KCNK16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK16
Entrez Gene ID	83795
Full Name	potassium two pore domain channel subfamily K member 16
Synonyms	K2p16.1,TALK-1,TALK1
General protein information	Preferred Names potassium two pore domain channel subfamily K member 16 Names potassium channel subfamily K member 16 2P domain potassium channel Talk-1 TWIK-related alkaline pH-activated K(+) channel 1 pancreatic potassium channel Talk-1 potassium channel, subfamily K, member 16 potassium channel, two pore domain subfamily K, member 16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.2
Summary	The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008].
Disorder MIM:	607369

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135107.1	NP_001128579.1	potassium channel subfamily K member 16 isoform 4
NM_001135105.1	NP_001128577.1	potassium channel subfamily K member 16 isoform 1
NM_001363784.1	NP_001350713.1	potassium channel subfamily K member 16 isoform 5
XM_017011346.1	XP_016866835.1	potassium channel subfamily K member 16 isoform X1
NM_001135106.2	NP_001128578.1	potassium channel subfamily K member 16 isoform 3
XM_011514935.2	XP_011513237.1	potassium channel subfamily K member 16 isoform X2
NM_032115.3	NP_115491.1	potassium channel subfamily K member 16 isoform 2
NM_001135107.2	NP_001128579.1	potassium channel subfamily K member 16 isoform 4
NM_001135105.2	NP_001128577.1	potassium channel subfamily K member 16 isoform 1
NM_001135106.1	NP_001128578.1	potassium channel subfamily K member 16 isoform 3
NM_032115.4	NP_115491.1	potassium channel subfamily K member 16 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnk16	NP_001102990.1
Danio rerio (zebrafish)	LOC101882139	XP_005158968.1
	LOC719585	XP_001117127.1
Gallus gallus (chicken)	KCNK16	XP_001235224.1
Xenopus tropicalis (tropical clawed frog)	kcnk16	XP_002942063.2
Canis lupus familiaris (dog)	KCNK16	XP_538902.2
Mus musculus (house mouse)	Kcnk16	NP_083282.1
Homo sapiens (human)	KCNK16	NP_001128578.1
Bos taurus (cattle)	KCNK16	XP_003587722.1

Gene Ontology
Bibliography

Related articles in PubMed

TALK-1 channels control ? cell endoplasmic reticulum Ca
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA
Science signaling10(497)(2017 Sep)

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells.
Dickerson MT, Vierra NC, Milian SC, Dadi PK, Jacobson DA
PloS one12(4)e0175069(2017)

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Vierra NC, Dadi PK, Jeong I, Dickerson M, Powell DR, Jacobson DA
Diabetes64(11)3818-28(2015 Nov)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
, , , , , Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JC, Chang LC, Chang TJ, Chang YC, Charpentier G, Chen CH, Chen H, Chen YT, Chia KS, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang LM, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney AS, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Grrop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han BG, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, J?ckel KH, Jonsson A, Jowett JB, Kadowaki T, Kang HM, Kanoni S, Kao WH, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi KM, Kelly AM, Khan H, Khaw KT, Khor CC, Kim HL, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hy?v?lti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee JM, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim WY, Lind L, Lindgren CM, Lindholm E, Liu CT, Liu JJ, Lobbens S, Long J, Loos RJ, Lu W, Luan J, Lyssenko V, Ma RC, Maeda S, M?gi R, M?nnisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, M?hleisen TW, M?ller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P, Ng PK, Nica AC, Nilsson PM, Nj?lstad I, N?then MM, Ohnaka K, Ong TH, Owen KR, Palmer CN, Pankow JS, Park KS, Parkin M, Pechlivanis S, Pedersen NL, Peltonen L, Perry JR, Peters A, Pinidiyapathirage JM, Platou CG, Potter S, Price JF, Qi L, Radha V, Rallidis L, Rasheed A, Rathman W, Rauramaa R, Raychaudhuri S, Rayner NW, Rees SD, Rehnberg E, Ripatti S, Robertson N, Roden M, Rossin EJ, Rudan I, Rybin D, Saaristo TE, Salomaa V, Saltevo J, Samuel M, Sanghera DK, Saramies J, Scott J, Scott LJ, Scott RA, Segr? AV, Sehmi J, Sennblad B, Shah N, Shah S, Shera AS, Shu XO, Shuldiner AR, Sigur?sson G, Sijbrands E, Silveira A, Sim X, Sivapalaratnam S, Small KS, So WY, Stan??kov? A, Stefansson K, Steinbach G, Steinthorsdottir V, Stirrups K, Strawbridge RJ, Stringham HM, Sun Q, Suo C, Syv?nen AC, Takayanagi R, Takeuchi F, Tay WT, Teslovich TM, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Trakalo J, Tremoli E, Trip MD, Tsai FJ, Tuomi T, Tuomilehto J, Uitterlinden AG, Valladares-Salgado A, Vedantam S, Veglia F, Voight BF, Wang C, Wareham NJ, Wennauer R, Wickremasinghe AR, Wilsgaard T, Wilson JF, Wiltshire S, Winckler W, Wong TY, Wood AR, Wu JY, Wu Y, Yamamoto K, Yamauchi T, Yang M, Yengo L, Yokota M, Young R, Zabaneh D, Zhang F, Zhang R, Zheng W, Zimmet PZ, Altshuler D, Bowden DW, Cho YS, Cox NJ, Cruz M, Hanis CL, Kooner J, Lee JY, Seielstad M, Teo YY, Boehnke M, Parra EJ, Chambers JC, Tai ES, McCarthy MI, Morris AP
Nature genetics46(3)234-44(2014 Mar)

