CREG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CREG1
Entrez Gene ID	8804
Full Name	cellular repressor of E1A stimulated genes 1
Synonyms	CREG
General protein information	Preferred Names cellular repressor of E1A stimulated genes 1 Names protein CREG1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Summary	The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_003851.3	NP_003842.1	protein CREG1 precursor
NM_003851.2	NP_003842.1	protein CREG1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CREG1	NP_003842.1
Rattus norvegicus (Norway rat)	Creg1	NP_001099436.1
Bos taurus (cattle)	CREG1	NP_001069410.1
Drosophila melanogaster (fruit fly)	CREG	NP_524385.2
Pan troglodytes (chimpanzee)	CREG1	XP_001157266.2
Mus musculus (house mouse)	Creg1	NP_035934.1
Danio rerio (zebrafish)	creg1	NP_001074159.1
	CREG1	XP_001089325.1
Canis lupus familiaris (dog)	CREG1	XP_003435040.2
Gallus gallus (chicken)	CREG1	XP_003640512.1
Xenopus tropicalis (tropical clawed frog)	creg1	XP_002936277.2

Gene Ontology
Bibliography

Related articles in PubMed

Cellular Repressor of E1A-stimulated Genes, A New Potential Therapeutic Target for Atherosclerosis.
Tian X, Yan C, Han Y
Current drug targets18(15)1800-1804(2017)

Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.
Clark DJ, Mei Y, Sun S, Zhang H, Yang AJ, Mao L
Theranostics6(1)65-77(2016)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

CREG1 promotes angiogenesis and neovascularization.
Yan C, Fang P, Zhang H, Tao J, Tian X, Li Y, Zhang J, Sun M, Li S, Wang H, Han Y
Frontiers in bioscience (Landmark edition)191151-61(2014 Jun)

CREG promotes the proliferation of human umbilical vein endothelial cells through the ERK/cyclin E signaling pathway.
Tao J, Yan C, Tian X, Liu S, Li Y, Zhang J, Sun M, Ma X, Han Y
International journal of molecular sciences14(9)18437-56(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer.
Title: Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.

Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation.
Title: CREG1 promotes angiogenesis and neovascularization.

The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway.
Title: CREG promotes the proliferation of human umbilical vein endothelial cells through the ERK/cyclin E signaling pathway.

CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells.
Title: Cellular repressor of E1A stimulated genes enhances endothelial monolayer integrity.

miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation.
Title: MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes.

The following CREG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CREG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13390	NM_003851.3 Latest version!	Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13390	NM_003851.2	Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CREG1 ( NM_003851.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003842.1 Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.

Price & Availability↑

CloneID	OHu13390
Clone ID Related Accession (Same CDS sequence)	NM_003851.3 , NM_003851.2
Accession Version	NM_003851.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein CREG1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF084523.1 and BC006786.1. On Nov 22, 2018 this sequence version replaced NM_003851.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006786.1, AF084523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370509.5/ ENSP00000359540.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGGGC TATCCCGCGG GTCCGCGCGC GCACTGCTCG CCGCCCTGCT GGCGTCGACG 
CTGTTGGCGC TGCTCGTGTC GCCCGCGCGG GGTCGCGGCG GCCGGGACCA CGGGGACTGG 
GACGAGGCCT CCCGGCTGCC GCCGCTACCA CCCCGCGAGG ACGCGGCGCG CGTGGCCCGC 
TTCGTGACGC ACGTCTCCGA CTGGGGCGCT CTGGCCACCA TCTCCACGCT GGAGGCGGTG 
CGCGGCCGGC CCTTCGCCGA CGTCCTCTCG CTCAGCGACG GGCCCCCGGG CGCGGGCAGC 
GGCGTGCCCT ATTTCTACCT GAGCCCGCTG CAGCTCTCCG TGAGCAACCT GCAGGAGAAT 
CCATATGCTA CACTGACCAT GACTTTGGCA CAGACCAACT TCTGCAAGAA ACATGGATTT 
GATCCACAAA GTCCCCTTTG TGTTCACATA ATGCTGTCAG GAACTGTGAC CAAGGTGAAT 
GAAACAGAAA TGGATATTGC AAAGCATTCG TTATTCATTC GACACCCTGA GATGAAAACC 
TGGCCTTCCA GCCATAATTG GTTCTTTGCT AAGTTGAATA TAACCAATAT CTGGGTCCTG 
GACTACTTTG GTGGACCAAA AATCGTGACA CCAGAAGAAT ATTATAATGT CACAGTTCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003842.1
CDS	22..684
Translation	MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ

Target ORF information:

RefSeq Version	NM_003851.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003851.3

ORF Insert Sequence:

ATGGCCGGGC TATCCCGCGG GTCCGCGCGC GCACTGCTCG CCGCCCTGCT GGCGTCGACG 
CTGTTGGCGC TGCTCGTGTC GCCCGCGCGG GGTCGCGGCG GCCGGGACCA CGGGGACTGG 
GACGAGGCCT CCCGGCTGCC GCCGCTACCA CCCCGCGAGG ACGCGGCGCG CGTGGCCCGC 
TTCGTGACGC ACGTCTCCGA CTGGGGCGCT CTGGCCACCA TCTCCACGCT GGAGGCGGTG 
CGCGGCCGGC CCTTCGCCGA CGTCCTCTCG CTCAGCGACG GGCCCCCGGG CGCGGGCAGC 
GGCGTGCCCT ATTTCTACCT GAGCCCGCTG CAGCTCTCCG TGAGCAACCT GCAGGAGAAT 
CCATATGCTA CACTGACCAT GACTTTGGCA CAGACCAACT TCTGCAAGAA ACATGGATTT 
GATCCACAAA GTCCCCTTTG TGTTCACATA ATGCTGTCAG GAACTGTGAC CAAGGTGAAT 
GAAACAGAAA TGGATATTGC AAAGCATTCG TTATTCATTC GACACCCTGA GATGAAAACC 
TGGCCTTCCA GCCATAATTG GTTCTTTGCT AAGTTGAATA TAACCAATAT CTGGGTCCTG 
GACTACTTTG GTGGACCAAA AATCGTGACA CCAGAAGAAT ATTATAATGT CACAGTTCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CREG1 ( NM_003851.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003842.1 Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.

Price & Availability↑

CloneID	OHu13390
Clone ID Related Accession (Same CDS sequence)	NM_003851.3 , NM_003851.2
Accession Version	NM_003851.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	protein CREG1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI552369.1, AF084523.1 and BC006786.1. On Oct 4, 2004 this sequence version replaced NM_003851.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006786.1, AF084523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGGGC TATCCCGCGG GTCCGCGCGC GCACTGCTCG CCGCCCTGCT GGCGTCGACG 
CTGTTGGCGC TGCTCGTGTC GCCCGCGCGG GGTCGCGGCG GCCGGGACCA CGGGGACTGG 
GACGAGGCCT CCCGGCTGCC GCCGCTACCA CCCCGCGAGG ACGCGGCGCG CGTGGCCCGC 
TTCGTGACGC ACGTCTCCGA CTGGGGCGCT CTGGCCACCA TCTCCACGCT GGAGGCGGTG 
CGCGGCCGGC CCTTCGCCGA CGTCCTCTCG CTCAGCGACG GGCCCCCGGG CGCGGGCAGC 
GGCGTGCCCT ATTTCTACCT GAGCCCGCTG CAGCTCTCCG TGAGCAACCT GCAGGAGAAT 
CCATATGCTA CACTGACCAT GACTTTGGCA CAGACCAACT TCTGCAAGAA ACATGGATTT 
GATCCACAAA GTCCCCTTTG TGTTCACATA ATGCTGTCAG GAACTGTGAC CAAGGTGAAT 
GAAACAGAAA TGGATATTGC AAAGCATTCG TTATTCATTC GACACCCTGA GATGAAAACC 
TGGCCTTCCA GCCATAATTG GTTCTTTGCT AAGTTGAATA TAACCAATAT CTGGGTCCTG 
GACTACTTTG GTGGACCAAA AATCGTGACA CCAGAAGAAT ATTATAATGT CACAGTTCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003842.1
CDS	79..741
Translation	MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ

Target ORF information:

RefSeq Version	NM_003851.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cellular repressor of E1A stimulated genes 1 (CREG1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003851.2

ORF Insert Sequence:

ATGGCCGGGC TATCCCGCGG GTCCGCGCGC GCACTGCTCG CCGCCCTGCT GGCGTCGACG 
CTGTTGGCGC TGCTCGTGTC GCCCGCGCGG GGTCGCGGCG GCCGGGACCA CGGGGACTGG 
GACGAGGCCT CCCGGCTGCC GCCGCTACCA CCCCGCGAGG ACGCGGCGCG CGTGGCCCGC 
TTCGTGACGC ACGTCTCCGA CTGGGGCGCT CTGGCCACCA TCTCCACGCT GGAGGCGGTG 
CGCGGCCGGC CCTTCGCCGA CGTCCTCTCG CTCAGCGACG GGCCCCCGGG CGCGGGCAGC 
GGCGTGCCCT ATTTCTACCT GAGCCCGCTG CAGCTCTCCG TGAGCAACCT GCAGGAGAAT 
CCATATGCTA CACTGACCAT GACTTTGGCA CAGACCAACT TCTGCAAGAA ACATGGATTT 
GATCCACAAA GTCCCCTTTG TGTTCACATA ATGCTGTCAG GAACTGTGAC CAAGGTGAAT 
GAAACAGAAA TGGATATTGC AAAGCATTCG TTATTCATTC GACACCCTGA GATGAAAACC 
TGGCCTTCCA GCCATAATTG GTTCTTTGCT AAGTTGAATA TAACCAATAT CTGGGTCCTG 
GACTACTTTG GTGGACCAAA AATCGTGACA CCAGAAGAAT ATTATAATGT CACAGTTCAG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular Repressor of E1A-stimulated Genes, A New Potential Therapeutic Target for Atherosclerosis.
Current drug targets18(15)1800-1804(2017)
Tian X,Yan C,Han Y

Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.
Theranostics6(1)65-77(2016)
Clark DJ,Mei Y,Sun S,Zhang H,Yang AJ,Mao L

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

CREG1 promotes angiogenesis and neovascularization.
Frontiers in bioscience (Landmark edition)191151-61(2014 Jun)
Yan C,Fang P,Zhang H,Tao J,Tian X,Li Y,Zhang J,Sun M,Li S,Wang H,Han Y

CREG promotes the proliferation of human umbilical vein endothelial cells through the ERK/cyclin E signaling pathway.
International journal of molecular sciences14(9)18437-56(2013 Sep)
Tao J,Yan C,Tian X,Liu S,Li Y,Zhang J,Sun M,Ma X,Han Y

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CREG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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