CLDN9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN9
Entrez Gene ID	9080
Full Name	claudin 9
General protein information	Preferred Names claudin 9 Names claudin-9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010].
Disorder MIM:	615799

mRNA and Protein(s)

mRNA	Protein	Name
NM_020982.3	NP_066192.1	claudin-9
NM_020982.4	NP_066192.1	claudin-9

Pathways from BioSystems

Homologies

	CLDN9	XP_001088610.1
Rattus norvegicus (Norway rat)	Cldn9	NP_001011889.1
Danio rerio (zebrafish)	cldnc	NP_571839.1
Bos taurus (cattle)	CLDN9	XP_002697981.1
Homo sapiens (human)	CLDN9	NP_066192.1
Pan troglodytes (chimpanzee)	CLDN9	XP_003314989.1
Mus musculus (house mouse)	Cldn9	NP_064689.2
Canis lupus familiaris (dog)	CLDN9	XP_005621712.1

Gene Ontology
Bibliography

Related articles in PubMed

TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.
Chavarr?a-Vel?zquez CO, Torres-Mart?nez AC, Monta?o LF, Rend?n-Huerta EP
Immunobiology223(1)38-48(2018 Jan)

Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.
Zhu J, Wang R, Cao H, Zhang H, Xu S, Wang A, Liu B, Wang Y, Wang R
International journal of clinical and experimental pathology8(8)9479-86(2015)

Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.
Hong L, Wu Y, Feng J, Yu S, Li C, Wu Y, Li Z, Cao L, Wang F, Zhang Y
Human pathology45(12)2423-9(2014 Dec)

Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
Fofana I, Zona L, Thumann C, Heydmann L, Durand SC, Lupberger J, Blum HE, Pessaux P, Gondeau C, Reynolds GM, McKeating JA, Grunert F, Thompson J, Zeisel MB, Baumert TF
Journal of virology87(18)10405-10(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.
Title: Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.

CLDN9 may be an important biomarker for invasive pituitary oncocytomas.
Title: Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.

Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9.
Title: Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.

Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line.
Title: Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate.

Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis.
Title: Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas.

The following CLDN9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24658	NM_020982.4 Latest version!	Homo sapiens claudin 9 (CLDN9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu24658	NM_020982.3	Homo sapiens claudin 9 (CLDN9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN9 ( NM_020982.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_066192.1 Homo sapiens claudin 9 (CLDN9), mRNA.

Price & Availability↑

CloneID	OHu24658
Clone ID Related Accession (Same CDS sequence)	NM_020982.3 , NM_020982.4
Accession Version	NM_020982.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	claudin-9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK091002.1, AC108134.3, BC051870.1 and AI791760.1. On or before Apr 4, 2009 this sequence version replaced XM_001715692.1, NM_020982.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGGCTTCGA CCGGCTTAGA ACTGCTGGGC ATGACCCTGG CTGTGCTGGG CTGGCTGGGG 
ACCCTGGTGT CCTGCGCCCT GCCCCTGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACGGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCTCTGC CGCAGGACCT GCAGGCCGCA 
CGTGCCCTCT GTGTCATTGC CCTCCTGCTG GCCCTGCTTG GCCTCCTGGT GGCCATCACA 
GGTGCCCAGT GTACCACGTG TGTGGAGGAC GAAGGTGCCA AGGCCCGTAT CGTGCTCACC 
GCGGGGGTCA TCCTCCTCCT CGCCGGCATC CTGGTGCTCA TCCCTGTGTG CTGGACGGCG 
CACGCCATCA TCCAGGACTT CTACAACCCC CTGGTGGCTG AGGCCCTCAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCGGCG GCTGCACTGC TTATGCTGGG CGGGGGGCTC 
CTCTGCTGCA CGTGCCCCCC GCCCCAGGTC GAGCGGCCCC GCGGACCTCG GCTGGGCTAC 
TCCATCCCCT CCCGCTCGGG TGCATCTGGA CTGGACAAGA GGGACTACGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066192.1
CDS	908..1561
Translation	MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV

Target ORF information:

RefSeq Version	NM_020982.3
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 9 (CLDN9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020982.3

ORF Insert Sequence:

ATGGCTTCGA CCGGCTTAGA ACTGCTGGGC ATGACCCTGG CTGTGCTGGG CTGGCTGGGG 
ACCCTGGTGT CCTGCGCCCT GCCCCTGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACGGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCTCTGC CGCAGGACCT GCAGGCCGCA 
CGTGCCCTCT GTGTCATTGC CCTCCTGCTG GCCCTGCTTG GCCTCCTGGT GGCCATCACA 
GGTGCCCAGT GTACCACGTG TGTGGAGGAC GAAGGTGCCA AGGCCCGTAT CGTGCTCACC 
GCGGGGGTCA TCCTCCTCCT CGCCGGCATC CTGGTGCTCA TCCCTGTGTG CTGGACGGCG 
CACGCCATCA TCCAGGACTT CTACAACCCC CTGGTGGCTG AGGCCCTCAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCGGCG GCTGCACTGC TTATGCTGGG CGGGGGGCTC 
CTCTGCTGCA CGTGCCCCCC GCCCCAGGTC GAGCGGCCCC GCGGACCTCG GCTGGGCTAC 
TCCATCCCCT CCCGCTCGGG TGCATCTGGA CTGGACAAGA GGGACTACGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN9 ( NM_020982.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066192.1 Homo sapiens claudin 9 (CLDN9), mRNA.

