PLPP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLPP3
Entrez Gene ID	8613
Full Name	phospholipid phosphatase 3
Synonyms	Dri42,LPP3,PAP2B,PPAP2B,VCIP
General protein information	Preferred Names phospholipid phosphatase 3 Names phospholipid phosphatase 3 PAP2 beta lipid phosphate phosphohydrolase 3 phosphatidate phosphohydrolase type 2b phosphatidic acid phosphatase type 2B type-2 phosphatidic acid phosphatase-beta vascular endothelial growth factor and type I collagen inducible
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p32.2
Summary	The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010].
Disorder MIM:	607125

mRNA and Protein(s)

mRNA	Protein	Name
NM_003713.4	NP_003704.3	phospholipid phosphatase 3
NM_003713.5	NP_003704.3	phospholipid phosphatase 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPAP2B	NP_003704.3
Bos taurus (cattle)	PPAP2B	NP_001069941.1
Gallus gallus (chicken)	PPAP2B	NP_001123960.1
Canis lupus familiaris (dog)	PPAP2B	XP_536696.2
Mus musculus (house mouse)	Ppap2b	NP_542122.1
Rattus norvegicus (Norway rat)	Ppap2b	NP_620260.2
Danio rerio (zebrafish)	ppap2b	XP_001919561.1
	LOC715993	XP_001114366.2
Pan troglodytes (chimpanzee)	PPAP2B	XP_003308181.1
Xenopus tropicalis (tropical clawed frog)	ppap2b	NP_001016858.3

Gene Ontology
Bibliography

Related articles in PubMed

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.
Susanto O, Koh YWH, Morrice N, Tumanov S, Thomason PA, Nielson M, Tweedy L, Muinonen-Martin AJ, Kamphorst JJ, Mackay GM, Insall RH
Journal of cell science130(20)3455-3466(2017 Oct)

Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.
Sun YX, Gao CY, Lu Y, Fu X, Jia JG, Zhao YJ, Li LD, Dui HZ, Zhang XY, Li ZY, Lei L, Zhang WF, Yuan YQ
Oncotarget8(8)13166-13173(2017 Feb)

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.
Touat-Hamici Z, Weidmann H, Blum Y, Proust C, Durand H, Iannacci F, Codoni V, Gaignard P, Th?rond P, Civelek M, Karabina SA, Lusis AJ, Cambien F, Ninio E
Cardiovascular research112(3)702-713(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show gender-related differences in the association between phosphatidic acid phosphatase type 2B (PPAP2B) gene single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) susceptibility in the Chinese Han population.
Title: Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.

LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in HAECs, suggesting a protective role of LPP3 against endothelial dysfunction.
Title: Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

Mechanosensitive PPAP2B plays a critical role in promoting anti-inflammatory phenotype and maintaining vascular integrity of endothelial monolayer under atheroprotective flow.
Title: Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.

study concludes polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations
Title: Association between TGM5, PPAP2B and PSMA4 polymorphisms and NSCLC in never-smoking Chinese population.

PPAP2B gene rearrangement is associated with lipomas.
Title: Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas.

The following PLPP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLPP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10769	NM_003713.5 Latest version!	Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu10769	NM_003713.4	Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLPP3 ( NM_003713.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003704.3 Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.

Price & Availability↑

CloneID	OHu10769
Clone ID Related Accession (Same CDS sequence)	NM_003713.4 , NM_003713.5
Accession Version	NM_003713.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	phospholipid phosphatase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA580891.1, AF043329.1, AC099562.2 and BQ027458.1. On Dec 24, 2010 this sequence version replaced NM_003713.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.265923.1, SRR1803614.20270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAAAACT ACAAGTACGA CAAAGCGATC GTCCCGGAGA GCAAGAACGG CGGCAGCCCG 
GCGCTCAACA ACAACCCGAG GAGGAGCGGC AGCAAGCGGG TGCTGCTCAT CTGCCTCGAC 
CTCTTCTGCC TCTTCATGGC GGGCCTCCCC TTCCTCATCA TCGAGACAAG CACCATCAAG 
CCTTACCACC GAGGGTTTTA CTGCAATGAT GAGAGCATCA AGTACCCACT GAAAACTGGT 
GAGACAATAA ATGACGCTGT GCTCTGTGCC GTGGGGATCG TCATTGCCAT CCTCGCGATC 
ATCACGGGGG AATTCTACCG GATCTATTAC CTGAAGAAGT CGCGGTCGAC GATTCAGAAC 
CCCTACGTGG CAGCACTCTA TAAGCAAGTG GGCTGCTTCC TCTTTGGCTG TGCCATCAGC 
CAGTCTTTCA CAGACATTGC CAAAGTGTCC ATAGGGCGCC TGCGTCCTCA CTTCTTGAGT 
GTCTGCAACC CTGATTTCAG CCAGATCAAC TGCTCTGAAG GCTACATTCA GAACTACAGA 
TGCAGAGGTG ATGACAGCAA AGTCCAGGAA GCCAGGAAGT CCTTCTTCTC TGGCCATGCC 
TCCTTCTCCA TGTACACTAT GCTGTATTTG GTGCTATACC TGCAGGCCCG CTTCACTTGG 
CGAGGAGCCC GCCTGCTCCG GCCCCTCCTG CAGTTCACCT TGATCATGAT GGCCTTCTAC 
ACGGGACTGT CTCGCGTATC AGACCACAAG CACCATCCCA GTGATGTTCT GGCAGGATTT 
GCTCAAGGAG CCCTGGTGGC CTGCTGCATA GTTTTCTTCG TGTCTGACCT CTTCAAGACT 
AAGACGACGC TCTCCCTGCC TGCCCCTGCT ATCCGGAAGG AAATCCTTTC ACCTGTGGAC 
ATTATTGACA GGAACAATCA CCACAACATG ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003704.3
CDS	569..1504
Translation	MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVDIIDRNNHHNMM

Target ORF information:

RefSeq Version	NM_003713.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003713.4

ORF Insert Sequence:

ATGCAAAACT ACAAGTACGA CAAAGCGATC GTCCCGGAGA GCAAGAACGG CGGCAGCCCG 
GCGCTCAACA ACAACCCGAG GAGGAGCGGC AGCAAGCGGG TGCTGCTCAT CTGCCTCGAC 
CTCTTCTGCC TCTTCATGGC GGGCCTCCCC TTCCTCATCA TCGAGACAAG CACCATCAAG 
CCTTACCACC GAGGGTTTTA CTGCAATGAT GAGAGCATCA AGTACCCACT GAAAACTGGT 
GAGACAATAA ATGACGCTGT GCTCTGTGCC GTGGGGATCG TCATTGCCAT CCTCGCGATC 
ATCACGGGGG AATTCTACCG GATCTATTAC CTGAAGAAGT CGCGGTCGAC GATTCAGAAC 
CCCTACGTGG CAGCACTCTA TAAGCAAGTG GGCTGCTTCC TCTTTGGCTG TGCCATCAGC 
CAGTCTTTCA CAGACATTGC CAAAGTGTCC ATAGGGCGCC TGCGTCCTCA CTTCTTGAGT 
GTCTGCAACC CTGATTTCAG CCAGATCAAC TGCTCTGAAG GCTACATTCA GAACTACAGA 
TGCAGAGGTG ATGACAGCAA AGTCCAGGAA GCCAGGAAGT CCTTCTTCTC TGGCCATGCC 
TCCTTCTCCA TGTACACTAT GCTGTATTTG GTGCTATACC TGCAGGCCCG CTTCACTTGG 
CGAGGAGCCC GCCTGCTCCG GCCCCTCCTG CAGTTCACCT TGATCATGAT GGCCTTCTAC 
ACGGGACTGT CTCGCGTATC AGACCACAAG CACCATCCCA GTGATGTTCT GGCAGGATTT 
GCTCAAGGAG CCCTGGTGGC CTGCTGCATA GTTTTCTTCG TGTCTGACCT CTTCAAGACT 
AAGACGACGC TCTCCCTGCC TGCCCCTGCT ATCCGGAAGG AAATCCTTTC ACCTGTGGAC 
ATTATTGACA GGAACAATCA CCACAACATG ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLPP3 ( NM_003713.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003704.3 Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.

