TICRR cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TICRR
Entrez Gene ID	90381
Full Name	TOPBP1 interacting checkpoint and replication regulator
Synonyms	C15orf42,SLD3,Treslin
General protein information	Preferred Names TOPBP1 interacting checkpoint and replication regulator Names treslin topBP1-interacting checkpoint and replication regulator topBP1-interacting replication-stimulating protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q26.1
Summary	Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010].
Disorder MIM:	613298

mRNA and Protein(s)

mRNA	Protein	Name
NM_152259.3	NP_689472.3	treslin isoform 2
NM_001308025.1	NP_001294954.1	treslin isoform 1
NM_152259.4	NP_689472.3	treslin isoform 2

Pathways from BioSystems

Homologies

	TICRR	XP_001093275.2
Bos taurus (cattle)	TICRR	XP_002696618.1
Mus musculus (house mouse)	Ticrr	NP_084111.1
Rattus norvegicus (Norway rat)	Ticrr	XP_218829.5
Gallus gallus (chicken)	C10H15ORF42	XP_413862.4
Homo sapiens (human)	TICRR	NP_689472.3
Pan troglodytes (chimpanzee)	TICRR	XP_003314917.2
Canis lupus familiaris (dog)	TICRR	XP_851592.2
Xenopus tropicalis (tropical clawed frog)	ticrr	XP_002944319.2

Gene Ontology
Bibliography

Related articles in PubMed

Ensa controls S-phase length by modulating Treslin levels.
Charrasse S, Gharbi-Ayachi A, Burgess A, Vera J, Hached K, Raynaud P, Schwob E, Lorca T, Castro A
Nature communications8(1)206(2017 08)

Kim S, Kleimeyer JP, Ahmed MA, Avins AL, Fredericson M, Dragoo JL, Ioannidis JPA
International journal of sports medicine38(7)508-514(2017 Jul)

Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Liu K, Lin FT, Graves JD, Lee YJ, Lin WC
Proceedings of the National Academy of Sciences of the United States of America114(19)E3766-E3775(2017 May)

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskait? ?, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altm?ller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, N?rnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS
Nature genetics49(4)537-549(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Variation at rs12913965 may affect the risk for shoulder dislocation by affecting the activity of either TICRR or ISG20.

phosphorylated TICRR is limiting for S-phase progression
Title: Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.

Treslin is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling
Title: Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.

MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells.
Title: Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.

Results indicate that Cdk-mediated phosphorylation of Treslin during S phase is necessary for both its effective association with TopBP1 and its ability to promote DNA replication in human cells.
Title: Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.

The following TICRR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TICRR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06702	NM_152259.4 Latest version!	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$951.30 $1359.00
OHu74220	NM_001308025.1 Latest version!	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$951.30 $1359.00
View Old Accession Versions >>
OHu06702	NM_152259.3	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$951.30 $1359.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TICRR ( NM_152259.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_689472.3 Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu06702
Clone ID Related Accession (Same CDS sequence)	NM_152259.3 , NM_152259.4
Accession Version	NM_152259.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5733bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	treslin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC013391.12, DR731357.1, DR731358.1, CN285632.1, AK123612.1, BX538335.1 and AW627706.1. On Nov 28, 2006 this sequence version replaced NM_152259.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGCAGGCA AAGAGATTCA AGAAACATGG 
ACAGTCACCC TAGAGCCCTT GGCCATGCAT CAGAGACATT TTCAGAAACC AGTCAGAATT 
TTTCTAAAAG GCTCAGTGGC CCAGTGGTCT CTCCCAACGA GCAGCACTTT GGGCACTGAC 
AGCTGGATGC TAGGAAGTCC AGAGGAGAGC ACAGCAACTC AAAGGCTGTT ATTTCAGCAG 
TTGGTAAGCA GGCTGACTGC TGAAGAGTTA CACCTGGTTG CTGATGTGGA CCCTGGTGAA 
GGCCGGCCCC CCATCACTGG AGTTATTTCC CCACTCTCTG CCAGTGCTAT GATCCTCACT 
GTGTGCCGCA CCAAGGAGGC TGAATTTCAA CGACATGTTC TCCAAACAGC TGTGGCTGAC 
AGCCCCCGGG ACACAGCTTC CCTTTTCTCA GATGTTGTGG ATAGTATATT GAATCAGACT 
CATGATTCGC TTGCAGATAC TGCTTCTGCT GCTTCTCCTG TTCCAGAGTG GGCCCAGCAG 
GAGCTTGGCC ACACCACTCC CTGGAGTCCA GCTGTTGTGG AAAAGTGGTT TCCTTTCTGT 
AACATCAGTG GTGCCAGTTC CGATTTGATG GAGTCATTTG GGTTACTACA GGCTGCCTCA 
GCTAATAAGG AAGAGTCTTC CAAAACTGAA GGCGAATTAA TACATTGCCT TGCCGAGCTC 
