KCNQ4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNQ4
Entrez Gene ID	9132
Full Name	potassium voltage-gated channel subfamily Q member 4
Synonyms	DFNA2,DFNA2A,KV7.4
General protein information	Preferred Names potassium voltage-gated channel subfamily Q member 4 Names potassium voltage-gated channel subfamily KQT member 4 potassium channel KQT-like 4 potassium channel subunit alpha KvLQT4 potassium channel, voltage gated KQT-like subfamily Q, member 4 potassium voltage-gated channel, KQT-like subfamily, member 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.2
Summary	The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	603537
Disorder Html:	Deafness, autosomal dominant 2A, 600101 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_172163.2	NP_751895.1	potassium voltage-gated channel subfamily KQT member 4 isoform b
NM_004700.4	NP_004691.2	potassium voltage-gated channel subfamily KQT member 4 isoform a
NM_172163.3	NP_751895.1	potassium voltage-gated channel subfamily KQT member 4 isoform b
NM_004700.3	NP_004691.2	potassium voltage-gated channel subfamily KQT member 4 isoform a
XM_017002792.1	XP_016858281.1	potassium voltage-gated channel subfamily KQT member 4 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNQ4	XP_513360.2
Xenopus tropicalis (tropical clawed frog)	kcnq4	NP_001072924.2
Rattus norvegicus (Norway rat)	Kcnq4	XP_233477.6
Homo sapiens (human)	KCNQ4	NP_004691.2
Mus musculus (house mouse)	Kcnq4	NP_001074611.1
Gallus gallus (chicken)	KCNQ4	XP_417791.4
Canis lupus familiaris (dog)	KCNQ4	XP_539568.2
Bos taurus (cattle)	KCNQ4	XP_002686584.3

Gene Ontology
Bibliography

Related articles in PubMed

[The genetic aspects of occupational hearing impairment].
Krasitskaya VV, Bashmakova EE, Dobretsov KG, Orlova NV, Frank LA
Vestnik otorinolaringologii82(5)71-76(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mutations in KCNQ4 gene are unlikely to be a major causative factor of ADNSHL in our studied patients from West Bengal, India, pointing to other genes might be responsible for ADNSHL in our studied patients
Title: Absence of KCNQ4 mutation in Bengali families with ADNSHL originated from West Bengal, India.

A novel KCNQ4 mutation, c.887 G > A (p.G296D), was identified in all five affected members in a Chinese family with autosomal dominant non-syndromic deafness 2. This mutation leads to a glycine-to-aspartic acid substitution at position 296 in the pore region of the KCNQ4 channel.
Title: A novel pore-region mutation, c.887G?>?A (p.G296D) in KCNQ4, causing hearing loss in a Chinese family with autosomal dominant non-syndromic deafness 2.

The fundamental processes that dictate Kv7.4 activity.
Title: Synergistic interplay of G?? and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity.

Gene and protein expression analyses show the predominance of KV7.4 channels over the other KV7 channel subtypes in human detrusor.
Title: K

Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation.
Title: Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.

