PLOD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLOD3
Entrez Gene ID	8985
Full Name	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
Synonyms	LH3
General protein information	Preferred Names procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Names procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 lysine hydroxylase 3 lysyl hydroxlase 3 lysyl hydroxylase 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	603066
Disorder Html:	Lysyl hydroxylase 3 deficiency, 612394 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001084.4	NP_001075.1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor
NM_001084.5	NP_001075.1	multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PLOD3	XP_536856.2
Mus musculus (house mouse)	Plod3	NP_036092.1
Pan troglodytes (chimpanzee)	PLOD3	XP_001153684.1
Bos taurus (cattle)	PLOD3	NP_001180184.1
Rattus norvegicus (Norway rat)	Plod3	NP_835202.2
Danio rerio (zebrafish)	wu:fb72h05	XP_002666609.1
Caenorhabditis elegans (roundworm)	let-268	NP_496170.1
Danio rerio (zebrafish)	plod3	NP_001037808.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001507	XP_321614.4
Homo sapiens (human)	PLOD3	NP_001075.1
	LOC714283	XP_002808395.1
Drosophila melanogaster (fruit fly)	Plod	NP_729687.1
Xenopus tropicalis (tropical clawed frog)	plod3	NP_001039229.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.
Amodio G, Sasso E, D'Ambrosio C, Scaloni A, Moltedo O, Franceschelli S, Zambrano N, Remondelli P
Cell biology and toxicology32(4)285-303(2016 Aug)

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.
Banushi B, Forneris F, Straatman-Iwanowska A, Strange A, Lyne AM, Rogerson C, Burden JJ, Heywood WE, Hanley J, Doykov I, Straatman KR, Smith H, Bem D, Kriston-Vizi J, Ariceta G, Risteli M, Wang C, Ardill RE, Zaniew M, Latka-Grot J, Waddington SN, Howe SJ, Ferraro F, Gjinovci A, Lawrence S, Marsh M, Girolami M, Bozec L, Mills K, Gissen P
Nature communications712111(2016 Jul)

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.
Watt SA, Dayal JH, Wright S, Riddle M, Pourreyron C, McMillan JR, Kimble RM, Prisco M, Gartner U, Warbrick E, McLean WH, Leigh IM, McGrath JA, Salas-Alanis JC, Tolar J, South AP
PloS one10(9)e0137639(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Proteomic analysis revealed that PLOD3, which is the gene encoding for collagen-modifying lysyl hydroxylase 3 (LH3), is regulated by miR-663a.
Title: Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.

MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation
Title: Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-? (TGF-?) Activation and Fibroblast Differentiation.

The study shows that lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa.
Title: Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.

LH3 molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on LH3 glycosyltransferase activity; LH3 found on the cell surface bypasses the Golgi complex
Title: Lysyl hydroxylase 3 is secreted from cells by two pathways.

Dimerization of human lysyl hydroxylase 3 is mediated by the amino acids 541-547
Title: Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547.

The following PLOD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLOD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19689	NM_001084.5 Latest version!	Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu19689	NM_001084.4	Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLOD3 ( NM_001084.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001075.1 Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.