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH, Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ?K, Morris AP, McCarthy MI, , , Takayanagi R, Park KS, Jia W, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M
Nature genetics44(1)67-72(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The TALK-1/iOPN complex caused Vm hyperpolarization and reduced beta-cell glucose-stimulated Ca2+ influx, which is predicted to inhibit glucose stimulated insulin secretion.
Title: Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells.

These findings reveal TALK-1 channels as important modulators of second-phase insulin secretion and suggest a clinically relevant mechanism for rs1535500, which may increase type 2 diabetes risk by limiting glucose-stimulated insulin secretion.
Title: Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.

at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas.
Title: Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.

The following KCNK16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31780	NM_001135105.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu30584	NM_032115.4 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu30594	NM_001135107.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu31355	NM_001135106.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu73170	NM_001363784.1 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu30594	XM_017011346.1 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu73170	XM_011514935.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30594	NM_001135107.1	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu31780	NM_001135105.1	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
OHu31355	NM_001135106.1	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu30584	NM_032115.3	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK16 ( NM_001135105.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128577.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31780
Clone ID Related Accession (Same CDS sequence)	NM_001135105.1 , NM_001135105.2
Accession Version	NM_001135105.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA843225.1, BC111860.1 and BP387644.1. Transcript Variant: This variant (1, also known as TALK-1c) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC111860.1, AY253146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCCACCCCC TTAACTTCAT CACTCCCTCT GGGCTCCTGC CTTCTCAAGA GCCTTTCCAA 
ACACCCCATG GGAAGCCAGA GAGCCAGCAG ATCCCAGGAT CCTTCCAGAA AGTGAGCTCC 
ATGAACGTCT GGCCTCTCTC AGGAATGCAT TCTCCAGGTC TGGCCTTTCC CCTGCCAGAC 
TGCAACATCC CTGACCAGGA GAGATTTAGA CCACTCCATC CCGGGGCCTG GAAATTTTGG 
CCTTTGCCTC TCCCATCATC CAACAGCAAG TGGGCTCCTA TGTGGCTGGG TTCCTCTGCA 
CAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128577.1
CDS	15..983
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHPLNFITPSGLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHSPGLAFPLPDCNIPDQERFRPLHPGAWKFWPLPLPSSNSKWAPMWLGSSAQV

Target ORF information:

RefSeq Version	NM_001135105.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135105.1

