ALDH4A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALDH4A1
Entrez Gene ID	8659
Full Name	aldehyde dehydrogenase 4 family member A1
Synonyms	ALDH4,P5CD,P5CDh
General protein information	Preferred Names aldehyde dehydrogenase 4 family member A1 Names delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial L-glutamate gamma-semialdehyde dehydrogenase P5C dehydrogenase aldehyde dehydrogenase family 4 member A1 mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p36.13
Summary	This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009].
Disorder MIM:	606811
Disorder Html:	Hyperprolinemia, type II, 239510 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001161504.1	NP_001154976.1	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform b
NM_170726.2	NP_733844.1	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
NM_001319218.1	NP_001306147.1	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform c precursor
NM_003748.3	NP_003739.2	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
NM_170726.3	NP_733844.1	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
NM_003748.4	NP_003739.2	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ALDH4A1	XP_003307883.1
Mus musculus (house mouse)	Aldh4a1	NP_780647.3
Rattus norvegicus (Norway rat)	Aldh4a1	NP_001128170.1
Gallus gallus (chicken)	ALDH4A1	NP_001239033.1
Magnaporthe oryzae (rice blast fungus)	MGG_17513	XP_003718931.1
Neurospora crassa	NCU03076	XP_964169.1
Homo sapiens (human)	ALDH4A1	NP_003739.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004366	XP_313649.4
	LOC714870	XP_001104847.2
Canis lupus familiaris (dog)	ALDH4A1	XP_855272.2
Caenorhabditis elegans (roundworm)	alh-6	NP_493946.1
Schizosaccharomyces pombe (fission yeast)	SPBC24C6.04	NP_595958.1
Xenopus tropicalis (tropical clawed frog)	aldh4a1	NP_001096184.1
Bos taurus (cattle)	ALDH4A1	NP_001099116.1
Danio rerio (zebrafish)	aldh4a1	NP_957452.1
Drosophila melanogaster (fruit fly)	P5CDh1	NP_730698.1
Saccharomyces cerevisiae (baker's yeast)	PUT2	NP_011902.1
Kluyveromyces lactis	KLLA0C10549g	XP_452670.1
Eremothecium gossypii	AGOS_AAL071C	NP_982471.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an ian family.
P?ttmann L, Stehr H, Garshasbi M, Hu H, Kahrizi K, Lipkowitz B, Jamali P, Tzschach A, Najmabadi H, Ropers HH, Musante L, Kuss AW
American journal of medical genetics. Part A161A(8)1915-22(2013 Aug)

The three-dimensional structural basis of type II hyperprolinemia.
Srivastava D, Singh RK, Moxley MA, Henzl MT, Becker DF, Tanner JJ
Journal of molecular biology420(3)176-89(2012 Jul)

Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT
PloS one6(10)e26021(2011)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis31(7)1259-63(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the impact of the hyperprolinemia-associated mutation of Ser352 to Leu on the structure and catalytic properties of the P5CDH
Title: The three-dimensional structural basis of type II hyperprolinemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

ALDH4 is transcriptionally induced by p53.
Title: Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.

The following ALDH4A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALDH4A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09049	NM_170726.3 Latest version!	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09049	NM_003748.4 Latest version!	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09132	NM_001161504.1 Latest version!	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu62100	NM_001319218.1 Latest version!	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00
View Old Accession Versions >>
OHu09049	NM_170726.2	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu09049	NM_003748.3	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALDH4A1 ( NM_170726.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_733844.1 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.

Price & Availability↑

CloneID	OHu09049
Clone ID Related Accession (Same CDS sequence)	NM_170726.2 , NM_003748.3 , NM_170726.3 , NM_003748.4
Accession Version	NM_170726.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-21
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC318624.1 and BC023600.2. This sequence is a reference standard in the RefSeqGene project. On Jun 4, 2009 this sequence version replaced NM_170726.1. Transcript Variant: This variant (P5CDhS) differs in the 3' UTR compared to variant P5CDhL. Both variants P5CDhL and P5CDhS encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733844.1
CDS	277..1968
Translation	MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_170726.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170726.2

ORF Insert Sequence:

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALDH4A1 ( NM_003748.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003739.2 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.

Price & Availability↑

CloneID	OHu09049
Clone ID Related Accession (Same CDS sequence)	NM_170726.2 , NM_003748.3 , NM_170726.3 , NM_003748.4
Accession Version	NM_003748.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC318624.1 and BC023600.2. On Jun 4, 2009 this sequence version replaced NM_003748.2. Transcript Variant: This variant (P5CDhL) represents the longest transcript. Both variants P5CDhL and P5CDhS encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023600.2, SRR1660805.145972.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003739.2
CDS	277..1968
Translation	MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_003748.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003748.3

ORF Insert Sequence:

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALDH4A1 ( NM_170726.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_733844.1 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.