Price & Availability↑

CloneID	OHu19689
Clone ID Related Accession (Same CDS sequence)	NM_001084.4 , NM_001084.5
Accession Version	NM_001084.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-24
Organism	Homo sapiens(human)
Product	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF941815.1, BC011674.2, AC004876.2 and AL049952.1. This sequence is a reference standard in the RefSeqGene project. On Apr 19, 2005 this sequence version replaced NM_001084.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011674.2, AK075338.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCTCCT CGGGGCCTGG ACCCCGGTTC CTGCTGCTGC TGCCGCTGCT GCTGCCCCCT 
GCGGCCTCAG CCTCCGACCG GCCCCGGGGC CGAGACCCGG TCAACCCAGA GAAGCTGCTG 
GTGATCACTG TGGCCACAGC TGAAACCGAG GGGTACCTGC GTTTCCTGCG CTCTGCGGAG 
TTCTTCAACT ACACTGTGCG GACCCTGGGC CTGGGAGAGG AGTGGCGAGG GGGTGATGTG 
GCTCGAACAG TTGGTGGAGG ACAGAAGGTC CGGTGGTTAA AGAAGGAAAT GGAGAAATAC 
GCTGACCGGG AGGATATGAT CATCATGTTT GTGGATAGCT ACGACGTGAT TCTGGCCGGC 
AGCCCCACAG AGCTGCTGAA GAAGTTCGTC CAGAGTGGCA GCCGCCTGCT CTTCTCTGCA 
GAGAGCTTCT GCTGGCCCGA GTGGGGGCTG GCGGAGCAGT ACCCTGAGGT GGGCACGGGG 
AAGCGCTTCC TCAATTCTGG TGGATTCATC GGTTTTGCCA CCACCATCCA CCAAATCGTG 
CGCCAGTGGA AGTACAAGGA TGATGACGAC GACCAGCTGT TCTACACACG GCTCTACCTG 
GACCCAGGAC TGAGGGAGAA ACTCAGCCTT AATCTGGATC ATAAGTCTCG GATCTTTCAG 
AACCTCAACG GGGCTTTAGA TGAAGTGGTT TTAAAGTTTG ATCGGAACCG TGTGCGTATC 
CGGAACGTGG CCTACGACAC GCTCCCCATT GTGGTCCATG GAAACGGTCC CACTAAGCTG 
CAGCTCAACT ACCTGGGAAA CTACGTCCCC AATGGCTGGA CTCCTGAGGG AGGCTGTGGC 
TTCTGCAACC AGGACCGGAG GACACTCCCG GGGGGGCAGC CTCCCCCCCG GGTGTTTCTG 
GCCGTGTTTG TGGAACAGCC TACTCCGTTT CTGCCCCGCT TCCTGCAGCG GCTGCTACTC 
CTGGACTATC CCCCCGACAG GGTCACCCTT TTCCTGCACA ACAACGAGGT CTTCCATGAA 
CCCCACATCG CTGACTCCTG GCCGCAGCTC CAGGACCACT TCTCAGCTGT GAAGCTCGTG 
GGGCCGGAGG AGGCTCTGAG CCCAGGCGAG GCCAGGGACA TGGCCATGGA CCTGTGTCGG 
CAGGACCCCG AGTGTGAGTT CTACTTCAGC CTGGACGCCG ACGCTGTCCT CACCAACCTG 
CAGACCCTGC GTATCCTCAT TGAGGAGAAC AGGAAGGTGA TCGCCCCCAT GCTGTCCCGC 
CACGGCAAGC TGTGGTCCAA CTTCTGGGGC GCCCTGAGCC CCGATGAGTA CTACGCCCGC 
TCCGAGGACT ACGTGGAGCT GGTGCAGCGG AAGCGAGTGG GTGTGTGGAA TGTACCATAC 
ATCTCCCAGG CCTATGTGAT CCGGGGTGAT ACCCTGCGGA TGGAGCTGCC CCAGAGGGAT 
GTGTTCTCGG GCAGTGACAC AGACCCGGAC ATGGCCTTCT GTAAGAGCTT TCGAGACAAG 
GGCATCTTCC TCCATCTGAG CAATCAGCAT GAATTTGGCC GGCTCCTGGC CACTTCCAGA 
TACGACACGG AGCACCTGCA CCCCGACCTC TGGCAGATCT TCGACAACCC CGTCGACTGG 
AAGGAGCAGT ACATCCACGA GAACTACAGC CGGGCCCTGG AAGGGGAAGG AATCGTGGAG 
CAGCCATGCC CGGACGTGTA CTGGTTCCCA CTGCTGTCAG AACAAATGTG TGATGAGCTG 
GTGGCAGAGA TGGAGCACTA CGGCCAGTGG TCAGGCGGCC GGCATGAGGA TTCAAGGCTG 
GCTGGAGGCT ACGAGAATGT GCCCACCGTG GACATCCACA TGAAGCAGGT GGGGTACGAG 
GACCAGTGGC TGCAGCTGCT GCGGACGTAT GTGGGCCCCA TGACCGAGAG CCTGTTTCCC 
GGTTACCACA CCAAGGCGCG GGCGGTGATG AACTTTGTGG TTCGCTACCG GCCAGACGAG 
CAGCCGTCTC TGCGGCCACA CCACGACTCA TCCACCTTCA CCCTCAACGT TGCCCTCAAC 
CACAAGGGCC TGGACTATGA GGGAGGTGGC TGCCGCTTCC TGCGCTACGA CTGTGTGATC 
TCCTCCCCGA GGAAGGGCTG GGCACTCCTG CACCCCGGCC GCCTCACCCA CTACCACGAG 
GGGCTGCCAA CGACCTGGGG CACACGCTAC ATCATGGTGT CCTTTGTCGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075.1
CDS	457..2673
Translation	MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP

Target ORF information:

RefSeq Version	NM_001084.4
Organism	Homo sapiens(human)
Definition	Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001084.4

ORF Insert Sequence:

ATGACCTCCT CGGGGCCTGG ACCCCGGTTC CTGCTGCTGC TGCCGCTGCT GCTGCCCCCT 
GCGGCCTCAG CCTCCGACCG GCCCCGGGGC CGAGACCCGG TCAACCCAGA GAAGCTGCTG 
GTGATCACTG TGGCCACAGC TGAAACCGAG GGGTACCTGC GTTTCCTGCG CTCTGCGGAG 
TTCTTCAACT ACACTGTGCG GACCCTGGGC CTGGGAGAGG AGTGGCGAGG GGGTGATGTG 
GCTCGAACAG TTGGTGGAGG ACAGAAGGTC CGGTGGTTAA AGAAGGAAAT GGAGAAATAC 
GCTGACCGGG AGGATATGAT CATCATGTTT GTGGATAGCT ACGACGTGAT TCTGGCCGGC 
AGCCCCACAG AGCTGCTGAA GAAGTTCGTC CAGAGTGGCA GCCGCCTGCT CTTCTCTGCA 
GAGAGCTTCT GCTGGCCCGA GTGGGGGCTG GCGGAGCAGT ACCCTGAGGT GGGCACGGGG 
AAGCGCTTCC TCAATTCTGG TGGATTCATC GGTTTTGCCA CCACCATCCA CCAAATCGTG 
CGCCAGTGGA AGTACAAGGA TGATGACGAC GACCAGCTGT TCTACACACG GCTCTACCTG 
GACCCAGGAC TGAGGGAGAA ACTCAGCCTT AATCTGGATC ATAAGTCTCG GATCTTTCAG 
AACCTCAACG GGGCTTTAGA TGAAGTGGTT TTAAAGTTTG ATCGGAACCG TGTGCGTATC 
CGGAACGTGG CCTACGACAC GCTCCCCATT GTGGTCCATG GAAACGGTCC CACTAAGCTG 
CAGCTCAACT ACCTGGGAAA CTACGTCCCC AATGGCTGGA CTCCTGAGGG AGGCTGTGGC 
TTCTGCAACC AGGACCGGAG GACACTCCCG GGGGGGCAGC CTCCCCCCCG GGTGTTTCTG 
GCCGTGTTTG TGGAACAGCC TACTCCGTTT CTGCCCCGCT TCCTGCAGCG GCTGCTACTC 
CTGGACTATC CCCCCGACAG GGTCACCCTT TTCCTGCACA ACAACGAGGT CTTCCATGAA 
CCCCACATCG CTGACTCCTG GCCGCAGCTC CAGGACCACT TCTCAGCTGT GAAGCTCGTG 
GGGCCGGAGG AGGCTCTGAG CCCAGGCGAG GCCAGGGACA TGGCCATGGA CCTGTGTCGG 
CAGGACCCCG AGTGTGAGTT CTACTTCAGC CTGGACGCCG ACGCTGTCCT CACCAACCTG 
CAGACCCTGC GTATCCTCAT TGAGGAGAAC AGGAAGGTGA TCGCCCCCAT GCTGTCCCGC 
CACGGCAAGC TGTGGTCCAA CTTCTGGGGC GCCCTGAGCC CCGATGAGTA CTACGCCCGC 
TCCGAGGACT ACGTGGAGCT GGTGCAGCGG AAGCGAGTGG GTGTGTGGAA TGTACCATAC 
ATCTCCCAGG CCTATGTGAT CCGGGGTGAT ACCCTGCGGA TGGAGCTGCC CCAGAGGGAT 
GTGTTCTCGG GCAGTGACAC AGACCCGGAC ATGGCCTTCT GTAAGAGCTT TCGAGACAAG 
GGCATCTTCC TCCATCTGAG CAATCAGCAT GAATTTGGCC GGCTCCTGGC CACTTCCAGA 
TACGACACGG AGCACCTGCA CCCCGACCTC TGGCAGATCT TCGACAACCC CGTCGACTGG 
AAGGAGCAGT ACATCCACGA GAACTACAGC CGGGCCCTGG AAGGGGAAGG AATCGTGGAG 
CAGCCATGCC CGGACGTGTA CTGGTTCCCA CTGCTGTCAG AACAAATGTG TGATGAGCTG 
GTGGCAGAGA TGGAGCACTA CGGCCAGTGG TCAGGCGGCC GGCATGAGGA TTCAAGGCTG 
GCTGGAGGCT ACGAGAATGT GCCCACCGTG GACATCCACA TGAAGCAGGT GGGGTACGAG 
GACCAGTGGC TGCAGCTGCT GCGGACGTAT GTGGGCCCCA TGACCGAGAG CCTGTTTCCC 
GGTTACCACA CCAAGGCGCG GGCGGTGATG AACTTTGTGG TTCGCTACCG GCCAGACGAG 
CAGCCGTCTC TGCGGCCACA CCACGACTCA TCCACCTTCA CCCTCAACGT TGCCCTCAAC 
CACAAGGGCC TGGACTATGA GGGAGGTGGC TGCCGCTTCC TGCGCTACGA CTGTGTGATC 
TCCTCCCCGA GGAAGGGCTG GGCACTCCTG CACCCCGGCC GCCTCACCCA CTACCACGAG 
GGGCTGCCAA CGACCTGGGG CACACGCTAC ATCATGGTGT CCTTTGTCGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLOD3 ( NM_001084.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001075.1 Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.

