PTCH2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTCH2
Entrez Gene ID	8643
Full Name	patched 2
Synonyms	PTC2
General protein information	Preferred Names patched 2 Names protein patched homolog 2 patched homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p34.1
Summary	This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009].
Disorder MIM:	603673
Disorder Html:	Medulloblastoma, somatic, 155255 (3); Basal cell carcinoma, somatic, 605462 (3); Basal cell nevus syndrome, 109400 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003738.4	NP_003729.3	protein patched homolog 2 isoform 1
NM_001166292.1	NP_001159764.1	protein patched homolog 2 isoform 2
NM_003738.5	NP_003729.3	protein patched homolog 2 isoform 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTCH2	NP_003729.3
Canis lupus familiaris (dog)	PTCH2	XP_539636.3
Mus musculus (house mouse)	Ptch2	NP_032984.1
Pan troglodytes (chimpanzee)	PTCH2	XP_003954411.1
Bos taurus (cattle)	PTCH2	XP_005204949.1

Gene Ontology
Bibliography

Related articles in PubMed

Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.
Taeubner J, Brozou T, Qin N, Bartl J, Ginzel S, Schaper J, Felsberg J, Fulda S, Vokuhl C, Borkhardt A, Kuhlen M
European journal of human genetics : EJHG(2017 Dec)

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
Sheybani-Deloui S, Chi L, Staite MV, Cain JE, Nieman BJ, Henkelman RM, Wainwright BJ, Potter SS, Bagli DJ, Lorenzo AJ, Rosenblum ND
Journal of the American Society of Nephrology : JASN(2017 Nov)

Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.
Fujii K, Ohashi H, Suzuki M, Hatsuse H, Shiohama T, Uchikawa H, Miyashita T
Familial cancer12(4)611-4(2013 Dec)

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PloS one5(7)e11493(2010 Jul)

[Studies on keratocystic odontogenic tumors].
Li TJ, Sun LS, Luo HY, Yuan JW, Gao L, Gu XM, Li XF, Xu LL
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences41(1)16-20(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.
Title: Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.

Observational study of gene-disease association. (HuGE Navigator)
Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported.
Title: A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation.

Observational study of gene-disease association. (HuGE Navigator)
Title: [Studies on keratocystic odontogenic tumors].

The following PTCH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTCH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03504	NM_003738.5 Latest version!	Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$459.50-$643.30 $919.00
OHu19169	NM_001166292.1 Latest version!	Homo sapiens patched 2 (PTCH2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
View Old Accession Versions >>
OHu03504	NM_003738.4	Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$853.30 $1219.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTCH2 ( NM_003738.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003729.3 Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03504
Clone ID Related Accession (Same CDS sequence)	NM_003738.4 , NM_003738.5
Accession Version	NM_003738.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	protein patched homolog 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136380.22, AF119569.1, AY359016.1 and AL592166.16. On Nov 24, 2018 this sequence version replaced NM_003738.4. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY359016.1, AF087651.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372192.4/ ENSP00000361266.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGTGGG GGGCATCCTC CTCCCTGCCC CAGAGCTTTG CCAGAGTGAC TACCTCCATG 
ACCGTGGCCA TCCACCCACC CCCCCTGCCT GGTGCCTACA TCCATCCAGC CCCTGATGAG 
CCCCCTTGGT CCCCTGCTGC CACTAGCTCT GGCAACCTCA GTTCCAGGGG ACCAGGTCCA 
GCCACTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003729.3
CDS	322..3933
Translation	MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGPATG

Target ORF information:

RefSeq Version	NM_003738.5
Organism	Homo sapiens(human)
Definition	Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003738.5

ORF Insert Sequence:

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGTGGG GGGCATCCTC CTCCCTGCCC CAGAGCTTTG CCAGAGTGAC TACCTCCATG 
ACCGTGGCCA TCCACCCACC CCCCCTGCCT GGTGCCTACA TCCATCCAGC CCCTGATGAG 
CCCCCTTGGT CCCCTGCTGC CACTAGCTCT GGCAACCTCA GTTCCAGGGG ACCAGGTCCA 
GCCACTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTCH2 ( NM_003738.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003729.3 Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03504
Clone ID Related Accession (Same CDS sequence)	NM_003738.4 , NM_003738.5
Accession Version	NM_003738.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	protein patched homolog 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF119569.1 and AY359016.1. On Oct 21, 2009 this sequence version replaced NM_003738.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AY359016.1, AF087651.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGTGGG GGGCATCCTC CTCCCTGCCC CAGAGCTTTG CCAGAGTGAC TACCTCCATG 
ACCGTGGCCA TCCACCCACC CCCCCTGCCT GGTGCCTACA TCCATCCAGC CCCTGATGAG 
CCCCCTTGGT CCCCTGCTGC CACTAGCTCT GGCAACCTCA GTTCCAGGGG ACCAGGTCCA 
GCCACTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003729.3
CDS	13..3624
Translation	MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGGLRWGASSSLPQSFARVTTSMTVAIHPPPLPGAYIHPAPDEPPWSPAATSSGNLSSRGPGPATG

Target ORF information:

RefSeq Version	NM_003738.4
Organism	Homo sapiens(human)
Definition	Homo sapiens patched 2 (PTCH2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003738.4

ORF Insert Sequence:

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGTGGG GGGCATCCTC CTCCCTGCCC CAGAGCTTTG CCAGAGTGAC TACCTCCATG 
ACCGTGGCCA TCCACCCACC CCCCCTGCCT GGTGCCTACA TCCATCCAGC CCCTGATGAG 
CCCCCTTGGT CCCCTGCTGC CACTAGCTCT GGCAACCTCA GTTCCAGGGG ACCAGGTCCA 
GCCACTGGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTCH2 ( NM_001166292.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159764.1 Homo sapiens patched 2 (PTCH2), transcript variant 2, mRNA.

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CloneID	OHu19169
Clone ID Related Accession (Same CDS sequence)	NM_001166292.1
Accession Version	NM_001166292.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	protein patched homolog 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF119569.1, AY359016.1, BX089003.1, AI798853.1 and AA781365.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF119569.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGCCCG AGGAGATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159764.1
CDS	13..3453
Translation	MTRSPPLRELPPSYTPPARTAAPQILAGSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQEGENILTPEALGLHLQAALTASKVQVSLYGKSWDLNKICYKSGVPLIENGMIERMIEKLFPCVILTPLDCFWEGAKLQGGSAYLPGRPDIQWTNLDPEQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSPCSAQVIQILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLVPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSYRNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPPAQPLEFAQFPFLLRGLQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFLTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGSHFDFIVRYFFAALTVLTLLGLLHGLVLLPVLLSILGPPPEVIQMYKESPEILSPPAPQGGGLRPEEI

Target ORF information:

RefSeq Version	NM_001166292.1
Organism	Homo sapiens(human)
Definition	Homo sapiens patched 2 (PTCH2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166292.1

ORF Insert Sequence:

ATGACTCGAT CGCCGCCCCT CAGAGAGCTG CCCCCGAGTT ACACACCCCC AGCTCGAACC 
GCAGCACCCC AGATCCTAGC TGGGAGCCTG AAGGCTCCAC TCTGGCTTCG TGCTTACTTC 
CAGGGCCTGC TCTTCTCTCT GGGATGCGGG ATCCAGAGAC ATTGTGGCAA AGTGCTCTTT 
CTGGGACTGT TGGCCTTTGG GGCCCTGGCA TTAGGTCTCC GCATGGCCAT TATTGAGACA 
AACTTGGAAC AGCTCTGGGT AGAAGTGGGC AGCCGGGTGA GCCAGGAGCT GCATTACACC 
AAGGAGAAGC TGGGGGAGGA GGCTGCATAC ACCTCTCAGA TGCTGATACA GACCGCACGC 
CAGGAGGGAG AGAACATCCT CACACCCGAA GCACTTGGCC TCCACCTCCA GGCAGCCCTC 
ACTGCCAGTA AAGTCCAAGT ATCACTCTAT GGGAAGTCCT GGGATTTGAA CAAAATCTGC 
TACAAGTCAG GAGTTCCCCT TATTGAAAAT GGAATGATTG AGCGGATGAT TGAGAAGCTG 
TTTCCGTGCG TGATCCTCAC CCCCCTCGAC TGCTTCTGGG AGGGAGCCAA ACTCCAAGGG 
GGCTCCGCCT ACCTGCCCGG CCGCCCGGAT ATCCAGTGGA CCAACCTGGA TCCAGAGCAG 
CTGCTGGAGG AGCTGGGTCC CTTTGCCTCC CTTGAGGGCT TCCGGGAGCT GCTAGACAAG 
GCACAGGTGG GCCAGGCCTA CGTGGGGCGG CCCTGTCTGC ACCCTGATGA CCTCCACTGC 
CCACCTAGTG CCCCCAACCA TCACAGCAGG CAGGCTCCCA ATGTGGCTCA CGAGCTGAGT 
GGGGGCTGCC ATGGCTTCTC CCACAAATTC ATGCACTGGC AGGAGGAATT GCTGCTGGGA 
GGCATGGCCA GAGACCCCCA AGGAGAGCTG CTGAGGGCAG AGGCCCTGCA GAGCACCTTC 
TTGCTGATGA GTCCCCGCCA GCTGTACGAG CATTTCCGGG GTGACTATCA GACACATGAC 
ATTGGCTGGA GTGAGGAGCA GGCCAGCACA GTGCTACAAG CCTGGCAGCG GCGCTTTGTG 
CAGCTGGCCC AGGAGGCCCT GCCTGAGAAC GCTTCCCAGC AGATCCATGC CTTCTCCTCC 
ACCACCCTGG ATGACATCCT GCATGCGTTC TCTGAAGTCA GTGCTGCCCG TGTGGTGGGA 
GGCTATCTGC TCATGCTGGC CTATGCCTGT GTGACCATGC TGCGGTGGGA CTGCGCCCAG 
TCCCAGGGTT CCGTGGGCCT TGCCGGGGTA CTGCTGGTGG CCCTGGCGGT GGCCTCAGGC 
CTTGGGCTCT GTGCCCTGCT CGGCATCACC TTCAATGCTG CCACTACCCA GGTGCTGCCC 
TTCTTGGCTC TGGGAATCGG CGTGGATGAC GTATTCCTGC TGGCGCATGC CTTCACAGAG 
GCTCTGCCTG GCACCCCTCT CCAGGAGCGC ATGGGCGAGT GTCTGCAGCG CACGGGCACC 
AGTGTCGTAC TCACATCCAT CAACAACATG GCCGCCTTCC TCATGGCTGC CCTCGTTCCC 
ATCCCTGCGC TGCGAGCCTT CTCCCTACAG GCGGCCATAG TGGTTGGCTG CACCTTTGTA 
GCCGTGATGC TTGTCTTCCC AGCCATCCTC AGCCTGGACC TACGGCGGCG CCACTGCCAG 
CGCCTTGATG TGCTCTGCTG CTTCTCCAGT CCCTGCTCTG CTCAGGTGAT TCAGATCCTG 
CCCCAGGAGC TGGGGGACGG GACAGTACCA GTGGGCATTG CCCACCTCAC TGCCACAGTT 
CAAGCCTTTA CCCACTGTGA AGCCAGCAGC CAGCATGTGG TCACCATCCT GCCTCCCCAA 
GCCCACCTGG TGCCCCCACC TTCTGACCCA CTGGGCTCTG AGCTCTTCAG CCCTGGAGGG 
TCCACACGGG ACCTTCTAGG CCAGGAGGAG GAGACAAGGC AGAAGGCAGC CTGCAAGTCC 
CTGCCCTGTG CCCGCTGGAA TCTTGCCCAT TTCGCCCGCT ATCAGTTTGC CCCGTTGCTG 
CTCCAGTCAC ATGCTAAGGC CATCGTGCTG GTGCTCTTTG GTGCTCTTCT GGGCCTGAGC 
CTCTACGGAG CCACCTTGGT GCAAGACGGC CTGGCCCTGA CGGATGTGGT GCCTCGGGGC 
ACCAAGGAGC ATGCCTTCCT GAGCGCCCAG CTCAGGTACT TCTCCCTGTA CGAGGTGGCC 
CTGGTGACCC AGGGTGGCTT TGACTACGCC CACTCCCAAC GCGCCCTCTT TGATCTGCAC 