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCCACCCCC TTAACTTCAT CACTCCCTCT GGGCTCCTGC CTTCTCAAGA GCCTTTCCAA 
ACACCCCATG GGAAGCCAGA GAGCCAGCAG ATCCCAGGAT CCTTCCAGAA AGTGAGCTCC 
ATGAACGTCT GGCCTCTCTC AGGAATGCAT TCTCCAGGTC TGGCCTTTCC CCTGCCAGAC 
TGCAACATCC CTGACCAGGA GAGATTTAGA CCACTCCATC CCGGGGCCTG GAAATTTTGG 
CCTTTGCCTC TCCCATCATC CAACAGCAAG TGGGCTCCTA TGTGGCTGGG TTCCTCTGCA 
CAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001135105.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128577.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31780
Clone ID Related Accession (Same CDS sequence)	NM_001135105.1 , NM_001135105.2
Accession Version	NM_001135105.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12, CA843225.1, BC111860.1 and BP387644.1. On Jun 2, 2019 this sequence version replaced NM_001135105.1. Transcript Variant: This variant (1, also known as TALK-1c) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC111860.1, AY253146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCCACCCCC TTAACTTCAT CACTCCCTCT GGGCTCCTGC CTTCTCAAGA GCCTTTCCAA 
ACACCCCATG GGAAGCCAGA GAGCCAGCAG ATCCCAGGAT CCTTCCAGAA AGTGAGCTCC 
ATGAACGTCT GGCCTCTCTC AGGAATGCAT TCTCCAGGTC TGGCCTTTCC CCTGCCAGAC 
TGCAACATCC CTGACCAGGA GAGATTTAGA CCACTCCATC CCGGGGCCTG GAAATTTTGG 
CCTTTGCCTC TCCCATCATC CAACAGCAAG TGGGCTCCTA TGTGGCTGGG TTCCTCTGCA 
CAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128577.1
CDS	163..1131
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGHPLNFITPSGLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHSPGLAFPLPDCNIPDQERFRPLHPGAWKFWPLPLPSSNSKWAPMWLGSSAQV

Target ORF information:

RefSeq Version	NM_001135105.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135105.2

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCCACCCCC TTAACTTCAT CACTCCCTCT GGGCTCCTGC CTTCTCAAGA GCCTTTCCAA 
ACACCCCATG GGAAGCCAGA GAGCCAGCAG ATCCCAGGAT CCTTCCAGAA AGTGAGCTCC 
ATGAACGTCT GGCCTCTCTC AGGAATGCAT TCTCCAGGTC TGGCCTTTCC CCTGCCAGAC 
TGCAACATCC CTGACCAGGA GAGATTTAGA CCACTCCATC CCGGGGCCTG GAAATTTTGG 
CCTTTGCCTC TCCCATCATC CAACAGCAAG TGGGCTCCTA TGTGGCTGGG TTCCTCTGCA 
CAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_032115.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115491.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30584
Clone ID Related Accession (Same CDS sequence)	NM_032115.3 , NM_032115.4
Accession Version	NM_032115.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA843225.1, BC111860.1, AF358909.1 and BP387644.1. On Sep 20, 2008 this sequence version replaced NM_032115.2. Transcript Variant: This variant (2, also known as TALK-1a) contains an additional coding exon and uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF358909.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTCTGAGG CAAGGCTGTG GAGCCAAGGC GGCTCCAGGC 
AGGAGACCCA GGAGAGGCTC TACAGCAGCA AGAGGAGTCC AAGTCACACC CCAGGACTTC 
CCCATATCCA AGAAAGGACT GGGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115491.1
CDS	15..944
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	NM_032115.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032115.3

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTCTGAGG CAAGGCTGTG GAGCCAAGGC GGCTCCAGGC 
AGGAGACCCA GGAGAGGCTC TACAGCAGCA AGAGGAGTCC AAGTCACACC CCAGGACTTC 
CCCATATCCA AGAAAGGACT GGGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_032115.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115491.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.

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CloneID	OHu30584
Clone ID Related Accession (Same CDS sequence)	NM_032115.3 , NM_032115.4
Accession Version	NM_032115.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12, CA843225.1, BC111860.1, AF358909.1 and BP387644.1. On Jun 2, 2019 this sequence version replaced NM_032115.3. Transcript Variant: This variant (2, also known as TALK-1a) contains an additional coding exon and uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF358909.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTCTGAGG CAAGGCTGTG GAGCCAAGGC GGCTCCAGGC 
AGGAGACCCA GGAGAGGCTC TACAGCAGCA AGAGGAGTCC AAGTCACACC CCAGGACTTC 
CCCATATCCA AGAAAGGACT GGGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115491.1
CDS	163..1092
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	NM_032115.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032115.4

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTCTGAGG CAAGGCTGTG GAGCCAAGGC GGCTCCAGGC 
AGGAGACCCA GGAGAGGCTC TACAGCAGCA AGAGGAGTCC AAGTCACACC CCAGGACTTC 
CCCATATCCA AGAAAGGACT GGGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001135107.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128579.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.

