FGF16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF16
Entrez Gene ID	8823
Full Name	fibroblast growth factor 16
Synonyms	FGF-16,MF4
General protein information	Preferred Names fibroblast growth factor 16 Names fibroblast growth factor 16 metacarpal 4-5 fusion
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq21.1
Summary	This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014].
Disorder MIM:	300827
Disorder Html:	Metacarpal 4-5 fusion, 309630 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003868.2	NP_003859.1	fibroblast growth factor 16
NM_003868.3	NP_003859.1	fibroblast growth factor 16

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FGF16	NP_001179706.1
	FGF16	XP_001098950.1
Canis lupus familiaris (dog)	FGF16	XP_549094.2
Mus musculus (house mouse)	Fgf16	NP_085117.2
Danio rerio (zebrafish)	fgf16	NP_001035497.1
Xenopus tropicalis (tropical clawed frog)	fgf16	XP_002931859.1
Homo sapiens (human)	FGF16	NP_003859.1
Pan troglodytes (chimpanzee)	FGF16	XP_529049.2
Rattus norvegicus (Norway rat)	Fgf16	NP_068639.1
Gallus gallus (chicken)	FGF16	NP_001038115.1

Gene Ontology
Bibliography

Related articles in PubMed

High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.
Cheng J, Fang Z, Yang H, Li Y, Tian H, Gong W, Chen T, Liu M, Li X, Jiang C
Preparative biochemistry & biotechnology47(7)720-729(2017 Aug)

Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.
Jones B, Byers H, Watson JS, Newman WG
Clinical dysmorphology23(3)95-7(2014 Jul)

Further evidence for FGF16 truncating mutations as the cause of X-linked recessive fusion of metacarpals 4 / 5.
Jamsheer A, Smigiel R, Jakubiak A, Zemojtel T, Socha M, Robinson PN, Mundlos S
Birth defects research. Part A, Clinical and molecular teratology100(4)314-8(2014 Apr)

FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of mitogen-activated protein kinase (MAPK) signaling pathway.
Basu M, Mukhopadhyay S, Chatterjee U, Roy SS
The Journal of biological chemistry289(3)1415-28(2014 Jan)

Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion.
Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S
Journal of medical genetics50(9)579-84(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Experiments demonstrated FGF16 could promote proliferation of NCL-H460 cells by activating Akt, Erk1/2, and p38 MAPK signaling, whereas JNK had no significant effect.
Title: High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.

Identification of an FGF16 mutation in metacarpal 4-5 fusion.
Title: Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.

impaired FGF16 function may also be responsible for connective tissue symptoms in MF4 patients.
Title: Further evidence for FGF16 truncating mutations as the cause of X-linked recessive fusion of metacarpals 4 / 5.

Fgf-16 gene is a target for NF-kappaB activation in the postnatal heart.
Title: FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.

HUVEC clearly demonstrated chemotaxis towards FGF16. FGF16 enhanced cell migration in response to mechanical damage & failed to induce endothelial cell proliferation or sprouting in a three-dimensional in vitro angiogenesis assay.
Title: Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.

The following FGF16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24041	NM_003868.3 Latest version!	Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OHu24041	NM_003868.2	Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF16 ( NM_003868.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003859.1 Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.

Price & Availability↑

CloneID	OHu24041
Clone ID Related Accession (Same CDS sequence)	NM_003868.2 , NM_003868.3
Accession Version	NM_003868.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	fibroblast growth factor 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB009391.1 and AC243316.3. This sequence is a reference standard in the RefSeqGene project. On Mar 6, 2014 this sequence version replaced NM_003868.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB009391.1, SRR1803612.347159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGAGG TGGGGGGCGT CTTCGCCTCC TTGGACTGGG ATCTACACGG CTTCTCCTCG 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCAGGTTTCC TGAACGAGCG CCTGGGCCAA 
ATCGAGGGGA AGCTGCAGCG TGGCTCACCC ACAGACTTCG CCCACCTAAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTGG AGATCTTCCC CAACGGCACG 
GTGCACGGGA CCCGCCACGA CCACAGCCGC TTCGGAATCC TGGAGTTTAT CAGCCTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAACTCT ATGGGTCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCAACC TTGTACAAAC ATTCGGACTC AGAGAGACAG 
TATTACGTGG CCCTGAACAA AGATGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCT GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TTCACTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003859.1
CDS	1..624
Translation	MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR

Target ORF information:

RefSeq Version	NM_003868.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003868.2

ORF Insert Sequence:

ATGGCAGAGG TGGGGGGCGT CTTCGCCTCC TTGGACTGGG ATCTACACGG CTTCTCCTCG 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCAGGTTTCC TGAACGAGCG CCTGGGCCAA 
ATCGAGGGGA AGCTGCAGCG TGGCTCACCC ACAGACTTCG CCCACCTAAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTGG AGATCTTCCC CAACGGCACG 
GTGCACGGGA CCCGCCACGA CCACAGCCGC TTCGGAATCC TGGAGTTTAT CAGCCTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAACTCT ATGGGTCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCAACC TTGTACAAAC ATTCGGACTC AGAGAGACAG 
TATTACGTGG CCCTGAACAA AGATGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCT GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TTCACTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF16 ( NM_003868.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003859.1 Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.