Price & Availability↑

CloneID	OHu19689
Clone ID Related Accession (Same CDS sequence)	NM_001084.4 , NM_001084.5
Accession Version	NM_001084.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC011674.2, AC004876.2 and AL049952.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001084.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011674.2, AK075338.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000223127.8/ ENSP00000223127.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCTCCT CGGGGCCTGG ACCCCGGTTC CTGCTGCTGC TGCCGCTGCT GCTGCCCCCT 
GCGGCCTCAG CCTCCGACCG GCCCCGGGGC CGAGACCCGG TCAACCCAGA GAAGCTGCTG 
GTGATCACTG TGGCCACAGC TGAAACCGAG GGGTACCTGC GTTTCCTGCG CTCTGCGGAG 
TTCTTCAACT ACACTGTGCG GACCCTGGGC CTGGGAGAGG AGTGGCGAGG GGGTGATGTG 
GCTCGAACAG TTGGTGGAGG ACAGAAGGTC CGGTGGTTAA AGAAGGAAAT GGAGAAATAC 
GCTGACCGGG AGGATATGAT CATCATGTTT GTGGATAGCT ACGACGTGAT TCTGGCCGGC 
AGCCCCACAG AGCTGCTGAA GAAGTTCGTC CAGAGTGGCA GCCGCCTGCT CTTCTCTGCA 
GAGAGCTTCT GCTGGCCCGA GTGGGGGCTG GCGGAGCAGT ACCCTGAGGT GGGCACGGGG 
AAGCGCTTCC TCAATTCTGG TGGATTCATC GGTTTTGCCA CCACCATCCA CCAAATCGTG 
CGCCAGTGGA AGTACAAGGA TGATGACGAC GACCAGCTGT TCTACACACG GCTCTACCTG 
GACCCAGGAC TGAGGGAGAA ACTCAGCCTT AATCTGGATC ATAAGTCTCG GATCTTTCAG 
AACCTCAACG GGGCTTTAGA TGAAGTGGTT TTAAAGTTTG ATCGGAACCG TGTGCGTATC 
CGGAACGTGG CCTACGACAC GCTCCCCATT GTGGTCCATG GAAACGGTCC CACTAAGCTG 
CAGCTCAACT ACCTGGGAAA CTACGTCCCC AATGGCTGGA CTCCTGAGGG AGGCTGTGGC 
TTCTGCAACC AGGACCGGAG GACACTCCCG GGGGGGCAGC CTCCCCCCCG GGTGTTTCTG 
GCCGTGTTTG TGGAACAGCC TACTCCGTTT CTGCCCCGCT TCCTGCAGCG GCTGCTACTC 
CTGGACTATC CCCCCGACAG GGTCACCCTT TTCCTGCACA ACAACGAGGT CTTCCATGAA 
CCCCACATCG CTGACTCCTG GCCGCAGCTC CAGGACCACT TCTCAGCTGT GAAGCTCGTG 
GGGCCGGAGG AGGCTCTGAG CCCAGGCGAG GCCAGGGACA TGGCCATGGA CCTGTGTCGG 
CAGGACCCCG AGTGTGAGTT CTACTTCAGC CTGGACGCCG ACGCTGTCCT CACCAACCTG 
CAGACCCTGC GTATCCTCAT TGAGGAGAAC AGGAAGGTGA TCGCCCCCAT GCTGTCCCGC 
CACGGCAAGC TGTGGTCCAA CTTCTGGGGC GCCCTGAGCC CCGATGAGTA CTACGCCCGC 
TCCGAGGACT ACGTGGAGCT GGTGCAGCGG AAGCGAGTGG GTGTGTGGAA TGTACCATAC 
ATCTCCCAGG CCTATGTGAT CCGGGGTGAT ACCCTGCGGA TGGAGCTGCC CCAGAGGGAT 
GTGTTCTCGG GCAGTGACAC AGACCCGGAC ATGGCCTTCT GTAAGAGCTT TCGAGACAAG 
GGCATCTTCC TCCATCTGAG CAATCAGCAT GAATTTGGCC GGCTCCTGGC CACTTCCAGA 
TACGACACGG AGCACCTGCA CCCCGACCTC TGGCAGATCT TCGACAACCC CGTCGACTGG 
AAGGAGCAGT ACATCCACGA GAACTACAGC CGGGCCCTGG AAGGGGAAGG AATCGTGGAG 
CAGCCATGCC CGGACGTGTA CTGGTTCCCA CTGCTGTCAG AACAAATGTG TGATGAGCTG 
GTGGCAGAGA TGGAGCACTA CGGCCAGTGG TCAGGCGGCC GGCATGAGGA TTCAAGGCTG 
GCTGGAGGCT ACGAGAATGT GCCCACCGTG GACATCCACA TGAAGCAGGT GGGGTACGAG 
GACCAGTGGC TGCAGCTGCT GCGGACGTAT GTGGGCCCCA TGACCGAGAG CCTGTTTCCC 
GGTTACCACA CCAAGGCGCG GGCGGTGATG AACTTTGTGG TTCGCTACCG GCCAGACGAG 
CAGCCGTCTC TGCGGCCACA CCACGACTCA TCCACCTTCA CCCTCAACGT TGCCCTCAAC 
CACAAGGGCC TGGACTATGA GGGAGGTGGC TGCCGCTTCC TGCGCTACGA CTGTGTGATC 
TCCTCCCCGA GGAAGGGCTG GGCACTCCTG CACCCCGGCC GCCTCACCCA CTACCACGAG 
GGGCTGCCAA CGACCTGGGG CACACGCTAC ATCATGGTGT CCTTTGTCGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075.1
CDS	308..2524
Translation	MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP

Target ORF information:

RefSeq Version	NM_001084.5
Organism	Homo sapiens(human)
Definition	Homo sapiens procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001084.5

ORF Insert Sequence:

ATGACCTCCT CGGGGCCTGG ACCCCGGTTC CTGCTGCTGC TGCCGCTGCT GCTGCCCCCT 
GCGGCCTCAG CCTCCGACCG GCCCCGGGGC CGAGACCCGG TCAACCCAGA GAAGCTGCTG 
GTGATCACTG TGGCCACAGC TGAAACCGAG GGGTACCTGC GTTTCCTGCG CTCTGCGGAG 
TTCTTCAACT ACACTGTGCG GACCCTGGGC CTGGGAGAGG AGTGGCGAGG GGGTGATGTG 
GCTCGAACAG TTGGTGGAGG ACAGAAGGTC CGGTGGTTAA AGAAGGAAAT GGAGAAATAC 
GCTGACCGGG AGGATATGAT CATCATGTTT GTGGATAGCT ACGACGTGAT TCTGGCCGGC 
AGCCCCACAG AGCTGCTGAA GAAGTTCGTC CAGAGTGGCA GCCGCCTGCT CTTCTCTGCA 
GAGAGCTTCT GCTGGCCCGA GTGGGGGCTG GCGGAGCAGT ACCCTGAGGT GGGCACGGGG 
AAGCGCTTCC TCAATTCTGG TGGATTCATC GGTTTTGCCA CCACCATCCA CCAAATCGTG 
CGCCAGTGGA AGTACAAGGA TGATGACGAC GACCAGCTGT TCTACACACG GCTCTACCTG 
GACCCAGGAC TGAGGGAGAA ACTCAGCCTT AATCTGGATC ATAAGTCTCG GATCTTTCAG 
AACCTCAACG GGGCTTTAGA TGAAGTGGTT TTAAAGTTTG ATCGGAACCG TGTGCGTATC 
CGGAACGTGG CCTACGACAC GCTCCCCATT GTGGTCCATG GAAACGGTCC CACTAAGCTG 
CAGCTCAACT ACCTGGGAAA CTACGTCCCC AATGGCTGGA CTCCTGAGGG AGGCTGTGGC 
TTCTGCAACC AGGACCGGAG GACACTCCCG GGGGGGCAGC CTCCCCCCCG GGTGTTTCTG 
GCCGTGTTTG TGGAACAGCC TACTCCGTTT CTGCCCCGCT TCCTGCAGCG GCTGCTACTC 
CTGGACTATC CCCCCGACAG GGTCACCCTT TTCCTGCACA ACAACGAGGT CTTCCATGAA 
CCCCACATCG CTGACTCCTG GCCGCAGCTC CAGGACCACT TCTCAGCTGT GAAGCTCGTG 
GGGCCGGAGG AGGCTCTGAG CCCAGGCGAG GCCAGGGACA TGGCCATGGA CCTGTGTCGG 
CAGGACCCCG AGTGTGAGTT CTACTTCAGC CTGGACGCCG ACGCTGTCCT CACCAACCTG 
CAGACCCTGC GTATCCTCAT TGAGGAGAAC AGGAAGGTGA TCGCCCCCAT GCTGTCCCGC 
CACGGCAAGC TGTGGTCCAA CTTCTGGGGC GCCCTGAGCC CCGATGAGTA CTACGCCCGC 
TCCGAGGACT ACGTGGAGCT GGTGCAGCGG AAGCGAGTGG GTGTGTGGAA TGTACCATAC 
ATCTCCCAGG CCTATGTGAT CCGGGGTGAT ACCCTGCGGA TGGAGCTGCC CCAGAGGGAT 
GTGTTCTCGG GCAGTGACAC AGACCCGGAC ATGGCCTTCT GTAAGAGCTT TCGAGACAAG 
