SLC25A2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC25A2
Entrez Gene ID	83884
Full Name	solute carrier family 25 member 2
Synonyms	ORC2,ORNT2
General protein information	Preferred Names solute carrier family 25 member 2 Names mitochondrial ornithine transporter 2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.3
Summary	This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014].
Disorder MIM:	608157

mRNA and Protein(s)

mRNA	Protein	Name
NM_031947.3	NP_114153.1	mitochondrial ornithine transporter 2
NM_031947.4	NP_114153.1	mitochondrial ornithine transporter 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SLC25A2	NP_001137558.1
Pan troglodytes (chimpanzee)	SLC25A2	XP_527046.1
Canis lupus familiaris (dog)	LOC102151234	XP_005617356.1
Xenopus tropicalis (tropical clawed frog)	MGC108450	NP_001015800.1
Homo sapiens (human)	SLC25A2	NP_114153.1
	SLC25A2	XP_001092357.1

Gene Ontology
Bibliography

Related articles in PubMed

The mitochondrial transporter family SLC25: identification, properties and physiopathology.
Palmieri F
Molecular aspects of medicine34(2-3)465-84(2013 Apr-Jun)

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.
Monn? M, Miniero DV, Daddabbo L, Robinson AJ, Kunji ER, Palmieri F
The Journal of biological chemistry287(11)7925-34(2012 Mar)

Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.
Camacho JA, Rioseco-Camacho N, Andrade D, Porter J, Kong J
Molecular genetics and metabolism79(4)257-71(2003 Aug)

The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.
Fiermonte G, Dolce V, David L, Santorelli FM, Dionisi-Vici C, Palmieri F, Walker JE
The Journal of biological chemistry278(35)32778-83(2003 Aug)

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.
Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM, Maniatis T
Genome research11(3)389-404(2001 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Compares and contrasts all the known human SLC25A* genes and includes functional information.
Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.

characterized mutations of the proposed substrate binding site in ORC1 and ORC2; demonstrated that the residue at position 179 in the 2 soforms is largely responsible for the difference in their substrate specificity;concluded that Arg-179 is a key residue in the opening of the carrier to the matrix side
Title: Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

Here we identify a new intronless gene, ORNT2, located on chromosome 5.
Title: Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.

The following SLC25A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC25A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu73212	NM_031947.4 Latest version!	Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu73212	NM_031947.3	Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC25A2 ( NM_031947.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_114153.1 Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.

Price & Availability↑

CloneID	OHu73212
Clone ID Related Accession (Same CDS sequence)	NM_031947.3 , NM_031947.4
Accession Version	NM_031947.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	mitochondrial ornithine transporter 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY048558.1, BC100935.2 and AF332005.1. On Dec 23, 2014 this sequence version replaced NM_031947.2. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCCG GTCCTGGCAT CCAAGCCGCC ATCGACCTCA CAGCGGGGGC CGCAGGGGGG 
ACAGCGTGTG TACTGACTGG GCAGCCCTTC GACACAATAA AAGTGAAGAT GCAGACGTTC 
CCTGACCTGT ACAAGGGCCT CACCGACTGC TTCCTGAAGA CATACGCTCA AGTGGGTCTC 
CGGGGCTTCT ACAAGGGCAC CGGCCCGGCA CTTATGGCCT ACGTCGCCGA AAACTCGGTC 
CTCTTCATGT GCTACGGGTT CTGCCAGCAG TTTGTCAGGA AAGTGGCTGG AATGGACAAG 
CAGGCAAAGC TGAGTGATCT CCAGACTGCA GCCGCGGGGT CCTTCGCCTC TGCATTTGCT 
GCACTGGCTC TCTGCCCCAC TGAGCTTGTG AAGTGCCGGC TACAGACCAT GTATGAAATG 
GAGATGTCAG GGAAGATAGC AAAAAGCCAT AATACAATTT GGTCTGTCGT GAAGGGTATC 
CTTAAAAAGG ATGGCCCCTT GGGCTTCTAC CATGGACTCT CGAGTACTCT ACTTCAAGAA 
GTACCGGGTT ATTTCTTTTT CTTTGGTGGC TATGAACTGA GCCGATCGTT TTTTGCGTCA 
GGGAGATCAA AAGATGAACT AGGCCCTGTC CATTTGATGT TAAGTGGTGG AGTTGCTGGA 
ATTTGCCTGT GGCTTGTCGT GTTCCCAGTG GATTGTATTA AATCCAGAAT TCAAGTTCTT 
TCCATGTATG GGAAACAGGC AGGATTTATT GGTACCCTCT TAAGTGTTGT GAGAAATGAA 
GGAATAGTAG CCTTATATTC TGGACTGAAA GCTACTATGA TTCGAGCAAT CCCTGCCAAT 
GGGGCACTGT TTGTGGCCTA CGAATACAGC AGGAAGATGA TGATGAAACA GTTGGAAGCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114153.1
CDS	199..1104
Translation	MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEAY

Target ORF information:

RefSeq Version	NM_031947.3
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031947.3

ORF Insert Sequence:

ATGAAGTCCG GTCCTGGCAT CCAAGCCGCC ATCGACCTCA CAGCGGGGGC CGCAGGGGGG 
ACAGCGTGTG TACTGACTGG GCAGCCCTTC GACACAATAA AAGTGAAGAT GCAGACGTTC 
CCTGACCTGT ACAAGGGCCT CACCGACTGC TTCCTGAAGA CATACGCTCA AGTGGGTCTC 
CGGGGCTTCT ACAAGGGCAC CGGCCCGGCA CTTATGGCCT ACGTCGCCGA AAACTCGGTC 
CTCTTCATGT GCTACGGGTT CTGCCAGCAG TTTGTCAGGA AAGTGGCTGG AATGGACAAG 
CAGGCAAAGC TGAGTGATCT CCAGACTGCA GCCGCGGGGT CCTTCGCCTC TGCATTTGCT 
GCACTGGCTC TCTGCCCCAC TGAGCTTGTG AAGTGCCGGC TACAGACCAT GTATGAAATG 
GAGATGTCAG GGAAGATAGC AAAAAGCCAT AATACAATTT GGTCTGTCGT GAAGGGTATC 
CTTAAAAAGG ATGGCCCCTT GGGCTTCTAC CATGGACTCT CGAGTACTCT ACTTCAAGAA 
GTACCGGGTT ATTTCTTTTT CTTTGGTGGC TATGAACTGA GCCGATCGTT TTTTGCGTCA 
GGGAGATCAA AAGATGAACT AGGCCCTGTC CATTTGATGT TAAGTGGTGG AGTTGCTGGA 
ATTTGCCTGT GGCTTGTCGT GTTCCCAGTG GATTGTATTA AATCCAGAAT TCAAGTTCTT 
TCCATGTATG GGAAACAGGC AGGATTTATT GGTACCCTCT TAAGTGTTGT GAGAAATGAA 
GGAATAGTAG CCTTATATTC TGGACTGAAA GCTACTATGA TTCGAGCAAT CCCTGCCAAT 
GGGGCACTGT TTGTGGCCTA CGAATACAGC AGGAAGATGA TGATGAAACA GTTGGAAGCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLC25A2 ( NM_031947.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_114153.1 Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.

Price & Availability↑

CloneID	OHu73212
Clone ID Related Accession (Same CDS sequence)	NM_031947.3 , NM_031947.4
Accession Version	NM_031947.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	mitochondrial ornithine transporter 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY048558.1, BC100935.2 and AF332005.1. On May 17, 2019 this sequence version replaced NM_031947.3. ##Evidence-Data-START## Transcript is intronless :: SRR5189667.155397.1, AF378119.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000239451.7/ ENSP00000239451.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCCG GTCCTGGCAT CCAAGCCGCC ATCGACCTCA CAGCGGGGGC CGCAGGGGGG 
ACAGCGTGTG TACTGACTGG GCAGCCCTTC GACACAATAA AAGTGAAGAT GCAGACGTTC 
CCTGACCTGT ACAAGGGCCT CACCGACTGC TTCCTGAAGA CATACGCTCA AGTGGGTCTC 
CGGGGCTTCT ACAAGGGCAC CGGCCCGGCA CTTATGGCCT ACGTCGCCGA AAACTCGGTC 
CTCTTCATGT GCTACGGGTT CTGCCAGCAG TTTGTCAGGA AAGTGGCTGG AATGGACAAG 
CAGGCAAAGC TGAGTGATCT CCAGACTGCA GCCGCGGGGT CCTTCGCCTC TGCATTTGCT 
GCACTGGCTC TCTGCCCCAC TGAGCTTGTG AAGTGCCGGC TACAGACCAT GTATGAAATG 
GAGATGTCAG GGAAGATAGC AAAAAGCCAT AATACAATTT GGTCTGTCGT GAAGGGTATC 
CTTAAAAAGG ATGGCCCCTT GGGCTTCTAC CATGGACTCT CGAGTACTCT ACTTCAAGAA 
GTACCGGGTT ATTTCTTTTT CTTTGGTGGC TATGAACTGA GCCGATCGTT TTTTGCGTCA 
GGGAGATCAA AAGATGAACT AGGCCCTGTC CATTTGATGT TAAGTGGTGG AGTTGCTGGA 
ATTTGCCTGT GGCTTGTCGT GTTCCCAGTG GATTGTATTA AATCCAGAAT TCAAGTTCTT 
TCCATGTATG GGAAACAGGC AGGATTTATT GGTACCCTCT TAAGTGTTGT GAGAAATGAA 
GGAATAGTAG CCTTATATTC TGGACTGAAA GCTACTATGA TTCGAGCAAT CCCTGCCAAT 
GGGGCACTGT TTGTGGCCTA CGAATACAGC AGGAAGATGA TGATGAAACA GTTGGAAGCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114153.1
CDS	185..1090
Translation	MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEAY

Target ORF information:

RefSeq Version	NM_031947.4
Organism	Homo sapiens(human)
Definition	Homo sapiens solute carrier family 25 member 2 (SLC25A2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031947.4

ORF Insert Sequence:

ATGAAGTCCG GTCCTGGCAT CCAAGCCGCC ATCGACCTCA CAGCGGGGGC CGCAGGGGGG 
ACAGCGTGTG TACTGACTGG GCAGCCCTTC GACACAATAA AAGTGAAGAT GCAGACGTTC 
CCTGACCTGT ACAAGGGCCT CACCGACTGC TTCCTGAAGA CATACGCTCA AGTGGGTCTC 
CGGGGCTTCT ACAAGGGCAC CGGCCCGGCA CTTATGGCCT ACGTCGCCGA AAACTCGGTC 
CTCTTCATGT GCTACGGGTT CTGCCAGCAG TTTGTCAGGA AAGTGGCTGG AATGGACAAG 
CAGGCAAAGC TGAGTGATCT CCAGACTGCA GCCGCGGGGT CCTTCGCCTC TGCATTTGCT 
GCACTGGCTC TCTGCCCCAC TGAGCTTGTG AAGTGCCGGC TACAGACCAT GTATGAAATG 
GAGATGTCAG GGAAGATAGC AAAAAGCCAT AATACAATTT GGTCTGTCGT GAAGGGTATC 
CTTAAAAAGG ATGGCCCCTT GGGCTTCTAC CATGGACTCT CGAGTACTCT ACTTCAAGAA 
GTACCGGGTT ATTTCTTTTT CTTTGGTGGC TATGAACTGA GCCGATCGTT TTTTGCGTCA 
GGGAGATCAA AAGATGAACT AGGCCCTGTC CATTTGATGT TAAGTGGTGG AGTTGCTGGA 
ATTTGCCTGT GGCTTGTCGT GTTCCCAGTG GATTGTATTA AATCCAGAAT TCAAGTTCTT 
TCCATGTATG GGAAACAGGC AGGATTTATT GGTACCCTCT TAAGTGTTGT GAGAAATGAA 
GGAATAGTAG CCTTATATTC TGGACTGAAA GCTACTATGA TTCGAGCAAT CCCTGCCAAT 
GGGGCACTGT TTGTGGCCTA CGAATACAGC AGGAAGATGA TGATGAAACA GTTGGAAGCA 
TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The mitochondrial transporter family SLC25: identification, properties and physiopathology.
Molecular aspects of medicine34(2-3)465-84(2013 Apr-Jun)
Palmieri F

Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.
The Journal of biological chemistry287(11)7925-34(2012 Mar)
Monn? M,Miniero DV,Daddabbo L,Robinson AJ,Kunji ER,Palmieri F

Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.
Molecular genetics and metabolism79(4)257-71(2003 Aug)
Camacho JA,Rioseco-Camacho N,Andrade D,Porter J,Kong J

The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms.
The Journal of biological chemistry278(35)32778-83(2003 Aug)
Fiermonte G,Dolce V,David L,Santorelli FM,Dionisi-Vici C,Palmieri F,Walker JE

Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.
Genome research11(3)389-404(2001 Mar)
Wu Q,Zhang T,Cheng JF,Kim Y,Grimwood J,Schmutz J,Dickson M,Noonan JP,Zhang MQ,Myers RM,Maniatis T

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SLC25A2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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