HOOK3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HOOK3
Entrez Gene ID	84376
Full Name	hook microtubule tethering protein 3
Synonyms	HK3
General protein information	Preferred Names hook microtubule tethering protein 3 Names protein Hook homolog 3 h-hook3 hHK3 hook homolog 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p11.21
Summary	Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004].
Disorder MIM:	607825

mRNA and Protein(s)

mRNA	Protein	Name
NM_032410.3	NP_115786.1	protein Hook homolog 3
NM_032410.4	NP_115786.1	protein Hook homolog 3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Hook3	NP_997542.1
Drosophila melanogaster (fruit fly)	hk	NP_476573.1
Pan troglodytes (chimpanzee)	HOOK3	XP_001145260.1
Gallus gallus (chicken)	HOOK3	XP_003643087.2
	HOOK3	XP_001099564.2
Anopheles gambiae (African malaria mosquito)	HOOK_ANOGA	XP_319596.4
Xenopus tropicalis (tropical clawed frog)	hook3	XP_004910960.1
Homo sapiens (human)	HOOK3	NP_115786.1
Canis lupus familiaris (dog)	HOOK3	XP_005629843.1
Bos taurus (cattle)	HOOK3	NP_001179529.1
Rattus norvegicus (Norway rat)	Hook3	NP_001129570.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
Olenick MA, Tokito M, Boczkowska M, Dominguez R, Holzbaur EL
The Journal of biological chemistry291(35)18239-51(2016 08)

Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
Schroeder CM, Vale RD
The Journal of cell biology214(3)309-18(2016 Aug)

High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.
Melling N, Harutyunyan L, Hube-Magg C, Kluth M, Simon R, Lebok P, Minner S, Tsourlakis MC, Koop C, Graefen M, Adam M, Haese A, Wittmer C, Steurer S, Izbicki J, Sauter G, Wilczak W, Schlomm T, Krech T
PloS one10(7)e0134614(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2).
Title: Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.

This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes.
Title: Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.

Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease.
Title: Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.

results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays
Title: High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.

Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1.
Title: Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.

The following HOOK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HOOK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31536	NM_032410.4 Latest version!	Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu31536	NM_032410.3	Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HOOK3 ( NM_032410.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115786.1 Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.

