EIF3D cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF3D
Entrez Gene ID	8664
Full Name	eukaryotic translation initiation factor 3 subunit D
Synonyms	EIF3S7,eIF3-p66,eIF3-zeta
General protein information	Preferred Names eukaryotic translation initiation factor 3 subunit D Names eukaryotic translation initiation factor 3 subunit D eIF3 p66 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa translation initiation factor eIF3 p66 subunit
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 22 Map Location: 22q12.3
Summary	Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008].
Disorder MIM:	603915

mRNA and Protein(s)

mRNA	Protein	Name
NM_003753.3	NP_003744.1	eukaryotic translation initiation factor 3 subunit D
NM_003753.4	NP_003744.1	eukaryotic translation initiation factor 3 subunit D
XM_011530479.1	XP_011528781.1	eukaryotic translation initiation factor 3 subunit D isoform X1

Pathways from BioSystems

Homologies

	EIF3D	XP_001084369.1
Mus musculus (house mouse)	Eif3d	NP_061219.2
Schizosaccharomyces pombe (fission yeast)	moe1	NP_594625.1
Neurospora crassa	NCU07380	XP_958873.1
Homo sapiens (human)	EIF3D	NP_003744.1
Pan troglodytes (chimpanzee)	EIF3D	NP_001233341.1
Magnaporthe oryzae (rice blast fungus)	MGG_00341	XP_003718741.1
Canis lupus familiaris (dog)	EIF3D	XP_850595.1
Rattus norvegicus (Norway rat)	Eif3d	NP_001004283.1
Drosophila melanogaster (fruit fly)	eIF-3p66	NP_524463.2
Arabidopsis thaliana (thale cress)	AT4G20980	NP_193830.1
Bos taurus (cattle)	EIF3D	NP_001029656.1
Danio rerio (zebrafish)	eif3d	NP_956310.1
Caenorhabditis elegans (roundworm)	eif-3.D	NP_498984.1
Xenopus tropicalis (tropical clawed frog)	eif3d	NP_989075.1
Gallus gallus (chicken)	EIF3D	XP_001234643.2
Anopheles gambiae (African malaria mosquito)	EIF3D_ANOGA	XP_312631.3
Arabidopsis thaliana (thale cress)	AT5G44320	NP_199245.1
Oryza sativa (rice)	Os05g0566500	NP_001056343.2

Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y
Molecular and cellular biochemistry438(1-2)191-198(2018 Jan)

EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.
Zhang F, Xiang S, Cao Y, Li M, Ma Q, Liang H, Li H, Ye Y, Zhang Y, Jiang L, Hu Y, Zhou J, Wang X, Zhang Y, Nie L, Liang X, Gong W, Liu Y
Cell death & disease8(6)e2868(2017 Jun)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
Shah M, Su D, Scheliga JS, Pluskal T, Boronat S, Motamedchaboki K, Campos AR, Qi F, Hidalgo E, Yanagida M, Wolf DA
Cell reports16(7)1891-902(2016 08)

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Lee AS, Kranzusch PJ, Doudna JA, Cate JH
Nature536(7614)96-9(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A transcript-specific eIF3 complex mediates global translational control of energy metabolism.
Title: A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.

eIF3d makes specific contacts with the RNA cap, as exemplified by cap analogue competition, and these interactions are essential for assembly of translation initiation complexes on eIF3-specialized mRNAs such as the cell proliferation regulator c-Jun
Title: eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.

Results provide evidences that EIF3D may function as a potential proto-oncogene that participates in the occurrence and progression of renal cell carcinoma.
Title: EIF3D silencing suppresses renal cell carcinoma tumorigenesis via inducing G2/M arrest through downregulation of Cyclin B1/CDK1 signaling.

EIF3D plays an important role in modulating glioma cell growth and migration.
Title: RNAi-Mediated Silencing of EIF3D Alleviates Proliferation and Migration of Glioma U251 and U87MG Cells.

Knockdown of eIF3D inhibited breast cancer cell proliferation and invasion.
Title: Knockdown of eIF3D inhibits breast cancer cell proliferation and invasion through suppressing the Wnt/?-catenin signaling pathway.

The following EIF3D gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF3D cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03519	NM_003753.4 Latest version!	Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu03519	XM_011530479.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 3, subunit D (EIF3D), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu03519	NM_003753.3	Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF3D ( NM_003753.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_003744.1 Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), mRNA.

Price & Availability↑

CloneID	OHu03519
Clone ID Related Accession (Same CDS sequence)	NM_003753.3 , NM_003753.4 , XM_011530479.1
Accession Version	NM_003753.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 3 subunit D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BG718662.1, BC014912.2 and AW575097.1. On Dec 8, 2005 this sequence version replaced NM_003753.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014912.2, SRR1660803.262104.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003744.1
CDS	166..1812
Translation	MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET

Target ORF information:

RefSeq Version	NM_003753.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003753.3

ORF Insert Sequence:

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF3D ( NM_003753.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_003744.1 Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03519
Clone ID Related Accession (Same CDS sequence)	NM_003753.3 , NM_003753.4 , XM_011530479.1
Accession Version	NM_003753.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 3 subunit D
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BG718662.1 and BC014912.2. On Nov 22, 2018 this sequence version replaced NM_003753.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.262104.1, SRR3476690.1146059.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216190.13/ ENSP00000216190.8 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003744.1
CDS	102..1748
Translation	MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET

Target ORF information:

RefSeq Version	NM_003753.4
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 3 subunit D (EIF3D), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003753.4

ORF Insert Sequence:

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF3D ( XM_011530479.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011528781.1 Homo sapiens eukaryotic translation initiation factor 3, subunit D (EIF3D), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03519
Clone ID Related Accession (Same CDS sequence)	NM_003753.3 , NM_003753.4 , XM_011530479.1
Accession Version	XM_011530479.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	eukaryotic translation initiation factor 3 subunit D isoform X1
Comment

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_011528781.1

Translation

MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLMKMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRYRRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAVIATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQINLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEEEEEEEEET

Target ORF information:

RefSeq Version	XM_011530479.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens eukaryotic translation initiation factor 3, subunit D (EIF3D), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011530479.1

ORF Insert Sequence:

ATGGCAAAGT TCATGACACC CGTGATCCAG GACAACCCCT CAGGCTGGGG TCCCTGTGCG 
GTTCCCGAGC AGTTTCGGGA TATGCCCTAC CAGCCGTTCA GCAAAGGAGA TCGGCTAGGA 
AAGGTTGCAG ACTGGACAGG AGCCACATAC CAAGATAAGA GGTACACAAA TAAGTACTCC 
TCTCAGTTTG GTGGTGGAAG TCAATATGCT TATTTCCATG AGGAGGATGA AAGTAGCTTC 
CAGCTGGTGG ATACAGCGCG CACACAGAAG ACGGCCTACC AGCGGAATCG AATGAGATTT 
GCCCAGAGGA ACCTCCGCAG AGACAAAGAT CGTCGGAACA TGTTGCAGTT CAACCTGCAG 
ATCCTGCCTA AGAGTGCCAA ACAGAAAGAG AGAGAACGCA TTCGACTGCA GAAAAAGTTC 
CAGAAACAAT TTGGGGTTAG GCAGAAATGG GATCAGAAAT CACAGAAACC CCGAGACTCT 
TCAGTTGAAG TTCGTAGTGA TTGGGAAGTG AAAGAGGAAA TGGATTTTCC TCAGTTGATG 
AAGATGCGCT ACTTGGAAGT ATCAGAGCCA CAGGACATTG AGTGTTGTGG GGCCCTAGAA 
TACTACGACA AAGCCTTTGA CCGCATCACC ACGAGGAGTG AGAAGCCACT GCGGAGCATC 
AAGCGCATCT TCCACACTGT CACCACCACA GACGACCCTG TCATCCGCAA GCTGGCAAAA 
ACTCAGGGGA ATGTGTTTGC CACTGATGCC ATCCTGGCCA CGCTGATGAG CTGTACCCGC 
TCAGTGTATT CCTGGGATAT TGTCGTCCAG AGAGTTGGGT CCAAACTCTT CTTTGACAAG 
AGAGACAACT CTGACTTTGA CCTCCTGACA GTGAGTGAGA CTGCCAATGA GCCCCCTCAA 
GATGAAGGTA ATTCCTTCAA TTCACCCCGC AACCTGGCCA TGGAGGCAAC CTACATCAAC 
CACAATTTCT CCCAGCAGTG CTTGAGAATG GGGAAGGAAA GATACAACTT CCCCAACCCA 
AACCCGTTTG TGGAGGACGA CATGGATAAG AATGAAATCG CCTCTGTTGC GTACCGTTAC 
CGCAGGTGGA AGCTTGGAGA TGATATTGAC CTTATTGTCC GTTGTGAGCA CGATGGCGTC 
ATGACTGGAG CCAACGGGGA AGTGTCCTTC ATCAACATCA AGACACTCAA TGAGTGGGAT 
TCCAGGCACT GTAATGGCGT TGACTGGCGT CAGAAGCTGG ACTCTCAGCG AGGGGCTGTC 
ATTGCCACGG AGCTGAAGAA CAACAGCTAC AAGTTGGCCC GGTGGACCTG CTGTGCTTTG 
CTGGCTGGAT CTGAGTACCT CAAGCTTGGT TATGTGTCTC GGTACCACGT GAAAGACTCC 
TCACGCCACG TCATCCTAGG CACCCAGCAG TTCAAGCCTA ATGAGTTTGC CAGCCAGATC 
AACCTGAGCG TGGAGAATGC CTGGGGCATT TTACGCTGCG TCATTGACAT CTGCATGAAG 
CTGGAGGAGG GCAAATACCT CATCCTCAAG GACCCCAACA AGCAGGTCAT CCGTGTCTAC 
AGCCTCCCTG ATGGCACCTT CAGCTCTGAT GAAGATGAGG AGGAAGAGGA GGAGGAAGAA 
GAGGAAGAAG AAGAGGAAGA AACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Molecular and cellular biochemistry438(1-2)191-198(2018 Jan)
Liu GZ,Liu JZ,Li XQ,Zhang L,Li SJ,Xiao TW,Wang JX,Li GY,Liu Y

EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.
Cell death & disease8(6)e2868(2017 Jun)
Zhang F,Xiang S,Cao Y,Li M,Ma Q,Liang H,Li H,Ye Y,Zhang Y,Jiang L,Hu Y,Zhou J,Wang X,Zhang Y,Nie L,Liang X,Gong W,Liu Y

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.
Cell reports16(7)1891-902(2016 08)
Shah M,Su D,Scheliga JS,Pluskal T,Boronat S,Motamedchaboki K,Campos AR,Qi F,Hidalgo E,Yanagida M,Wolf DA

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature536(7614)96-9(2016 08)
Lee AS,Kranzusch PJ,Doudna JA,Cate JH

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EIF3D cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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