CLDN6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLDN6
Entrez Gene ID	9074
Full Name	claudin 6
General protein information	Preferred Names claudin 6 Names claudin-6 skullin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010].
Disorder MIM:	615798

mRNA and Protein(s)

mRNA	Protein	Name
NM_021195.4	NP_067018.2	claudin-6 precursor
NM_021195.5	NP_067018.2	claudin-6 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CLDN6	XP_523276.1
	CLDN6	XP_001088715.1
Mus musculus (house mouse)	Cldn6	NP_061247.1
Xenopus tropicalis (tropical clawed frog)	cldn6.1	NP_988873.1
Rattus norvegicus (Norway rat)	Cldn6	NP_001095834.1
Bos taurus (cattle)	CLDN6	NP_001192626.1
Homo sapiens (human)	CLDN6	NP_067018.2
Canis lupus familiaris (dog)	CLDN6	XP_547168.2
Danio rerio (zebrafish)	cldne	NP_571840.1
Danio rerio (zebrafish)	cldnd	NP_851295.1
Xenopus tropicalis (tropical clawed frog)	LOC100493413	XP_002941739.1

Gene Ontology
Bibliography

Related articles in PubMed

TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.
Chavarr?a-Vel?zquez CO, Torres-Mart?nez AC, Monta?o LF, Rend?n-Huerta EP
Immunobiology223(1)38-48(2018 Jan)

CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.
Yang M, Li Y, Ruan Y, Lu Y, Lin D, Xie Y, Dong B, Dang Q, Quan C
Molecular and cellular biochemistry(2017 Nov)

Displaying Tetra-Membrane Spanning Claudins on Enveloped Virus-Like Particles for Cancer Immunotherapy.
Schneider IC, Hartmann J, Braun G, Stitz J, Klamp T, Bihi M, Sahin U, Buchholz CJ
Biotechnology journal(2017 Nov)

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer.
Yang M, Li Y, Shen X, Ruan Y, Lu Y, Jin X, Song P, Guo Y, Zhang X, Qu H, Shao Y, Quan C
Journal of experimental & clinical cancer research : CR36(1)157(2017 Nov)

SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells.
Lu Y, Wang L, Li H, Li Y, Ruan Y, Lin D, Yang M, Jin X, Guo Y, Zhang X, Quan C
International journal of molecular sciences18(9)(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cldn6 was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells when exposed to cigarette smoke ext
Title: Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression.

suggest that claudin-6 induces MMP-2 activation through claudin-1 membrane expression
Title: Claudin-6 enhances cell invasiveness through claudin-1 in AGS human adenocarcinoma gastric cancer cells.

Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells.
Title: DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac.

Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry.
Title: Claudin-6 and Occludin Natural Variants Found in a Patient Highly Exposed but Not Infected with Hepatitis C Virus (HCV) Do Not Confer HCV Resistance In Vitro.

The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues.
Title: Expression of apoptosis signal-regulating kinase 1 is associated with tight junction protein claudin-6 in cervical carcinoma.

The following CLDN6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLDN6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24673	NM_021195.5 Latest version!	Homo sapiens claudin 6 (CLDN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu24673	NM_021195.4	Homo sapiens claudin 6 (CLDN6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLDN6 ( NM_021195.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067018.2 Homo sapiens claudin 6 (CLDN6), mRNA.

Price & Availability↑

CloneID	OHu24673
Clone ID Related Accession (Same CDS sequence)	NM_021195.4 , NM_021195.5
Accession Version	NM_021195.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	claudin-6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX444798.2, CN420342.1 and BC008934.2. On Jul 25, 2007 this sequence version replaced NM_021195.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX444798.2, AK075329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCTG CCGGAATGCA GATCCTGGGA GTCGTCCTGA CACTGCTGGG CTGGGTGAAT 
GGCCTGGTCT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CTTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACCGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCGCTGC CACAGGACCT GCAGGCTGCA 
CGTGCCCTCT GTGTCATCGC CCTCCTTGTG GCCCTGTTCG GCTTGCTGGT CTACCTTGCT 
GGGGCCAAGT GTACCACCTG TGTGGAGGAG AAGGATTCCA AGGCCCGCCT GGTGCTCACC 
TCTGGGATTG TCTTTGTCAT CTCAGGGGTC CTGACGCTAA TCCCCGTGTG CTGGACGGCG 
CATGCCATCA TCCGGGACTT CTATAACCCC CTGGTGGCTG AGGCCCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACTTGGG CTGGGCGGCC TCAGGCCTTT TGTTGCTGGG TGGGGGGTTG 
CTGTGCTGCA CTTGCCCCTC GGGGGGGTCC CAGGGCCCCA GCCATTACAT GGCCCGCTAC 
TCAACATCTG CCCCTGCCAT CTCTCGGGGG CCCTCTGAGT ACCCTACCAA GAATTACGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067018.2
CDS	61..723
Translation	MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

Target ORF information:

RefSeq Version	NM_021195.4
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 6 (CLDN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021195.4

ORF Insert Sequence:

ATGGCCTCTG CCGGAATGCA GATCCTGGGA GTCGTCCTGA CACTGCTGGG CTGGGTGAAT 
GGCCTGGTCT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CTTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACCGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCGCTGC CACAGGACCT GCAGGCTGCA 
CGTGCCCTCT GTGTCATCGC CCTCCTTGTG GCCCTGTTCG GCTTGCTGGT CTACCTTGCT 
GGGGCCAAGT GTACCACCTG TGTGGAGGAG AAGGATTCCA AGGCCCGCCT GGTGCTCACC 
TCTGGGATTG TCTTTGTCAT CTCAGGGGTC CTGACGCTAA TCCCCGTGTG CTGGACGGCG 
CATGCCATCA TCCGGGACTT CTATAACCCC CTGGTGGCTG AGGCCCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACTTGGG CTGGGCGGCC TCAGGCCTTT TGTTGCTGGG TGGGGGGTTG 
CTGTGCTGCA CTTGCCCCTC GGGGGGGTCC CAGGGCCCCA GCCATTACAT GGCCCGCTAC 
TCAACATCTG CCCCTGCCAT CTCTCGGGGG CCCTCTGAGT ACCCTACCAA GAATTACGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLDN6 ( NM_021195.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_067018.2 Homo sapiens claudin 6 (CLDN6), mRNA.

