T,Milenkovic A,Schulz HL,von Strachwitz CN,Bettecken T,Lichtner P,Meitinger T,Arend N,Wolf A,Haritoglou C,Rudolph G,Chakravarthy U,Silvestri G,McKay GJ,Freitag-Wolf S,Krawczak M,Smith RT,Merriam JC,Merriam JE,Allikmets R,Heid IM,Weber BH

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research694(1-2)13-9(2010 Dec)
Flachsbart F,Franke A,Kleindorp R,Caliebe A,Blanch? H,Schreiber S,Nebel A

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DAPL1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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