CCNG2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCNG2
Entrez Gene ID	901
Full Name	cyclin G2
General protein information	Preferred Names cyclin G2 Names cyclin-G2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q21.1
Summary	The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008].
Disorder MIM:	603203

mRNA and Protein(s)

mRNA	Protein	Name
XM_011532398.1	XP_011530700.1	cyclin-G2 isoform X1
NM_004354.2	NP_004345.1	cyclin-G2
NM_004354.3	NP_004345.1	cyclin-G2
XM_011532399.2	XP_011530701.1	cyclin-G2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CCNG2	XP_002688407.1
Mus musculus (house mouse)	Ccng2	NP_031661.3
Gallus gallus (chicken)	CCNG2	XP_420475.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001730	XP_321356.5
Pan troglodytes (chimpanzee)	CCNG2	XP_001147453.1
Canis lupus familiaris (dog)	CCNG2	XP_005639153.1
Homo sapiens (human)	CCNG2	NP_004345.1
	LOC699793	XP_002804117.1
Rattus norvegicus (Norway rat)	Ccng2	NP_001099195.1
Danio rerio (zebrafish)	ccng2	NP_998337.1
Xenopus tropicalis (tropical clawed frog)	ccng2	NP_001016447.2

Gene Ontology
Bibliography

Related articles in PubMed

Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells.
Bernaudo S, Khazai S, Honarparvar E, Kopteva A, Peng C
PloS one12(6)e0179906(2017)

Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival.
Zimmermann M, Arachchige-Don AP, Donaldson MS, Patriarchi T, Horne MC
Cell cycle (Georgetown, Tex.)15(23)3278-3295(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EGF-induced, calpain-mediated proteolysis contributes to the rapid destruction of cyclin G2 and that the PEST domain is critical for EGF/calpain actions
Title: Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells.

CycG2 contributes to signaling networks that limit breast cancer.
Title: Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival.

Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in Epithelial ovarian cancer (EOC) by inhibiting EMT through attenuating Wnt/beta-catenin signaling.
Title: Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/?-catenin signaling.

CCNG2 knockdown eradicated the effects of miR-340 silencing.
Title: MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2.

Upregulation of miR1246 mediated the malignant progression of colorectal cancer and is partly attributed to the downregulation of the expression of CycG2.
Title: MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.

The following CCNG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCNG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13681	NM_004354.3 Latest version!	Homo sapiens cyclin G2 (CCNG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu13681	XM_011532399.2 Latest version!	Homo sapiens cyclin G2 (CCNG2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
OHu13681	XM_011532398.1 Latest version!	Homo sapiens cyclin G2 (CCNG2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
View Old Accession Versions >>
OHu13681	NM_004354.2	Homo sapiens cyclin G2 (CCNG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$144.50-$202.30 $289.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCNG2 ( NM_004354.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004345.1 Homo sapiens cyclin G2 (CCNG2), mRNA.

Price & Availability↑

CloneID	OHu13681
Clone ID Related Accession (Same CDS sequence)	XM_011532398.1 , NM_004354.2 , NM_004354.3 , XM_011532399.2
Accession Version	NM_004354.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Homo sapiens(human)
Product	cyclin-G2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC344594.1, U47414.1, AC104771.4 and CA429362.1. On May 7, 2008 this sequence version replaced NM_004354.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.56692.1, SRR1660809.58435.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004345.1
CDS	304..1338
Translation	MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETLKSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS

Target ORF information:

RefSeq Version	NM_004354.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin G2 (CCNG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004354.2

ORF Insert Sequence:

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCNG2 ( NM_004354.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004345.1 Homo sapiens cyclin G2 (CCNG2), mRNA.

Price & Availability↑

CloneID	OHu13681
Clone ID Related Accession (Same CDS sequence)	XM_011532398.1 , NM_004354.2 , NM_004354.3 , XM_011532399.2
Accession Version	NM_004354.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	cyclin-G2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC344594.1, U47414.1, AC104771.4 and CA429362.1. On Nov 22, 2018 this sequence version replaced NM_004354.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.195415.1, SRR1660805.56692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000316355.10/ ENSP00000315743.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004345.1
CDS	301..1335
Translation	MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETLKSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS

Target ORF information:

RefSeq Version	NM_004354.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin G2 (CCNG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004354.3

ORF Insert Sequence:

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCNG2 ( XM_011532398.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530700.1 Homo sapiens cyclin G2 (CCNG2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu13681
Clone ID Related Accession (Same CDS sequence)	XM_011532398.1 , NM_004354.2 , NM_004354.3 , XM_011532399.2
Accession Version	XM_011532398.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cyclin-G2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530700.1
CDS	25..1059
Translation	MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETLKSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS

Target ORF information:

RefSeq Version	XM_011532398.1
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin G2 (CCNG2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532398.1

ORF Insert Sequence:

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CCNG2 ( XM_011532399.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530701.1 Homo sapiens cyclin G2 (CCNG2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu13681
Clone ID Related Accession (Same CDS sequence)	XM_011532398.1 , NM_004354.2 , NM_004354.3 , XM_011532399.2
Accession Version	XM_011532399.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1035bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	cyclin-G2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532399.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530701.1
CDS	444..1478
Translation	MKDLGAEHLAGHEGVQLLGLLNVYLEQEERFQPREKGLSLIEATPENDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDCNIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTIILCHTSERKEILSLDKLEAQLKACNCRLIFSKAKPSVLALCLLNLEVETLKSVELLEILLLVKKHSKINDTEFFYWRELVSKCLAEYSSPECCKPDLKKLVWIVSRRTAQNLHNSYYSVPELPTIPEGGCFDESESEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS

Target ORF information:

RefSeq Version	XM_011532399.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cyclin G2 (CCNG2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532399.2

ORF Insert Sequence:

ATGAAGGATT TGGGGGCAGA GCACTTGGCA GGTCATGAAG GGGTCCAACT TCTCGGGTTG 
TTGAACGTCT ACCTGGAACA AGAAGAGAGA TTCCAACCTC GAGAAAAAGG GCTGAGTTTG 
ATTGAGGCTA CCCCGGAGAA TGATAACACT TTGTGTCCAG GATTGAGAAA TGCCAAAGTT 
GAAGATTTAA GGAGTTTAGC CAACTTTTTT GGATCTTGCA CTGAAACTTT TGTCCTGGCT 
GTCAATATTT TGGACAGGTT CTTGGCTCTT ATGAAGGTGA AACCTAAACA TTTGTCTTGC 
ATTGGAGTCT GTTCTTTTTT GCTGGCTGCT AGAATAGTTG AAGAAGACTG CAATATTCCA 
TCCACTCATG ATGTGATCCG GATTAGTCAG TGTAAATGTA CTGCTTCTGA CATAAAACGG 
ATGGAAAAAA TAATTTCAGA AAAATTGCAC TATGAATTGG AAGCTACTAC TGCCTTAAAC 
TTTTTGCACT TATACCATAC TATTATACTT TGTCATACTT CAGAAAGGAA AGAAATACTG 
AGCCTTGATA AACTAGAAGC TCAGCTGAAA GCTTGCAACT GCCGACTCAT CTTTTCAAAA 
GCAAAACCAT CTGTATTAGC CTTGTGCCTT CTCAATTTGG AAGTGGAAAC TTTGAAATCT 
GTTGAATTAC TGGAAATTCT CTTGCTAGTT AAAAAACATT CCAAGATTAA TGACACTGAG 
TTCTTCTACT GGAGAGAGTT GGTTTCTAAA TGCCTAGCCG AGTATTCTTC TCCTGAATGT 
TGCAAACCAG ATCTTAAGAA GTTGGTTTGG ATCGTTTCAA GGCGCACAGC CCAGAACCTC 
CACAACAGCT ACTATAGTGT TCCTGAGCTG CCAACGATAC CTGAGGGGGG TTGTTTTGAT 
GAAAGTGAAA GTGAGGACTC TTGTGAAGAT ATGAGTTGTG GAGAGGAGAG TCTCAGCAGC 
TCTCCTCCCA GTGATCAAGA GTGCACCTTC TTTTTCAACT TCAAAGTGGC ACAAACACTG 
TGCTTTCCAT CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells.
PloS one12(6)e0179906(2017)
Bernaudo S,Khazai S,Honarparvar E,Kopteva A,Peng C

Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival.
Cell cycle (Georgetown, Tex.)15(23)3278-3295(2016 Dec)
Zimmermann M,Arachchige-Don AP,Donaldson MS,Patriarchi T,Horne MC

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CCNG2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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