TACCAGAGAA AATCTCGTGA AGAATCCACT ATAGCTCATC AAGAAGACAG CAAAAAGAAA 
CGAGGGGTCC CTCGTACTCC AGTGAGACAG AAGATGAATA CCATGTGCCG TTCCTTAAAG 
ATGTTGAATG TCGCAAGGCT GAATGTGAAG GCCCAGAAGT TACATCCAGA TGGCAGTCCG 
GATGTGGCTG GGGAGAAAGG AATCCAAAAG ATACCTAGTG GGAGAACAGT GGATAAATTG 
GAAGACAGAG GAAGAACACT AAGAAGTTCT AAACCTAAAG ATTTTAAAAC TGAGGAAGAG 
CTGCTATCAT ATATACGTGA AAATTACCAA AAGACTGTGG CCACAGGAGA AATCATGTTG 
TATGCATGTG CTCGAAACAT GATCTCAACC GTTAAAATGT TCCTAAAATC AAAAGGCACC 
AAGGAATTAG AAGTGAACTG CCTGAATCAA GTAAAAAGTA GTCTCTTAAA AACTAGTAAA 
AGTCTTCGAC AGAATCTAGG AAAAAAACTG GATAAGGAAG ACAAAGTTAG AGAGTGCCAG 
CTTCAGGTAT TTCTTCGTTT GGAGATGTGT CTGCAATGCC CTTCAATAAA TGAAAGTACA 
GATGATATGG AACAAGTAGT GGAGGAGGTG ACAGATTTGC TGCGCATGGT GTGTTTAACT 
GAGGATTCAG CGTACCTAGC AGAGTTTCTG GAGGAAATTT TGAGATTGTA TATTGACTCT 
ATCCCAAAGA CACTTGGAAA TCTTTACAAC AGCCTAGGGT TTGTGATTCC TCAGAAGCTG 
GCTGGTGTCC TTCCTACAGA TTTTTTCAGT GATGACTCCA TGACACAAGA GAACAAATCA 
CCACTTCTTT CTGTGCCTTT TTTGTCAAGT GCTCGTAGAT CAGTGTCAGG CAGCCCTGAA 
TCTGATGAAC TGCAGGAACT TCGTACCAGA TCAGCCAAGA AGAGAAGGAA AAATGCATTA 
ATAAGACATA AAAGCATTGC TGAGGTTTCA CAGAATCTTC GACAAATTGA AATTCCTAAA 
GTGTCAAAGA GAGCTACGAA AAAAGAGAAC TCTCACCCTG CTCCTCAGCA GCCTTCCCAG 
CCAGTGAAAG ATACAGTGCA AGAAGTGACC AAAGTTCGAA GAAATCTTTT CAACCAGGAA 
TTGCTTTCCC CTTCAAAGAG ATCACTAAAG CGGGGGTTGC CTAGAAGCCA TTCTGTGTCA 
GCTGTGGATG GTCTAGAGGA TAAACTTGAC AACTTCAAGA AGAACAAAGG TTATCACAAA 
CTGCTGACTA AGAGTGTGGC CGAGACTCCA GTGCATAAGC AGATCTCCAA AAGGCTGCTG 
CACAGACAAA TCAAGGGCAG GTCCTCTGAT CCTGGTCCTG ATATTGGTGT TGTTGAAGAG 
TCCCCTGAAA AAGGAGATGA AATAAGTCTG AGACGAAGTC CTCGAATCAA GCAGTTGTCA 
TTTAGCAGGA CACATTCTGC CTCCTTCTAT TCTGTGTCTC AGCCGAAGTC TCGAAGTGTG 
CAAAGAGTCC ACTCTTTCCA GCAAGATAAG TCAGACCAAA GAGAAAATTC TCCAGTCCAA 
AGTATTCGGT CTCCCAAGAG TCTTCTTTTT GGGGCAATGT CTGAGATGAT CAGCCCCTCA 
GAAAAGGGTT CAGCTCGAAT GAAAAAGCGT TCAAGAAACA CTTTGGATTC GGAGGTACCT 
GCAGCTTACC AGACTCCCAA GAAGAGTCAC CAGAAATCTC TGAGCTTTTC TAAAACTACA 
CCAAGAAGGA TCTCTCATAC ACCACAAACT CCGTTGTATA CTCCAGAAAG GCTGCAGAAG 
TCCCCTGCAA AAATGACCCC TACAAAGCAG GCAGCTTTTA AGGAGTCCTT AAAAGACTCC 
TCCTCACCCG GCCATGACTC ACCATTGGAT TCAAAAATCA CTCCTCAAAA ACGACATACC 
CAGGCAGGAG AAGGTACCTC TCTTGAAACG AAGACACCAA GAACTCCTAA GAGGCAAGGT 
ACTCAGCCGC CTGGGTTTTT GCCAAACTGT ACTTGGCCAC ATTCAGTGAA TTCCAGTCCA 
GAAAGCCCCT CCTGTCCAGC CCCTCCAACT TCATCGACTG CCCAGCCCAG GAGAGAGTGT 
CTCACTCCCA TCAGAGACCC TCTCAGAACA CCTCCGAGAG CAGCAGCCTT CATGGGCACG 
CCTCAGAATC AAACACACCA ACAGCCCCAT GTCCTCAGAG CTGCTCGGGC AGAGGAACCA 
GCCCAGAAAC TAAAGGATAA AGCTATCAAA ACTCCAAAAA GACCAGGGAA TTCAACTGTG 
ACTTCTTCCC CACCTGTTAC GCCAAAGAAA CTGTTTACCT CTCCTTTATG TGATGTCTCC 
AAGAAGAGTC CATTTAGGAA ATCTAAAATA GAGTGTCCTT CCCCAGGAGA ACTGGATCAG 
AAAGAGCCCC AGATGTCACC CAGCGTAGCT GCATCTCTCT CCTGCCCTGT TCCCTCAACT 
CCCCCTGAAC TCTCACAGAG AGCTACATTG GACACCGTCC CTCCTCCACC CCCTTCTAAA 
GTTGGGAAAC GGTGTAGAAA GACCTCTGAT CCCAGAAGGA GCATCGTGGA GTGTCAGCCT 
GATGCCTCCG CTACTCCTGG GGTTGGCACA GCTGACAGCC CAGCTGCCCC CACAGACTCT 
AGAGATGACC AGAAGGGACT GAGCCTCTCT CCTCAGTCTC CTCCTGAAAG ACGGGGCTAC 
CCAGGCCCTG GTCTCAGGAG TGATTGGCAT GCATCCTCTC CTCTGCTCAT TACAAGTGAC 
ACAGAGCATG TCACTCTCCT CAGTGAAGCC GAACACCATG GCATTGGTGA CTTGAAAAGT 
AACGTCTTAT CAGTGGAAGA GGGTGAGGGG CTAAGGACAG CAGATGCTGA GAAGTCTTCT 
CTGTCTCACC CTGGGATTCC CCCATCTCCT CCTTCCTGTG GGCCTGGCTC TCCTCTGATG 
CCTTCCCGTG ACGTGCACTG TACCACAGAT GGGAGACAGT GCCAGGCTTC GGCACAACTA 
GACAACCTGC CAGCATCAGC TTGGCATTCC ACAGACTCTG CCAGCCCACA GACCTATGAG 
GTTGAGCTGG AGATGCAAGC TTCTGGCCTT CCCAAACTTC GAATTAAGAA GATAGACCCC 
AGCTCTTCAT TAGAGGCTGA GCCCCTCAGC AAGGAGGAGA GCTCTCTGGG AGAAGAGAGC 
TTCCTCCCTG CTCTCAGCAT GCCCAGGGCC AGCAGGTCCT TAAGCAAACC TGAACCCACC 
TATGTGTCAC CCCCCTGCCC CCGCCTCTCC CACAGCACAC CTGGCAAGAG CAGGGGGCAA 
ACCTACATCT GCCAGGCCTG TACCCCCACC CACGGCCCTT CTAGTACCCC CTCTCCATTT 
CAAACAGATG GGGTTCCTTG GACACCATCC CCCAAGCACA GTGGGAAGAC AACTCCAGAC 
ATAATTAAAG ACTGGCCCAG GAGGAAGAGG GCGGTGGGCT GTGGCGCCGG CTCCTCTTCC 
GGGAGGGGCG AGGTCGGTGC AGACCTTCCT GGGAGCCTGT CACTGCTTGA GTCAGAGGGC 
AAGGACCACG GCCTTGAACT CAGCATCCAC AGGACGCCCA TCTTGGAGGA TTTTGAGCTC 
GAGGGAGTGT GCCAGCTCCC AGACCAGTCG CCTCCCAGGA ACAGCATGCC TAAGGCCGAG 
GAAGCCTCTT CCTGGGGACA GTTTGGGTTG AGTTCCAGGA AGAGAGTCCT GTTGGCCAAG 
GAAGAAGCTG ACCGTGGAGC CAAAAGGATC TGTGACCTGA GAGAAGATTC AGAAGTTAGT 
AAGAGTAAAG AGGGGTCTCC AAGTTGGAGT GCATGGCAGC TACCCTCCAC GGGAGACGAA 
GAGGTGTTTG TTTCCGGCTC CACCCCACCT CCCAGCTGTG CCGTGCGGAG CTGCCTCTCT 
GCCAGTGCCC TCCAGGCTCT GACCCAGTCT CCGCTGCTGT TCCAGGGGAA AACACCTTCC 
TCTCAGAGCA AAGACCCCAG AGATGAGGAT GTGGATGTTC TTCCCTCCAC TGTAGAAGAC 
TCTCCTTTCA GTCGCGCTTT CTCCAGGAGG CGCCCCATCA GCAGAACTTA TACACGGAAG 
AAGCTCATGG GAACCTGGCT GGAGGACTTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689472.3
CDS	1..5733
Translation	MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL

Target ORF information:

RefSeq Version	NM_152259.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152259.3

ORF Insert Sequence:

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGCAGGCA AAGAGATTCA AGAAACATGG 
ACAGTCACCC TAGAGCCCTT GGCCATGCAT CAGAGACATT TTCAGAAACC AGTCAGAATT 
TTTCTAAAAG GCTCAGTGGC CCAGTGGTCT CTCCCAACGA GCAGCACTTT GGGCACTGAC 
AGCTGGATGC TAGGAAGTCC AGAGGAGAGC ACAGCAACTC AAAGGCTGTT ATTTCAGCAG 
TTGGTAAGCA GGCTGACTGC TGAAGAGTTA CACCTGGTTG CTGATGTGGA CCCTGGTGAA 
GGCCGGCCCC CCATCACTGG AGTTATTTCC CCACTCTCTG CCAGTGCTAT GATCCTCACT 
GTGTGCCGCA CCAAGGAGGC TGAATTTCAA CGACATGTTC TCCAAACAGC TGTGGCTGAC 
AGCCCCCGGG ACACAGCTTC CCTTTTCTCA GATGTTGTGG ATAGTATATT GAATCAGACT 
CATGATTCGC TTGCAGATAC TGCTTCTGCT GCTTCTCCTG TTCCAGAGTG GGCCCAGCAG 
GAGCTTGGCC ACACCACTCC CTGGAGTCCA GCTGTTGTGG AAAAGTGGTT TCCTTTCTGT 
AACATCAGTG GTGCCAGTTC CGATTTGATG GAGTCATTTG GGTTACTACA GGCTGCCTCA 
GCTAATAAGG AAGAGTCTTC CAAAACTGAA GGCGAATTAA TACATTGCCT TGCCGAGCTC 
TACCAGAGAA AATCTCGTGA AGAATCCACT ATAGCTCATC AAGAAGACAG CAAAAAGAAA 
CGAGGGGTCC CTCGTACTCC AGTGAGACAG AAGATGAATA CCATGTGCCG TTCCTTAAAG 
ATGTTGAATG TCGCAAGGCT GAATGTGAAG GCCCAGAAGT TACATCCAGA TGGCAGTCCG 
GATGTGGCTG GGGAGAAAGG AATCCAAAAG ATACCTAGTG GGAGAACAGT GGATAAATTG 
GAAGACAGAG GAAGAACACT AAGAAGTTCT AAACCTAAAG ATTTTAAAAC TGAGGAAGAG 
CTGCTATCAT ATATACGTGA AAATTACCAA AAGACTGTGG CCACAGGAGA AATCATGTTG 
TATGCATGTG CTCGAAACAT GATCTCAACC GTTAAAATGT TCCTAAAATC AAAAGGCACC 
AAGGAATTAG AAGTGAACTG CCTGAATCAA GTAAAAAGTA GTCTCTTAAA AACTAGTAAA 
AGTCTTCGAC AGAATCTAGG AAAAAAACTG GATAAGGAAG ACAAAGTTAG AGAGTGCCAG 
CTTCAGGTAT TTCTTCGTTT GGAGATGTGT CTGCAATGCC CTTCAATAAA TGAAAGTACA 
GATGATATGG AACAAGTAGT GGAGGAGGTG ACAGATTTGC TGCGCATGGT GTGTTTAACT 
GAGGATTCAG CGTACCTAGC AGAGTTTCTG GAGGAAATTT TGAGATTGTA TATTGACTCT 
ATCCCAAAGA CACTTGGAAA TCTTTACAAC AGCCTAGGGT TTGTGATTCC TCAGAAGCTG 
GCTGGTGTCC TTCCTACAGA TTTTTTCAGT GATGACTCCA TGACACAAGA GAACAAATCA 
CCACTTCTTT CTGTGCCTTT TTTGTCAAGT GCTCGTAGAT CAGTGTCAGG CAGCCCTGAA 
TCTGATGAAC TGCAGGAACT TCGTACCAGA TCAGCCAAGA AGAGAAGGAA AAATGCATTA 
ATAAGACATA AAAGCATTGC TGAGGTTTCA CAGAATCTTC GACAAATTGA AATTCCTAAA 
GTGTCAAAGA GAGCTACGAA AAAAGAGAAC TCTCACCCTG CTCCTCAGCA GCCTTCCCAG 
CCAGTGAAAG ATACAGTGCA AGAAGTGACC AAAGTTCGAA GAAATCTTTT CAACCAGGAA 
TTGCTTTCCC CTTCAAAGAG ATCACTAAAG CGGGGGTTGC CTAGAAGCCA TTCTGTGTCA 
GCTGTGGATG GTCTAGAGGA TAAACTTGAC AACTTCAAGA AGAACAAAGG TTATCACAAA 
CTGCTGACTA AGAGTGTGGC CGAGACTCCA GTGCATAAGC AGATCTCCAA AAGGCTGCTG 
CACAGACAAA TCAAGGGCAG GTCCTCTGAT CCTGGTCCTG ATATTGGTGT TGTTGAAGAG 
TCCCCTGAAA AAGGAGATGA AATAAGTCTG AGACGAAGTC CTCGAATCAA GCAGTTGTCA 
TTTAGCAGGA CACATTCTGC CTCCTTCTAT TCTGTGTCTC AGCCGAAGTC TCGAAGTGTG 
CAAAGAGTCC ACTCTTTCCA GCAAGATAAG TCAGACCAAA GAGAAAATTC TCCAGTCCAA 
AGTATTCGGT CTCCCAAGAG TCTTCTTTTT GGGGCAATGT CTGAGATGAT CAGCCCCTCA 
GAAAAGGGTT CAGCTCGAAT GAAAAAGCGT TCAAGAAACA CTTTGGATTC GGAGGTACCT 
GCAGCTTACC AGACTCCCAA GAAGAGTCAC CAGAAATCTC TGAGCTTTTC TAAAACTACA 
CCAAGAAGGA TCTCTCATAC ACCACAAACT CCGTTGTATA CTCCAGAAAG GCTGCAGAAG 
TCCCCTGCAA AAATGACCCC TACAAAGCAG GCAGCTTTTA AGGAGTCCTT AAAAGACTCC 
TCCTCACCCG GCCATGACTC ACCATTGGAT TCAAAAATCA CTCCTCAAAA ACGACATACC 
CAGGCAGGAG AAGGTACCTC TCTTGAAACG AAGACACCAA GAACTCCTAA GAGGCAAGGT 
ACTCAGCCGC CTGGGTTTTT GCCAAACTGT ACTTGGCCAC ATTCAGTGAA TTCCAGTCCA 
GAAAGCCCCT CCTGTCCAGC CCCTCCAACT TCATCGACTG CCCAGCCCAG GAGAGAGTGT 
CTCACTCCCA TCAGAGACCC TCTCAGAACA CCTCCGAGAG CAGCAGCCTT CATGGGCACG 
CCTCAGAATC AAACACACCA ACAGCCCCAT GTCCTCAGAG CTGCTCGGGC AGAGGAACCA 
GCCCAGAAAC TAAAGGATAA AGCTATCAAA ACTCCAAAAA GACCAGGGAA TTCAACTGTG 
ACTTCTTCCC CACCTGTTAC GCCAAAGAAA CTGTTTACCT CTCCTTTATG TGATGTCTCC 
AAGAAGAGTC CATTTAGGAA ATCTAAAATA GAGTGTCCTT CCCCAGGAGA ACTGGATCAG 
AAAGAGCCCC AGATGTCACC CAGCGTAGCT GCATCTCTCT CCTGCCCTGT TCCCTCAACT 
CCCCCTGAAC TCTCACAGAG AGCTACATTG GACACCGTCC CTCCTCCACC CCCTTCTAAA 
GTTGGGAAAC GGTGTAGAAA GACCTCTGAT CCCAGAAGGA GCATCGTGGA GTGTCAGCCT 
GATGCCTCCG CTACTCCTGG GGTTGGCACA GCTGACAGCC CAGCTGCCCC CACAGACTCT 
AGAGATGACC AGAAGGGACT GAGCCTCTCT CCTCAGTCTC CTCCTGAAAG ACGGGGCTAC 
CCAGGCCCTG GTCTCAGGAG TGATTGGCAT GCATCCTCTC CTCTGCTCAT TACAAGTGAC 
ACAGAGCATG TCACTCTCCT CAGTGAAGCC GAACACCATG GCATTGGTGA CTTGAAAAGT 
AACGTCTTAT CAGTGGAAGA GGGTGAGGGG CTAAGGACAG CAGATGCTGA GAAGTCTTCT 
CTGTCTCACC CTGGGATTCC CCCATCTCCT CCTTCCTGTG GGCCTGGCTC TCCTCTGATG 
CCTTCCCGTG ACGTGCACTG TACCACAGAT GGGAGACAGT GCCAGGCTTC GGCACAACTA 
GACAACCTGC CAGCATCAGC TTGGCATTCC ACAGACTCTG CCAGCCCACA GACCTATGAG 
GTTGAGCTGG AGATGCAAGC TTCTGGCCTT CCCAAACTTC GAATTAAGAA GATAGACCCC 
AGCTCTTCAT TAGAGGCTGA GCCCCTCAGC AAGGAGGAGA GCTCTCTGGG AGAAGAGAGC 
TTCCTCCCTG CTCTCAGCAT GCCCAGGGCC AGCAGGTCCT TAAGCAAACC TGAACCCACC 
TATGTGTCAC CCCCCTGCCC CCGCCTCTCC CACAGCACAC CTGGCAAGAG CAGGGGGCAA 
ACCTACATCT GCCAGGCCTG TACCCCCACC CACGGCCCTT CTAGTACCCC CTCTCCATTT 
CAAACAGATG GGGTTCCTTG GACACCATCC CCCAAGCACA GTGGGAAGAC AACTCCAGAC 
ATAATTAAAG ACTGGCCCAG GAGGAAGAGG GCGGTGGGCT GTGGCGCCGG CTCCTCTTCC 
GGGAGGGGCG AGGTCGGTGC AGACCTTCCT GGGAGCCTGT CACTGCTTGA GTCAGAGGGC 
AAGGACCACG GCCTTGAACT CAGCATCCAC AGGACGCCCA TCTTGGAGGA TTTTGAGCTC 
GAGGGAGTGT GCCAGCTCCC AGACCAGTCG CCTCCCAGGA ACAGCATGCC TAAGGCCGAG 
GAAGCCTCTT CCTGGGGACA GTTTGGGTTG AGTTCCAGGA AGAGAGTCCT GTTGGCCAAG 
GAAGAAGCTG ACCGTGGAGC CAAAAGGATC TGTGACCTGA GAGAAGATTC AGAAGTTAGT 
AAGAGTAAAG AGGGGTCTCC AAGTTGGAGT GCATGGCAGC TACCCTCCAC GGGAGACGAA 
GAGGTGTTTG TTTCCGGCTC CACCCCACCT CCCAGCTGTG CCGTGCGGAG CTGCCTCTCT 
GCCAGTGCCC TCCAGGCTCT GACCCAGTCT CCGCTGCTGT TCCAGGGGAA AACACCTTCC 
TCTCAGAGCA AAGACCCCAG AGATGAGGAT GTGGATGTTC TTCCCTCCAC TGTAGAAGAC 
TCTCCTTTCA GTCGCGCTTT CTCCAGGAGG CGCCCCATCA GCAGAACTTA TACACGGAAG 
AAGCTCATGG GAACCTGGCT GGAGGACTTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TICRR ( NM_152259.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_689472.3 Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.

