DYRK2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DYRK2
Entrez Gene ID	8445
Full Name	dual specificity tyrosine phosphorylation regulated kinase 2
General protein information	Preferred Names dual specificity tyrosine phosphorylation regulated kinase 2 Names dual specificity tyrosine-phosphorylation-regulated kinase 2 dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Summary	DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].
Disorder MIM:	603496

mRNA and Protein(s)

mRNA	Protein	Name
NM_006482.2	NP_006473.2	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
NM_006482.3	NP_006473.2	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
XM_017020032.1	XP_016875521.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1
NM_003583.4	NP_003574.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
NM_003583.3	NP_003574.1	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DYRK2	XP_001161394.2
Canis lupus familiaris (dog)	DYRK2	XP_005625654.1
Mus musculus (house mouse)	Dyrk2	NP_001014412.1
Xenopus tropicalis (tropical clawed frog)	dyrk2	XP_002937581.2
Drosophila melanogaster (fruit fly)	Dyrk3	NP_001033810.1
Caenorhabditis elegans (roundworm)	mbk-2	NP_001040950.1
Neurospora crassa	NCU06638	XP_960871.1
Rattus norvegicus (Norway rat)	Dyrk2	NP_001101570.1
Gallus gallus (chicken)	DYRK2	NP_001026651.1
Magnaporthe oryzae (rice blast fungus)	MGG_00760	XP_003718240.1
Homo sapiens (human)	DYRK2	NP_006473.2
	DYRK2	XP_001117146.1
Bos taurus (cattle)	DYRK2	XP_002687443.1
Danio rerio (zebrafish)	dyrk2	NP_001038298.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008241	XP_317229.4

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer.
Imawari Y, Mimoto R, Hirooka S, Morikawa T, Takeyama H, Yoshida K
Cancer science(2017 Nov)

Regulation of Glioma Cells Migration by DYRK2.
Shen Y, Zhang L, Wang D, Bao Y, Liu C, Xu Z, Huang W, Cheng C
Neurochemical research42(11)3093-3102(2017 Nov)

Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer.
Ito D, Yogosawa S, Mimoto R, Hirooka S, Horiuchi T, Eto K, Yanaga K, Yoshida K
Cancer science108(8)1565-1573(2017 Aug)

Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.
Yamamoto T, Taira Nihira N, Yogosawa S, Aoki K, Takeda H, Sawasaki T, Yoshida K
FEBS letters591(6)842-853(2017 Mar)

Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.
Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K
Cancer letters38427-38(2017 01)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study found that DYRK2 regulates liver metastases of colorectal cancer cells through the activation of EMT, and that patients with low DYRK2-expressing colorectal cancer liver metastases had worse outcomes than those with high DYRK2-expressing metastases.
Title: Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer.

our results delineate a novel mechanism of cancer stem cell regulation by the DYRK2-AR-KLF4 axis. Restoration of the expression and function of DYRK2 is a potential therapeutic strategy against breast cancer stem cells.
Title: Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer.

Findings indicate direct interaction of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with ring finger protein (C3HC4 type) 8 (RNF8) in regulating response to DNA damage.
Title: Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.

Diminished DYRK2 expression sensitizes hormone receptor-positive breast cancer to everolimus by preventing mTOR degradation.
Title: Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.

lower DYRK2 levels were correlated with tumor sites, advanced clinical stages, and shorter survival in the advanced clinical stages. DYRK2 is a novel prognostic biomarker of human colorectal cancer.
Title: Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.

The following DYRK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DYRK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23456	NM_003583.4 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu23982	NM_006482.3 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu23456	XM_017020032.1 Latest version!	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu23982	NM_006482.2	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu23456	NM_003583.3	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DYRK2 ( NM_003583.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003574.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23456
Clone ID Related Accession (Same CDS sequence)	XM_017020032.1 , NM_003583.4 , NM_003583.3
Accession Version	NM_003583.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461362.1, BC005809.2, BC006375.2, DA768075.1, CN303286.1, AK025018.1 and AC078777.15. On Jun 2, 2019 this sequence version replaced NM_003583.3. Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.161235.1, SRR1660809.147520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003574.1
CDS	460..2046
Translation	MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS

Target ORF information:

RefSeq Version	NM_003583.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003583.4

ORF Insert Sequence:

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK2 ( NM_003583.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003574.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu23456
Clone ID Related Accession (Same CDS sequence)	XM_017020032.1 , NM_003583.4 , NM_003583.3
Accession Version	NM_003583.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461362.1, BC005809.2, BC006375.2, DA768075.1, CN303286.1, AK025018.1 and AC078777.15. On Jul 24, 2007 this sequence version replaced NM_003583.2. Transcript Variant: This variant (1) does not include the 149 bp insert in the 5' end of the transcript and thus results in a shorter amino-terminal protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.161235.1, SRR1803612.116294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003574.1
CDS	473..2059
Translation	MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS

Target ORF information:

RefSeq Version	NM_003583.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003583.3

ORF Insert Sequence:

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK2 ( NM_006482.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006473.2 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23982
Clone ID Related Accession (Same CDS sequence)	NM_006482.2 , NM_006482.3
Accession Version	NM_006482.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461362.1, BC005809.2, BC006375.2, DA768075.1, CN303286.1, AK025018.1 and AC078777.15. On Jul 24, 2007 this sequence version replaced NM_006482.1. Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.151541.1, SRR1660809.228246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCGCCGCCT ACCCGACCGG CCGAGGTGGG 
GACAGCGCCG TTCGTCAGCT TCAGGCTTCC CCGGGGCTCG GTGCAGGGGC CACCCGGAGC 
GGAGTGGGGA CTGGCCCGCC CTCCCCCATC GCCCTGCCGC CTCTCCGGGC CAGCAACGCT 