Price & Availability↑

CloneID	OHu24041
Clone ID Related Accession (Same CDS sequence)	NM_003868.2 , NM_003868.3
Accession Version	NM_003868.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	fibroblast growth factor 16
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243316.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003868.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.347159.1, AB009391.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000439435.3/ ENSP00000399324.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAGAGG TGGGGGGCGT CTTCGCCTCC TTGGACTGGG ATCTACACGG CTTCTCCTCG 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCAGGTTTCC TGAACGAGCG CCTGGGCCAA 
ATCGAGGGGA AGCTGCAGCG TGGCTCACCC ACAGACTTCG CCCACCTAAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTGG AGATCTTCCC CAACGGCACG 
GTGCACGGGA CCCGCCACGA CCACAGCCGC TTCGGAATCC TGGAGTTTAT CAGCCTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAACTCT ATGGGTCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCAACC TTGTACAAAC ATTCGGACTC AGAGAGACAG 
TATTACGTGG CCCTGAACAA AGATGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCT GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TTCACTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003859.1
CDS	287..910
Translation	MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR

Target ORF information:

RefSeq Version	NM_003868.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 16 (FGF16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003868.3

ORF Insert Sequence:

ATGGCAGAGG TGGGGGGCGT CTTCGCCTCC TTGGACTGGG ATCTACACGG CTTCTCCTCG 
TCTCTGGGGA ACGTGCCCTT AGCTGACTCC CCAGGTTTCC TGAACGAGCG CCTGGGCCAA 
ATCGAGGGGA AGCTGCAGCG TGGCTCACCC ACAGACTTCG CCCACCTAAA GGGGATCCTG 
CGGCGCCGCC AGCTCTACTG CCGCACCGGC TTCCACCTGG AGATCTTCCC CAACGGCACG 
GTGCACGGGA CCCGCCACGA CCACAGCCGC TTCGGAATCC TGGAGTTTAT CAGCCTGGCT 
GTGGGGCTGA TCAGCATCCG GGGAGTGGAC TCTGGCCTGT ACCTAGGAAT GAATGAGCGA 
GGAGAACTCT ATGGGTCGAA GAAACTCACA CGTGAATGTG TTTTCCGGGA ACAGTTTGAA 
GAAAACTGGT ACAACACCTA TGCCTCAACC TTGTACAAAC ATTCGGACTC AGAGAGACAG 
TATTACGTGG CCCTGAACAA AGATGGCTCA CCCCGGGAGG GATACAGGAC TAAACGACAC 
CAGAAATTCA CTCACTTTTT ACCCAGGCCT GTAGATCCTT CTAAGTTGCC CTCCATGTCC 
AGAGACCTCT TTCACTATAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.
Preparative biochemistry & biotechnology47(7)720-729(2017 Aug)
Cheng J,Fang Z,Yang H,Li Y,Tian H,Gong W,Chen T,Liu M,Li X,Jiang C

Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.
Clinical dysmorphology23(3)95-7(2014 Jul)
Jones B,Byers H,Watson JS,Newman WG

Further evidence for FGF16 truncating mutations as the cause of X-linked recessive fusion of metacarpals 4 / 5.
Birth defects research. Part A, Clinical and molecular teratology100(4)314-8(2014 Apr)
Jamsheer A,Smigiel R,Jakubiak A,Zemojtel T,Socha M,Robinson PN,Mundlos S

FGF16 promotes invasive behavior of SKOV-3 ovarian cancer cells through activation of mitogen-activated protein kinase (MAPK) signaling pathway.
The Journal of biological chemistry289(3)1415-28(2014 Jan)
Basu M,Mukhopadhyay S,Chatterjee U,Roy SS

Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion.
Journal of medical genetics50(9)579-84(2013 Sep)
Jamsheer A,Zemojtel T,Kolanczyk M,Stricker S,Hecht J,Krawitz P,Doelken SC,Glazar R,Socha M,Mundlos S

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

FGF16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報