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CloneID	OHu06702
Clone ID Related Accession (Same CDS sequence)	NM_152259.3 , NM_152259.4
Accession Version	NM_152259.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5733bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-12
Organism	Homo sapiens(human)
Product	treslin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC013391.12, DR731357.1, DR731358.1, CN285632.1, AK123612.1, BX538335.1 and AW627706.1. On May 17, 2019 this sequence version replaced NM_152259.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology MANE Ensembl match :: ENST00000268138.12/ ENSP00000268138.7 RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGCAGGCA AAGAGATTCA AGAAACATGG 
ACAGTCACCC TAGAGCCCTT GGCCATGCAT CAGAGACATT TTCAGAAACC AGTCAGAATT 
TTTCTAAAAG GCTCAGTGGC CCAGTGGTCT CTCCCAACGA GCAGCACTTT GGGCACTGAC 
AGCTGGATGC TAGGAAGTCC AGAGGAGAGC ACAGCAACTC AAAGGCTGTT ATTTCAGCAG 
TTGGTAAGCA GGCTGACTGC TGAAGAGTTA CACCTGGTTG CTGATGTGGA CCCTGGTGAA 
GGCCGGCCCC CCATCACTGG AGTTATTTCC CCACTCTCTG CCAGTGCTAT GATCCTCACT 
GTGTGCCGCA CCAAGGAGGC TGAATTTCAA CGACATGTTC TCCAAACAGC TGTGGCTGAC 
AGCCCCCGGG ACACAGCTTC CCTTTTCTCA GATGTTGTGG ATAGTATATT GAATCAGACT 
CATGATTCGC TTGCAGATAC TGCTTCTGCT GCTTCTCCTG TTCCAGAGTG GGCCCAGCAG 
GAGCTTGGCC ACACCACTCC CTGGAGTCCA GCTGTTGTGG AAAAGTGGTT TCCTTTCTGT 
AACATCAGTG GTGCCAGTTC CGATTTGATG GAGTCATTTG GGTTACTACA GGCTGCCTCA 
GCTAATAAGG AAGAGTCTTC CAAAACTGAA GGCGAATTAA TACATTGCCT TGCCGAGCTC 
TACCAGAGAA AATCTCGTGA AGAATCCACT ATAGCTCATC AAGAAGACAG CAAAAAGAAA 
CGAGGGGTCC CTCGTACTCC AGTGAGACAG AAGATGAATA CCATGTGCCG TTCCTTAAAG 
ATGTTGAATG TCGCAAGGCT GAATGTGAAG GCCCAGAAGT TACATCCAGA TGGCAGTCCG 
GATGTGGCTG GGGAGAAAGG AATCCAAAAG ATACCTAGTG GGAGAACAGT GGATAAATTG 
GAAGACAGAG GAAGAACACT AAGAAGTTCT AAACCTAAAG ATTTTAAAAC TGAGGAAGAG 
CTGCTATCAT ATATACGTGA AAATTACCAA AAGACTGTGG CCACAGGAGA AATCATGTTG 
TATGCATGTG CTCGAAACAT GATCTCAACC GTTAAAATGT TCCTAAAATC AAAAGGCACC 
AAGGAATTAG AAGTGAACTG CCTGAATCAA GTAAAAAGTA GTCTCTTAAA AACTAGTAAA 
AGTCTTCGAC AGAATCTAGG AAAAAAACTG GATAAGGAAG ACAAAGTTAG AGAGTGCCAG 
CTTCAGGTAT TTCTTCGTTT GGAGATGTGT CTGCAATGCC CTTCAATAAA TGAAAGTACA 
GATGATATGG AACAAGTAGT GGAGGAGGTG ACAGATTTGC TGCGCATGGT GTGTTTAACT 
GAGGATTCAG CGTACCTAGC AGAGTTTCTG GAGGAAATTT TGAGATTGTA TATTGACTCT 
ATCCCAAAGA CACTTGGAAA TCTTTACAAC AGCCTAGGGT TTGTGATTCC TCAGAAGCTG 
GCTGGTGTCC TTCCTACAGA TTTTTTCAGT GATGACTCCA TGACACAAGA GAACAAATCA 
CCACTTCTTT CTGTGCCTTT TTTGTCAAGT GCTCGTAGAT CAGTGTCAGG CAGCCCTGAA 
TCTGATGAAC TGCAGGAACT TCGTACCAGA TCAGCCAAGA AGAGAAGGAA AAATGCATTA 
ATAAGACATA AAAGCATTGC TGAGGTTTCA CAGAATCTTC GACAAATTGA AATTCCTAAA 
GTGTCAAAGA GAGCTACGAA AAAAGAGAAC TCTCACCCTG CTCCTCAGCA GCCTTCCCAG 
CCAGTGAAAG ATACAGTGCA AGAAGTGACC AAAGTTCGAA GAAATCTTTT CAACCAGGAA 
TTGCTTTCCC CTTCAAAGAG ATCACTAAAG CGGGGGTTGC CTAGAAGCCA TTCTGTGTCA 
GCTGTGGATG GTCTAGAGGA TAAACTTGAC AACTTCAAGA AGAACAAAGG TTATCACAAA 
CTGCTGACTA AGAGTGTGGC CGAGACTCCA GTGCATAAGC AGATCTCCAA AAGGCTGCTG 
CACAGACAAA TCAAGGGCAG GTCCTCTGAT CCTGGTCCTG ATATTGGTGT TGTTGAAGAG 
TCCCCTGAAA AAGGAGATGA AATAAGTCTG AGACGAAGTC CTCGAATCAA GCAGTTGTCA 
TTTAGCAGGA CACATTCTGC CTCCTTCTAT TCTGTGTCTC AGCCGAAGTC TCGAAGTGTG 
CAAAGAGTCC ACTCTTTCCA GCAAGATAAG TCAGACCAAA GAGAAAATTC TCCAGTCCAA 
AGTATTCGGT CTCCCAAGAG TCTTCTTTTT GGGGCAATGT CTGAGATGAT CAGCCCCTCA 
GAAAAGGGTT CAGCTCGAAT GAAAAAGCGT TCAAGAAACA CTTTGGATTC GGAGGTACCT 
GCAGCTTACC AGACTCCCAA GAAGAGTCAC CAGAAATCTC TGAGCTTTTC TAAAACTACA 
CCAAGAAGGA TCTCTCATAC ACCACAAACT CCGTTGTATA CTCCAGAAAG GCTGCAGAAG 
TCCCCTGCAA AAATGACCCC TACAAAGCAG GCAGCTTTTA AGGAGTCCTT AAAAGACTCC 
TCCTCACCCG GCCATGACTC ACCATTGGAT TCAAAAATCA CTCCTCAAAA ACGACATACC 
CAGGCAGGAG AAGGTACCTC TCTTGAAACG AAGACACCAA GAACTCCTAA GAGGCAAGGT 
ACTCAGCCGC CTGGGTTTTT GCCAAACTGT ACTTGGCCAC ATTCAGTGAA TTCCAGTCCA 
GAAAGCCCCT CCTGTCCAGC CCCTCCAACT TCATCGACTG CCCAGCCCAG GAGAGAGTGT 
CTCACTCCCA TCAGAGACCC TCTCAGAACA CCTCCGAGAG CAGCAGCCTT CATGGGCACG 
CCTCAGAATC AAACACACCA ACAGCCCCAT GTCCTCAGAG CTGCTCGGGC AGAGGAACCA 
GCCCAGAAAC TAAAGGATAA AGCTATCAAA ACTCCAAAAA GACCAGGGAA TTCAACTGTG 
ACTTCTTCCC CACCTGTTAC GCCAAAGAAA CTGTTTACCT CTCCTTTATG TGATGTCTCC 
AAGAAGAGTC CATTTAGGAA ATCTAAAATA GAGTGTCCTT CCCCAGGAGA ACTGGATCAG 
AAAGAGCCCC AGATGTCACC CAGCGTAGCT GCATCTCTCT CCTGCCCTGT TCCCTCAACT 
CCCCCTGAAC TCTCACAGAG AGCTACATTG GACACCGTCC CTCCTCCACC CCCTTCTAAA 
GTTGGGAAAC GGTGTAGAAA GACCTCTGAT CCCAGAAGGA GCATCGTGGA GTGTCAGCCT 
GATGCCTCCG CTACTCCTGG GGTTGGCACA GCTGACAGCC CAGCTGCCCC CACAGACTCT 
AGAGATGACC AGAAGGGACT GAGCCTCTCT CCTCAGTCTC CTCCTGAAAG ACGGGGCTAC 
CCAGGCCCTG GTCTCAGGAG TGATTGGCAT GCATCCTCTC CTCTGCTCAT TACAAGTGAC 
ACAGAGCATG TCACTCTCCT CAGTGAAGCC GAACACCATG GCATTGGTGA CTTGAAAAGT 
AACGTCTTAT CAGTGGAAGA GGGTGAGGGG CTAAGGACAG CAGATGCTGA GAAGTCTTCT 
CTGTCTCACC CTGGGATTCC CCCATCTCCT CCTTCCTGTG GGCCTGGCTC TCCTCTGATG 
CCTTCCCGTG ACGTGCACTG TACCACAGAT GGGAGACAGT GCCAGGCTTC GGCACAACTA 
GACAACCTGC CAGCATCAGC TTGGCATTCC ACAGACTCTG CCAGCCCACA GACCTATGAG 
GTTGAGCTGG AGATGCAAGC TTCTGGCCTT CCCAAACTTC GAATTAAGAA GATAGACCCC 
AGCTCTTCAT TAGAGGCTGA GCCCCTCAGC AAGGAGGAGA GCTCTCTGGG AGAAGAGAGC 
TTCCTCCCTG CTCTCAGCAT GCCCAGGGCC AGCAGGTCCT TAAGCAAACC TGAACCCACC 
TATGTGTCAC CCCCCTGCCC CCGCCTCTCC CACAGCACAC CTGGCAAGAG CAGGGGGCAA 
ACCTACATCT GCCAGGCCTG TACCCCCACC CACGGCCCTT CTAGTACCCC CTCTCCATTT 
CAAACAGATG GGGTTCCTTG GACACCATCC CCCAAGCACA GTGGGAAGAC AACTCCAGAC 
ATAATTAAAG ACTGGCCCAG GAGGAAGAGG GCGGTGGGCT GTGGCGCCGG CTCCTCTTCC 
GGGAGGGGCG AGGTCGGTGC AGACCTTCCT GGGAGCCTGT CACTGCTTGA GTCAGAGGGC 
AAGGACCACG GCCTTGAACT CAGCATCCAC AGGACGCCCA TCTTGGAGGA TTTTGAGCTC 
GAGGGAGTGT GCCAGCTCCC AGACCAGTCG CCTCCCAGGA ACAGCATGCC TAAGGCCGAG 
GAAGCCTCTT CCTGGGGACA GTTTGGGTTG AGTTCCAGGA AGAGAGTCCT GTTGGCCAAG 
GAAGAAGCTG ACCGTGGAGC CAAAAGGATC TGTGACCTGA GAGAAGATTC AGAAGTTAGT 
AAGAGTAAAG AGGGGTCTCC AAGTTGGAGT GCATGGCAGC TACCCTCCAC GGGAGACGAA 
GAGGTGTTTG TTTCCGGCTC CACCCCACCT CCCAGCTGTG CCGTGCGGAG CTGCCTCTCT 
GCCAGTGCCC TCCAGGCTCT GACCCAGTCT CCGCTGCTGT TCCAGGGGAA AACACCTTCC 
TCTCAGAGCA AAGACCCCAG AGATGAGGAT GTGGATGTTC TTCCCTCCAC TGTAGAAGAC 
TCTCCTTTCA GTCGCGCTTT CTCCAGGAGG CGCCCCATCA GCAGAACTTA TACACGGAAG 
AAGCTCATGG GAACCTGGCT GGAGGACTTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_689472.3
CDS	119..5851
Translation	MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEAGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL

Target ORF information:

RefSeq Version	NM_152259.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152259.4

ORF Insert Sequence:

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGCAGGCA AAGAGATTCA AGAAACATGG 
ACAGTCACCC TAGAGCCCTT GGCCATGCAT CAGAGACATT TTCAGAAACC AGTCAGAATT 
TTTCTAAAAG GCTCAGTGGC CCAGTGGTCT CTCCCAACGA GCAGCACTTT GGGCACTGAC 
AGCTGGATGC TAGGAAGTCC AGAGGAGAGC ACAGCAACTC AAAGGCTGTT ATTTCAGCAG 
TTGGTAAGCA GGCTGACTGC TGAAGAGTTA CACCTGGTTG CTGATGTGGA CCCTGGTGAA 
GGCCGGCCCC CCATCACTGG AGTTATTTCC CCACTCTCTG CCAGTGCTAT GATCCTCACT 
GTGTGCCGCA CCAAGGAGGC TGAATTTCAA CGACATGTTC TCCAAACAGC TGTGGCTGAC 
AGCCCCCGGG ACACAGCTTC CCTTTTCTCA GATGTTGTGG ATAGTATATT GAATCAGACT 
CATGATTCGC TTGCAGATAC TGCTTCTGCT GCTTCTCCTG TTCCAGAGTG GGCCCAGCAG 
GAGCTTGGCC ACACCACTCC CTGGAGTCCA GCTGTTGTGG AAAAGTGGTT TCCTTTCTGT 
AACATCAGTG GTGCCAGTTC CGATTTGATG GAGTCATTTG GGTTACTACA GGCTGCCTCA 
GCTAATAAGG AAGAGTCTTC CAAAACTGAA GGCGAATTAA TACATTGCCT TGCCGAGCTC 
TACCAGAGAA AATCTCGTGA AGAATCCACT ATAGCTCATC AAGAAGACAG CAAAAAGAAA 
CGAGGGGTCC CTCGTACTCC AGTGAGACAG AAGATGAATA CCATGTGCCG TTCCTTAAAG 
ATGTTGAATG TCGCAAGGCT GAATGTGAAG GCCCAGAAGT TACATCCAGA TGGCAGTCCG 
GATGTGGCTG GGGAGAAAGG AATCCAAAAG ATACCTAGTG GGAGAACAGT GGATAAATTG 
GAAGACAGAG GAAGAACACT AAGAAGTTCT AAACCTAAAG ATTTTAAAAC TGAGGAAGAG 
CTGCTATCAT ATATACGTGA AAATTACCAA AAGACTGTGG CCACAGGAGA AATCATGTTG 
TATGCATGTG CTCGAAACAT GATCTCAACC GTTAAAATGT TCCTAAAATC AAAAGGCACC 
AAGGAATTAG AAGTGAACTG CCTGAATCAA GTAAAAAGTA GTCTCTTAAA AACTAGTAAA 
AGTCTTCGAC AGAATCTAGG AAAAAAACTG GATAAGGAAG ACAAAGTTAG AGAGTGCCAG 
CTTCAGGTAT TTCTTCGTTT GGAGATGTGT CTGCAATGCC CTTCAATAAA TGAAAGTACA 
GATGATATGG AACAAGTAGT GGAGGAGGTG ACAGATTTGC TGCGCATGGT GTGTTTAACT 
GAGGATTCAG CGTACCTAGC AGAGTTTCTG GAGGAAATTT TGAGATTGTA TATTGACTCT 
ATCCCAAAGA CACTTGGAAA TCTTTACAAC AGCCTAGGGT TTGTGATTCC TCAGAAGCTG 
GCTGGTGTCC TTCCTACAGA TTTTTTCAGT GATGACTCCA TGACACAAGA GAACAAATCA 
CCACTTCTTT CTGTGCCTTT TTTGTCAAGT GCTCGTAGAT CAGTGTCAGG CAGCCCTGAA 
TCTGATGAAC TGCAGGAACT TCGTACCAGA TCAGCCAAGA AGAGAAGGAA AAATGCATTA 
ATAAGACATA AAAGCATTGC TGAGGTTTCA CAGAATCTTC GACAAATTGA AATTCCTAAA 
GTGTCAAAGA GAGCTACGAA AAAAGAGAAC TCTCACCCTG CTCCTCAGCA GCCTTCCCAG 
CCAGTGAAAG ATACAGTGCA AGAAGTGACC AAAGTTCGAA GAAATCTTTT CAACCAGGAA 
TTGCTTTCCC CTTCAAAGAG ATCACTAAAG CGGGGGTTGC CTAGAAGCCA TTCTGTGTCA 
GCTGTGGATG GTCTAGAGGA TAAACTTGAC AACTTCAAGA AGAACAAAGG TTATCACAAA 
CTGCTGACTA AGAGTGTGGC CGAGACTCCA GTGCATAAGC AGATCTCCAA AAGGCTGCTG 
CACAGACAAA TCAAGGGCAG GTCCTCTGAT CCTGGTCCTG ATATTGGTGT TGTTGAAGAG 
TCCCCTGAAA AAGGAGATGA AATAAGTCTG AGACGAAGTC CTCGAATCAA GCAGTTGTCA 
TTTAGCAGGA CACATTCTGC CTCCTTCTAT TCTGTGTCTC AGCCGAAGTC TCGAAGTGTG 
CAAAGAGTCC ACTCTTTCCA GCAAGATAAG TCAGACCAAA GAGAAAATTC TCCAGTCCAA 
AGTATTCGGT CTCCCAAGAG TCTTCTTTTT GGGGCAATGT CTGAGATGAT CAGCCCCTCA 
GAAAAGGGTT CAGCTCGAAT GAAAAAGCGT TCAAGAAACA CTTTGGATTC GGAGGTACCT 
GCAGCTTACC AGACTCCCAA GAAGAGTCAC CAGAAATCTC TGAGCTTTTC TAAAACTACA 
CCAAGAAGGA TCTCTCATAC ACCACAAACT CCGTTGTATA CTCCAGAAAG GCTGCAGAAG 
TCCCCTGCAA AAATGACCCC TACAAAGCAG GCAGCTTTTA AGGAGTCCTT AAAAGACTCC 
TCCTCACCCG GCCATGACTC ACCATTGGAT TCAAAAATCA CTCCTCAAAA ACGACATACC 
CAGGCAGGAG AAGGTACCTC TCTTGAAACG AAGACACCAA GAACTCCTAA GAGGCAAGGT 
ACTCAGCCGC CTGGGTTTTT GCCAAACTGT ACTTGGCCAC ATTCAGTGAA TTCCAGTCCA 
GAAAGCCCCT CCTGTCCAGC CCCTCCAACT TCATCGACTG CCCAGCCCAG GAGAGAGTGT 
CTCACTCCCA TCAGAGACCC TCTCAGAACA CCTCCGAGAG CAGCAGCCTT CATGGGCACG 
CCTCAGAATC AAACACACCA ACAGCCCCAT GTCCTCAGAG CTGCTCGGGC AGAGGAACCA 
GCCCAGAAAC TAAAGGATAA AGCTATCAAA ACTCCAAAAA GACCAGGGAA TTCAACTGTG 
ACTTCTTCCC CACCTGTTAC GCCAAAGAAA CTGTTTACCT CTCCTTTATG TGATGTCTCC 
AAGAAGAGTC CATTTAGGAA ATCTAAAATA GAGTGTCCTT CCCCAGGAGA ACTGGATCAG 
AAAGAGCCCC AGATGTCACC CAGCGTAGCT GCATCTCTCT CCTGCCCTGT TCCCTCAACT 
CCCCCTGAAC TCTCACAGAG AGCTACATTG GACACCGTCC CTCCTCCACC CCCTTCTAAA 
GTTGGGAAAC GGTGTAGAAA GACCTCTGAT CCCAGAAGGA GCATCGTGGA GTGTCAGCCT 
GATGCCTCCG CTACTCCTGG GGTTGGCACA GCTGACAGCC CAGCTGCCCC CACAGACTCT 
AGAGATGACC AGAAGGGACT GAGCCTCTCT CCTCAGTCTC CTCCTGAAAG ACGGGGCTAC 
CCAGGCCCTG GTCTCAGGAG TGATTGGCAT GCATCCTCTC CTCTGCTCAT TACAAGTGAC 
ACAGAGCATG TCACTCTCCT CAGTGAAGCC GAACACCATG GCATTGGTGA CTTGAAAAGT 
AACGTCTTAT CAGTGGAAGA GGGTGAGGGG CTAAGGACAG CAGATGCTGA GAAGTCTTCT 
CTGTCTCACC CTGGGATTCC CCCATCTCCT CCTTCCTGTG GGCCTGGCTC TCCTCTGATG 
CCTTCCCGTG ACGTGCACTG TACCACAGAT GGGAGACAGT GCCAGGCTTC GGCACAACTA 
GACAACCTGC CAGCATCAGC TTGGCATTCC ACAGACTCTG CCAGCCCACA GACCTATGAG 
GTTGAGCTGG AGATGCAAGC TTCTGGCCTT CCCAAACTTC GAATTAAGAA GATAGACCCC 
AGCTCTTCAT TAGAGGCTGA GCCCCTCAGC AAGGAGGAGA GCTCTCTGGG AGAAGAGAGC 
TTCCTCCCTG CTCTCAGCAT GCCCAGGGCC AGCAGGTCCT TAAGCAAACC TGAACCCACC 
TATGTGTCAC CCCCCTGCCC CCGCCTCTCC CACAGCACAC CTGGCAAGAG CAGGGGGCAA 
ACCTACATCT GCCAGGCCTG TACCCCCACC CACGGCCCTT CTAGTACCCC CTCTCCATTT 
CAAACAGATG GGGTTCCTTG GACACCATCC CCCAAGCACA GTGGGAAGAC AACTCCAGAC 
ATAATTAAAG ACTGGCCCAG GAGGAAGAGG GCGGTGGGCT GTGGCGCCGG CTCCTCTTCC 
GGGAGGGGCG AGGTCGGTGC AGACCTTCCT GGGAGCCTGT CACTGCTTGA GTCAGAGGGC 
AAGGACCACG GCCTTGAACT CAGCATCCAC AGGACGCCCA TCTTGGAGGA TTTTGAGCTC 
GAGGGAGTGT GCCAGCTCCC AGACCAGTCG CCTCCCAGGA ACAGCATGCC TAAGGCCGAG 
GAAGCCTCTT CCTGGGGACA GTTTGGGTTG AGTTCCAGGA AGAGAGTCCT GTTGGCCAAG 
GAAGAAGCTG ACCGTGGAGC CAAAAGGATC TGTGACCTGA GAGAAGATTC AGAAGTTAGT 
AAGAGTAAAG AGGGGTCTCC AAGTTGGAGT GCATGGCAGC TACCCTCCAC GGGAGACGAA 
GAGGTGTTTG TTTCCGGCTC CACCCCACCT CCCAGCTGTG CCGTGCGGAG CTGCCTCTCT 
GCCAGTGCCC TCCAGGCTCT GACCCAGTCT CCGCTGCTGT TCCAGGGGAA AACACCTTCC 
TCTCAGAGCA AAGACCCCAG AGATGAGGAT GTGGATGTTC TTCCCTCCAC TGTAGAAGAC 
TCTCCTTTCA GTCGCGCTTT CTCCAGGAGG CGCCCCATCA GCAGAACTTA TACACGGAAG 
AAGCTCATGG GAACCTGGCT GGAGGACTTA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TICRR ( NM_001308025.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001294954.1 Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 1, mRNA.

