H1-10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H1-10
Entrez Gene ID	8971
Full Name	H1 histone family member X
Synonyms	H1.10,H1X
General protein information	Preferred Names H1 histone family member X Names histone H1x
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q21.3
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015].
Disorder MIM:	602785

mRNA and Protein(s)

mRNA	Protein	Name
NM_006026.3	NP_006017.1	histone H1x
NM_006026.4	NP_006017.1	histone H1x

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	H1FX	XP_005632137.1
Pan troglodytes (chimpanzee)	H1FX	XP_003310048.1
	H1FX	XP_001095420.2
Rattus norvegicus (Norway rat)	H1fx	XP_575600.1
Bos taurus (cattle)	H1FX	XP_002697189.1
Homo sapiens (human)	H1FX	NP_006017.1
Mus musculus (house mouse)	H1fx	NP_941024.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Pan C, Fan Y
Biochimica et biophysica acta1859(3)496-509(2016 Mar)

Genome distribution of replication-independent histone H1 variants shows H1.0 associated with nucleolar domains and H1X associated with RNA polymerase II-enriched regions.
Mayor R, Izquierdo-Bouldstridge A, Mill?n-Ari?o L, Bustillos A, Sampaio C, Luque N, Jordan A
The Journal of biological chemistry290(12)7474-91(2015 Mar)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Every amino acid matters: essential contributions of histone variants to mammalian development and disease.
Maze I, Noh KM, Soshnev AA, Allis CD
Nature reviews. Genetics15(4)259-71(2014 Apr)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study concludes that the high expression of histone H1x in neuroendocrine tumours is probably due to the abundance of this protein in the cells from which these tumours originate
Title: Histone H1x is highly expressed in human neuroendocrine cells and tumours.

These results suggest that the differential localization of H1x provides a mechanism for a control of H1x activity by means of shuttling between nuclear subcompartments instead of a controlled turnover of the protein.
Title: G1 phase-dependent nucleolar accumulation of human histone H1x.

comparison of primary aa sequence with other human H1 subtypes, and H1x from different species, generation of specific antibody, expression in different cell lines
Title: Characterisation of human histone H1x.

The following H1-10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H1-10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16581	NM_006026.4 Latest version!	Homo sapiens H1.10 linker histone (H1-10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16581	NM_006026.3	Homo sapiens H1 histone family member X (H1FX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H1-10 ( NM_006026.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006017.1 Homo sapiens H1 histone family member X (H1FX), mRNA.

Price & Availability↑

CloneID	OHu16581
Clone ID Related Accession (Same CDS sequence)	NM_006026.3 , NM_006026.4
Accession Version	NM_006026.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	histone H1x
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000426.2 and BC010435.1. On May 28, 2009 this sequence version replaced NM_006026.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC000426.2 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-independent histone :: PMID: 25645921 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCGTGG AGCTCGAGGA GGCCCTGCCA GTGACGACCG CCGAGGGAAT GGCCAAGAAG 
GTGACCAAGG CTGGCGGCTC GGCGGCGTTG TCCCCATCTA AGAAGAGGAA GAATAGCAAG 
AAGAAGAACC AGCCGGGCAA GTACAGCCAG CTGGTGGTGG AGACCATCCG TAGGCTGGGC 
GAGCGCAACG GCTCGTCGCT GGCCAAGATC TACACCGAGG CCAAGAAGGT TCCGTGGTTC 
GACCAGCAGA ATGGGCGCAC CTACCTCAAG TACTCGATCA AGGCGCTGGT GCAGAACGAC 
ACGCTTCTGC AGGTGAAGGG CACCGGCGCC AACGGTTCCT TCAAGCTCAA CCGCAAGAAG 
CTGGAGGGCG GCGGGGAGCG GCGCGGAGCC CCGGCGGCCG CCACCGCCCC GGCCCCCACC 
GCGCACAAAG CGAAGAAGGC AGCCCCGGGC GCGGCCGGCT CCCGGCGCGC GGACAAGAAG 
CCCGCCAGGG GCCAGAAGCC GGAGCAGCGC TCGCACAAGA AGGGCGCTGG CGCCAAGAAG 
GACAAAGGCG GCAAGGCCAA GAAGACGGCG GCCGCCGGGG GCAAGAAGGT GAAGAAGGCG 
GCCAAGCCCA GCGTCCCCAA AGTGCCCAAG GGCCGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006017.1
CDS	376..1017
Translation	MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK

Target ORF information:

RefSeq Version	NM_006026.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H1 histone family member X (H1FX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006026.3

ORF Insert Sequence:

ATGTCCGTGG AGCTCGAGGA GGCCCTGCCA GTGACGACCG CCGAGGGAAT GGCCAAGAAG 
GTGACCAAGG CTGGCGGCTC GGCGGCGTTG TCCCCATCTA AGAAGAGGAA GAATAGCAAG 
AAGAAGAACC AGCCGGGCAA GTACAGCCAG CTGGTGGTGG AGACCATCCG TAGGCTGGGC 
GAGCGCAACG GCTCGTCGCT GGCCAAGATC TACACCGAGG CCAAGAAGGT TCCGTGGTTC 
GACCAGCAGA ATGGGCGCAC CTACCTCAAG TACTCGATCA AGGCGCTGGT GCAGAACGAC 
ACGCTTCTGC AGGTGAAGGG CACCGGCGCC AACGGTTCCT TCAAGCTCAA CCGCAAGAAG 
CTGGAGGGCG GCGGGGAGCG GCGCGGAGCC CCGGCGGCCG CCACCGCCCC GGCCCCCACC 
GCGCACAAAG CGAAGAAGGC AGCCCCGGGC GCGGCCGGCT CCCGGCGCGC GGACAAGAAG 
CCCGCCAGGG GCCAGAAGCC GGAGCAGCGC TCGCACAAGA AGGGCGCTGG CGCCAAGAAG 
GACAAAGGCG GCAAGGCCAA GAAGACGGCG GCCGCCGGGG GCAAGAAGGT GAAGAAGGCG 
GCCAAGCCCA GCGTCCCCAA AGTGCCCAAG GGCCGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H1-10 ( NM_006026.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006017.1 Homo sapiens H1.10 linker histone (H1-10), mRNA.