GCCGCCGCAG CCCACACGAT TGGCGGCAGT AAGCACACAA TGAATGATCA CCTGCATGTC 
GGCAGCCACG CTCACGGACA GATCCAGGTT CAACAGTTGT TTGAGGATAA CAGTAACAAG 
CGGACAGTGC TCACGACACA ACCAAATGGG CTTACAACAG TGGGCAAAAC GGGCTTGCCA 
GTGGTGCCAG AGCGGCAGCT GGACAGCATT CATAGACGGC AGGGGAGCTC CACCTCTCTA 
AAGTCCATGG AAGGCATGGG GAAGGTGAAA GCCACCCCCA TGACACCTGA ACAAGCAATG 
AAGCAATACA TGCAAAAACT CACAGCCTTC GAACACCATG AGATTTTCAG CTACCCTGAA 
ATATATTTCT TGGGTCTAAA TGCTAAGAAG CGCCAGGGCA TGACAGGTGG GCCCAACAAT 
GGTGGCTATG ATGATGACCA GGGATCATAT GTGCAGGTGC CCCACGATCA CGTGGCTTAC 
AGGTATGAGG TCCTCAAGGT CATTGGGAAG GGGAGCTTTG GGCAGGTGGT CAAGGCCTAC 
GATCACAAAG TCCACCAGCA CGTGGCCCTA AAGATGGTGC GGAATGAGAA GCGCTTCCAC 
CGGCAAGCAG CGGAGGAGAT CCGAATCCTG GAACACCTGC GGAAGCAGGA CAAGGATAAC 
ACAATGAATG TCATCCATAT GCTGGAGAAT TTCACCTTCC GCAACCACAT CTGCATGACG 
TTTGAGCTGC TGAGCATGAA CCTCTATGAG CTCATCAAGA AGAATAAATT CCAGGGCTTC 
AGTCTGCCTT TGGTTCGCAA GTTTGCCCAC TCGATTCTGC AGTGCTTGGA TGCTTTGCAC 
AAAAACAGAA TAATTCACTG TGACCTTAAG CCCGAGAACA TTTTGTTAAA GCAGCAGGGT 
AGAAGCGGTA TTAAAGTAAT TGATTTTGGC TCCAGTTGTT ACGAGCATCA GCGTGTCTAC 
ACGTACATCC AGTCGCGTTT TTACCGGGCT CCAGAAGTGA TCCTTGGGGC CAGGTATGGC 
ATGCCCATTG ATATGTGGAG CCTGGGCTGC ATTTTAGCAG AGCTCCTGAC GGGTTACCCC 
CTCTTGCCTG GGGAAGATGA AGGGGACCAG CTGGCCTGTA TGATTGAACT GTTGGGCATG 
CCCTCACAGA AACTGCTGGA TGCATCCAAA CGAGCCAAAA ATTTTGTGAG CTCCAAGGGT 
TATCCCCGTT ACTGCACTGT CACGACTCTC TCAGATGGCT CTGTGGTCCT AAACGGAGGC 
CGTTCCCGGA GGGGGAAACT GAGGGGCCCA CCGGAGAGCA GAGAGTGGGG GAACGCGCTG 
AAGGGGTGTG ATGATCCCCT TTTCCTTGAC TTCTTAAAAC AGTGTTTAGA GTGGGATCCT 
GCAGTGCGCA TGACCCCAGG CCAGGCTTTG CGGCACCCCT GGCTGAGGAG GCGGTTGCCA 
AAGCCTCCCA CCGGGGAGAA AACGTCAGTG AAAAGGATAA CTGAGAGCAC CGGTGCTATC 
ACATCTATAT CCAAGTTACC TCCACCTTCT AGCTCAGCTT CCAAACTGAG GACTAATTTG 
GCGCAGATGA CAGATGCCAA TGGGAATATT CAGCAGAGGA CAGTGTTGCC AAAACTTGTT 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006473.2
CDS	403..2208
Translation	MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS

Target ORF information:

RefSeq Version	NM_006482.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006482.2

ORF Insert Sequence:

ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCGCCGCCT ACCCGACCGG CCGAGGTGGG 
GACAGCGCCG TTCGTCAGCT TCAGGCTTCC CCGGGGCTCG GTGCAGGGGC CACCCGGAGC 
GGAGTGGGGA CTGGCCCGCC CTCCCCCATC GCCCTGCCGC CTCTCCGGGC CAGCAACGCT 
GCCGCCGCAG CCCACACGAT TGGCGGCAGT AAGCACACAA TGAATGATCA CCTGCATGTC 
GGCAGCCACG CTCACGGACA GATCCAGGTT CAACAGTTGT TTGAGGATAA CAGTAACAAG 
CGGACAGTGC TCACGACACA ACCAAATGGG CTTACAACAG TGGGCAAAAC GGGCTTGCCA 
GTGGTGCCAG AGCGGCAGCT GGACAGCATT CATAGACGGC AGGGGAGCTC CACCTCTCTA 
AAGTCCATGG AAGGCATGGG GAAGGTGAAA GCCACCCCCA TGACACCTGA ACAAGCAATG 
AAGCAATACA TGCAAAAACT CACAGCCTTC GAACACCATG AGATTTTCAG CTACCCTGAA 
ATATATTTCT TGGGTCTAAA TGCTAAGAAG CGCCAGGGCA TGACAGGTGG GCCCAACAAT 
GGTGGCTATG ATGATGACCA GGGATCATAT GTGCAGGTGC CCCACGATCA CGTGGCTTAC 
AGGTATGAGG TCCTCAAGGT CATTGGGAAG GGGAGCTTTG GGCAGGTGGT CAAGGCCTAC 
GATCACAAAG TCCACCAGCA CGTGGCCCTA AAGATGGTGC GGAATGAGAA GCGCTTCCAC 
CGGCAAGCAG CGGAGGAGAT CCGAATCCTG GAACACCTGC GGAAGCAGGA CAAGGATAAC 
ACAATGAATG TCATCCATAT GCTGGAGAAT TTCACCTTCC GCAACCACAT CTGCATGACG 
TTTGAGCTGC TGAGCATGAA CCTCTATGAG CTCATCAAGA AGAATAAATT CCAGGGCTTC 
AGTCTGCCTT TGGTTCGCAA GTTTGCCCAC TCGATTCTGC AGTGCTTGGA TGCTTTGCAC 
AAAAACAGAA TAATTCACTG TGACCTTAAG CCCGAGAACA TTTTGTTAAA GCAGCAGGGT 
AGAAGCGGTA TTAAAGTAAT TGATTTTGGC TCCAGTTGTT ACGAGCATCA GCGTGTCTAC 
ACGTACATCC AGTCGCGTTT TTACCGGGCT CCAGAAGTGA TCCTTGGGGC CAGGTATGGC 
ATGCCCATTG ATATGTGGAG CCTGGGCTGC ATTTTAGCAG AGCTCCTGAC GGGTTACCCC 
CTCTTGCCTG GGGAAGATGA AGGGGACCAG CTGGCCTGTA TGATTGAACT GTTGGGCATG 
CCCTCACAGA AACTGCTGGA TGCATCCAAA CGAGCCAAAA ATTTTGTGAG CTCCAAGGGT 
TATCCCCGTT ACTGCACTGT CACGACTCTC TCAGATGGCT CTGTGGTCCT AAACGGAGGC 
CGTTCCCGGA GGGGGAAACT GAGGGGCCCA CCGGAGAGCA GAGAGTGGGG GAACGCGCTG 
AAGGGGTGTG ATGATCCCCT TTTCCTTGAC TTCTTAAAAC AGTGTTTAGA GTGGGATCCT 
GCAGTGCGCA TGACCCCAGG CCAGGCTTTG CGGCACCCCT GGCTGAGGAG GCGGTTGCCA 
AAGCCTCCCA CCGGGGAGAA AACGTCAGTG AAAAGGATAA CTGAGAGCAC CGGTGCTATC 
ACATCTATAT CCAAGTTACC TCCACCTTCT AGCTCAGCTT CCAAACTGAG GACTAATTTG 
GCGCAGATGA CAGATGCCAA TGGGAATATT CAGCAGAGGA CAGTGTTGCC AAAACTTGTT 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK2 ( NM_006482.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006473.2 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.