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CloneID	OHu74220
Clone ID Related Accession (Same CDS sequence)	NM_001308025.1
Accession Version	NM_001308025.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5730bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	treslin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from GQ227787.1, AC013787.15 and AW627706.1. On Apr 21, 2015 this sequence version replaced XM_011522161.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ227787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGGCAAAG AGATTCAAGA AACATGGACA 
GTCACCCTAG AGCCCTTGGC CATGCATCAG AGACATTTTC AGAAACCAGT CAGAATTTTT 
CTAAAAGGCT CAGTGGCCCA GTGGTCTCTC CCAACGAGCA GCACTTTGGG CACTGACAGC 
TGGATGCTAG GAAGTCCAGA GGAGAGCACA GCAACTCAAA GGCTGTTATT TCAGCAGTTG 
GTAAGCAGGC TGACTGCTGA AGAGTTACAC CTGGTTGCTG ATGTGGACCC TGGTGAAGGC 
CGGCCCCCCA TCACTGGAGT TATTTCCCCA CTCTCTGCCA GTGCTATGAT CCTCACTGTG 
TGCCGCACCA AGGAGGCTGA ATTTCAACGA CATGTTCTCC AAACAGCTGT GGCTGACAGC 
CCCCGGGACA CAGCTTCCCT TTTCTCAGAT GTTGTGGATA GTATATTGAA TCAGACTCAT 
GATTCGCTTG CAGATACTGC TTCTGCTGCT TCTCCTGTTC CAGAGTGGGC CCAGCAGGAG 
CTTGGCCACA CCACTCCCTG GAGTCCAGCT GTTGTGGAAA AGTGGTTTCC TTTCTGTAAC 
ATCAGTGGTG CCAGTTCCGA TTTGATGGAG TCATTTGGGT TACTACAGGC TGCCTCAGCT 
AATAAGGAAG AGTCTTCCAA AACTGAAGGC GAATTAATAC ATTGCCTTGC CGAGCTCTAC 
CAGAGAAAAT CTCGTGAAGA ATCCACTATA GCTCATCAAG AAGACAGCAA AAAGAAACGA 
GGGGTCCCTC GTACTCCAGT GAGACAGAAG ATGAATACCA TGTGCCGTTC CTTAAAGATG 
TTGAATGTCG CAAGGCTGAA TGTGAAGGCC CAGAAGTTAC ATCCAGATGG CAGTCCGGAT 
GTGGCTGGGG AGAAAGGAAT CCAAAAGATA CCTAGTGGGA GAACAGTGGA TAAATTGGAA 
GACAGAGGAA GAACACTAAG AAGTTCTAAA CCTAAAGATT TTAAAACTGA GGAAGAGCTG 
CTATCATATA TACGTGAAAA TTACCAAAAG ACTGTGGCCA CAGGAGAAAT CATGTTGTAT 
GCATGTGCTC GAAACATGAT CTCAACCGTT AAAATGTTCC TAAAATCAAA AGGCACCAAG 
GAATTAGAAG TGAACTGCCT GAATCAAGTA AAAAGTAGTC TCTTAAAAAC TAGTAAAAGT 
CTTCGACAGA ATCTAGGAAA AAAACTGGAT AAGGAAGACA AAGTTAGAGA GTGCCAGCTT 
CAGGTATTTC TTCGTTTGGA GATGTGTCTG CAATGCCCTT CAATAAATGA AAGTACAGAT 
GATATGGAAC AAGTAGTGGA GGAGGTGACA GATTTGCTGC GCATGGTGTG TTTAACTGAG 
GATTCAGCGT ACCTAGCAGA GTTTCTGGAG GAAATTTTGA GATTGTATAT TGACTCTATC 
CCAAAGACAC TTGGAAATCT TTACAACAGC CTAGGGTTTG TGATTCCTCA GAAGCTGGCT 
GGTGTCCTTC CTACAGATTT TTTCAGTGAT GACTCCATGA CACAAGAGAA CAAATCACCA 
CTTCTTTCTG TGCCTTTTTT GTCAAGTGCT CGTAGATCAG TGTCAGGCAG CCCTGAATCT 
GATGAACTGC AGGAACTTCG TACCAGATCA GCCAAGAAGA GAAGGAAAAA TGCATTAATA 
AGACATAAAA GCATTGCTGA GGTTTCACAG AATCTTCGAC AAATTGAAAT TCCTAAAGTG 
TCAAAGAGAG CTACGAAAAA AGAGAACTCT CACCCTGCTC CTCAGCAGCC TTCCCAGCCA 
GTGAAAGATA CAGTGCAAGA AGTGACCAAA GTTCGAAGAA ATCTTTTCAA CCAGGAATTG 
CTTTCCCCTT CAAAGAGATC ACTAAAGCGG GGGTTGCCTA GAAGCCATTC TGTGTCAGCT 
GTGGATGGTC TAGAGGATAA ACTTGACAAC TTCAAGAAGA ACAAAGGTTA TCACAAACTG 
CTGACTAAGA GTGTGGCCGA GACTCCAGTG CATAAGCAGA TCTCCAAAAG GCTGCTGCAC 
AGACAAATCA AGGGCAGGTC CTCTGATCCT GGTCCTGATA TTGGTGTTGT TGAAGAGTCC 
CCTGAAAAAG GAGATGAAAT AAGTCTGAGA CGAAGTCCTC GAATCAAGCA GTTGTCATTT 
AGCAGGACAC ATTCTGCCTC CTTCTATTCT GTGTCTCAGC CGAAGTCTCG AAGTGTGCAA 
AGAGTCCACT CTTTCCAGCA AGATAAGTCA GACCAAAGAG AAAATTCTCC AGTCCAAAGT 
ATTCGGTCTC CCAAGAGTCT TCTTTTTGGG GCAATGTCTG AGATGATCAG CCCCTCAGAA 
AAGGGTTCAG CTCGAATGAA AAAGCGTTCA AGAAACACTT TGGATTCGGA GGTACCTGCA 
GCTTACCAGA CTCCCAAGAA GAGTCACCAG AAATCTCTGA GCTTTTCTAA AACTACACCA 
AGAAGGATCT CTCATACACC ACAAACTCCG TTGTATACTC CAGAAAGGCT GCAGAAGTCC 
CCTGCAAAAA TGACCCCTAC AAAGCAGGCA GCTTTTAAGG AGTCCTTAAA AGACTCCTCC 
TCACCCGGCC ATGACTCACC ATTGGATTCA AAAATCACTC CTCAAAAACG ACATACCCAG 
GCAGGAGAAG GTACCTCTCT TGAAACGAAG ACACCAAGAA CTCCTAAGAG GCAAGGTACT 
CAGCCGCCTG GGTTTTTGCC AAACTGTACT TGGCCACATT CAGTGAATTC CAGTCCAGAA 
AGCCCCTCCT GTCCAGCCCC TCCAACTTCA TCGACTGCCC AGCCCAGGAG AGAGTGTCTC 
ACTCCCATCA GAGACCCTCT CAGAACACCT CCGAGAGCAG CAGCCTTCAT GGGCACGCCT 
CAGAATCAAA CACACCAACA GCCCCATGTC CTCAGAGCTG CTCGGGCAGA GGAACCAGCC 
CAGAAACTAA AGGATAAAGC TATCAAAACT CCAAAAAGAC CAGGGAATTC AACTGTGACT 
TCTTCCCCAC CTGTTACGCC AAAGAAACTG TTTACCTCTC CTTTATGTGA TGTCTCCAAG 
AAGAGTCCAT TTAGGAAATC TAAAATAGAG TGTCCTTCCC CAGGAGAACT GGATCAGAAA 
GAGCCCCAGA TGTCACCCAG CGTAGCTGCA TCTCTCTCCT GCCCTGTTCC CTCAACTCCC 
CCTGAACTCT CACAGAGAGC TACATTGGAC ACCGTCCCTC CTCCACCCCC TTCTAAAGTT 
GGGAAACGGT GTAGAAAGAC CTCTGATCCC AGAAGGAGCA TCGTGGAGTG TCAGCCTGAT 
GCCTCCGCTA CTCCTGGGGT TGGCACAGCT GACAGCCCAG CTGCCCCCAC AGACTCTAGA 
GATGACCAGA AGGGACTGAG CCTCTCTCCT CAGTCTCCTC CTGAAAGACG GGGCTACCCA 
GGCCCTGGTC TCAGGAGTGA TTGGCATGCA TCCTCTCCTC TGCTCATTAC AAGTGACACA 
GAGCATGTCA CTCTCCTCAG TGAAGCCGAA CACCATGGCA TTGGTGACTT GAAAAGTAAC 
GTCTTATCAG TGGAAGAGGG TGAGGGGCTA AGGACAGCAG ATGCTGAGAA GTCTTCTCTG 
TCTCACCCTG GGATTCCCCC ATCTCCTCCT TCCTGTGGGC CTGGCTCTCC TCTGATGCCT 
TCCCGTGACG TGCACTGTAC CACAGATGGG AGACAGTGCC AGGCTTCGGC ACAACTAGAC 
AACCTGCCAG CATCAGCTTG GCATTCCACA GACTCTGCCA GCCCACAGAC CTATGAGGTT 
GAGCTGGAGA TGCAAGCTTC TGGCCTTCCC AAACTTCGAA TTAAGAAGAT AGACCCCAGC 
TCTTCATTAG AGGCTGAGCC CCTCAGCAAG GAGGAGAGCT CTCTGGGAGA AGAGAGCTTC 
CTCCCTGCTC TCAGCATGCC CAGGGCCAGC AGGTCCTTAA GCAAACCTGA ACCCACCTAT 
GTGTCACCCC CCTGCCCCCG CCTCTCCCAC AGCACACCTG GCAAGAGCAG GGGGCAAACC 
TACATCTGCC AGGCCTGTAC CCCCACCCAC GGCCCTTCTA GTACCCCCTC TCCATTTCAA 
ACAGATGGGG TTCCTTGGAC ACCATCCCCC AAGCACAGTG GGAAGACAAC TCCAGACATA 
ATTAAAGACT GGCCCAGGAG GAAGAGGGCG GTGGGCTGTG GCGCCGGCTC CTCTTCCGGG 
AGGGGCGAGG TCGGTGCAGA CCTTCCTGGG AGCCTGTCAC TGCTTGAGTC AGAGGGCAAG 
GACCACGGCC TTGAACTCAG CATCCACAGG ACGCCCATCT TGGAGGATTT TGAGCTCGAG 
GGAGTGTGCC AGCTCCCAGA CCAGTCGCCT CCCAGGAACA GCATGCCTAA GGCCGAGGAA 
GCCTCTTCCT GGGGACAGTT TGGGTTGAGT TCCAGGAAGA GAGTCCTGTT GGCCAAGGAA 
GAAGCTGACC GTGGAGCCAA AAGGATCTGT GACCTGAGAG AAGATTCAGA AGTTAGTAAG 
AGTAAAGAGG GGTCTCCAAG TTGGAGTGCA TGGCAGCTAC CCTCCACGGG AGACGAAGAG 
GTGTTTGTTT CCGGCTCCAC CCCACCTCCC AGCTGTGCCG TGCGGAGCTG CCTCTCTGCC 
AGTGCCCTCC AGGCTCTGAC CCAGTCTCCG CTGCTGTTCC AGGGGAAAAC ACCTTCCTCT 
CAGAGCAAAG ACCCCAGAGA TGAGGATGTG GATGTTCTTC CCTCCACTGT AGAAGACTCT 
CCTTTCAGTC GCGCTTTCTC CAGGAGGCGC CCCATCAGCA GAACTTATAC ACGGAAGAAG 
CTCATGGGAA CCTGGCTGGA GGACTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001294954.1
CDS	1..5730
Translation	MACCHKVMLLLDTAGGAARHSRVRRAALRLLTYLSCRFGLARVHWAFKFFDSQGARSRPSRVSDFRELGSRSWEDFEEELEARLEDRAHLPGPAPRATHTHGALMETLLDYQWDRPEITSPTKPILRSSGRRLLDVESEAKEAEAALGGLVNAVFLLAPCPHSQRELLQFVSGCEAQAQRLPPTPKQVMEKLLPKRVREVMVARKITFYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNRLLYNSPEYEASFPRMEGMLFLPVEGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPEESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASLFSDVVDSILNQTHDSLADTASAASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKEESSKTEGELIHCLAELYQRKSREESTIAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVAGEKGIQKIPSGRTVDKLEDRGRTLRSSKPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTKELEVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDSAYLAEFLEEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGSPESDELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQPVKDTVQEVTKVRRNLFNQELLSPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVEESPEKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPKSRSVQRVHSFQQDKSDQRENSPVQSIRSPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVTLLSEAEHHGIGDLKSNVLSVEEGEGLRTADAEKSSLSHPGIPPSPPSCGPGSPLMPSRDVHCTTDGRQCQASAQLDNLPASAWHSTDSASPQTYEVELEMQASGLPKLRIKKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTPGKSRGQTYICQACTPTHGPSSTPSPFQTDGVPWTPSPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGADLPGSLSLLESEGKDHGLELSIHRTPILEDFELEGVCQLPDQSPPRNSMPKAEEASSWGQFGLSSRKRVLLAKEEADRGAKRICDLREDSEVSKSKEGSPSWSAWQLPSTGDEEVFVSGSTPPPSCAVRSCLSASALQALTQSPLLFQGKTPSSQSKDPRDEDVDVLPSTVEDSPFSRAFSRRRPISRTYTRKKLMGTWLEDL