CAGCGCTTCA GTTCCCTCAA GGCGGTGCTG CCCCCACCGG CCACCCAGGC ACCCCGCACC 
TGGCTGCACT ATTACCGCAA CTGGCTACAG GGAATCCAGG CTGCCTTTGA CCAGGACTGG 
GCTTCTGGGC GCATCACCCG CCACTCGTAC CGCAATGGCT CTGAGGATGG GGCCCTGGCC 
TACAAGCTGC TCATCCAGAC TGGAGACGCC CAGGAGCCTC TGGATTTCAG CCAGCTGACC 
ACAAGGAAGC TGGTGGACAG AGAGGGACTG ATTCCACCCG AGCTCTTCTA CATGGGGCTG 
ACCGTGTGGG TGAGCAGTGA CCCCCTGGGT CTGGCAGCCT CACAGGCCAA CTTCTACCCC 
CCACCTCCTG AATGGCTGCA CGACAAATAC GACACCACGG GGGAGAACCT TCGCATCCCG 
CCAGCTCAGC CCTTGGAGTT TGCCCAGTTC CCCTTCCTGC TGCGTGGCCT CCAGAAGACT 
GCAGACTTTG TGGAGGCCAT CGAGGGGGCC CGGGCAGCAT GCGCAGAGGC CGGCCAGGCT 
GGGGTGCACG CCTACCCCAG CGGCTCCCCC TTCCTCTTCT GGGAACAGTA TCTGGGCCTG 
CGGCGCTGCT TCCTGCTGGC CGTCTGCATC CTGCTGGTGT GCACTTTCCT CGTCTGTGCT 
CTGCTGCTCC TCAACCCCTG GACGGCTGGC CTCATAGTGC TGGTCCTGGC GATGATGACA 
GTGGAACTCT TTGGTATCAT GGGTTTCCTG GGCATCAAGC TGAGTGCCAT CCCCGTGGTG 
ATCCTTGTGG CCTCTGTAGG CATTGGCGTT GAGTTCACAG TCCACGTGGC TCTGGGCTTC 
CTGACCACCC AGGGCAGCCG GAACCTGCGG GCCGCCCATG CCCTTGAGCA CACATTTGCC 
CCCGTGACCG ATGGGGCCAT CTCCACATTG CTGGGTCTGC TCATGCTTGC TGGTTCCCAC 
TTTGACTTCA TTGTAAGGTA CTTCTTTGCG GCGCTGACAG TGCTCACGCT CCTGGGCCTC 
CTCCATGGAC TCGTGCTGCT GCCTGTGCTG CTGTCCATCC TGGGCCCGCC GCCAGAGGTG 
ATACAGATGT ACAAGGAAAG CCCAGAGATC CTGAGTCCAC CAGCTCCACA GGGAGGCGGG 
CTTAGGCCCG AGGAGATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Congenital embryonal rhabdomyosarcoma caused by heterozygous concomitant PTCH1 and PTCH2 germline mutations.
European journal of human genetics : EJHG(2017 Dec)
Taeubner J,Brozou T,Qin N,Bartl J,Ginzel S,Schaper J,Felsberg J,Fulda S,Vokuhl C,Borkhardt A,Kuhlen M

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction.
Journal of the American Society of Nephrology : JASN(2017 Nov)
Sheybani-Deloui S,Chi L,Staite MV,Cain JE,Nieman BJ,Henkelman RM,Wainwright BJ,Potter SS,Bagli DJ,Lorenzo AJ,Rosenblum ND

Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.
Familial cancer12(4)611-4(2013 Dec)
Fujii K,Ohashi H,Suzuki M,Hatsuse H,Shiohama T,Uchikawa H,Miyashita T

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
PloS one5(7)e11493(2010 Jul)
Jugessur A,Shi M,Gjessing HK,Lie RT,Wilcox AJ,Weinberg CR,Christensen K,Boyles AL,Daack-Hirsch S,Nguyen TT,Christiansen L,Lidral AC,Murray JC

[Studies on keratocystic odontogenic tumors].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences41(1)16-20(2009 Feb)
Li TJ,Sun LS,Luo HY,Yuan JW,Gao L,Gu XM,Li XF,Xu LL

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PTCH2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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