Price & Availability↑

CloneID	OHu31536
Clone ID Related Accession (Same CDS sequence)	NM_032410.3 , NM_032410.4
Accession Version	NM_032410.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	protein Hook homolog 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC048304.1, BC056146.1, AC110275.13 and BM716064.1. On Oct 28, 2008 this sequence version replaced NM_032410.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.131458.1, SRR1660809.7356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTTCAGCG TAGAGTCGCT GGAGCGGGCG GAGCTGTGCG AGAGCCTCCT CACTTGGATC 
CAGACATTTA ATGTGGATGC ACCATGCCAG ACCGTGGAAG ATTTAACGAA TGGGGTTGTG 
ATGGCCCAGG TTCTTCAAAA GATAGATCCT GCATATTTTG ATGAAAATTG GCTAAACAGA 
ATCAAAACTG AAGTAGGAGA TAATTGGAGG CTAAAGATAA GCAATTTAAA GAAAATTTTA 
AAAGGAATCT TGGATTATAA TCATGAGATT TTAGGACAGC AAATTAATGA CTTTACCCTT 
CCTGATGTGA ACCTTATTGG GGAGCATTCT GATGCAGCAG AGCTTGGAAG GATGCTTCAG 
CTCATCTTAG GCTGTGCTGT GAACTGTGAA CAGAAGCAAG AGTACATCCA AGCCATTATG 
ATGATGGAGG AATCTGTTCA ACATGTTGTC ATGACAGCCA TTCAAGAGCT GATGAGTAAA 
GAATCTCCTG TCTCTGCTGG AAATGATGCC TATGTTGACC TTGATCGTCA GCTGAAGAAA 
ACTACAGAGG AACTAAATGA AGCTTTGTCA GCAAAGGAAG AAATTGCTCA AAGATGCCAT 
GAACTGGATA TGCAGGTTGC AGCATTGCAG GAAGAGAAAA GTAGTTTGTT GGCAGAGAAT 
CAGGTATTAA TGGAAAGACT CAATCAATCT GATTCTATAG AAGACCCTAA CAGTCCAGCA 
GGAAGAAGGC ATTTGCAGCT CCAGACTCAA TTAGAACAGC TCCAAGAAGA AACATTCAGA 
CTAGAAGCAG CCAAAGATGA TTATCGAATA CGTTGTGAAG AGTTAGAAAA GGAGATCTCT 
GAACTTCGGC AACAGAATGA TGAACTGACC ACTTTGGCAG ATGAAGCTCA GTCTCTGAAA 
GATGAGATCG ACGTGCTGAG ACATTCTTCT GATAAAGTAT CTAAACTAGA AGGTCAAGTA 
GAATCTTATA AAAAGAAGCT AGAAGACCTT GGTGATTTAA GGCGGCAGGT TAAACTCTTA 
GAAGAGAAGA ATACCATGTA TATGCAGAAT ACTGTCAGTC TAGAGGAAGA GTTAAGAAAG 
GCCAACGCAG CGCGAAGTCA ACTTGAAACC TACAAGAGAC AGGTAGTAGA ACTACAAAAC 
AGATTATCCG AAGAATCAAA GAAAGCAGAT AAACTAGATT TTGAATATAA GCGGCTAAAA 
GAAAAAGTTG ACAGTCTTCA AAAAGAAAAG GACAGGCTGA GAACAGAAAG GGATTCTCTG 
AAGGAAACCA TTGAAGAGCT TCGTTGTGTA CAAGCTCAAG AAGGGCAGCT CACAACACAA 
GGGTTAATGC CTCTTGGAAG TCAGGAGTCT TCAGACAGTC TAGCTGCAGA GATTGTTACA 
CCTGAAATCA GGGAGAAACT TATTCGTCTT CAGCATGAGA ATAAGATGTT AAAGCTTAAC 
CAAGAAGGTT CGGACAATGA AAAAATAGCC TTATTGCAGA GCCTTCTAGA TGATGCAAAT 
CTACGCAAGA ATGAACTGGA GACAGAGAAT AGGCTGGTGA ATCAAAGACT TCTGGAAGTA 
CAGTCACAAG TTGAAGAATT ACAAAAATCT TTACAGGATC AAGGCTCAAA AGCAGAAGAT 
TCAGTCCTTC TAAAAAAGAA GCTTGAAGAA CATCTAGAGA AGCTGCATGA GGCCAATAAT 
GAACTACAGA AGAAGAGAGC CATTATTGAA GATCTCGAGC CAAGATTTAA CAACAGCTCC 
TTAAAAATTG AAGAATTACA AGAAGCTTTA CGAAAGAAAG AGGAAGAAAT GAAGCAAATG 
GAAGAACGAT ACAAAAAATA CTTAGAGAAA GCCAAAAGTG TCATCCGTAC TTTAGATCCT 
AAACAGAATC AAGGAGCAGC ACCAGAAATA CAAGCTCTTA AAAATCAGCT CCAGGAACGA 
GACCGACTGT TCCACTCATT AGAGAAAGAA TATGAGAAAA CAAAGAGTCA GAGAGAGATG 
GAAGAGAAAT ATATTGTTAG TGCCTGGTAC AATATGGGAA TGACCCTGCA TAAAAAGGCA 
GCTGAAGATA GACTGGCAAG CACAGGCTCA GGGCAGTCAT TTCTGGCGAG GCAGAGGCAA 
GCGACCAGCA GCAGAAGATC ATACCCAGGC CACGTGCAGC CGGCCACAGC AAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115786.1
CDS	243..2399
Translation	MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR

Target ORF information:

RefSeq Version	NM_032410.3
Organism	Homo sapiens(human)
Definition	Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032410.3

ORF Insert Sequence:

ATGTTCAGCG TAGAGTCGCT GGAGCGGGCG GAGCTGTGCG AGAGCCTCCT CACTTGGATC 
CAGACATTTA ATGTGGATGC ACCATGCCAG ACCGTGGAAG ATTTAACGAA TGGGGTTGTG 
ATGGCCCAGG TTCTTCAAAA GATAGATCCT GCATATTTTG ATGAAAATTG GCTAAACAGA 
ATCAAAACTG AAGTAGGAGA TAATTGGAGG CTAAAGATAA GCAATTTAAA GAAAATTTTA 
AAAGGAATCT TGGATTATAA TCATGAGATT TTAGGACAGC AAATTAATGA CTTTACCCTT 
CCTGATGTGA ACCTTATTGG GGAGCATTCT GATGCAGCAG AGCTTGGAAG GATGCTTCAG 
CTCATCTTAG GCTGTGCTGT GAACTGTGAA CAGAAGCAAG AGTACATCCA AGCCATTATG 
ATGATGGAGG AATCTGTTCA ACATGTTGTC ATGACAGCCA TTCAAGAGCT GATGAGTAAA 
GAATCTCCTG TCTCTGCTGG AAATGATGCC TATGTTGACC TTGATCGTCA GCTGAAGAAA 
ACTACAGAGG AACTAAATGA AGCTTTGTCA GCAAAGGAAG AAATTGCTCA AAGATGCCAT 
GAACTGGATA TGCAGGTTGC AGCATTGCAG GAAGAGAAAA GTAGTTTGTT GGCAGAGAAT 
CAGGTATTAA TGGAAAGACT CAATCAATCT GATTCTATAG AAGACCCTAA CAGTCCAGCA 
GGAAGAAGGC ATTTGCAGCT CCAGACTCAA TTAGAACAGC TCCAAGAAGA AACATTCAGA 
CTAGAAGCAG CCAAAGATGA TTATCGAATA CGTTGTGAAG AGTTAGAAAA GGAGATCTCT 
GAACTTCGGC AACAGAATGA TGAACTGACC ACTTTGGCAG ATGAAGCTCA GTCTCTGAAA 
GATGAGATCG ACGTGCTGAG ACATTCTTCT GATAAAGTAT CTAAACTAGA AGGTCAAGTA 
GAATCTTATA AAAAGAAGCT AGAAGACCTT GGTGATTTAA GGCGGCAGGT TAAACTCTTA 
GAAGAGAAGA ATACCATGTA TATGCAGAAT ACTGTCAGTC TAGAGGAAGA GTTAAGAAAG 
GCCAACGCAG CGCGAAGTCA ACTTGAAACC TACAAGAGAC AGGTAGTAGA ACTACAAAAC 
AGATTATCCG AAGAATCAAA GAAAGCAGAT AAACTAGATT TTGAATATAA GCGGCTAAAA 
GAAAAAGTTG ACAGTCTTCA AAAAGAAAAG GACAGGCTGA GAACAGAAAG GGATTCTCTG 
AAGGAAACCA TTGAAGAGCT TCGTTGTGTA CAAGCTCAAG AAGGGCAGCT CACAACACAA 
GGGTTAATGC CTCTTGGAAG TCAGGAGTCT TCAGACAGTC TAGCTGCAGA GATTGTTACA 
CCTGAAATCA GGGAGAAACT TATTCGTCTT CAGCATGAGA ATAAGATGTT AAAGCTTAAC 
CAAGAAGGTT CGGACAATGA AAAAATAGCC TTATTGCAGA GCCTTCTAGA TGATGCAAAT 
CTACGCAAGA ATGAACTGGA GACAGAGAAT AGGCTGGTGA ATCAAAGACT TCTGGAAGTA 
CAGTCACAAG TTGAAGAATT ACAAAAATCT TTACAGGATC AAGGCTCAAA AGCAGAAGAT 
TCAGTCCTTC TAAAAAAGAA GCTTGAAGAA CATCTAGAGA AGCTGCATGA GGCCAATAAT 
GAACTACAGA AGAAGAGAGC CATTATTGAA GATCTCGAGC CAAGATTTAA CAACAGCTCC 
TTAAAAATTG AAGAATTACA AGAAGCTTTA CGAAAGAAAG AGGAAGAAAT GAAGCAAATG 
GAAGAACGAT ACAAAAAATA CTTAGAGAAA GCCAAAAGTG TCATCCGTAC TTTAGATCCT 
AAACAGAATC AAGGAGCAGC ACCAGAAATA CAAGCTCTTA AAAATCAGCT CCAGGAACGA 
GACCGACTGT TCCACTCATT AGAGAAAGAA TATGAGAAAA CAAAGAGTCA GAGAGAGATG 
GAAGAGAAAT ATATTGTTAG TGCCTGGTAC AATATGGGAA TGACCCTGCA TAAAAAGGCA 
GCTGAAGATA GACTGGCAAG CACAGGCTCA GGGCAGTCAT TTCTGGCGAG GCAGAGGCAA 
GCGACCAGCA GCAGAAGATC ATACCCAGGC CACGTGCAGC CGGCCACAGC AAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HOOK3 ( NM_032410.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115786.1 Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.