Price & Availability↑

CloneID	OHu24658
Clone ID Related Accession (Same CDS sequence)	NM_020982.3 , NM_020982.4
Accession Version	NM_020982.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	claudin-9
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK091002.1, BC051870.1 and AI791760.1. On Nov 23, 2018 this sequence version replaced NM_020982.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK091002.1, BC065830.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000445369.3/ ENSP00000398017.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCGA CCGGCTTAGA ACTGCTGGGC ATGACCCTGG CTGTGCTGGG CTGGCTGGGG 
ACCCTGGTGT CCTGCGCCCT GCCCCTGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACGGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCTCTGC CGCAGGACCT GCAGGCCGCA 
CGTGCCCTCT GTGTCATTGC CCTCCTGCTG GCCCTGCTTG GCCTCCTGGT GGCCATCACA 
GGTGCCCAGT GTACCACGTG TGTGGAGGAC GAAGGTGCCA AGGCCCGTAT CGTGCTCACC 
GCGGGGGTCA TCCTCCTCCT CGCCGGCATC CTGGTGCTCA TCCCTGTGTG CTGGACGGCG 
CACGCCATCA TCCAGGACTT CTACAACCCC CTGGTGGCTG AGGCCCTCAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCGGCG GCTGCACTGC TTATGCTGGG CGGGGGGCTC 
CTCTGCTGCA CGTGCCCCCC GCCCCAGGTC GAGCGGCCCC GCGGACCTCG GCTGGGCTAC 
TCCATCCCCT CCCGCTCGGG TGCATCTGGA CTGGACAAGA GGGACTACGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066192.1
CDS	441..1094
Translation	MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV

Target ORF information:

RefSeq Version	NM_020982.4
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 9 (CLDN9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020982.4

ORF Insert Sequence:

ATGGCTTCGA CCGGCTTAGA ACTGCTGGGC ATGACCCTGG CTGTGCTGGG CTGGCTGGGG 
ACCCTGGTGT CCTGCGCCCT GCCCCTGTGG AAGGTGACCG CCTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACGGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCTCTGC CGCAGGACCT GCAGGCCGCA 
CGTGCCCTCT GTGTCATTGC CCTCCTGCTG GCCCTGCTTG GCCTCCTGGT GGCCATCACA 
GGTGCCCAGT GTACCACGTG TGTGGAGGAC GAAGGTGCCA AGGCCCGTAT CGTGCTCACC 
GCGGGGGTCA TCCTCCTCCT CGCCGGCATC CTGGTGCTCA TCCCTGTGTG CTGGACGGCG 
CACGCCATCA TCCAGGACTT CTACAACCCC CTGGTGGCTG AGGCCCTCAA GCGGGAGCTG 
GGGGCCTCCC TCTACCTGGG CTGGGCGGCG GCTGCACTGC TTATGCTGGG CGGGGGGCTC 
CTCTGCTGCA CGTGCCCCCC GCCCCAGGTC GAGCGGCCCC GCGGACCTCG GCTGGGCTAC 
TCCATCCCCT CCCGCTCGGG TGCATCTGGA CTGGACAAGA GGGACTACGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.
Immunobiology223(1)38-48(2018 Jan)
Chavarr?a-Vel?zquez CO,Torres-Mart?nez AC,Monta?o LF,Rend?n-Huerta EP

Expression of claudin-5, -7, -8 and -9 in cervical carcinoma tissues and adjacent non-neoplastic tissues.
International journal of clinical and experimental pathology8(8)9479-86(2015)
Zhu J,Wang R,Cao H,Zhang H,Xu S,Wang A,Liu B,Wang Y,Wang R

Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.
Human pathology45(12)2423-9(2014 Dec)
Hong L,Wu Y,Feng J,Yu S,Li C,Wu Y,Li Z,Cao L,Wang F,Zhang Y

Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
Journal of virology87(18)10405-10(2013 Sep)
Fofana I,Zona L,Thumann C,Heydmann L,Durand SC,Lupberger J,Blum HE,Pessaux P,Gondeau C,Reynolds GM,McKeating JA,Grunert F,Thompson J,Zeisel MB,Baumert TF

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CLDN9 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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