SPSB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPSB2
Entrez Gene ID	84727
Full Name	splA/ryanodine receptor domain and SOCS box containing 2
Synonyms	GRCC9,SSB2
General protein information	Preferred Names splA/ryanodine receptor domain and SOCS box containing 2 Names SPRY domain-containing SOCS box protein 2 SPRY domain-containing SOCS box protein SSB-2 gene-rich cluster protein C9
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.31
Summary	This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Disorder MIM:	611658

mRNA and Protein(s)

mRNA	Protein	Name
XM_011521033.1	XP_011519335.1	SPRY domain-containing SOCS box protein 2 isoform X1
NM_001146316.1	NP_001139788.1	SPRY domain-containing SOCS box protein 2
NM_032641.3	NP_116030.1	SPRY domain-containing SOCS box protein 2
NM_001146316.2	NP_001139788.1	SPRY domain-containing SOCS box protein 2
NM_001319670.1	NP_001306599.1	SPRY domain-containing SOCS box protein 2
NM_032641.4	NP_116030.1	SPRY domain-containing SOCS box protein 2
NM_001319670.2	NP_001306599.1	SPRY domain-containing SOCS box protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPSB2	NP_116030.1
Mus musculus (house mouse)	Spsb2	NP_038567.1
Pan troglodytes (chimpanzee)	SPSB2	XP_003313510.1
Canis lupus familiaris (dog)	SPSB2	XP_005637269.1
Bos taurus (cattle)	SPSB2	NP_001069748.1

Gene Ontology
Bibliography

Related articles in PubMed

Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.
You T, Wang Y, Li K, Zhang D, Wei H, Luo Y, Li H, Lu Y, Su X, Kuang Z
Biochemical and biophysical research communications489(3)346-352(2017 07)

Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S
The Journal of biological chemistry286(11)9009-19(2011 Mar)

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN
Journal of molecular biology401(3)389-402(2010 Aug)

Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential.
Krol M, Pawlowski KM, Skierski J, Rao NA, Hellmen E, Mol JA, Motyl T
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society60 Suppl 195-106(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

crystal structure of SPSB2 in complex with cyclic peptide inhibitor cR8, at a resolution of 1.34 A
Title: Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.

Shows that this gene is associated with the regulation of cell proliferation in canine mammary cancer cell lines.
Title: Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential.

The following SPSB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPSB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02981	NM_001146316.2 Latest version!	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02981	NM_001319670.2 Latest version!	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02981	NM_032641.4 Latest version!	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02981	XM_011521033.1 Latest version!	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu02981	NM_001146316.1	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02981	NM_032641.3	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu02981	NM_001319670.1	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPSB2 ( NM_001146316.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139788.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_001146316.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-16
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC071933.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BC071933.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2467146, SAMN01820691 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139788.1
CDS	157..948
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_001146316.1
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146316.1

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( NM_032641.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_116030.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_032641.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-16
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT220163.1 and BC002983.1. This sequence is a reference standard in the RefSeqGene project. On Sep 23, 2009 this sequence version replaced NM_032641.2. Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, and 4 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.466684.1, SRR1163658.409068.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116030.1
CDS	209..1000
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_032641.3
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032641.3

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( NM_001146316.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139788.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_001146316.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U47924.1 and BC071933.1. On Jun 2, 2019 this sequence version replaced NM_001146316.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC071933.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2467146, SAMN01820691 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139788.1
CDS	175..966
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_001146316.2
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146316.2

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( NM_001319670.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306599.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_001319670.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-16
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U47924.1. On Feb 4, 2016 this sequence version replaced XM_011521033.1. Transcript Variant: This variant (4) contains an alternate segment in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##Evidence-Data-START## Transcript exon combination :: BQ649808.1, SRR1163657.572636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306599.1
CDS	457..1248
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_001319670.1
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319670.1

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( NM_032641.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_116030.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.

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CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_032641.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT220163.1 and BC002983.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_032641.3. Transcript Variant: This variant (1) is the reference variant. Variants 1, 2, and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.274015.1, BC002983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820691 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116030.1
CDS	155..946
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_032641.4
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032641.4

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( NM_001319670.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306599.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.