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CloneID	OHu09049
Clone ID Related Accession (Same CDS sequence)	NM_170726.2 , NM_003748.3 , NM_170726.3 , NM_003748.4
Accession Version	NM_170726.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC318624.1 and BC023600.2. This sequence is a reference standard in the RefSeqGene project. On Jun 1, 2019 this sequence version replaced NM_170726.2. Transcript Variant: This variant (P5CDhS) differs in the 3' UTR compared to variant P5CDhL. Both variants P5CDhL and P5CDhS encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733844.1
CDS	33..1724
Translation	MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_170726.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhS, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170726.3

ORF Insert Sequence:

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALDH4A1 ( NM_003748.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003739.2 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.

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CloneID	OHu09049
Clone ID Related Accession (Same CDS sequence)	NM_170726.2 , NM_003748.3 , NM_170726.3 , NM_003748.4
Accession Version	NM_003748.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1692bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC318624.1 and BC023600.2. On Nov 22, 2018 this sequence version replaced NM_003748.3. Transcript Variant: This variant (P5CDhL) represents the longest transcript. Both variants P5CDhL and P5CDhS encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC023600.2, U24266.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000375341.8/ ENSP00000364490.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003739.2
CDS	33..1724
Translation	MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_003748.4
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant P5CDhL, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003748.4

ORF Insert Sequence:

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALDH4A1 ( NM_001161504.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001154976.1 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 3, mRNA.

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CloneID	OHu09132
Clone ID Related Accession (Same CDS sequence)	NM_001161504.1
Accession Version	NM_001161504.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK294552.1 and BC023600.2. Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant P5CDhL, resulting in a downstream AUG start codon. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294552.1, SRR1803616.68708.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001154976.1
CDS	317..1828
Translation	MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_001161504.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001161504.1

ORF Insert Sequence:

ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGTCCTT TGCCCGTATC 
AAGAAGTGGC TGGAGCACGC ACGCTCCTCA CCCAGCCTCA CCATCCTGGC CGGGGGCAAG 
TGTGATGACT CCGTGGGCTA CTTTGTGGAG CCCTGCATCG TGGAGAGCAA GGACCCTCAG 
GAGCCCATCA TGAAGGAGGA GATCTTCGGG CCTGTACTGT CTGTGTACGT CTACCCGGAT 
GACAAGTACA AGGAGACGCT GCAGCTGGTT GACAGCACCA CCAGCTATGG CCTCACGGGG 
GCAGTGTTCT CCCAGGATAA GGACGTCGTG CAGGAGGCCA CAAAGGTGCT GAGGAATGCT 
GCCGGCAACT TCTACATCAA CGACAAGTCC ACTGGCTCGA TAGTGGGCCA GCAGCCCTTT 
GGGGGGGCCC GAGCCTCTGG AACCAATGAC AAGCCAGGGG GCCCACACTA CATCCTGCGC 
TGGACGTCGC CGCAGGTCAT CAAGGAGACA CATAAGCCCC TGGGGGACTG GAGCTACGCG 
TACATGCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALDH4A1 ( NM_001319218.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306147.1 Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 4, mRNA.

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CloneID	OHu62100
Clone ID Related Accession (Same CDS sequence)	NM_001319218.1
Accession Version	NM_001319218.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Homo sapiens(human)
Product	delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC342814.1, FJ462711.1, AL954340.4 and BC023600.2. On Jan 30, 2016 this sequence version replaced XM_011542352.1. Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant P5CDhL. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.186107.1, SRR1803616.11561.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGGAGAT CTTCGGGCCT 
GTACTGTCTG TGTACGTCTA CCCGGATGAC AAGTACAAGG AGACGCTGCA GCTGGTTGAC 
AGCACCACCA GCTATGGCCT CACGGGGGCA GTGTTCTCCC AGGATAAGGA CGTCGTGCAG 
GAGGCCACAA AGGTGCTGAG GAATGCTGCC GGCAACTTCT ACATCAACGA CAAGTCCACT 
GGCTCGATAG TGGGCCAGCA GCCCTTTGGG GGGGCCCGAG CCTCTGGAAC CAATGACAAG 
CCAGGGGGCC CACACTACAT CCTGCGCTGG ACGTCGCCGC AGGTCATCAA GGAGACACAT 
AAGCCCCTGG GGGACTGGAG CTACGCGTAC ATGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306147.1
CDS	277..1815
Translation	MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

Target ORF information:

RefSeq Version	NM_001319218.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aldehyde dehydrogenase 4 family member A1 (ALDH4A1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319218.1