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CloneID	OHu23982
Clone ID Related Accession (Same CDS sequence)	NM_006482.2 , NM_006482.3
Accession Version	NM_006482.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461362.1, BC005809.2, BC006375.2, DA768075.1, CN303286.1, AK025018.1 and AC078777.15. On Jun 2, 2019 this sequence version replaced NM_006482.2. Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.151541.1, SRR1660809.228246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCGCCGCCT ACCCGACCGG CCGAGGTGGG 
GACAGCGCCG TTCGTCAGCT TCAGGCTTCC CCGGGGCTCG GTGCAGGGGC CACCCGGAGC 
GGAGTGGGGA CTGGCCCGCC CTCCCCCATC GCCCTGCCGC CTCTCCGGGC CAGCAACGCT 
GCCGCCGCAG CCCACACGAT TGGCGGCAGT AAGCACACAA TGAATGATCA CCTGCATGTC 
GGCAGCCACG CTCACGGACA GATCCAGGTT CAACAGTTGT TTGAGGATAA CAGTAACAAG 
CGGACAGTGC TCACGACACA ACCAAATGGG CTTACAACAG TGGGCAAAAC GGGCTTGCCA 
GTGGTGCCAG AGCGGCAGCT GGACAGCATT CATAGACGGC AGGGGAGCTC CACCTCTCTA 
AAGTCCATGG AAGGCATGGG GAAGGTGAAA GCCACCCCCA TGACACCTGA ACAAGCAATG 
AAGCAATACA TGCAAAAACT CACAGCCTTC GAACACCATG AGATTTTCAG CTACCCTGAA 
ATATATTTCT TGGGTCTAAA TGCTAAGAAG CGCCAGGGCA TGACAGGTGG GCCCAACAAT 
GGTGGCTATG ATGATGACCA GGGATCATAT GTGCAGGTGC CCCACGATCA CGTGGCTTAC 
AGGTATGAGG TCCTCAAGGT CATTGGGAAG GGGAGCTTTG GGCAGGTGGT CAAGGCCTAC 
GATCACAAAG TCCACCAGCA CGTGGCCCTA AAGATGGTGC GGAATGAGAA GCGCTTCCAC 
CGGCAAGCAG CGGAGGAGAT CCGAATCCTG GAACACCTGC GGAAGCAGGA CAAGGATAAC 
ACAATGAATG TCATCCATAT GCTGGAGAAT TTCACCTTCC GCAACCACAT CTGCATGACG 
TTTGAGCTGC TGAGCATGAA CCTCTATGAG CTCATCAAGA AGAATAAATT CCAGGGCTTC 
AGTCTGCCTT TGGTTCGCAA GTTTGCCCAC TCGATTCTGC AGTGCTTGGA TGCTTTGCAC 
AAAAACAGAA TAATTCACTG TGACCTTAAG CCCGAGAACA TTTTGTTAAA GCAGCAGGGT 
AGAAGCGGTA TTAAAGTAAT TGATTTTGGC TCCAGTTGTT ACGAGCATCA GCGTGTCTAC 
ACGTACATCC AGTCGCGTTT TTACCGGGCT CCAGAAGTGA TCCTTGGGGC CAGGTATGGC 
ATGCCCATTG ATATGTGGAG CCTGGGCTGC ATTTTAGCAG AGCTCCTGAC GGGTTACCCC 
CTCTTGCCTG GGGAAGATGA AGGGGACCAG CTGGCCTGTA TGATTGAACT GTTGGGCATG 
CCCTCACAGA AACTGCTGGA TGCATCCAAA CGAGCCAAAA ATTTTGTGAG CTCCAAGGGT 
TATCCCCGTT ACTGCACTGT CACGACTCTC TCAGATGGCT CTGTGGTCCT AAACGGAGGC 
CGTTCCCGGA GGGGGAAACT GAGGGGCCCA CCGGAGAGCA GAGAGTGGGG GAACGCGCTG 
AAGGGGTGTG ATGATCCCCT TTTCCTTGAC TTCTTAAAAC AGTGTTTAGA GTGGGATCCT 
GCAGTGCGCA TGACCCCAGG CCAGGCTTTG CGGCACCCCT GGCTGAGGAG GCGGTTGCCA 
AAGCCTCCCA CCGGGGAGAA AACGTCAGTG AAAAGGATAA CTGAGAGCAC CGGTGCTATC 
ACATCTATAT CCAAGTTACC TCCACCTTCT AGCTCAGCTT CCAAACTGAG GACTAATTTG 
GCGCAGATGA CAGATGCCAA TGGGAATATT CAGCAGAGGA CAGTGTTGCC AAAACTTGTT 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006473.2
CDS	390..2195
Translation	MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS

Target ORF information:

RefSeq Version	NM_006482.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006482.3

ORF Insert Sequence:

ATGTTAACCA GGAAACCTTC GGCCGCCGCT CCCGCCGCCT ACCCGACCGG CCGAGGTGGG 
GACAGCGCCG TTCGTCAGCT TCAGGCTTCC CCGGGGCTCG GTGCAGGGGC CACCCGGAGC 
GGAGTGGGGA CTGGCCCGCC CTCCCCCATC GCCCTGCCGC CTCTCCGGGC CAGCAACGCT 
GCCGCCGCAG CCCACACGAT TGGCGGCAGT AAGCACACAA TGAATGATCA CCTGCATGTC 
GGCAGCCACG CTCACGGACA GATCCAGGTT CAACAGTTGT TTGAGGATAA CAGTAACAAG 
CGGACAGTGC TCACGACACA ACCAAATGGG CTTACAACAG TGGGCAAAAC GGGCTTGCCA 
GTGGTGCCAG AGCGGCAGCT GGACAGCATT CATAGACGGC AGGGGAGCTC CACCTCTCTA 
AAGTCCATGG AAGGCATGGG GAAGGTGAAA GCCACCCCCA TGACACCTGA ACAAGCAATG 
AAGCAATACA TGCAAAAACT CACAGCCTTC GAACACCATG AGATTTTCAG CTACCCTGAA 
ATATATTTCT TGGGTCTAAA TGCTAAGAAG CGCCAGGGCA TGACAGGTGG GCCCAACAAT 
GGTGGCTATG ATGATGACCA GGGATCATAT GTGCAGGTGC CCCACGATCA CGTGGCTTAC 
AGGTATGAGG TCCTCAAGGT CATTGGGAAG GGGAGCTTTG GGCAGGTGGT CAAGGCCTAC 
GATCACAAAG TCCACCAGCA CGTGGCCCTA AAGATGGTGC GGAATGAGAA GCGCTTCCAC 
CGGCAAGCAG CGGAGGAGAT CCGAATCCTG GAACACCTGC GGAAGCAGGA CAAGGATAAC 
ACAATGAATG TCATCCATAT GCTGGAGAAT TTCACCTTCC GCAACCACAT CTGCATGACG 
TTTGAGCTGC TGAGCATGAA CCTCTATGAG CTCATCAAGA AGAATAAATT CCAGGGCTTC 
AGTCTGCCTT TGGTTCGCAA GTTTGCCCAC TCGATTCTGC AGTGCTTGGA TGCTTTGCAC 
AAAAACAGAA TAATTCACTG TGACCTTAAG CCCGAGAACA TTTTGTTAAA GCAGCAGGGT 
AGAAGCGGTA TTAAAGTAAT TGATTTTGGC TCCAGTTGTT ACGAGCATCA GCGTGTCTAC 
ACGTACATCC AGTCGCGTTT TTACCGGGCT CCAGAAGTGA TCCTTGGGGC CAGGTATGGC 
ATGCCCATTG ATATGTGGAG CCTGGGCTGC ATTTTAGCAG AGCTCCTGAC GGGTTACCCC 
CTCTTGCCTG GGGAAGATGA AGGGGACCAG CTGGCCTGTA TGATTGAACT GTTGGGCATG 
CCCTCACAGA AACTGCTGGA TGCATCCAAA CGAGCCAAAA ATTTTGTGAG CTCCAAGGGT 
TATCCCCGTT ACTGCACTGT CACGACTCTC TCAGATGGCT CTGTGGTCCT AAACGGAGGC 
CGTTCCCGGA GGGGGAAACT GAGGGGCCCA CCGGAGAGCA GAGAGTGGGG GAACGCGCTG 
AAGGGGTGTG ATGATCCCCT TTTCCTTGAC TTCTTAAAAC AGTGTTTAGA GTGGGATCCT 
GCAGTGCGCA TGACCCCAGG CCAGGCTTTG CGGCACCCCT GGCTGAGGAG GCGGTTGCCA 
AAGCCTCCCA CCGGGGAGAA AACGTCAGTG AAAAGGATAA CTGAGAGCAC CGGTGCTATC 
ACATCTATAT CCAAGTTACC TCCACCTTCT AGCTCAGCTT CCAAACTGAG GACTAATTTG 
GCGCAGATGA CAGATGCCAA TGGGAATATT CAGCAGAGGA CAGTGTTGCC AAAACTTGTT 
AGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DYRK2 ( XM_017020032.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016875521.1 Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant X1, mRNA.

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CloneID	OHu23456
Clone ID Related Accession (Same CDS sequence)	XM_017020032.1 , NM_003583.4 , NM_003583.3
Accession Version	XM_017020032.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016875521.1
CDS	765..2351
Translation	MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS

Target ORF information:

RefSeq Version	XM_017020032.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017020032.1

ORF Insert Sequence:

ATGAATGATC ACCTGCATGT CGGCAGCCAC GCTCACGGAC AGATCCAGGT TCAACAGTTG 
TTTGAGGATA ACAGTAACAA GCGGACAGTG CTCACGACAC AACCAAATGG GCTTACAACA 
GTGGGCAAAA CGGGCTTGCC AGTGGTGCCA GAGCGGCAGC TGGACAGCAT TCATAGACGG 
CAGGGGAGCT CCACCTCTCT AAAGTCCATG GAAGGCATGG GGAAGGTGAA AGCCACCCCC 
ATGACACCTG AACAAGCAAT GAAGCAATAC ATGCAAAAAC TCACAGCCTT CGAACACCAT 
GAGATTTTCA GCTACCCTGA AATATATTTC TTGGGTCTAA ATGCTAAGAA GCGCCAGGGC 
ATGACAGGTG GGCCCAACAA TGGTGGCTAT GATGATGACC AGGGATCATA TGTGCAGGTG 
CCCCACGATC ACGTGGCTTA CAGGTATGAG GTCCTCAAGG TCATTGGGAA GGGGAGCTTT 
GGGCAGGTGG TCAAGGCCTA CGATCACAAA GTCCACCAGC ACGTGGCCCT AAAGATGGTG 
CGGAATGAGA AGCGCTTCCA CCGGCAAGCA GCGGAGGAGA TCCGAATCCT GGAACACCTG 
CGGAAGCAGG ACAAGGATAA CACAATGAAT GTCATCCATA TGCTGGAGAA TTTCACCTTC 
CGCAACCACA TCTGCATGAC GTTTGAGCTG CTGAGCATGA ACCTCTATGA GCTCATCAAG 
AAGAATAAAT TCCAGGGCTT CAGTCTGCCT TTGGTTCGCA AGTTTGCCCA CTCGATTCTG 
CAGTGCTTGG ATGCTTTGCA CAAAAACAGA ATAATTCACT GTGACCTTAA GCCCGAGAAC 
ATTTTGTTAA AGCAGCAGGG TAGAAGCGGT ATTAAAGTAA TTGATTTTGG CTCCAGTTGT 
TACGAGCATC AGCGTGTCTA CACGTACATC CAGTCGCGTT TTTACCGGGC TCCAGAAGTG 
ATCCTTGGGG CCAGGTATGG CATGCCCATT GATATGTGGA GCCTGGGCTG CATTTTAGCA 
GAGCTCCTGA CGGGTTACCC CCTCTTGCCT GGGGAAGATG AAGGGGACCA GCTGGCCTGT 
ATGATTGAAC TGTTGGGCAT GCCCTCACAG AAACTGCTGG ATGCATCCAA ACGAGCCAAA 
AATTTTGTGA GCTCCAAGGG TTATCCCCGT TACTGCACTG TCACGACTCT CTCAGATGGC 
TCTGTGGTCC TAAACGGAGG CCGTTCCCGG AGGGGGAAAC TGAGGGGCCC ACCGGAGAGC 
AGAGAGTGGG GGAACGCGCT GAAGGGGTGT GATGATCCCC TTTTCCTTGA CTTCTTAAAA 
CAGTGTTTAG AGTGGGATCC TGCAGTGCGC ATGACCCCAG GCCAGGCTTT GCGGCACCCC 
TGGCTGAGGA GGCGGTTGCC AAAGCCTCCC ACCGGGGAGA AAACGTCAGT GAAAAGGATA 
ACTGAGAGCA CCGGTGCTAT CACATCTATA TCCAAGTTAC CTCCACCTTC TAGCTCAGCT 
TCCAAACTGA GGACTAATTT GGCGCAGATG ACAGATGCCA ATGGGAATAT TCAGCAGAGG 
ACAGTGTTGC CAAAACTTGT TAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin-dependent kinase 14 expression in breast cancer.
Cancer science(2017 Nov)
Imawari Y,Mimoto R,Hirooka S,Morikawa T,Takeyama H,Yoshida K

Regulation of Glioma Cells Migration by DYRK2.
Neurochemical research42(11)3093-3102(2017 Nov)
Shen Y,Zhang L,Wang D,Bao Y,Liu C,Xu Z,Huang W,Cheng C

Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer.
Cancer science108(8)1565-1573(2017 Aug)
Ito D,Yogosawa S,Mimoto R,Hirooka S,Horiuchi T,Eto K,Yanaga K,Yoshida K

Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks.
FEBS letters591(6)842-853(2017 Mar)
Yamamoto T,Taira Nihira N,Yogosawa S,Aoki K,Takeda H,Sawasaki T,Yoshida K

Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.
Cancer letters38427-38(2017 01)
Mimoto R,Nihira NT,Hirooka S,Takeyama H,Yoshida K

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DYRK2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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