FADD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FADD
Entrez Gene ID	8772
Full Name	Fas associated via death domain
Synonyms	GIG3,MORT1
General protein information	Preferred Names Fas associated via death domain Names FAS-associated death domain protein Fas (TNFRSF6)-associated via death domain Fas-associating death domain-containing protein Fas-associating protein with death domain growth-inhibiting gene 3 protein mediator of receptor-induced toxicity
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.3
Summary	The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
Disorder MIM:	602457
Disorder Html:	Infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovascular malformations, 613759 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003824.3	NP_003815.1	FAS-associated death domain protein
NM_003824.4	NP_003815.1	FAS-associated death domain protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FADD	NP_001007817.1
Xenopus tropicalis (tropical clawed frog)	fadd	XP_002934114.1
Mus musculus (house mouse)	Fadd	NP_034305.1
	LOC708606	XP_001100468.1
Rattus norvegicus (Norway rat)	Fadd	NP_690920.1
Gallus gallus (chicken)	FADD	XP_421073.2
Homo sapiens (human)	FADD	NP_003815.1
Pan troglodytes (chimpanzee)	FADD	XP_508611.2
Danio rerio (zebrafish)	fadd	XP_001923893.1

Gene Ontology

The following FADD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FADD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27397	NM_003824.4 Latest version!	Homo sapiens Fas associated via death domain (FADD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu27397	NM_003824.3	Homo sapiens Fas associated via death domain (FADD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FADD ( NM_003824.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003815.1 Homo sapiens Fas associated via death domain (FADD), mRNA.

Price & Availability↑

CloneID	OHu27397
Clone ID Related Accession (Same CDS sequence)	NM_003824.3 , NM_003824.4
Accession Version	NM_003824.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	FAS-associated death domain protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL575732.1, AP000879.4, BC000334.2 and AI886015.1. This sequence is a reference standard in the RefSeqGene project. On Dec 5, 2008 this sequence version replaced NM_003824.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL575732.1, SRR1163655.278317.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCGT TCCTGGTGCT GCTGCACTCG GTGTCGTCCA GCCTGTCGAG CAGCGAGCTG 
ACCGAGCTCA AGTTCCTATG CCTCGGGCGC GTGGGCAAGC GCAAGCTGGA GCGCGTGCAG 
AGCGGCCTAG ACCTCTTCTC CATGCTGCTG GAGCAGAACG ACCTGGAGCC CGGGCACACC 
GAGCTCCTGC GCGAGCTGCT CGCCTCCCTG CGGCGCCACG ACCTGCTGCG GCGCGTCGAC 
GACTTCGAGG CGGGGGCGGC GGCCGGGGCC GCGCCTGGGG AAGAAGACCT GTGTGCAGCA 
TTTAACGTCA TATGTGATAA TGTGGGGAAA GATTGGAGAA GGCTGGCTCG TCAGCTCAAA 
GTCTCAGACA CCAAGATCGA CAGCATCGAG GACAGATACC CCCGCAACCT GACAGAGCGT 
GTGCGGGAGT CACTGAGAAT CTGGAAGAAC ACAGAGAAGG AGAACGCAAC AGTGGCCCAC 
CTGGTGGGGG CTCTCAGGTC CTGCCAGATG AACCTGGTGG CTGACCTGGT ACAAGAGGTT 
CAGCAGGCCC GTGACCTCCA GAACAGGAGT GGGGCCATGT CCCCGATGTC ATGGAACTCA 
GACGCATCTA CCTCCGAAGC GTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003815.1
CDS	298..924
Translation	MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS

Target ORF information:

RefSeq Version	NM_003824.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Fas associated via death domain (FADD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003824.3

ORF Insert Sequence:

ATGGACCCGT TCCTGGTGCT GCTGCACTCG GTGTCGTCCA GCCTGTCGAG CAGCGAGCTG 
ACCGAGCTCA AGTTCCTATG CCTCGGGCGC GTGGGCAAGC GCAAGCTGGA GCGCGTGCAG 
AGCGGCCTAG ACCTCTTCTC CATGCTGCTG GAGCAGAACG ACCTGGAGCC CGGGCACACC 
GAGCTCCTGC GCGAGCTGCT CGCCTCCCTG CGGCGCCACG ACCTGCTGCG GCGCGTCGAC 
GACTTCGAGG CGGGGGCGGC GGCCGGGGCC GCGCCTGGGG AAGAAGACCT GTGTGCAGCA 
TTTAACGTCA TATGTGATAA TGTGGGGAAA GATTGGAGAA GGCTGGCTCG TCAGCTCAAA 
GTCTCAGACA CCAAGATCGA CAGCATCGAG GACAGATACC CCCGCAACCT GACAGAGCGT 
GTGCGGGAGT CACTGAGAAT CTGGAAGAAC ACAGAGAAGG AGAACGCAAC AGTGGCCCAC 
CTGGTGGGGG CTCTCAGGTC CTGCCAGATG AACCTGGTGG CTGACCTGGT ACAAGAGGTT 
CAGCAGGCCC GTGACCTCCA GAACAGGAGT GGGGCCATGT CCCCGATGTC ATGGAACTCA 
GACGCATCTA CCTCCGAAGC GTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FADD ( NM_003824.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003815.1 Homo sapiens Fas associated via death domain (FADD), mRNA.

Price & Availability↑

CloneID	OHu27397
Clone ID Related Accession (Same CDS sequence)	NM_003824.3 , NM_003824.4
Accession Version	NM_003824.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	FAS-associated death domain protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL575732.1, BC000334.2, AP000879.4 and AI886015.1. On Dec 4, 2019 this sequence version replaced NM_003824.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X84709.1, BC025733.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGACCCGT TCCTGGTGCT GCTGCACTCG GTGTCGTCCA GCCTGTCGAG CAGCGAGCTG 
ACCGAGCTCA AGTTCCTATG CCTCGGGCGC GTGGGCAAGC GCAAGCTGGA GCGCGTGCAG 
AGCGGCCTAG ACCTCTTCTC CATGCTGCTG GAGCAGAACG ACCTGGAGCC CGGGCACACC 
GAGCTCCTGC GCGAGCTGCT CGCCTCCCTG CGGCGCCACG ACCTGCTGCG GCGCGTCGAC 
GACTTCGAGG CGGGGGCGGC GGCCGGGGCC GCGCCTGGGG AAGAAGACCT GTGTGCAGCA 
TTTAACGTCA TATGTGATAA TGTGGGGAAA GATTGGAGAA GGCTGGCTCG TCAGCTCAAA 
GTCTCAGACA CCAAGATCGA CAGCATCGAG GACAGATACC CCCGCAACCT GACAGAGCGT 
GTGCGGGAGT CACTGAGAAT CTGGAAGAAC ACAGAGAAGG AGAACGCAAC AGTGGCCCAC 
CTGGTGGGGG CTCTCAGGTC CTGCCAGATG AACCTGGTGG CTGACCTGGT ACAAGAGGTT 
CAGCAGGCCC GTGACCTCCA GAACAGGAGT GGGGCCATGT CCCCGATGTC ATGGAACTCA 
GACGCATCTA CCTCCGAAGC GTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003815.1
CDS	165..791
Translation	MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS

Target ORF information:

RefSeq Version	NM_003824.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Fas associated via death domain (FADD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003824.4

ORF Insert Sequence:

ATGGACCCGT TCCTGGTGCT GCTGCACTCG GTGTCGTCCA GCCTGTCGAG CAGCGAGCTG 
ACCGAGCTCA AGTTCCTATG CCTCGGGCGC GTGGGCAAGC GCAAGCTGGA GCGCGTGCAG 
AGCGGCCTAG ACCTCTTCTC CATGCTGCTG GAGCAGAACG ACCTGGAGCC CGGGCACACC 
GAGCTCCTGC GCGAGCTGCT CGCCTCCCTG CGGCGCCACG ACCTGCTGCG GCGCGTCGAC 
GACTTCGAGG CGGGGGCGGC GGCCGGGGCC GCGCCTGGGG AAGAAGACCT GTGTGCAGCA 
TTTAACGTCA TATGTGATAA TGTGGGGAAA GATTGGAGAA GGCTGGCTCG TCAGCTCAAA 
GTCTCAGACA CCAAGATCGA CAGCATCGAG GACAGATACC CCCGCAACCT GACAGAGCGT 
GTGCGGGAGT CACTGAGAAT CTGGAAGAAC ACAGAGAAGG AGAACGCAAC AGTGGCCCAC 
CTGGTGGGGG CTCTCAGGTC CTGCCAGATG AACCTGGTGG CTGACCTGGT ACAAGAGGTT 
CAGCAGGCCC GTGACCTCCA GAACAGGAGT GGGGCCATGT CCCCGATGTC ATGGAACTCA 
GACGCATCTA CCTCCGAAGC GTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.