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CloneID	OHu30594
Clone ID Related Accession (Same CDS sequence)	NM_001135107.1 , XM_017011346.1 , NM_001135107.2
Accession Version	NM_001135107.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA843225.1, BC111860.1 and BP387644.1. Transcript Variant: This variant (4, also known as TALK-1d) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (4) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY253147.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128579.1
CDS	15..803
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	NM_001135107.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135107.1

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001135107.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128579.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu30594
Clone ID Related Accession (Same CDS sequence)	NM_001135107.1 , XM_017011346.1 , NM_001135107.2
Accession Version	NM_001135107.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12, CA843225.1, BC111860.1 and BP387644.1. On Jun 2, 2019 this sequence version replaced NM_001135107.1. Transcript Variant: This variant (4, also known as TALK-1d) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (4) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY253147.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128579.1
CDS	163..951
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	NM_001135107.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135107.2

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001135106.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128578.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu31355
Clone ID Related Accession (Same CDS sequence)	NM_001135106.2 , NM_001135106.1
Accession Version	NM_001135106.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12, CA843225.1, BC111860.1, AF358909.1 and EU978943.1. On Jun 2, 2019 this sequence version replaced NM_001135106.1. Transcript Variant: This variant (3, also known as TALK-1b) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU978943.1, AY253145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2151405 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTAGGGGC CTCGGCGTCA AGGATGGGGC AGCCTCTGAC 
CCCAGTGGGC TCCCCAGGCC TCAGAAGATC CCCATCTCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128578.1
CDS	163..1047
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSRGLGVKDGAASDPSGLPRPQKIPISA

Target ORF information:

RefSeq Version	NM_001135106.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135106.2

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTAGGGGC CTCGGCGTCA AGGATGGGGC AGCCTCTGAC 
CCCAGTGGGC TCCCCAGGCC TCAGAAGATC CCCATCTCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001135106.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128578.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.

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CloneID	OHu31355
Clone ID Related Accession (Same CDS sequence)	NM_001135106.2 , NM_001135106.1
Accession Version	NM_001135106.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 885bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-02
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA843225.1, BC111860.1, AF358909.1 and EU978943.1. Transcript Variant: This variant (3, also known as TALK-1b) contains an alternative 3' terminal exon compared to transcript variant 1, resulting in a shorter isoform (3) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU978943.1, AY253145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2151405 [ECO:0000348] ##Evidence-Data-END##

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTAGGGGC CTCGGCGTCA AGGATGGGGC AGCCTCTGAC 
CCCAGTGGGC TCCCCAGGCC TCAGAAGATC CCCATCTCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128578.1
CDS	15..899
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSRGLGVKDGAASDPSGLPRPQKIPISA

Target ORF information:

RefSeq Version	NM_001135106.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135106.1

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGCACAGACC CCAGCAAGCA TTATATCTCA GTGTATCGGA GCCTGGCAGC CATCTGGATC 
CTCCTGGGCC TGGCGTGGCT GGCGCTGATC CTCCCACTGG GCCCCCTGCT TCTGCACAGA 
TGCTGCCAGC TCTGGCTGCT CAGTAGGGGC CTCGGCGTCA AGGATGGGGC AGCCTCTGAC 
CCCAGTGGGC TCCCCAGGCC TCAGAAGATC CCCATCTCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( NM_001363784.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350713.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 5, mRNA.