The following KCNQ4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNQ4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu90794	XM_017002792.1 Latest version!	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu21859	NM_172163.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu22778	NM_004700.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$489.30 $699.00
View Old Accession Versions >>
OHu21859	NM_172163.2	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
OHu22778	NM_004700.3	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$489.30 $699.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNQ4 ( XM_017002792.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858281.1 Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu90794
Clone ID Related Accession (Same CDS sequence)	XM_017002792.1
Accession Version	XM_017002792.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily KQT member 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGGCAG CCAACCTCAT CCAGGCTGCC TGGCGCCTGT ACTCCACCGA TATGAGCCGG 
GCCTACCTGA CAGCCACCTG GTACTACTAT GACAGTATCC TCCCATCCTT CAGAGAGCTG 
GCCCTCTTGT TTGAGCACGT GCAACGGGCC CGCAATGGGG GCCTACGGCC CCTGGAGGTG 
CGGCGGGCGC CGGTACCCGA CGGAGCACCC TCCCGTTACC CGCCCGTTGC CACCTGCCAC 
CGGCCGGGCA GCACCTCCTT CTGCCCTGGG GAAAGCAGCC GGATGGGCAT CAAAGACCGC 
ATCCGCATGG GCAGCTCCCA GCGGCGGACG GGTCCTTCCA AGCAGCATCT GGCACCTCCA 
ACAATGCCCA CCTCCCCAAG CAGCGAGCAG GTGGGTGAGG CCACCAGCCC CACCAAGGTG 
CAAAAGAGCT GGAGCTTCAA TGACCGCACC CGCTTCCGGG CATCTCTGAG ACTCAAACCC 
CGCACCTCTG CTGAGGATGC CCCCTCAGAG GAAGTAGCAG AGGAGAAGAG CTACCAGTGT 
GAGCTCACGG TGGACGACAT CATGCCTGCT GTGAAGACAG TCATCCGCTC CATCAGGATT 
CTCAAGTTCC TGGTGGCCAA AAGGAAATTC AAGGAGACAC TGCGACCGTA CGACGTGAAG 
GACGTCATTG AGCAGTACTC AGCAGGCCAC CTGGACATGC TGGGCCGGAT CAAGAGCCTG 
CAAACTCGGG TGGACCAAAT TGTGGGTCGG GGGCCCGGGG ACAGGAAGGC CCGGGAGAAG 
GGCGACAAGG GGCCCTCCGA CGCGGAGGTG GTGGATGAAA TCAGCATGAT GGGACGCGTG 
GTCAAGGTGG AGAAGCAGGT GCAGTCCATC GAGCACAAGC TGGACCTGCT GTTGGGCTTC 
TATTCGCGCT GCCTGCGCTC TGGCACCTCG GCCAGCCTGG GCGCCGTGCA AGTGCCGCTG 
TTCGACCCCG ACATCACCTC CGACTACCAC AGCCCTGTGG ACCACGAGGA CATCTCCGTC 
TCCGCACAGA CGCTCAGCAT CTCCCGCTCG GTCAGCACCA ACATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858281.1
CDS	341..1411
Translation	MPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target ORF information:

RefSeq Version	XM_017002792.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002792.1

ORF Insert Sequence:

ATGCCGGCAG CCAACCTCAT CCAGGCTGCC TGGCGCCTGT ACTCCACCGA TATGAGCCGG 
GCCTACCTGA CAGCCACCTG GTACTACTAT GACAGTATCC TCCCATCCTT CAGAGAGCTG 
GCCCTCTTGT TTGAGCACGT GCAACGGGCC CGCAATGGGG GCCTACGGCC CCTGGAGGTG 
CGGCGGGCGC CGGTACCCGA CGGAGCACCC TCCCGTTACC CGCCCGTTGC CACCTGCCAC 
CGGCCGGGCA GCACCTCCTT CTGCCCTGGG GAAAGCAGCC GGATGGGCAT CAAAGACCGC 
ATCCGCATGG GCAGCTCCCA GCGGCGGACG GGTCCTTCCA AGCAGCATCT GGCACCTCCA 
ACAATGCCCA CCTCCCCAAG CAGCGAGCAG GTGGGTGAGG CCACCAGCCC CACCAAGGTG 
CAAAAGAGCT GGAGCTTCAA TGACCGCACC CGCTTCCGGG CATCTCTGAG ACTCAAACCC 
CGCACCTCTG CTGAGGATGC CCCCTCAGAG GAAGTAGCAG AGGAGAAGAG CTACCAGTGT 
GAGCTCACGG TGGACGACAT CATGCCTGCT GTGAAGACAG TCATCCGCTC CATCAGGATT 
CTCAAGTTCC TGGTGGCCAA AAGGAAATTC AAGGAGACAC TGCGACCGTA CGACGTGAAG 
GACGTCATTG AGCAGTACTC AGCAGGCCAC CTGGACATGC TGGGCCGGAT CAAGAGCCTG 
CAAACTCGGG TGGACCAAAT TGTGGGTCGG GGGCCCGGGG ACAGGAAGGC CCGGGAGAAG 
GGCGACAAGG GGCCCTCCGA CGCGGAGGTG GTGGATGAAA TCAGCATGAT GGGACGCGTG 
GTCAAGGTGG AGAAGCAGGT GCAGTCCATC GAGCACAAGC TGGACCTGCT GTTGGGCTTC 
TATTCGCGCT GCCTGCGCTC TGGCACCTCG GCCAGCCTGG GCGCCGTGCA AGTGCCGCTG 
TTCGACCCCG ACATCACCTC CGACTACCAC AGCCCTGTGG ACCACGAGGA CATCTCCGTC 
TCCGCACAGA CGCTCAGCAT CTCCCGCTCG GTCAGCACCA ACATGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNQ4 ( NM_172163.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_751895.1 Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21859
Clone ID Related Accession (Same CDS sequence)	NM_172163.2 , NM_172163.3
Accession Version	NM_172163.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily KQT member 4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF105202.1, DA782056.1, AK074957.1, AC119677.2 and CA411644.1. On Aug 10, 2010 this sequence version replaced NM_172163.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. There are no publicly available transcripts supporting this variant; it is represented based on data in PMID:10025409. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2161920 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG CAGCCGGATG 
GGCATCAAAG ACCGCATCCG CATGGGCAGC TCCCAGCGGC GGACGGGTCC TTCCAAGCAG 
CATCTGGCAC CTCCAACAAT GCCCACCTCC CCAAGCAGCG AGCAGGTGGG TGAGGCCACC 
AGCCCCACCA AGGTGCAAAA GAGCTGGAGC TTCAATGACC GCACCCGCTT CCGGGCATCT 
CTGAGACTCA AACCCCGCAC CTCTGCTGAG GATGCCCCCT CAGAGGAAGT AGCAGAGGAG 
AAGAGCTACC AGTGTGAGCT CACGGTGGAC GACATCATGC CTGCTGTGAA GACAGTCATC 
CGCTCCATCA GGATTCTCAA GTTCCTGGTG GCCAAAAGGA AATTCAAGGA GACACTGCGA 
CCGTACGACG TGAAGGACGT CATTGAGCAG TACTCAGCAG GCCACCTGGA CATGCTGGGC 
CGGATCAAGA GCCTGCAAAC TCGGGTGGAC CAAATTGTGG GTCGGGGGCC CGGGGACAGG 
AAGGCCCGGG AGAAGGGCGA CAAGGGGCCC TCCGACGCGG AGGTGGTGGA TGAAATCAGC 
ATGATGGGAC GCGTGGTCAA GGTGGAGAAG CAGGTGCAGT CCATCGAGCA CAAGCTGGAC 
CTGCTGTTGG GCTTCTATTC GCGCTGCCTG CGCTCTGGCA CCTCGGCCAG CCTGGGCGCC 
GTGCAAGTGC CGCTGTTCGA CCCCGACATC ACCTCCGACT ACCACAGCCC TGTGGACCAC 
GAGGACATCT CCGTCTCCGC ACAGACGCTC AGCATCTCCC GCTCGGTCAG CACCAACATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751895.1
CDS	83..2008
Translation	MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target ORF information:

RefSeq Version	NM_172163.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172163.2

ORF Insert Sequence:

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG CAGCCGGATG 
GGCATCAAAG ACCGCATCCG CATGGGCAGC TCCCAGCGGC GGACGGGTCC TTCCAAGCAG 
CATCTGGCAC CTCCAACAAT GCCCACCTCC CCAAGCAGCG AGCAGGTGGG TGAGGCCACC 
AGCCCCACCA AGGTGCAAAA GAGCTGGAGC TTCAATGACC GCACCCGCTT CCGGGCATCT 
CTGAGACTCA AACCCCGCAC CTCTGCTGAG GATGCCCCCT CAGAGGAAGT AGCAGAGGAG 
AAGAGCTACC AGTGTGAGCT CACGGTGGAC GACATCATGC CTGCTGTGAA GACAGTCATC 
CGCTCCATCA GGATTCTCAA GTTCCTGGTG GCCAAAAGGA AATTCAAGGA GACACTGCGA 
CCGTACGACG TGAAGGACGT CATTGAGCAG TACTCAGCAG GCCACCTGGA CATGCTGGGC 
CGGATCAAGA GCCTGCAAAC TCGGGTGGAC CAAATTGTGG GTCGGGGGCC CGGGGACAGG 
AAGGCCCGGG AGAAGGGCGA CAAGGGGCCC TCCGACGCGG AGGTGGTGGA TGAAATCAGC 
ATGATGGGAC GCGTGGTCAA GGTGGAGAAG CAGGTGCAGT CCATCGAGCA CAAGCTGGAC 
CTGCTGTTGG GCTTCTATTC GCGCTGCCTG CGCTCTGGCA CCTCGGCCAG CCTGGGCGCC 
GTGCAAGTGC CGCTGTTCGA CCCCGACATC ACCTCCGACT ACCACAGCCC TGTGGACCAC 
GAGGACATCT CCGTCTCCGC ACAGACGCTC AGCATCTCCC GCTCGGTCAG CACCAACATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNQ4 ( NM_172163.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_751895.1 Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu21859
Clone ID Related Accession (Same CDS sequence)	NM_172163.2 , NM_172163.3
Accession Version	NM_172163.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily KQT member 4 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119677.2, AF105202.1, DA782056.1, AK074957.1 and CA411644.1. On May 31, 2019 this sequence version replaced NM_172163.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. There are no publicly available transcripts supporting this variant; it is represented based on data in PMID:10025409. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2158800, SAMEA2161920 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG CAGCCGGATG 
GGCATCAAAG ACCGCATCCG CATGGGCAGC TCCCAGCGGC GGACGGGTCC TTCCAAGCAG 
CATCTGGCAC CTCCAACAAT GCCCACCTCC CCAAGCAGCG AGCAGGTGGG TGAGGCCACC 
AGCCCCACCA AGGTGCAAAA GAGCTGGAGC TTCAATGACC GCACCCGCTT CCGGGCATCT 
CTGAGACTCA AACCCCGCAC CTCTGCTGAG GATGCCCCCT CAGAGGAAGT AGCAGAGGAG 
AAGAGCTACC AGTGTGAGCT CACGGTGGAC GACATCATGC CTGCTGTGAA GACAGTCATC 
CGCTCCATCA GGATTCTCAA GTTCCTGGTG GCCAAAAGGA AATTCAAGGA GACACTGCGA 
CCGTACGACG TGAAGGACGT CATTGAGCAG TACTCAGCAG GCCACCTGGA CATGCTGGGC 
CGGATCAAGA GCCTGCAAAC TCGGGTGGAC CAAATTGTGG GTCGGGGGCC CGGGGACAGG 
AAGGCCCGGG AGAAGGGCGA CAAGGGGCCC TCCGACGCGG AGGTGGTGGA TGAAATCAGC 
ATGATGGGAC GCGTGGTCAA GGTGGAGAAG CAGGTGCAGT CCATCGAGCA CAAGCTGGAC 
CTGCTGTTGG GCTTCTATTC GCGCTGCCTG CGCTCTGGCA CCTCGGCCAG CCTGGGCGCC 
GTGCAAGTGC CGCTGTTCGA CCCCGACATC ACCTCCGACT ACCACAGCCC TGTGGACCAC 
GAGGACATCT CCGTCTCCGC ACAGACGCTC AGCATCTCCC GCTCGGTCAG CACCAACATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_751895.1
CDS	308..2233
Translation	MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFSSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target ORF information:

RefSeq Version	NM_172163.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172163.3

ORF Insert Sequence:

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG CAGCCGGATG 
GGCATCAAAG ACCGCATCCG CATGGGCAGC TCCCAGCGGC GGACGGGTCC TTCCAAGCAG 
CATCTGGCAC CTCCAACAAT GCCCACCTCC CCAAGCAGCG AGCAGGTGGG TGAGGCCACC 
AGCCCCACCA AGGTGCAAAA GAGCTGGAGC TTCAATGACC GCACCCGCTT CCGGGCATCT 
CTGAGACTCA AACCCCGCAC CTCTGCTGAG GATGCCCCCT CAGAGGAAGT AGCAGAGGAG 
AAGAGCTACC AGTGTGAGCT CACGGTGGAC GACATCATGC CTGCTGTGAA GACAGTCATC 
CGCTCCATCA GGATTCTCAA GTTCCTGGTG GCCAAAAGGA AATTCAAGGA GACACTGCGA 
CCGTACGACG TGAAGGACGT CATTGAGCAG TACTCAGCAG GCCACCTGGA CATGCTGGGC 
CGGATCAAGA GCCTGCAAAC TCGGGTGGAC CAAATTGTGG GTCGGGGGCC CGGGGACAGG 
AAGGCCCGGG AGAAGGGCGA CAAGGGGCCC TCCGACGCGG AGGTGGTGGA TGAAATCAGC 
ATGATGGGAC GCGTGGTCAA GGTGGAGAAG CAGGTGCAGT CCATCGAGCA CAAGCTGGAC 
CTGCTGTTGG GCTTCTATTC GCGCTGCCTG CGCTCTGGCA CCTCGGCCAG CCTGGGCGCC 
GTGCAAGTGC CGCTGTTCGA CCCCGACATC ACCTCCGACT ACCACAGCCC TGTGGACCAC 
GAGGACATCT CCGTCTCCGC ACAGACGCTC AGCATCTCCC GCTCGGTCAG CACCAACATG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNQ4 ( NM_004700.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004691.2 Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.

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CloneID	OHu22778
Clone ID Related Accession (Same CDS sequence)	NM_004700.4 , NM_004700.3
Accession Version	NM_004700.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily KQT member 4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC119677.2, AF105202.1, DA782056.1, AK074957.1 and CA411644.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004700.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer and predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF105202.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000347132.10/ ENSP00000262916.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG AGAGCTGGCC 
CTCTTGTTTG AGCACGTGCA ACGGGCCCGC AATGGGGGCC TACGGCCCCT GGAGGTGCGG 
CGGGCGCCGG TACCCGACGG AGCACCCTCC CGTTACCCGC CCGTTGCCAC CTGCCACCGG 
CCGGGCAGCA CCTCCTTCTG CCCTGGGGAA AGCAGCCGGA TGGGCATCAA AGACCGCATC 
CGCATGGGCA GCTCCCAGCG GCGGACGGGT CCTTCCAAGC AGCATCTGGC ACCTCCAACA 
ATGCCCACCT CCCCAAGCAG CGAGCAGGTG GGTGAGGCCA CCAGCCCCAC CAAGGTGCAA 
AAGAGCTGGA GCTTCAATGA CCGCACCCGC TTCCGGGCAT CTCTGAGACT CAAACCCCGC 
ACCTCTGCTG AGGATGCCCC CTCAGAGGAA GTAGCAGAGG AGAAGAGCTA CCAGTGTGAG 
CTCACGGTGG ACGACATCAT GCCTGCTGTG AAGACAGTCA TCCGCTCCAT CAGGATTCTC 
AAGTTCCTGG TGGCCAAAAG GAAATTCAAG GAGACACTGC GACCGTACGA CGTGAAGGAC 
GTCATTGAGC AGTACTCAGC AGGCCACCTG GACATGCTGG GCCGGATCAA GAGCCTGCAA 
ACTCGGGTGG ACCAAATTGT GGGTCGGGGG CCCGGGGACA GGAAGGCCCG GGAGAAGGGC 
GACAAGGGGC CCTCCGACGC GGAGGTGGTG GATGAAATCA GCATGATGGG ACGCGTGGTC 
AAGGTGGAGA AGCAGGTGCA GTCCATCGAG CACAAGCTGG ACCTGCTGTT GGGCTTCTAT 
TCGCGCTGCC TGCGCTCTGG CACCTCGGCC AGCCTGGGCG CCGTGCAAGT GCCGCTGTTC 
GACCCCGACA TCACCTCCGA CTACCACAGC CCTGTGGACC ACGAGGACAT CTCCGTCTCC 
GCACAGACGC TCAGCATCTC CCGCTCGGTC AGCACCAACA TGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004691.2
CDS	308..2395
Translation	MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target ORF information:

RefSeq Version	NM_004700.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004700.4

ORF Insert Sequence:

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG AGAGCTGGCC 
CTCTTGTTTG AGCACGTGCA ACGGGCCCGC AATGGGGGCC TACGGCCCCT GGAGGTGCGG 
CGGGCGCCGG TACCCGACGG AGCACCCTCC CGTTACCCGC CCGTTGCCAC CTGCCACCGG 
CCGGGCAGCA CCTCCTTCTG CCCTGGGGAA AGCAGCCGGA TGGGCATCAA AGACCGCATC 
CGCATGGGCA GCTCCCAGCG GCGGACGGGT CCTTCCAAGC AGCATCTGGC ACCTCCAACA 
ATGCCCACCT CCCCAAGCAG CGAGCAGGTG GGTGAGGCCA CCAGCCCCAC CAAGGTGCAA 
AAGAGCTGGA GCTTCAATGA CCGCACCCGC TTCCGGGCAT CTCTGAGACT CAAACCCCGC 
ACCTCTGCTG AGGATGCCCC CTCAGAGGAA GTAGCAGAGG AGAAGAGCTA CCAGTGTGAG 
CTCACGGTGG ACGACATCAT GCCTGCTGTG AAGACAGTCA TCCGCTCCAT CAGGATTCTC 
AAGTTCCTGG TGGCCAAAAG GAAATTCAAG GAGACACTGC GACCGTACGA CGTGAAGGAC 
GTCATTGAGC AGTACTCAGC AGGCCACCTG GACATGCTGG GCCGGATCAA GAGCCTGCAA 
ACTCGGGTGG ACCAAATTGT GGGTCGGGGG CCCGGGGACA GGAAGGCCCG GGAGAAGGGC 
GACAAGGGGC CCTCCGACGC GGAGGTGGTG GATGAAATCA GCATGATGGG ACGCGTGGTC 
AAGGTGGAGA AGCAGGTGCA GTCCATCGAG CACAAGCTGG ACCTGCTGTT GGGCTTCTAT 
TCGCGCTGCC TGCGCTCTGG CACCTCGGCC AGCCTGGGCG CCGTGCAAGT GCCGCTGTTC 
GACCCCGACA TCACCTCCGA CTACCACAGC CCTGTGGACC ACGAGGACAT CTCCGTCTCC 
GCACAGACGC TCAGCATCTC CCGCTCGGTC AGCACCAACA TGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNQ4 ( NM_004700.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004691.2 Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.