Price & Availability↑

CloneID	OHu10769
Clone ID Related Accession (Same CDS sequence)	NM_003713.4 , NM_003713.5
Accession Version	NM_003713.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	phospholipid phosphatase 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA580891.1, AF043329.1, AC099562.2 and BQ027458.1. On Nov 23, 2018 this sequence version replaced NM_003713.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.265923.1, SRR1660807.251446.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371250.4/ ENSP00000360296.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAAAACT ACAAGTACGA CAAAGCGATC GTCCCGGAGA GCAAGAACGG CGGCAGCCCG 
GCGCTCAACA ACAACCCGAG GAGGAGCGGC AGCAAGCGGG TGCTGCTCAT CTGCCTCGAC 
CTCTTCTGCC TCTTCATGGC GGGCCTCCCC TTCCTCATCA TCGAGACAAG CACCATCAAG 
CCTTACCACC GAGGGTTTTA CTGCAATGAT GAGAGCATCA AGTACCCACT GAAAACTGGT 
GAGACAATAA ATGACGCTGT GCTCTGTGCC GTGGGGATCG TCATTGCCAT CCTCGCGATC 
ATCACGGGGG AATTCTACCG GATCTATTAC CTGAAGAAGT CGCGGTCGAC GATTCAGAAC 
CCCTACGTGG CAGCACTCTA TAAGCAAGTG GGCTGCTTCC TCTTTGGCTG TGCCATCAGC 
CAGTCTTTCA CAGACATTGC CAAAGTGTCC ATAGGGCGCC TGCGTCCTCA CTTCTTGAGT 
GTCTGCAACC CTGATTTCAG CCAGATCAAC TGCTCTGAAG GCTACATTCA GAACTACAGA 
TGCAGAGGTG ATGACAGCAA AGTCCAGGAA GCCAGGAAGT CCTTCTTCTC TGGCCATGCC 
TCCTTCTCCA TGTACACTAT GCTGTATTTG GTGCTATACC TGCAGGCCCG CTTCACTTGG 
CGAGGAGCCC GCCTGCTCCG GCCCCTCCTG CAGTTCACCT TGATCATGAT GGCCTTCTAC 
ACGGGACTGT CTCGCGTATC AGACCACAAG CACCATCCCA GTGATGTTCT GGCAGGATTT 
GCTCAAGGAG CCCTGGTGGC CTGCTGCATA GTTTTCTTCG TGTCTGACCT CTTCAAGACT 
AAGACGACGC TCTCCCTGCC TGCCCCTGCT ATCCGGAAGG AAATCCTTTC ACCTGTGGAC 
ATTATTGACA GGAACAATCA CCACAACATG ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003704.3
CDS	548..1483
Translation	MQNYKYDKAIVPESKNGGSPALNNNPRRSGSKRVLLICLDLFCLFMAGLPFLIIETSTIKPYHRGFYCNDESIKYPLKTGETINDAVLCAVGIVIAILAIITGEFYRIYYLKKSRSTIQNPYVAALYKQVGCFLFGCAISQSFTDIAKVSIGRLRPHFLSVCNPDFSQINCSEGYIQNYRCRGDDSKVQEARKSFFSGHASFSMYTMLYLVLYLQARFTWRGARLLRPLLQFTLIMMAFYTGLSRVSDHKHHPSDVLAGFAQGALVACCIVFFVSDLFKTKTTLSLPAPAIRKEILSPVDIIDRNNHHNMM

Target ORF information:

RefSeq Version	NM_003713.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipid phosphatase 3 (PLPP3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003713.5

ORF Insert Sequence:

ATGCAAAACT ACAAGTACGA CAAAGCGATC GTCCCGGAGA GCAAGAACGG CGGCAGCCCG 
GCGCTCAACA ACAACCCGAG GAGGAGCGGC AGCAAGCGGG TGCTGCTCAT CTGCCTCGAC 
CTCTTCTGCC TCTTCATGGC GGGCCTCCCC TTCCTCATCA TCGAGACAAG CACCATCAAG 
CCTTACCACC GAGGGTTTTA CTGCAATGAT GAGAGCATCA AGTACCCACT GAAAACTGGT 
GAGACAATAA ATGACGCTGT GCTCTGTGCC GTGGGGATCG TCATTGCCAT CCTCGCGATC 
ATCACGGGGG AATTCTACCG GATCTATTAC CTGAAGAAGT CGCGGTCGAC GATTCAGAAC 
CCCTACGTGG CAGCACTCTA TAAGCAAGTG GGCTGCTTCC TCTTTGGCTG TGCCATCAGC 
CAGTCTTTCA CAGACATTGC CAAAGTGTCC ATAGGGCGCC TGCGTCCTCA CTTCTTGAGT 
GTCTGCAACC CTGATTTCAG CCAGATCAAC TGCTCTGAAG GCTACATTCA GAACTACAGA 
TGCAGAGGTG ATGACAGCAA AGTCCAGGAA GCCAGGAAGT CCTTCTTCTC TGGCCATGCC 
TCCTTCTCCA TGTACACTAT GCTGTATTTG GTGCTATACC TGCAGGCCCG CTTCACTTGG 
CGAGGAGCCC GCCTGCTCCG GCCCCTCCTG CAGTTCACCT TGATCATGAT GGCCTTCTAC 
ACGGGACTGT CTCGCGTATC AGACCACAAG CACCATCCCA GTGATGTTCT GGCAGGATTT 
GCTCAAGGAG CCCTGGTGGC CTGCTGCATA GTTTTCTTCG TGTCTGACCT CTTCAAGACT 
AAGACGACGC TCTCCCTGCC TGCCCCTGCT ATCCGGAAGG AAATCCTTTC ACCTGTGGAC 
ATTATTGACA GGAACAATCA CCACAACATG ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.
Journal of cell science130(20)3455-3466(2017 Oct)
Susanto O,Koh YWH,Morrice N,Tumanov S,Thomason PA,Nielson M,Tweedy L,Muinonen-Martin AJ,Kamphorst JJ,Mackay GM,Insall RH

Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females.
Oncotarget8(8)13166-13173(2017 Feb)
Sun YX,Gao CY,Lu Y,Fu X,Jia JG,Zhao YJ,Li LD,Dui HZ,Zhang XY,Li ZY,Lei L,Zhang WF,Yuan YQ

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.
Cardiovascular research112(3)702-713(2016 Dec)
Touat-Hamici Z,Weidmann H,Blum Y,Proust C,Durand H,Iannacci F,Codoni V,Gaignard P,Th?rond P,Civelek M,Karabina SA,Lusis AJ,Cambien F,Ninio E

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PLPP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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