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CloneID	OHu73170
Clone ID Related Accession (Same CDS sequence)	NM_001363784.1 , XM_011514935.2
Accession Version	NM_001363784.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-14
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136087.12. On Jun 3, 2018 this sequence version replaced XM_011514935.2. Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ925824.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142586, SAMEA2144120 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAGT TTGTGCAGGT CATCATGGAA GCCTGGGTGA AAGGTGTGAA CCCCAAAGGC 
AACTCTACCA ACCCCAGCAA CTGGGACTTT GGCAGCAGTT TCTTCTTTGC AGGCACAGTC 
GTCACTACCA TAGGATATGG GAACCTGGCA CCCAGCACAG AGGCAGGTCA GGTCTTCTGT 
GTCTTCTATG CCCTGTTGGG CATCCCGCTT AACGTGATCT TCCTCAACCA CCTGGGCACA 
GGGCTGCGTG CCCATCTGGC CGCCATTGAA AGATGGGAGG ACCGTCCCAG GCGCTCCCAG 
GTACTGCAAG TCCTGGGCCT GGCTCTGTTC CTGACCCTGG GGACGCTGGT CATTCTCATC 
TTCCCACCCA TGGTCTTCAG CCATGTGGAG GGCTGGAGCT TCAGCGAGGG CTTCTACTTT 
GCTTTCATCA CTCTCAGCAC CATTGGCTTT GGGGACTATG TTGTTGGTCT GAGGCAAGGC 
TGTGGAGCCA AGGCGGCTCC AGGCAGGAGA CCCAGGAGAG GCTCTACAGC AGCAAGAGGA 
GTCCAAGTCA CACCCCAGGA CTTCCCCATA TCCAAGAAAG GACTGGGAAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350713.1
CDS	242..835
Translation	MEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	NM_001363784.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363784.1

ORF Insert Sequence:

ATGGAGCAGT TTGTGCAGGT CATCATGGAA GCCTGGGTGA AAGGTGTGAA CCCCAAAGGC 
AACTCTACCA ACCCCAGCAA CTGGGACTTT GGCAGCAGTT TCTTCTTTGC AGGCACAGTC 
GTCACTACCA TAGGATATGG GAACCTGGCA CCCAGCACAG AGGCAGGTCA GGTCTTCTGT 
GTCTTCTATG CCCTGTTGGG CATCCCGCTT AACGTGATCT TCCTCAACCA CCTGGGCACA 
GGGCTGCGTG CCCATCTGGC CGCCATTGAA AGATGGGAGG ACCGTCCCAG GCGCTCCCAG 
GTACTGCAAG TCCTGGGCCT GGCTCTGTTC CTGACCCTGG GGACGCTGGT CATTCTCATC 
TTCCCACCCA TGGTCTTCAG CCATGTGGAG GGCTGGAGCT TCAGCGAGGG CTTCTACTTT 
GCTTTCATCA CTCTCAGCAC CATTGGCTTT GGGGACTATG TTGTTGGTCT GAGGCAAGGC 
TGTGGAGCCA AGGCGGCTCC AGGCAGGAGA CCCAGGAGAG GCTCTACAGC AGCAAGAGGA 
GTCCAAGTCA CACCCCAGGA CTTCCCCATA TCCAAGAAAG GACTGGGAAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( XM_017011346.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866835.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30594
Clone ID Related Accession (Same CDS sequence)	NM_001135107.1 , XM_017011346.1 , NM_001135107.2
Accession Version	XM_017011346.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 789bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866835.1
CDS	109..897
Translation	MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	XM_017011346.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011346.1

ORF Insert Sequence:

ATGCCCAGTG CTGGGCTCTG CAGCTGCTGG GGTGGCCGGG TGCTGCCCCT GCTGCTGGCC 
TATGTCTGCT ACCTGCTGCT CGGTGCCACT ATCTTCCAGC TGCTAGAGAG GCAGGCGGAG 
GCTCAGTCCA GGGACCAGTT TCAGTTGGAG AAGCTGCGCT TCCTGGAGAA CTACACCTGC 
CTGGACCAGT GGGCCATGGA GCAGTTTGTG CAGGTCATCA TGGAAGCCTG GGTGAAAGGT 
GTGAACCCCA AAGGCAACTC TACCAACCCC AGCAACTGGG ACTTTGGCAG CAGTTTCTTC 
TTTGCAGGCA CAGTCGTCAC TACCATAGGA TATGGGAACC TGGCACCCAG CACAGAGGCA 
GGTCAGGTCT TCTGTGTCTT CTATGCCCTG TTGGGCATCC CGCTTAACGT GATCTTCCTC 
AACCACCTGG GCACAGGGCT GCGTGCCCAT CTGGCCGCCA TTGAAAGATG GGAGGACCGT 
CCCAGGCGCT CCCAGGTACT GCAAGTCCTG GGCCTGGCTC TGTTCCTGAC CCTGGGGACG 
CTGGTCATTC TCATCTTCCC ACCCATGGTC TTCAGCCATG TGGAGGGCTG GAGCTTCAGC 
GAGGGCTTCT ACTTTGCTTT CATCACTCTC AGCACCATTG GCTTTGGGGA CTATGTTGTT 
GGTCTGAGGC AAGGCTGTGG AGCCAAGGCG GCTCCAGGCA GGAGACCCAG GAGAGGCTCT 
ACAGCAGCAA GAGGAGTCCA AGTCACACCC CAGGACTTCC CCATATCCAA GAAAGGACTG 
GGAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK16 ( XM_011514935.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011513237.1 Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu73170
Clone ID Related Accession (Same CDS sequence)	NM_001363784.1 , XM_011514935.2
Accession Version	XM_011514935.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 16 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011514935.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCAGT TTGTGCAGGT CATCATGGAA GCCTGGGTGA AAGGTGTGAA CCCCAAAGGC 
AACTCTACCA ACCCCAGCAA CTGGGACTTT GGCAGCAGTT TCTTCTTTGC AGGCACAGTC 
GTCACTACCA TAGGATATGG GAACCTGGCA CCCAGCACAG AGGCAGGTCA GGTCTTCTGT 
GTCTTCTATG CCCTGTTGGG CATCCCGCTT AACGTGATCT TCCTCAACCA CCTGGGCACA 
GGGCTGCGTG CCCATCTGGC CGCCATTGAA AGATGGGAGG ACCGTCCCAG GCGCTCCCAG 
GTACTGCAAG TCCTGGGCCT GGCTCTGTTC CTGACCCTGG GGACGCTGGT CATTCTCATC 
TTCCCACCCA TGGTCTTCAG CCATGTGGAG GGCTGGAGCT TCAGCGAGGG CTTCTACTTT 
GCTTTCATCA CTCTCAGCAC CATTGGCTTT GGGGACTATG TTGTTGGTCT GAGGCAAGGC 
TGTGGAGCCA AGGCGGCTCC AGGCAGGAGA CCCAGGAGAG GCTCTACAGC AGCAAGAGGA 
GTCCAAGTCA CACCCCAGGA CTTCCCCATA TCCAAGAAAG GACTGGGAAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011513237.1
CDS	266..859
Translation	MEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS

Target ORF information:

RefSeq Version	XM_011514935.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 16 (KCNK16), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011514935.2

ORF Insert Sequence:

ATGGAGCAGT TTGTGCAGGT CATCATGGAA GCCTGGGTGA AAGGTGTGAA CCCCAAAGGC 
AACTCTACCA ACCCCAGCAA CTGGGACTTT GGCAGCAGTT TCTTCTTTGC AGGCACAGTC 
GTCACTACCA TAGGATATGG GAACCTGGCA CCCAGCACAG AGGCAGGTCA GGTCTTCTGT 
GTCTTCTATG CCCTGTTGGG CATCCCGCTT AACGTGATCT TCCTCAACCA CCTGGGCACA 
GGGCTGCGTG CCCATCTGGC CGCCATTGAA AGATGGGAGG ACCGTCCCAG GCGCTCCCAG 
GTACTGCAAG TCCTGGGCCT GGCTCTGTTC CTGACCCTGG GGACGCTGGT CATTCTCATC 
TTCCCACCCA TGGTCTTCAG CCATGTGGAG GGCTGGAGCT TCAGCGAGGG CTTCTACTTT 
GCTTTCATCA CTCTCAGCAC CATTGGCTTT GGGGACTATG TTGTTGGTCT GAGGCAAGGC 
TGTGGAGCCA AGGCGGCTCC AGGCAGGAGA CCCAGGAGAG GCTCTACAGC AGCAAGAGGA 
GTCCAAGTCA CACCCCAGGA CTTCCCCATA TCCAAGAAAG GACTGGGAAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TALK-1 channels control ? cell endoplasmic reticulum Ca
Science signaling10(497)(2017 Sep)
Vierra NC,Dadi PK,Milian SC,Dickerson MT,Jordan KL,Gilon P,Jacobson DA

Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic ?-cells.
PloS one12(4)e0175069(2017)
Dickerson MT,Vierra NC,Milian SC,Dadi PK,Jacobson DA

Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates ?-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Diabetes64(11)3818-28(2015 Nov)
Vierra NC,Dadi PK,Jeong I,Dickerson M,Powell DR,Jacobson DA

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Nature genetics46(3)234-44(2014 Mar)
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Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
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KCNK16 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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