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CloneID	OHu22778
Clone ID Related Accession (Same CDS sequence)	NM_004700.4 , NM_004700.3
Accession Version	NM_004700.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily KQT member 4 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF105202.1, DA782056.1, AK074957.1, AC119677.2 and CA411644.1. This sequence is a reference standard in the RefSeqGene project. On Aug 10, 2010 this sequence version replaced NM_004700.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer and predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF105202.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG AGAGCTGGCC 
CTCTTGTTTG AGCACGTGCA ACGGGCCCGC AATGGGGGCC TACGGCCCCT GGAGGTGCGG 
CGGGCGCCGG TACCCGACGG AGCACCCTCC CGTTACCCGC CCGTTGCCAC CTGCCACCGG 
CCGGGCAGCA CCTCCTTCTG CCCTGGGGAA AGCAGCCGGA TGGGCATCAA AGACCGCATC 
CGCATGGGCA GCTCCCAGCG GCGGACGGGT CCTTCCAAGC AGCATCTGGC ACCTCCAACA 
ATGCCCACCT CCCCAAGCAG CGAGCAGGTG GGTGAGGCCA CCAGCCCCAC CAAGGTGCAA 
AAGAGCTGGA GCTTCAATGA CCGCACCCGC TTCCGGGCAT CTCTGAGACT CAAACCCCGC 
ACCTCTGCTG AGGATGCCCC CTCAGAGGAA GTAGCAGAGG AGAAGAGCTA CCAGTGTGAG 
CTCACGGTGG ACGACATCAT GCCTGCTGTG AAGACAGTCA TCCGCTCCAT CAGGATTCTC 
AAGTTCCTGG TGGCCAAAAG GAAATTCAAG GAGACACTGC GACCGTACGA CGTGAAGGAC 
GTCATTGAGC AGTACTCAGC AGGCCACCTG GACATGCTGG GCCGGATCAA GAGCCTGCAA 
ACTCGGGTGG ACCAAATTGT GGGTCGGGGG CCCGGGGACA GGAAGGCCCG GGAGAAGGGC 
GACAAGGGGC CCTCCGACGC GGAGGTGGTG GATGAAATCA GCATGATGGG ACGCGTGGTC 
AAGGTGGAGA AGCAGGTGCA GTCCATCGAG CACAAGCTGG ACCTGCTGTT GGGCTTCTAT 
TCGCGCTGCC TGCGCTCTGG CACCTCGGCC AGCCTGGGCG CCGTGCAAGT GCCGCTGTTC 
GACCCCGACA TCACCTCCGA CTACCACAGC CCTGTGGACC ACGAGGACAT CTCCGTCTCC 
GCACAGACGC TCAGCATCTC CCGCTCGGTC AGCACCAACA TGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004691.2
CDS	83..2170
Translation	MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target ORF information:

RefSeq Version	NM_004700.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily Q member 4 (KCNQ4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004700.3

ORF Insert Sequence:

ATGGCCGAGG CCCCCCCGCG CCGCCTCGGC CTGGGTCCCC CGCCCGGGGA CGCCCCCCGC 
GCGGAGCTAG TGGCGCTCAC GGCCGTGCAG AGCGAACAGG GCGAGGCGGG CGGGGGCGGC 
TCCCCGCGCC GCCTCGGCCT CCTGGGCAGC CCCCTGCCGC CGGGCGCGCC CCTCCCTGGG 
CCGGGCTCCG GCTCGGGCTC CGCCTGCGGC CAGCGCTCCT CGGCCGCGCA CAAGCGCTAC 
CGCCGCCTGC AGAACTGGGT CTACAACGTG CTGGAGCGGC CCCGCGGCTG GGCCTTCGTC 
TACCACGTCT TCATATTTTT GCTGGTCTTC AGCTGCCTGG TGCTGTCTGT GCTGTCCACT 
ATCCAGGAGC ACCAGGAACT TGCCAACGAG TGTCTCCTCA TCTTGGAATT CGTGATGATC 
GTGGTTTTCG GCTTGGAGTA CATCGTCCGG GTCTGGTCCG CCGGATGCTG CTGCCGCTAC 
CGAGGATGGC AGGGTCGCTT CCGCTTTGCC AGAAAGCCCT TCTGTGTCAT CGACTTCATC 
GTGTTCGTGG CCTCGGTGGC CGTCATCGCC GCGGGTACCC AGGGCAACAT CTTCGCCACG 
TCCGCGCTGC GCAGCATGCG CTTCCTGCAG ATCCTGCGCA TGGTGCGCAT GGACCGCCGC 
GGCGGCACCT GGAAGCTGCT GGGCTCAGTG GTCTACGCGC ATAGCAAGGA GCTGATCACC 
GCCTGGTACA TCGGGTTCCT GGTGCTCATC TTCGCCTCCT TCCTGGTCTA CCTGGCTGAG 
AAGGACGCCA ACTCCGACTT CTCCTCCTAC GCCGACTCGC TCTGGTGGGG GACGATTACA 
TTGACAACCA TCGGCTATGG TGACAAGACA CCGCACACAT GGCTGGGCAG GGTCCTGGCT 
GCTGGCTTCG CCTTACTGGG CATCTCTTTC TTTGCCCTGC CTGCCGGCAT CCTAGGCTCC 
GGCTTTGCCC TGAAGGTCCA GGAGCAGCAC CGGCAGAAGC ACTTCGAGAA GCGGAGGATG 
CCGGCAGCCA ACCTCATCCA GGCTGCCTGG CGCCTGTACT CCACCGATAT GAGCCGGGCC 
TACCTGACAG CCACCTGGTA CTACTATGAC AGTATCCTCC CATCCTTCAG AGAGCTGGCC 
CTCTTGTTTG AGCACGTGCA ACGGGCCCGC AATGGGGGCC TACGGCCCCT GGAGGTGCGG 
CGGGCGCCGG TACCCGACGG AGCACCCTCC CGTTACCCGC CCGTTGCCAC CTGCCACCGG 
CCGGGCAGCA CCTCCTTCTG CCCTGGGGAA AGCAGCCGGA TGGGCATCAA AGACCGCATC 
CGCATGGGCA GCTCCCAGCG GCGGACGGGT CCTTCCAAGC AGCATCTGGC ACCTCCAACA 
ATGCCCACCT CCCCAAGCAG CGAGCAGGTG GGTGAGGCCA CCAGCCCCAC CAAGGTGCAA 
AAGAGCTGGA GCTTCAATGA CCGCACCCGC TTCCGGGCAT CTCTGAGACT CAAACCCCGC 
ACCTCTGCTG AGGATGCCCC CTCAGAGGAA GTAGCAGAGG AGAAGAGCTA CCAGTGTGAG 
CTCACGGTGG ACGACATCAT GCCTGCTGTG AAGACAGTCA TCCGCTCCAT CAGGATTCTC 
AAGTTCCTGG TGGCCAAAAG GAAATTCAAG GAGACACTGC GACCGTACGA CGTGAAGGAC 
GTCATTGAGC AGTACTCAGC AGGCCACCTG GACATGCTGG GCCGGATCAA GAGCCTGCAA 
ACTCGGGTGG ACCAAATTGT GGGTCGGGGG CCCGGGGACA GGAAGGCCCG GGAGAAGGGC 
GACAAGGGGC CCTCCGACGC GGAGGTGGTG GATGAAATCA GCATGATGGG ACGCGTGGTC 
AAGGTGGAGA AGCAGGTGCA GTCCATCGAG CACAAGCTGG ACCTGCTGTT GGGCTTCTAT 
TCGCGCTGCC TGCGCTCTGG CACCTCGGCC AGCCTGGGCG CCGTGCAAGT GCCGCTGTTC 
GACCCCGACA TCACCTCCGA CTACCACAGC CCTGTGGACC ACGAGGACAT CTCCGTCTCC 
GCACAGACGC TCAGCATCTC CCGCTCGGTC AGCACCAACA TGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[The genetic aspects of occupational hearing impairment].
Vestnik otorinolaringologii82(5)71-76(2017)
Krasitskaya VV,Bashmakova EE,Dobretsov KG,Orlova NV,Frank LA

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KCNQ4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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