FCGR2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FCGR2C
Entrez Gene ID	9103
Full Name	Fc fragment of IgG receptor IIc (gene/pseudogene)
Synonyms	CD32,CD32C,CDW32,FCG2,FCRIIC,IGFR2
General protein information	Preferred Names Fc fragment of IgG receptor IIc (gene/pseudogene) Names low affinity immunoglobulin gamma Fc region receptor II-c Fc fragment of IgG, low affinity IIc, receptor for (CD32) Fc gamma receptor IIC IgG Fc receptor II-c fc-gamma-RIIc immunoglobulin G Fc receptor II-c
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012].
Disorder MIM:	612169
Disorder Html:	Thrombocytopenic purpura, autoimmune, 188030 (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_201563.5	NP_963857.3	low affinity immunoglobulin gamma Fc region receptor II-c precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Nonclassical
Meinderts SM, Sins JWR, Fijnvandraat K, Nagelkerke SQ, Geissler J, Tanck MW, Bruggeman C, Biemond BJ, Rijneveld AW, Kerkhoffs JH, Pakdaman S, Habibi A, van Bruggen R, Kuijpers TW, Pirenne F, van den Berg TK
Blood130(19)2121-2130(2017 11)

Pyruvate Kinase and Fc? Receptor Gene Copy Numbers Associated With Malaria Phenotypes.
Faik I, van Tong H, Lell B, Meyer CG, Kremsner PG, Velavan TP
The Journal of infectious diseases216(2)276-282(2017 Jul)

FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma.
Erbe AK, Wang W, Goldberg J, Gallenberger M, Kim K, Carmichael L, Hess D, Mendonca EA, Song Y, Hank JA, Cheng SC, Signoretti S, Atkins M, Carlson A, Mier JW, Panka DJ, McDermott DF, Sondel PM
Clinical cancer research : an official journal of the American Association for Cancer Research23(9)2159-2168(2017 May)

FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-? Receptors in Human B Cells.
Peng X, Li SS, Gilbert PB, Geraghty DE, Katze MG
PloS one11(3)e0152425(2016)

Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis.
Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, Wan B, Kwak LW, Yu L, Yi Q
Cancer cell12(3)252-65(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The nonclassical open reading frame in the FCGR2C gene (FCGR2C.nc-ORF) was strongly associated with a decreased alloimmunization risk (odds ratio [OR] 0.26, 95% confidence [CI] 0.11-0.64).
Title: Nonclassical

Gene copy number variation (CNV) of the PKLR, FCGR2A, FCGR2C, and FCGR3 genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.
Title: Pyruvate Kinase and Fc? Receptor Gene Copy Numbers Associated With Malaria Phenotypes.

The findings of this study highlight further ethnic variation at the FCGR gene locus, in particular for FCGR2C, a gene with increasingly recognized clinical significance.
Title: Variability at the FCGR locus: characterization in Black South Africans and evidence for ethnic variation in and out of Africa.

FCGR2A and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis.
Title: Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis.

FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A/C and one of them also associated with the expression of Fc receptor-like A (FCRLA), another Fc-gamma receptor (FcgammaR) gene
Title: FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-? Receptors in Human B Cells.

The following FCGR2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FCGR2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu28053	NM_201563.5 Latest version!	Homo sapiens Fc fragment of IgG receptor IIc (gene/pseudogene) (FCGR2C), transcript variant 1, coding, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FCGR2C ( NM_201563.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_963857.3 Homo sapiens Fc fragment of IgG receptor IIc (gene/pseudogene) (FCGR2C), transcript variant 1, coding, mRNA.

Price & Availability↑

CloneID	OHu28053
Clone ID Related Accession (Same CDS sequence)	NM_201563.5
Accession Version	NM_201563.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Homo sapiens(human)
Product	low affinity immunoglobulin gamma Fc region receptor II-c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA851200.1, U90938.1 and AL451067.12. This sequence is a reference standard in the RefSeqGene project. On Feb 22, 2014 this sequence version replaced NM_201563.4. Transcript Variant: This variant (1, coding) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.35654.1, SRR1163657.561582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 12215903 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGAATCC TGTCATTCTT ACCTGTCCTT GCCACTGAGA GTGACTGGGC TGACTGCAAG 
TCCCCCCAGC CTTGGGGTCA TATGCTTCTG TGGACAGCTG TGCTATTCCT GGCTCCTGTT 
GCTGGGACAC CTGCAGCTCC CCCAAAGGCT GTGCTGAAAC TCGAGCCCCA GTGGATCAAC 
GTGCTCCAAG AGGACTCTGT GACTCTGACA TGCCGGGGGA CTCACAGCCC TGAGAGCGAC 
TCCATTCCGT GGTTCCACAA TGGGAATCTC ATTCCCACCC ACACGCAGCC CAGCTACAGG 
TTCAAGGCCA ACAACAATGA CAGCGGGGAG TACACGTGCC AGACTGGCCA GACCAGCCTC 
AGCGACCCTG TGCATCTGAC TGTGCTTTCT GAGTGGCTGG TGCTCCAGAC CCCTCACCTG 
GAGTTCCAGG AGGGAGAAAC CATCGTGCTG AGGTGCCACA GCTGGAAGGA CAAGCCTCTG 
GTCAAGGTCA CATTCTTCCA GAATGGAAAA TCCAAGAAAT TTTCCCGTTC GGATCCCAAC 
TTCTCCATCC CACAAGCAAA CCACAGTCAC AGTGGTGATT ACCACTGCAC AGGAAACATA 
GGCTACACGC TGTACTCATC CAAGCCTGTG ACCATCACTG TCCAAGCTCC CAGCTCTTCA 
CCGATGGGGA TCATTGTGGC TGTGGTCACT GGGATTGCTG TAGCGGCCAT TGTTGCTGCT 
GTAGTGGCCT TGATCTACTG CAGGAAAAAG CGGATTTCAG CCAATTCCAC TGATCCTGTG 
AAGGCTGCCC AATTTGAGCC ACCTGGACGT CAAATGATTG CCATCAGAAA GAGACAACCT 
GAAGAAACCA ACAATGACTA TGAAACAGCT GACGGCGGCT ACATGACTCT GAACCCCAGG 
GCACCTACTG ACGATGATAA AAACATCTAC CTGACTCTTC CTCCCAACGA CCATGTCAAC 
AGTAATAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_963857.3
CDS	100..1071
Translation	MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIPWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQPEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN

Target ORF information:

RefSeq Version	NM_201563.5
Organism	Homo sapiens(human)
Definition	Homo sapiens Fc fragment of IgG receptor IIc (gene/pseudogene) (FCGR2C), transcript variant 1, coding, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201563.5

ORF Insert Sequence:

ATGGGAATCC TGTCATTCTT ACCTGTCCTT GCCACTGAGA GTGACTGGGC TGACTGCAAG 
TCCCCCCAGC CTTGGGGTCA TATGCTTCTG TGGACAGCTG TGCTATTCCT GGCTCCTGTT 
GCTGGGACAC CTGCAGCTCC CCCAAAGGCT GTGCTGAAAC TCGAGCCCCA GTGGATCAAC 
GTGCTCCAAG AGGACTCTGT GACTCTGACA TGCCGGGGGA CTCACAGCCC TGAGAGCGAC 
TCCATTCCGT GGTTCCACAA TGGGAATCTC ATTCCCACCC ACACGCAGCC CAGCTACAGG 
TTCAAGGCCA ACAACAATGA CAGCGGGGAG TACACGTGCC AGACTGGCCA GACCAGCCTC 
AGCGACCCTG TGCATCTGAC TGTGCTTTCT GAGTGGCTGG TGCTCCAGAC CCCTCACCTG 
GAGTTCCAGG AGGGAGAAAC CATCGTGCTG AGGTGCCACA GCTGGAAGGA CAAGCCTCTG 
GTCAAGGTCA CATTCTTCCA GAATGGAAAA TCCAAGAAAT TTTCCCGTTC GGATCCCAAC 
TTCTCCATCC CACAAGCAAA CCACAGTCAC AGTGGTGATT ACCACTGCAC AGGAAACATA 
GGCTACACGC TGTACTCATC CAAGCCTGTG ACCATCACTG TCCAAGCTCC CAGCTCTTCA 
CCGATGGGGA TCATTGTGGC TGTGGTCACT GGGATTGCTG TAGCGGCCAT TGTTGCTGCT 
GTAGTGGCCT TGATCTACTG CAGGAAAAAG CGGATTTCAG CCAATTCCAC TGATCCTGTG 
AAGGCTGCCC AATTTGAGCC ACCTGGACGT CAAATGATTG CCATCAGAAA GAGACAACCT 
GAAGAAACCA ACAATGACTA TGAAACAGCT GACGGCGGCT ACATGACTCT GAACCCCAGG 
GCACCTACTG ACGATGATAA AAACATCTAC CTGACTCTTC CTCCCAACGA CCATGTCAAC 
AGTAATAACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nonclassical
Blood130(19)2121-2130(2017 11)
Meinderts SM,Sins JWR,Fijnvandraat K,Nagelkerke SQ,Geissler J,Tanck MW,Bruggeman C,Biemond BJ,Rijneveld AW,Kerkhoffs JH,Pakdaman S,Habibi A,van Bruggen R,Kuijpers TW,Pirenne F,van den Berg TK

Pyruvate Kinase and Fc? Receptor Gene Copy Numbers Associated With Malaria Phenotypes.
The Journal of infectious diseases216(2)276-282(2017 Jul)
Faik I,van Tong H,Lell B,Meyer CG,Kremsner PG,Velavan TP

FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research23(9)2159-2168(2017 May)
Erbe AK,Wang W,Goldberg J,Gallenberger M,Kim K,Carmichael L,Hess D,Mendonca EA,Song Y,Hank JA,Cheng SC,Signoretti S,Atkins M,Carlson A,Mier JW,Panka DJ,McDermott DF,Sondel PM

FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-? Receptors in Human B Cells.
PloS one11(3)e0152425(2016)
Peng X,Li SS,Gilbert PB,Geraghty DE,Katze MG

Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis.
Cancer cell12(3)252-65(2007 Sep)
Yang J,Wezeman M,Zhang X,Lin P,Wang M,Qian J,Wan B,Kwak LW,Yu L,Yi Q

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FCGR2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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