ORF Insert Sequence:

ATGCTGCTGC CGGCGCCCGC GCTCCGCCGC GCCCTGCTGT CCCGCCCCTG GACCGGGGCC 
GGCCTGCGGT GGAAGCACAC CTCCTCCCTG AAGGTGGCCA ACGAGCCCGT CTTAGCCTTC 
ACGCAGGGCA GCCCTGAGCG AGATGCCCTG CAAAAGGCCT TGAAGGACCT GAAGGGCCGG 
ATGGAAGCCA TCCCATGCGT GGTGGGGGAT GAGGAGGTGT GGACGTCGGA CGTGCAGTAC 
CAAGTGTCGC CTTTTAACCA TGGACATAAG GTGGCCAAGT TCTGTTATGC AGACAAGAGC 
CTGCTCAACA AAGCCATTGA GGCTGCCCTG GCTGCCCGGA AAGAGTGGGA CCTGAAGCCT 
ATTGCAGACC GGGCCCAGAT CTTCCTGAAG GCGGCAGACA TGCTGAGTGG GCCGCGCAGG 
GCTGAGATCC TCGCCAAGAC CATGGTGGGA CAGGGTAAGA CCGTGATCCA AGCGGAGATT 
GACGCTGCAG CGGAACTCAT CGACTTCTTC CGGTTCAATG CCAAGTATGC GGTGGAGCTG 
GAGGGGCAGC AGCCCATCAG CGTGCCCCCG AGCACCAACA GCACGGTGTA CCGGGGTCTG 
GAGGGCTTCG TGGCGGCCAT CTCGCCCTTT AACTTCACTG CAATCGGCGG CAACCTGGCG 
GGGGCACCGG CCCTGATGGG CAACGTGGTC CTATGGAAGC CCAGTGACAC TGCCATGCTG 
GCCAGCTATG CTGTCTACCG CATCCTTCGG GAGGCTGGCC TGCCCCCCAA CATCATCCAG 
TTTGTGCCAG CTGATGGGCC CCTATTTGGG GACACTGTCA CCAGCTCAGA GCACCTCTGT 
GGCATCAACT TCACAGGCAG TGTGCCCACC TTCAAACACC TGTGGAAGCA GGTGGCCCAG 
AACCTGGACC GGTTCCACAC CTTCCCACGC CTGGCTGGAG AGTGCGGCGG AAAGAACTTC 
CACTTCGTGC ACCGCTCGGC CGACGTGGAG AGCGTGGTGA GCGGGACCCT CCGCTCAGCC 
TTCGAGTACG GTGGCCAGAA GTGTTCCGCG TGCTCGCGTC TCTACGTGCC GCACTCGCTG 
TGGCCGCAGA TCAAAGGGCG GCTGCTGGAG GAGCACAGTC GGATCAAAGT GGGCGACCCT 
GCAGAGGATT TTGGGACCTT CTTCTCTGCA GTGATTGATG CCAAGGAGAT CTTCGGGCCT 
GTACTGTCTG TGTACGTCTA CCCGGATGAC AAGTACAAGG AGACGCTGCA GCTGGTTGAC 
AGCACCACCA GCTATGGCCT CACGGGGGCA GTGTTCTCCC AGGATAAGGA CGTCGTGCAG 
GAGGCCACAA AGGTGCTGAG GAATGCTGCC GGCAACTTCT ACATCAACGA CAAGTCCACT 
GGCTCGATAG TGGGCCAGCA GCCCTTTGGG GGGGCCCGAG CCTCTGGAAC CAATGACAAG 
CCAGGGGGCC CACACTACAT CCTGCGCTGG ACGTCGCCGC AGGTCATCAA GGAGACACAT 
AAGCCCCTGG GGGACTGGAG CTACGCGTAC ATGCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family.
American journal of medical genetics. Part A161A(8)1915-22(2013 Aug)
P?ttmann L,Stehr H,Garshasbi M,Hu H,Kahrizi K,Lipkowitz B,Jamali P,Tzschach A,Najmabadi H,Ropers HH,Musante L,Kuss AW

The three-dimensional structural basis of type II hyperprolinemia.
Journal of molecular biology420(3)176-89(2012 Jul)
Srivastava D,Singh RK,Moxley MA,Henzl MT,Becker DF,Tanner JJ

Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
PloS one6(10)e26021(2011)
Riedel TJ,Johnson LC,Knight J,Hantgan RR,Holmes RP,Lowther WT

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ

A Large-scale genetic association study of esophageal adenocarcinoma risk.
Carcinogenesis31(7)1259-63(2010 Jul)
Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DC

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ALDH4A1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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