Price & Availability↑

CloneID	OHu31536
Clone ID Related Accession (Same CDS sequence)	NM_032410.3 , NM_032410.4
Accession Version	NM_032410.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	protein Hook homolog 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC048304.1, BC056146.1, AC110275.13 and BM716064.1. On Nov 23, 2018 this sequence version replaced NM_032410.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.131458.1, SRR1660809.7356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307602.9/ ENSP00000305699.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCAGCG TAGAGTCGCT GGAGCGGGCG GAGCTGTGCG AGAGCCTCCT CACTTGGATC 
CAGACATTTA ATGTGGATGC ACCATGCCAG ACCGTGGAAG ATTTAACGAA TGGGGTTGTG 
ATGGCCCAGG TTCTTCAAAA GATAGATCCT GCATATTTTG ATGAAAATTG GCTAAACAGA 
ATCAAAACTG AAGTAGGAGA TAATTGGAGG CTAAAGATAA GCAATTTAAA GAAAATTTTA 
AAAGGAATCT TGGATTATAA TCATGAGATT TTAGGACAGC AAATTAATGA CTTTACCCTT 
CCTGATGTGA ACCTTATTGG GGAGCATTCT GATGCAGCAG AGCTTGGAAG GATGCTTCAG 
CTCATCTTAG GCTGTGCTGT GAACTGTGAA CAGAAGCAAG AGTACATCCA AGCCATTATG 
ATGATGGAGG AATCTGTTCA ACATGTTGTC ATGACAGCCA TTCAAGAGCT GATGAGTAAA 
GAATCTCCTG TCTCTGCTGG AAATGATGCC TATGTTGACC TTGATCGTCA GCTGAAGAAA 
ACTACAGAGG AACTAAATGA AGCTTTGTCA GCAAAGGAAG AAATTGCTCA AAGATGCCAT 
GAACTGGATA TGCAGGTTGC AGCATTGCAG GAAGAGAAAA GTAGTTTGTT GGCAGAGAAT 
CAGGTATTAA TGGAAAGACT CAATCAATCT GATTCTATAG AAGACCCTAA CAGTCCAGCA 
GGAAGAAGGC ATTTGCAGCT CCAGACTCAA TTAGAACAGC TCCAAGAAGA AACATTCAGA 
CTAGAAGCAG CCAAAGATGA TTATCGAATA CGTTGTGAAG AGTTAGAAAA GGAGATCTCT 
GAACTTCGGC AACAGAATGA TGAACTGACC ACTTTGGCAG ATGAAGCTCA GTCTCTGAAA 
GATGAGATCG ACGTGCTGAG ACATTCTTCT GATAAAGTAT CTAAACTAGA AGGTCAAGTA 
GAATCTTATA AAAAGAAGCT AGAAGACCTT GGTGATTTAA GGCGGCAGGT TAAACTCTTA 
GAAGAGAAGA ATACCATGTA TATGCAGAAT ACTGTCAGTC TAGAGGAAGA GTTAAGAAAG 
GCCAACGCAG CGCGAAGTCA ACTTGAAACC TACAAGAGAC AGGTAGTAGA ACTACAAAAC 
AGATTATCCG AAGAATCAAA GAAAGCAGAT AAACTAGATT TTGAATATAA GCGGCTAAAA 
GAAAAAGTTG ACAGTCTTCA AAAAGAAAAG GACAGGCTGA GAACAGAAAG GGATTCTCTG 
AAGGAAACCA TTGAAGAGCT TCGTTGTGTA CAAGCTCAAG AAGGGCAGCT CACAACACAA 
GGGTTAATGC CTCTTGGAAG TCAGGAGTCT TCAGACAGTC TAGCTGCAGA GATTGTTACA 
CCTGAAATCA GGGAGAAACT TATTCGTCTT CAGCATGAGA ATAAGATGTT AAAGCTTAAC 
CAAGAAGGTT CGGACAATGA AAAAATAGCC TTATTGCAGA GCCTTCTAGA TGATGCAAAT 
CTACGCAAGA ATGAACTGGA GACAGAGAAT AGGCTGGTGA ATCAAAGACT TCTGGAAGTA 
CAGTCACAAG TTGAAGAATT ACAAAAATCT TTACAGGATC AAGGCTCAAA AGCAGAAGAT 
TCAGTCCTTC TAAAAAAGAA GCTTGAAGAA CATCTAGAGA AGCTGCATGA GGCCAATAAT 
GAACTACAGA AGAAGAGAGC CATTATTGAA GATCTCGAGC CAAGATTTAA CAACAGCTCC 
TTAAAAATTG AAGAATTACA AGAAGCTTTA CGAAAGAAAG AGGAAGAAAT GAAGCAAATG 
GAAGAACGAT ACAAAAAATA CTTAGAGAAA GCCAAAAGTG TCATCCGTAC TTTAGATCCT 
AAACAGAATC AAGGAGCAGC ACCAGAAATA CAAGCTCTTA AAAATCAGCT CCAGGAACGA 
GACCGACTGT TCCACTCATT AGAGAAAGAA TATGAGAAAA CAAAGAGTCA GAGAGAGATG 
GAAGAGAAAT ATATTGTTAG TGCCTGGTAC AATATGGGAA TGACCCTGCA TAAAAAGGCA 
GCTGAAGATA GACTGGCAAG CACAGGCTCA GGGCAGTCAT TTCTGGCGAG GCAGAGGCAA 
GCGACCAGCA GCAGAAGATC ATACCCAGGC CACGTGCAGC CGGCCACAGC AAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115786.1
CDS	155..2311
Translation	MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR

Target ORF information:

RefSeq Version	NM_032410.4
Organism	Homo sapiens(human)
Definition	Homo sapiens hook microtubule tethering protein 3 (HOOK3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032410.4

ORF Insert Sequence:

ATGTTCAGCG TAGAGTCGCT GGAGCGGGCG GAGCTGTGCG AGAGCCTCCT CACTTGGATC 
CAGACATTTA ATGTGGATGC ACCATGCCAG ACCGTGGAAG ATTTAACGAA TGGGGTTGTG 
ATGGCCCAGG TTCTTCAAAA GATAGATCCT GCATATTTTG ATGAAAATTG GCTAAACAGA 
ATCAAAACTG AAGTAGGAGA TAATTGGAGG CTAAAGATAA GCAATTTAAA GAAAATTTTA 
AAAGGAATCT TGGATTATAA TCATGAGATT TTAGGACAGC AAATTAATGA CTTTACCCTT 
CCTGATGTGA ACCTTATTGG GGAGCATTCT GATGCAGCAG AGCTTGGAAG GATGCTTCAG 
CTCATCTTAG GCTGTGCTGT GAACTGTGAA CAGAAGCAAG AGTACATCCA AGCCATTATG 
ATGATGGAGG AATCTGTTCA ACATGTTGTC ATGACAGCCA TTCAAGAGCT GATGAGTAAA 
GAATCTCCTG TCTCTGCTGG AAATGATGCC TATGTTGACC TTGATCGTCA GCTGAAGAAA 
ACTACAGAGG AACTAAATGA AGCTTTGTCA GCAAAGGAAG AAATTGCTCA AAGATGCCAT 
GAACTGGATA TGCAGGTTGC AGCATTGCAG GAAGAGAAAA GTAGTTTGTT GGCAGAGAAT 
CAGGTATTAA TGGAAAGACT CAATCAATCT GATTCTATAG AAGACCCTAA CAGTCCAGCA 
GGAAGAAGGC ATTTGCAGCT CCAGACTCAA TTAGAACAGC TCCAAGAAGA AACATTCAGA 
CTAGAAGCAG CCAAAGATGA TTATCGAATA CGTTGTGAAG AGTTAGAAAA GGAGATCTCT 
GAACTTCGGC AACAGAATGA TGAACTGACC ACTTTGGCAG ATGAAGCTCA GTCTCTGAAA 
GATGAGATCG ACGTGCTGAG ACATTCTTCT GATAAAGTAT CTAAACTAGA AGGTCAAGTA 
GAATCTTATA AAAAGAAGCT AGAAGACCTT GGTGATTTAA GGCGGCAGGT TAAACTCTTA 
GAAGAGAAGA ATACCATGTA TATGCAGAAT ACTGTCAGTC TAGAGGAAGA GTTAAGAAAG 
GCCAACGCAG CGCGAAGTCA ACTTGAAACC TACAAGAGAC AGGTAGTAGA ACTACAAAAC 
AGATTATCCG AAGAATCAAA GAAAGCAGAT AAACTAGATT TTGAATATAA GCGGCTAAAA 
GAAAAAGTTG ACAGTCTTCA AAAAGAAAAG GACAGGCTGA GAACAGAAAG GGATTCTCTG 
AAGGAAACCA TTGAAGAGCT TCGTTGTGTA CAAGCTCAAG AAGGGCAGCT CACAACACAA 