Price & Availability↑

CloneID	OHu24673
Clone ID Related Accession (Same CDS sequence)	NM_021195.4 , NM_021195.5
Accession Version	NM_021195.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	claudin-6 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX444798.2, CN420342.1 and BC008934.2. On Nov 22, 2018 this sequence version replaced NM_021195.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA733985.1, AK075329.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000328796.5/ ENSP00000328674.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTCTG CCGGAATGCA GATCCTGGGA GTCGTCCTGA CACTGCTGGG CTGGGTGAAT 
GGCCTGGTCT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CTTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACCGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCGCTGC CACAGGACCT GCAGGCTGCA 
CGTGCCCTCT GTGTCATCGC CCTCCTTGTG GCCCTGTTCG GCTTGCTGGT CTACCTTGCT 
GGGGCCAAGT GTACCACCTG TGTGGAGGAG AAGGATTCCA AGGCCCGCCT GGTGCTCACC 
TCTGGGATTG TCTTTGTCAT CTCAGGGGTC CTGACGCTAA TCCCCGTGTG CTGGACGGCG 
CATGCCATCA TCCGGGACTT CTATAACCCC CTGGTGGCTG AGGCCCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACTTGGG CTGGGCGGCC TCAGGCCTTT TGTTGCTGGG TGGGGGGTTG 
CTGTGCTGCA CTTGCCCCTC GGGGGGGTCC CAGGGCCCCA GCCATTACAT GGCCCGCTAC 
TCAACATCTG CCCCTGCCAT CTCTCGGGGG CCCTCTGAGT ACCCTACCAA GAATTACGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067018.2
CDS	57..719
Translation	MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

Target ORF information:

RefSeq Version	NM_021195.5
Organism	Homo sapiens(human)
Definition	Homo sapiens claudin 6 (CLDN6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021195.5

ORF Insert Sequence:

ATGGCCTCTG CCGGAATGCA GATCCTGGGA GTCGTCCTGA CACTGCTGGG CTGGGTGAAT 
GGCCTGGTCT CCTGTGCCCT GCCCATGTGG AAGGTGACCG CTTTCATCGG CAACAGCATC 
GTGGTGGCCC AGGTGGTGTG GGAGGGCCTG TGGATGTCCT GCGTGGTGCA GAGCACCGGC 
CAGATGCAGT GCAAGGTGTA CGACTCACTG CTGGCGCTGC CACAGGACCT GCAGGCTGCA 
CGTGCCCTCT GTGTCATCGC CCTCCTTGTG GCCCTGTTCG GCTTGCTGGT CTACCTTGCT 
GGGGCCAAGT GTACCACCTG TGTGGAGGAG AAGGATTCCA AGGCCCGCCT GGTGCTCACC 
TCTGGGATTG TCTTTGTCAT CTCAGGGGTC CTGACGCTAA TCCCCGTGTG CTGGACGGCG 
CATGCCATCA TCCGGGACTT CTATAACCCC CTGGTGGCTG AGGCCCAAAA GCGGGAGCTG 
GGGGCCTCCC TCTACTTGGG CTGGGCGGCC TCAGGCCTTT TGTTGCTGGG TGGGGGGTTG 
CTGTGCTGCA CTTGCCCCTC GGGGGGGTCC CAGGGCCCCA GCCATTACAT GGCCCGCTAC 
TCAACATCTG CCCCTGCCAT CTCTCGGGGG CCCTCTGAGT ACCCTACCAA GAATTACGTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells.
Immunobiology223(1)38-48(2018 Jan)
Chavarr?a-Vel?zquez CO,Torres-Mart?nez AC,Monta?o LF,Rend?n-Huerta EP

CLDN6 enhances chemoresistance to ADM via AF-6/ERKs pathway in TNBC cell line MDAMB231.
Molecular and cellular biochemistry(2017 Nov)
Yang M,Li Y,Ruan Y,Lu Y,Lin D,Xie Y,Dong B,Dang Q,Quan C

Displaying Tetra-Membrane Spanning Claudins on Enveloped Virus-Like Particles for Cancer Immunotherapy.
Biotechnology journal(2017 Nov)
Schneider IC,Hartmann J,Braun G,Stitz J,Klamp T,Bihi M,Sahin U,Buchholz CJ

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer.
Journal of experimental & clinical cancer research : CR36(1)157(2017 Nov)
Yang M,Li Y,Shen X,Ruan Y,Lu Y,Jin X,Song P,Guo Y,Zhang X,Qu H,Shao Y,Quan C

SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells.
International journal of molecular sciences18(9)(2017 Aug)
Lu Y,Wang L,Li H,Li Y,Ruan Y,Lin D,Yang M,Jin X,Guo Y,Zhang X,Quan C

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CLDN6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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