Target ORF information:

RefSeq Version	NM_001308025.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TOPBP1 interacting checkpoint and replication regulator (TICRR), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001308025.1

ORF Insert Sequence:

ATGGCATGCT GTCACAAAGT AATGCTGCTG CTGGACACCG CGGGCGGCGC CGCCCGCCAC 
AGCCGGGTCC GGCGGGCCGC CCTGCGCCTC CTCACCTATC TGAGTTGCCG ATTCGGCCTG 
GCCAGGGTCC ACTGGGCCTT CAAGTTCTTT GACTCGCAGG GGGCGCGGAG CCGGCCGTCC 
CGCGTGTCTG ACTTCCGCGA GCTGGGGTCC CGCTCGTGGG AGGACTTTGA GGAGGAGCTG 
GAGGCCAGGC TCGAGGATCG CGCCCACCTG CCCGGCCCGG CGCCCAGGGC CACCCACACG 
CACGGCGCCC TGATGGAGAC GCTGCTAGAC TACCAGTGGG ACCGGCCCGA GATCACGTCG 
CCCACGAAGC CGATCCTGCG GAGCAGCGGG AGGAGACTGC TGGACGTGGA GAGCGAGGCC 
AAGGAGGCCG AGGCCGCGCT CGGGGGCTTG GTGAACGCCG TCTTCCTCCT GGCCCCCTGT 
CCGCACTCGC AGAGGGAGCT GCTGCAGTTC GTGTCTGGGT GCGAGGCCCA GGCCCAGCGC 
CTGCCGCCCA CCCCTAAGCA GGTGATGGAG AAGTTGTTGC CCAAGAGAGT CCGGGAAGTC 
ATGGTCGCCC GAAAAATCAC CTTCTACTGG GTGGATACCA CCGAATGGTC TAAGTTGTGG 
GAATCCCCAG ACCACCTTGG ATACTGGACT GTTTGTGAAC TGCTCCACCA CGGAGGTGGC 
ACTGTCTTGC CATCTGAATC TTTCAGCTGG GATTTTGCTC AAGCTGGGGA AATGCTGCTC 
AGGAGTGGAA TAAAGCTGTC AAGTGAACCT CATCTTTCTC CGTGGATTTC AATGCTGCCA 
ACTGATGCCA CTTTAAACCG TTTGCTCTAC AATTCTCCTG AGTATGAGGC CTCGTTTCCA 
CGAATGGAAG GAATGTTATT TCTCCCTGTT GAAGGCAAAG AGATTCAAGA AACATGGACA 
GTCACCCTAG AGCCCTTGGC CATGCATCAG AGACATTTTC AGAAACCAGT CAGAATTTTT 
CTAAAAGGCT CAGTGGCCCA GTGGTCTCTC CCAACGAGCA GCACTTTGGG CACTGACAGC 
TGGATGCTAG GAAGTCCAGA GGAGAGCACA GCAACTCAAA GGCTGTTATT TCAGCAGTTG 
GTAAGCAGGC TGACTGCTGA AGAGTTACAC CTGGTTGCTG ATGTGGACCC TGGTGAAGGC 
CGGCCCCCCA TCACTGGAGT TATTTCCCCA CTCTCTGCCA GTGCTATGAT CCTCACTGTG 
TGCCGCACCA AGGAGGCTGA ATTTCAACGA CATGTTCTCC AAACAGCTGT GGCTGACAGC 
CCCCGGGACA CAGCTTCCCT TTTCTCAGAT GTTGTGGATA GTATATTGAA TCAGACTCAT 
GATTCGCTTG CAGATACTGC TTCTGCTGCT TCTCCTGTTC CAGAGTGGGC CCAGCAGGAG 
CTTGGCCACA CCACTCCCTG GAGTCCAGCT GTTGTGGAAA AGTGGTTTCC TTTCTGTAAC 
ATCAGTGGTG CCAGTTCCGA TTTGATGGAG TCATTTGGGT TACTACAGGC TGCCTCAGCT 
AATAAGGAAG AGTCTTCCAA AACTGAAGGC GAATTAATAC ATTGCCTTGC CGAGCTCTAC 
CAGAGAAAAT CTCGTGAAGA ATCCACTATA GCTCATCAAG AAGACAGCAA AAAGAAACGA 
GGGGTCCCTC GTACTCCAGT GAGACAGAAG ATGAATACCA TGTGCCGTTC CTTAAAGATG 
TTGAATGTCG CAAGGCTGAA TGTGAAGGCC CAGAAGTTAC ATCCAGATGG CAGTCCGGAT 
GTGGCTGGGG AGAAAGGAAT CCAAAAGATA CCTAGTGGGA GAACAGTGGA TAAATTGGAA 
GACAGAGGAA GAACACTAAG AAGTTCTAAA CCTAAAGATT TTAAAACTGA GGAAGAGCTG 
CTATCATATA TACGTGAAAA TTACCAAAAG ACTGTGGCCA CAGGAGAAAT CATGTTGTAT 
GCATGTGCTC GAAACATGAT CTCAACCGTT AAAATGTTCC TAAAATCAAA AGGCACCAAG 
GAATTAGAAG TGAACTGCCT GAATCAAGTA AAAAGTAGTC TCTTAAAAAC TAGTAAAAGT 
CTTCGACAGA ATCTAGGAAA AAAACTGGAT AAGGAAGACA AAGTTAGAGA GTGCCAGCTT 
CAGGTATTTC TTCGTTTGGA GATGTGTCTG CAATGCCCTT CAATAAATGA AAGTACAGAT 
GATATGGAAC AAGTAGTGGA GGAGGTGACA GATTTGCTGC GCATGGTGTG TTTAACTGAG 
GATTCAGCGT ACCTAGCAGA GTTTCTGGAG GAAATTTTGA GATTGTATAT TGACTCTATC 
CCAAAGACAC TTGGAAATCT TTACAACAGC CTAGGGTTTG TGATTCCTCA GAAGCTGGCT 
GGTGTCCTTC CTACAGATTT TTTCAGTGAT GACTCCATGA CACAAGAGAA CAAATCACCA 
CTTCTTTCTG TGCCTTTTTT GTCAAGTGCT CGTAGATCAG TGTCAGGCAG CCCTGAATCT 
GATGAACTGC AGGAACTTCG TACCAGATCA GCCAAGAAGA GAAGGAAAAA TGCATTAATA 
AGACATAAAA GCATTGCTGA GGTTTCACAG AATCTTCGAC AAATTGAAAT TCCTAAAGTG 
TCAAAGAGAG CTACGAAAAA AGAGAACTCT CACCCTGCTC CTCAGCAGCC TTCCCAGCCA 
GTGAAAGATA CAGTGCAAGA AGTGACCAAA GTTCGAAGAA ATCTTTTCAA CCAGGAATTG 
CTTTCCCCTT CAAAGAGATC ACTAAAGCGG GGGTTGCCTA GAAGCCATTC TGTGTCAGCT 
GTGGATGGTC TAGAGGATAA ACTTGACAAC TTCAAGAAGA ACAAAGGTTA TCACAAACTG 
CTGACTAAGA GTGTGGCCGA GACTCCAGTG CATAAGCAGA TCTCCAAAAG GCTGCTGCAC 
AGACAAATCA AGGGCAGGTC CTCTGATCCT GGTCCTGATA TTGGTGTTGT TGAAGAGTCC 
CCTGAAAAAG GAGATGAAAT AAGTCTGAGA CGAAGTCCTC GAATCAAGCA GTTGTCATTT 
AGCAGGACAC ATTCTGCCTC CTTCTATTCT GTGTCTCAGC CGAAGTCTCG AAGTGTGCAA 
AGAGTCCACT CTTTCCAGCA AGATAAGTCA GACCAAAGAG AAAATTCTCC AGTCCAAAGT 
ATTCGGTCTC CCAAGAGTCT TCTTTTTGGG GCAATGTCTG AGATGATCAG CCCCTCAGAA 
AAGGGTTCAG CTCGAATGAA AAAGCGTTCA AGAAACACTT TGGATTCGGA GGTACCTGCA 
GCTTACCAGA CTCCCAAGAA GAGTCACCAG AAATCTCTGA GCTTTTCTAA AACTACACCA 
AGAAGGATCT CTCATACACC ACAAACTCCG TTGTATACTC CAGAAAGGCT GCAGAAGTCC 
