CGGBP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CGGBP1
Entrez Gene ID	8545
Full Name	CGG triplet repeat binding protein 1
Synonyms	CGGBP,p20-CGGBP
General protein information	Preferred Names CGG triplet repeat binding protein 1 Names CGG triplet repeat-binding protein 1 20 kDa CGG-binding protein CGG-binding protein 1 p20-CGG binding protein p20-CGGBP DNA-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p11.1
Summary	This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017].
Disorder MIM:	603363

mRNA and Protein(s)

mRNA	Protein	Name
XM_011534170.1	XP_011532472.1	CGG triplet repeat-binding protein 1 isoform X1
XM_017007355.1	XP_016862844.1	CGG triplet repeat-binding protein 1 isoform X1
NM_003663.3	NP_003654.3	CGG triplet repeat-binding protein 1
NM_001195308.1	NP_001182237.1	CGG triplet repeat-binding protein 1
NM_001008390.2	NP_001008391.1	CGG triplet repeat-binding protein 1
XM_024453797.1	XP_024309565.1	CGG triplet repeat-binding protein 1 isoform X1
NM_001008390.1	NP_001008391.1	CGG triplet repeat-binding protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CGGBP1	NP_003654.3
Canis lupus familiaris (dog)	CGGBP1	XP_005638795.1
Bos taurus (cattle)	CGGBP1	NP_001178066.1
Rattus norvegicus (Norway rat)	Cggbp1	NP_001099370.1
Pan troglodytes (chimpanzee)	CGGBP1	XP_001135424.2
	CGGBP1	XP_001082766.1
Mus musculus (house mouse)	Cggbp1	NP_848762.1
Gallus gallus (chicken)	CGGBP1	XP_004938360.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Defining the role of the CGGBP1 protein in FMR1 gene expression.
Goracci M, Lanni S, Mancano G, Palumbo F, Chiurazzi P, Neri G, Tabolacci E
European journal of human genetics : EJHG24(5)697-703(2016 May)

CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.
Agarwal P, Collier P, Fritz MH, Benes V, Wiklund HJ, Westermark B, Singh U
BMC genomics16390(2015 May)

CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.
Singh U, Westermark B
Upsala journal of medical sciences120(4)219-32(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA.
Title: Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs.

CGGBP1 has no direct effect on FMR1 transcription and CGG repeat stability.
Title: Defining the role of the CGGBP1 protein in FMR1 gene expression.

CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons.
Title: CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.

CGGBP1 protein play an important cytoprotective role in patients with cancer.
Title: CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.

Over-expression of miR-7 could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1
Title: [Over-expressed microRNA-7 inhibits the growth of human lung cancer cells via suppressing CGGBP1 expression].

The following CGGBP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CGGBP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03457	NM_003663.3 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03457	NM_001008390.2 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03457	NM_001195308.1 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03457	XM_017007355.1 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03457	XM_011534170.1 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03457	XM_024453797.1 Latest version!	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu03457	NM_001008390.1	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CGGBP1 ( NM_003663.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003654.3 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	NM_003663.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU537042.1, BC052980.1 and AL117392.1. On Dec 10, 2004 this sequence version replaced NM_003663.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.78255.1, SRR1803615.6031.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2144335 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003654.3
CDS	411..914
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	NM_003663.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003663.3

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( NM_001195308.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001182237.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	NM_001195308.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC005222.1, AC119733.2 and BC052980.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BE565654.1, SRR1803616.196007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689, SAMN03267752 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001182237.1
CDS	494..997
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	NM_001195308.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001195308.1

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( NM_001008390.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008391.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	NM_001008390.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC119733.2, BU537042.1, BE501563.1, AJ000258.1, AL117392.1 and BC052980.1. On Nov 23, 2018 this sequence version replaced NM_001008390.1. Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.50644.1, SRR1660807.127182.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000482016.6/ ENSP00000420374.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008391.1
CDS	522..1025
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	NM_001008390.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008390.2

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( NM_001008390.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001008391.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	NM_001008390.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU537042.1, BE501563.1, AJ000258.1, AL117392.1 and BC052980.1. Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.127182.1, SRR1660805.25260.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008391.1
CDS	513..1016
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	NM_001008390.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008390.1

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( XM_011534170.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011532472.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	XM_011534170.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	CGG triplet repeat-binding protein 1 isoform X1
Comment

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011532472.1
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	XM_011534170.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011534170.1

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( XM_017007355.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016862844.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	XM_017007355.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016862844.1
CDS	319..822
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	XM_017007355.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017007355.1

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CGGBP1 ( XM_024453797.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024309565.1 Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03457
Clone ID Related Accession (Same CDS sequence)	XM_011534170.1 , XM_017007355.1 , NM_003663.3 , NM_001195308.1 , NM_001008390.2 , XM_024453797.1 , NM_001008390.1
Accession Version	XM_024453797.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	CGG triplet repeat-binding protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024309565.1
CDS	545..1048
Translation	MERFVVTAPPARNRSKTALYVTPLDRVTEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC

Target ORF information:

RefSeq Version	XM_024453797.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024453797.1

ORF Insert Sequence:

ATGGAGCGAT TTGTAGTAAC AGCACCACCT GCTCGAAACC GTTCTAAGAC TGCTTTGTAT 
GTGACTCCCC TGGATCGAGT CACTGAGTTT GGAGGTGAGC TGCATGAAGA TGGAGGAAAA 
CTCTTCTGCA CTTCTTGCAA TGTGGTTCTG AATCATGTTC GCAAGTCTGC CATTAGTGAC 
CACCTCAAGT CAAAGACTCA TACCAAGAGG AAGGCAGAAT TTGAAGAGCA GAATGTGAGA 
AAGAAGCAGA GGCCCCTAAC TGCATCTCTT CAGTGCAACA GTACTGCGCA AACAGAGAAA 
GTCAGTGTTA TCCAGGACTT TGTGAAAATG TGCCTGGAAG CCAACATCCC ACTTGAGAAG 
GCTGATCACC CAGCAGTCCG TGCTTTCCTA TCTCGCCATG TGAAGAATGG AGGCTCCATA 
CCTAAGTCAG ACCAGCTACG GAGGGCATAT CTTCCTGATG GATATGAGAA TGAGAATCAA 
CTCCTCAACT CACAAGATTG TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Defining the role of the CGGBP1 protein in FMR1 gene expression.
European journal of human genetics : EJHG24(5)697-703(2016 May)
Goracci M,Lanni S,Mancano G,Palumbo F,Chiurazzi P,Neri G,Tabolacci E

CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.
BMC genomics16390(2015 May)
Agarwal P,Collier P,Fritz MH,Benes V,Wiklund HJ,Westermark B,Singh U

CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.
Upsala journal of medical sciences120(4)219-32(2015)
Singh U,Westermark B

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CGGBP1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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