GGGTTAATGC CTCTTGGAAG TCAGGAGTCT TCAGACAGTC TAGCTGCAGA GATTGTTACA 
CCTGAAATCA GGGAGAAACT TATTCGTCTT CAGCATGAGA ATAAGATGTT AAAGCTTAAC 
CAAGAAGGTT CGGACAATGA AAAAATAGCC TTATTGCAGA GCCTTCTAGA TGATGCAAAT 
CTACGCAAGA ATGAACTGGA GACAGAGAAT AGGCTGGTGA ATCAAAGACT TCTGGAAGTA 
CAGTCACAAG TTGAAGAATT ACAAAAATCT TTACAGGATC AAGGCTCAAA AGCAGAAGAT 
TCAGTCCTTC TAAAAAAGAA GCTTGAAGAA CATCTAGAGA AGCTGCATGA GGCCAATAAT 
GAACTACAGA AGAAGAGAGC CATTATTGAA GATCTCGAGC CAAGATTTAA CAACAGCTCC 
TTAAAAATTG AAGAATTACA AGAAGCTTTA CGAAAGAAAG AGGAAGAAAT GAAGCAAATG 
GAAGAACGAT ACAAAAAATA CTTAGAGAAA GCCAAAAGTG TCATCCGTAC TTTAGATCCT 
AAACAGAATC AAGGAGCAGC ACCAGAAATA CAAGCTCTTA AAAATCAGCT CCAGGAACGA 
GACCGACTGT TCCACTCATT AGAGAAAGAA TATGAGAAAA CAAAGAGTCA GAGAGAGATG 
GAAGAGAAAT ATATTGTTAG TGCCTGGTAC AATATGGGAA TGACCCTGCA TAAAAAGGCA 
GCTGAAGATA GACTGGCAAG CACAGGCTCA GGGCAGTCAT TTCTGGCGAG GCAGAGGCAA 
GCGACCAGCA GCAGAAGATC ATACCCAGGC CACGTGCAGC CGGCCACAGC AAGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction.
The Journal of biological chemistry291(35)18239-51(2016 08)
Olenick MA,Tokito M,Boczkowska M,Dominguez R,Holzbaur EL

Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.
The Journal of cell biology214(3)309-18(2016 Aug)
Schroeder CM,Vale RD

High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.
PloS one10(7)e0134614(2015)
Melling N,Harutyunyan L,Hube-Magg C,Kluth M,Simon R,Lebok P,Minner S,Tsourlakis MC,Koop C,Graefen M,Adam M,Haese A,Wittmer C,Steurer S,Izbicki J,Sauter G,Wilczak W,Schlomm T,Krech T

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HOOK3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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