Gene Symbol | PLCZ1 |
Entrez Gene ID | 89869 |
Full Name | phospholipase C zeta 1 |
Synonyms | NYD-SP27,PLC-zeta-1,PLCzeta,SPGF17 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. |
Disorder MIM: | |
Disorder Html: | ?Spermatogenic failure 17, 617214 (3) |