GGCATCTTCC TCCATCTGAG CAATCAGCAT GAATTTGGCC GGCTCCTGGC CACTTCCAGA 
TACGACACGG AGCACCTGCA CCCCGACCTC TGGCAGATCT TCGACAACCC CGTCGACTGG 
AAGGAGCAGT ACATCCACGA GAACTACAGC CGGGCCCTGG AAGGGGAAGG AATCGTGGAG 
CAGCCATGCC CGGACGTGTA CTGGTTCCCA CTGCTGTCAG AACAAATGTG TGATGAGCTG 
GTGGCAGAGA TGGAGCACTA CGGCCAGTGG TCAGGCGGCC GGCATGAGGA TTCAAGGCTG 
GCTGGAGGCT ACGAGAATGT GCCCACCGTG GACATCCACA TGAAGCAGGT GGGGTACGAG 
GACCAGTGGC TGCAGCTGCT GCGGACGTAT GTGGGCCCCA TGACCGAGAG CCTGTTTCCC 
GGTTACCACA CCAAGGCGCG GGCGGTGATG AACTTTGTGG TTCGCTACCG GCCAGACGAG 
CAGCCGTCTC TGCGGCCACA CCACGACTCA TCCACCTTCA CCCTCAACGT TGCCCTCAAC 
CACAAGGGCC TGGACTATGA GGGAGGTGGC TGCCGCTTCC TGCGCTACGA CTGTGTGATC 
TCCTCCCCGA GGAAGGGCTG GGCACTCCTG CACCCCGGCC GCCTCACCCA CTACCACGAG 
GGGCTGCCAA CGACCTGGGG CACACGCTAC ATCATGGTGT CCTTTGTCGA CCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.
Cell biology and toxicology32(4)285-303(2016 Aug)
Amodio G,Sasso E,D'Ambrosio C,Scaloni A,Moltedo O,Franceschelli S,Zambrano N,Remondelli P

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.
Nature communications712111(2016 Jul)
Banushi B,Forneris F,Straatman-Iwanowska A,Strange A,Lyne AM,Rogerson C,Burden JJ,Heywood WE,Hanley J,Doykov I,Straatman KR,Smith H,Bem D,Kriston-Vizi J,Ariceta G,Risteli M,Wang C,Ardill RE,Zaniew M,Latka-Grot J,Waddington SN,Howe SJ,Ferraro F,Gjinovci A,Lawrence S,Marsh M,Girolami M,Bozec L,Mills K,Gissen P

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.
PloS one10(9)e0137639(2015)
Watt SA,Dayal JH,Wright S,Riddle M,Pourreyron C,McMillan JR,Kimble RM,Prisco M,Gartner U,Warbrick E,McLean WH,Leigh IM,McGrath JA,Salas-Alanis JC,Tolar J,South AP

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PLOD3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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