Price & Availability↑

CloneID	OHu16581
Clone ID Related Accession (Same CDS sequence)	NM_006026.3 , NM_006026.4
Accession Version	NM_006026.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	histone H1x
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC137695.3. On Nov 22, 2018 this sequence version replaced NM_006026.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC010435.1, D64142.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333762.6/ ENSP00000329662.4 RefSeq Select criteria :: based on single protein-coding transcript replication-independent histone :: PMID: 25645921 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGTGG AGCTCGAGGA GGCCCTGCCA GTGACGACCG CCGAGGGAAT GGCCAAGAAG 
GTGACCAAGG CTGGCGGCTC GGCGGCGTTG TCCCCATCTA AGAAGAGGAA GAATAGCAAG 
AAGAAGAACC AGCCGGGCAA GTACAGCCAG CTGGTGGTGG AGACCATCCG TAGGCTGGGC 
GAGCGCAACG GCTCGTCGCT GGCCAAGATC TACACCGAGG CCAAGAAGGT TCCGTGGTTC 
GACCAGCAGA ATGGGCGCAC CTACCTCAAG TACTCGATCA AGGCGCTGGT GCAGAACGAC 
ACGCTTCTGC AGGTGAAGGG CACCGGCGCC AACGGTTCCT TCAAGCTCAA CCGCAAGAAG 
CTGGAGGGCG GCGGGGAGCG GCGCGGAGCC CCGGCGGCCG CCACCGCCCC GGCCCCCACC 
GCGCACAAAG CGAAGAAGGC AGCCCCGGGC GCGGCCGGCT CCCGGCGCGC GGACAAGAAG 
CCCGCCAGGG GCCAGAAGCC GGAGCAGCGC TCGCACAAGA AGGGCGCTGG CGCCAAGAAG 
GACAAAGGCG GCAAGGCCAA GAAGACGGCG GCCGCCGGGG GCAAGAAGGT GAAGAAGGCG 
GCCAAGCCCA GCGTCCCCAA AGTGCCCAAG GGCCGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006017.1
CDS	385..1026
Translation	MSVELEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGGGERRGAPAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKAKKTAAAGGKKVKKAAKPSVPKVPKGRK

Target ORF information:

RefSeq Version	NM_006026.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H1.10 linker histone (H1-10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006026.4

ORF Insert Sequence:

ATGTCCGTGG AGCTCGAGGA GGCCCTGCCA GTGACGACCG CCGAGGGAAT GGCCAAGAAG 
GTGACCAAGG CTGGCGGCTC GGCGGCGTTG TCCCCATCTA AGAAGAGGAA GAATAGCAAG 
AAGAAGAACC AGCCGGGCAA GTACAGCCAG CTGGTGGTGG AGACCATCCG TAGGCTGGGC 
GAGCGCAACG GCTCGTCGCT GGCCAAGATC TACACCGAGG CCAAGAAGGT TCCGTGGTTC 
GACCAGCAGA ATGGGCGCAC CTACCTCAAG TACTCGATCA AGGCGCTGGT GCAGAACGAC 
ACGCTTCTGC AGGTGAAGGG CACCGGCGCC AACGGTTCCT TCAAGCTCAA CCGCAAGAAG 
CTGGAGGGCG GCGGGGAGCG GCGCGGAGCC CCGGCGGCCG CCACCGCCCC GGCCCCCACC 
GCGCACAAAG CGAAGAAGGC AGCCCCGGGC GCGGCCGGCT CCCGGCGCGC GGACAAGAAG 
CCCGCCAGGG GCCAGAAGCC GGAGCAGCGC TCGCACAAGA AGGGCGCTGG CGCCAAGAAG 
GACAAAGGCG GCAAGGCCAA GAAGACGGCG GCCGCCGGGG GCAAGAAGGT GAAGAAGGCG 
GCCAAGCCCA GCGTCCCCAA AGTGCCCAAG GGCCGCAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of H1 linker histones in mammalian development and stem cell differentiation.
Biochimica et biophysica acta1859(3)496-509(2016 Mar)
Pan C,Fan Y

Genome distribution of replication-independent histone H1 variants shows H1.0 associated with nucleolar domains and H1X associated with RNA polymerase II-enriched regions.
The Journal of biological chemistry290(12)7474-91(2015 Mar)
Mayor R,Izquierdo-Bouldstridge A,Mill?n-Ari?o L,Bustillos A,Sampaio C,Luque N,Jordan A

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Every amino acid matters: essential contributions of histone variants to mammalian development and disease.
Nature reviews. Genetics15(4)259-71(2014 Apr)
Maze I,Noh KM,Soshnev AA,Allis CD

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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H1-10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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