CCTGCAAAAA TGACCCCTAC AAAGCAGGCA GCTTTTAAGG AGTCCTTAAA AGACTCCTCC 
TCACCCGGCC ATGACTCACC ATTGGATTCA AAAATCACTC CTCAAAAACG ACATACCCAG 
GCAGGAGAAG GTACCTCTCT TGAAACGAAG ACACCAAGAA CTCCTAAGAG GCAAGGTACT 
CAGCCGCCTG GGTTTTTGCC AAACTGTACT TGGCCACATT CAGTGAATTC CAGTCCAGAA 
AGCCCCTCCT GTCCAGCCCC TCCAACTTCA TCGACTGCCC AGCCCAGGAG AGAGTGTCTC 
ACTCCCATCA GAGACCCTCT CAGAACACCT CCGAGAGCAG CAGCCTTCAT GGGCACGCCT 
CAGAATCAAA CACACCAACA GCCCCATGTC CTCAGAGCTG CTCGGGCAGA GGAACCAGCC 
CAGAAACTAA AGGATAAAGC TATCAAAACT CCAAAAAGAC CAGGGAATTC AACTGTGACT 
TCTTCCCCAC CTGTTACGCC AAAGAAACTG TTTACCTCTC CTTTATGTGA TGTCTCCAAG 
AAGAGTCCAT TTAGGAAATC TAAAATAGAG TGTCCTTCCC CAGGAGAACT GGATCAGAAA 
GAGCCCCAGA TGTCACCCAG CGTAGCTGCA TCTCTCTCCT GCCCTGTTCC CTCAACTCCC 
CCTGAACTCT CACAGAGAGC TACATTGGAC ACCGTCCCTC CTCCACCCCC TTCTAAAGTT 
GGGAAACGGT GTAGAAAGAC CTCTGATCCC AGAAGGAGCA TCGTGGAGTG TCAGCCTGAT 
GCCTCCGCTA CTCCTGGGGT TGGCACAGCT GACAGCCCAG CTGCCCCCAC AGACTCTAGA 
GATGACCAGA AGGGACTGAG CCTCTCTCCT CAGTCTCCTC CTGAAAGACG GGGCTACCCA 
GGCCCTGGTC TCAGGAGTGA TTGGCATGCA TCCTCTCCTC TGCTCATTAC AAGTGACACA 
GAGCATGTCA CTCTCCTCAG TGAAGCCGAA CACCATGGCA TTGGTGACTT GAAAAGTAAC 
GTCTTATCAG TGGAAGAGGG TGAGGGGCTA AGGACAGCAG ATGCTGAGAA GTCTTCTCTG 
TCTCACCCTG GGATTCCCCC ATCTCCTCCT TCCTGTGGGC CTGGCTCTCC TCTGATGCCT 
TCCCGTGACG TGCACTGTAC CACAGATGGG AGACAGTGCC AGGCTTCGGC ACAACTAGAC 
AACCTGCCAG CATCAGCTTG GCATTCCACA GACTCTGCCA GCCCACAGAC CTATGAGGTT 
GAGCTGGAGA TGCAAGCTTC TGGCCTTCCC AAACTTCGAA TTAAGAAGAT AGACCCCAGC 
TCTTCATTAG AGGCTGAGCC CCTCAGCAAG GAGGAGAGCT CTCTGGGAGA AGAGAGCTTC 
CTCCCTGCTC TCAGCATGCC CAGGGCCAGC AGGTCCTTAA GCAAACCTGA ACCCACCTAT 
GTGTCACCCC CCTGCCCCCG CCTCTCCCAC AGCACACCTG GCAAGAGCAG GGGGCAAACC 
TACATCTGCC AGGCCTGTAC CCCCACCCAC GGCCCTTCTA GTACCCCCTC TCCATTTCAA 
ACAGATGGGG TTCCTTGGAC ACCATCCCCC AAGCACAGTG GGAAGACAAC TCCAGACATA 
ATTAAAGACT GGCCCAGGAG GAAGAGGGCG GTGGGCTGTG GCGCCGGCTC CTCTTCCGGG 
AGGGGCGAGG TCGGTGCAGA CCTTCCTGGG AGCCTGTCAC TGCTTGAGTC AGAGGGCAAG 
GACCACGGCC TTGAACTCAG CATCCACAGG ACGCCCATCT TGGAGGATTT TGAGCTCGAG 
GGAGTGTGCC AGCTCCCAGA CCAGTCGCCT CCCAGGAACA GCATGCCTAA GGCCGAGGAA 
GCCTCTTCCT GGGGACAGTT TGGGTTGAGT TCCAGGAAGA GAGTCCTGTT GGCCAAGGAA 
GAAGCTGACC GTGGAGCCAA AAGGATCTGT GACCTGAGAG AAGATTCAGA AGTTAGTAAG 
AGTAAAGAGG GGTCTCCAAG TTGGAGTGCA TGGCAGCTAC CCTCCACGGG AGACGAAGAG 
GTGTTTGTTT CCGGCTCCAC CCCACCTCCC AGCTGTGCCG TGCGGAGCTG CCTCTCTGCC 
AGTGCCCTCC AGGCTCTGAC CCAGTCTCCG CTGCTGTTCC AGGGGAAAAC ACCTTCCTCT 
CAGAGCAAAG ACCCCAGAGA TGAGGATGTG GATGTTCTTC CCTCCACTGT AGAAGACTCT 
CCTTTCAGTC GCGCTTTCTC CAGGAGGCGC CCCATCAGCA GAACTTATAC ACGGAAGAAG 
CTCATGGGAA CCTGGCTGGA GGACTTATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ensa controls S-phase length by modulating Treslin levels.
Nature communications8(1)206(2017 08)
Charrasse S,Gharbi-Ayachi A,Burgess A,Vera J,Hached K,Raynaud P,Schwob E,Lorca T,Castro A

International journal of sports medicine38(7)508-514(2017 Jul)
Kim S,Kleimeyer JP,Ahmed MA,Avins AL,Fredericson M,Dragoo JL,Ioannidis JPA

Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Proceedings of the National Academy of Sciences of the United States of America114(19)E3766-E3775(2017 May)
Liu K,Lin FT,Graves JD,Lee YJ,Lin WC

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.
Nature genetics49(4)537-549(2017 Apr)
Reynolds JJ,Bicknell LS,Carroll P,Higgs MR,Shaheen R,Murray JE,Papadopoulos DK,Leitch A,Murina O,Tarnauskait? ?,Wessel SR,Zlatanou A,Vernet A,von Kriegsheim A,Mottram RM,Logan CV,Bye H,Li Y,Brean A,Maddirevula S,Challis RC,Skouloudaki K,Almoisheer A,Alsaif HS,Amar A,Prescott NJ,Bober MB,Duker A,Faqeih E,Seidahmed MZ,Al Tala S,Alswaid A,Ahmed S,Al-Aama JY,Altm?ller J,Al Balwi M,Brady AF,Chessa L,Cox H,Fischetto R,Heller R,Henderson BD,Hobson E,N?rnberg P,Percin EF,Peron A,Spaccini L,Quigley AJ,Thakur S,Wise CA,Yoon G,Alnemer M,Tomancak P,Yigit G,Taylor AM,Reijns MA,Simpson MA,Cortez D,Alkuraya FS,Mathew CG,Jackson AP,Stewart GS

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TICRR cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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