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CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	NM_001319670.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Homo sapiens(human)
Product	SPRY domain-containing SOCS box protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U47924.1. On Jun 2, 2019 this sequence version replaced NM_001319670.1. Transcript Variant: This variant (4) contains an alternate segment in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.133708.1, DRR138528.95392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306599.1
CDS	403..1194
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	NM_001319670.2
Organism	Homo sapiens(human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319670.2

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPSB2 ( XM_011521033.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011519335.1 Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu02981
Clone ID Related Accession (Same CDS sequence)	XM_011521033.1 , NM_001146316.1 , NM_032641.3 , NM_001146316.2 , NM_001319670.1 , NM_032641.4 , NM_001319670.2
Accession Version	XM_011521033.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 792bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	SPRY domain-containing SOCS box protein 2 isoform X1
Comment

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011519335.1
Translation	MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ

Target ORF information:

RefSeq Version	XM_011521033.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011521033.1

ORF Insert Sequence:

ATGGGCCAGA CAGCTCTGGC AGGGGGCAGC AGCAGCACCC CCACGCCACA GGCCCTGTAC 
CCTGACCTCT CCTGTCCCGA GGGCTTGGAA GAGCTGCTGT CTGCACCCCC TCCTGACCTG 
GGGGCCCAGC GGCGCCACGG TTGGAACCCC AAAGACTGTT CAGAGAACAT CGAGGTCAAG 
GAAGGAGGGT TGTACTTTGA GCGGCGGCCC GTGGCCCAGA GCACTGATGG GGCCCGGGGT 
AAGAGGGGCT ATTCAAGGGG CCTGCACGCC TGGGAGATCA GCTGGCCCCT AGAGCAGAGG 
GGCACGCATG CCGTGGTGGG CGTGGCCACG GCCCTCGCCC CGCTGCAGAC TGACCACTAC 
GCGGCGCTGC TGGGCAGCAA CAGCGAGTCG TGGGGCTGGG ACATCGGGCG GGGGAAGCTG 
TACCATCAGA GCAAGGGGCC CGGAGCCCCC CAGTATCCAG CGGGAACTCA GGGTGAGCAG 
CTGGAGGTGC CAGAGAGACT GCTGGTGGTT CTGGACATGG AGGAGGGAAC TCTGGGCTAC 
GCTATTGGGG GCACCTACCT GGGGCCAGCA TTCCGCGGAC TGAAGGGCAG GACCCTCTAT 
CCGGCAGTAA GCGCTGTCTG GGGCCAGTGC CAGGTCCGCA TCCGCTACCT GGGCGAAAGG 
AGAGCGGAGC CACACTCCCT TCTGCACCTG AGCCGCCTGT GTGTGCGCCA CAACCTGGGG 
GATACCCGGC TCGGCCAGGT GTCTGCCCTG CCCTTGCCCC CTGCCATGAA GCGCTACCTG 
CTCTACCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.
Biochemical and biophysical research communications489(3)346-352(2017 07)
You T,Wang Y,Li K,Zhang D,Wei H,Luo Y,Li H,Lu Y,Su X,Kuang Z

Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
The Journal of biological chemistry286(11)9009-19(2011 Mar)
Nishiya T,Matsumoto K,Maekawa S,Kajita E,Horinouchi T,Fujimuro M,Ogasawara K,Uehara T,Miwa S

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Journal of molecular biology401(3)389-402(2010 Aug)
Filippakopoulos P,Low A,Sharpe TD,Uppenberg J,Yao S,Kuang Z,Savitsky P,Lewis RS,Nicholson SE,Norton RS,Bullock AN

Transcriptomic profile of two canine mammary cancer cell lines with different proliferative and anti-apoptotic potential.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society60 Suppl 195-106(2009 May)
Krol M,Pawlowski KM,Skierski J,Rao NA,Hellmen E,Mol JA,Motyl T

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SPSB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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