HIST1H4C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	HIST1H4C
Entrez Gene ID	8364
Full Name	histone cluster 1 H4 family member c
Synonyms	H4/g,H4FG,dJ221C16.1
General protein information	Preferred Names histone cluster 1 H4 family member c Names histone H4 H4 histone family, member G histone 1, H4c histone cluster 1, H4c
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602827

mRNA and Protein(s)

mRNA	Protein	Name
NM_003542.4	NP_003533.1	histone H4
NM_003542.3	NP_003533.1	histone H4

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H4C	NP_003533.1
Caenorhabditis elegans (roundworm)	his-38	NP_509231.1
Oryza sativa (rice)	Os09g0433600	NP_001063245.1
Pan troglodytes (chimpanzee)	LOC465305	XP_003313563.1
	LOC695214	XP_001083731.1
Bos taurus (cattle)	LOC526789	XP_002684676.1
Mus musculus (house mouse)	Hist2h4	NP_291074.1
Gallus gallus (chicken)	HIST1H46L6	XP_001233180.1
Arabidopsis thaliana (thale cress)	AT3G46320	NP_850660.1
Rattus norvegicus (Norway rat)	LOC100912489	XP_006237606.1
Drosophila melanogaster (fruit fly)	His4:CG33897	NP_001027312.1
Canis lupus familiaris (dog)	LOC100855431	XP_003639662.1
Danio rerio (zebrafish)	si:ch211-113a14.17	XP_688877.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003909	XP_318361.3
Xenopus tropicalis (tropical clawed frog)	hist1h4a	NP_001016869.1

Gene Ontology
Bibliography

Related articles in PubMed

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.
Tessadori F, Giltay JC, Hurst JA, Massink MP, Duran K, Vos HR, van Es RM, , Scott RH, van Gassen KLI, Bakkers J, van Haaften G
Nature genetics49(11)1642-1646(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Mavrakis KJ, McDonald ER 3rd, Schlabach MR, Billy E, Hoffman GR, deWeck A, Ruddy DA, Venkatesan K, Yu J, McAllister G, Stump M, deBeaumont R, Ho S, Yue Y, Liu Y, Yan-Neale Y, Yang G, Lin F, Yin H, Gao H, Kipp DR, Zhao S, McNamara JT, Sprague ER, Zheng B, Lin Y, Cho YS, Gu J, Crawford K, Ciccone D, Vitari AC, Lai A, Capka V, Hurov K, Porter JA, Tallarico J, Mickanin C, Lees E, Pagliarini R, Keen N, Schmelzle T, Hofmann F, Stegmeier F, Sellers WR
Science (New York, N.Y.)351(6278)1208-13(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.
Title: Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.

Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.

The following HIST1H4C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST1H4C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30163	NM_003542.4 Latest version!	Homo sapiens H4 clustered histone 3 (H4C3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30163	NM_003542.3	Homo sapiens histone cluster 1 H4 family member c (HIST1H4C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HIST1H4C ( NM_003542.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003533.1 Homo sapiens H4 clustered histone 3 (H4C3), mRNA.

Price & Availability↑

CloneID	OHu30163
Clone ID Related Accession (Same CDS sequence)	NM_003542.4 , NM_003542.3
Accession Version	NM_003542.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U91328.1. On Dec 3, 2019 this sequence version replaced NM_003542.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AV712095.1, AV764539.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGTC GCGGCAAAGG CGGAAAAGGC TTGGGGAAGG GTGGTGCTAA GCGCCATCGT 
AAGGTGCTCC GGGATAACAT CCAGGGCATT ACAAAACCGG CTATTCGCCG TTTGGCTCGG 
CGCGGTGGCG TCAAGCGCAT TTCCGGTCTT ATCTATGAGG AGACTCGAGG TGTGCTTAAG 
GTTTTCTTAG AGAACGTTAT TCGAGACGCC GTCACCTATA CGGAGCACGC CAAGCGCAAA 
ACTGTCACAG CCATGGATGT AGTATATGCC CTAAAACGTC AGGGGCGCAC TCTGTATGGC 
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003533.1
CDS	16..327
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_003542.4
Organism	Homo sapiens(human)
Definition	Homo sapiens H4 clustered histone 3 (H4C3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003542.4

ORF Insert Sequence:

ATGTCTGGTC GCGGCAAAGG CGGAAAAGGC TTGGGGAAGG GTGGTGCTAA GCGCCATCGT 
AAGGTGCTCC GGGATAACAT CCAGGGCATT ACAAAACCGG CTATTCGCCG TTTGGCTCGG 
CGCGGTGGCG TCAAGCGCAT TTCCGGTCTT ATCTATGAGG AGACTCGAGG TGTGCTTAAG 
GTTTTCTTAG AGAACGTTAT TCGAGACGCC GTCACCTATA CGGAGCACGC CAAGCGCAAA 
ACTGTCACAG CCATGGATGT AGTATATGCC CTAAAACGTC AGGGGCGCAC TCTGTATGGC 
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HIST1H4C ( NM_003542.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003533.1 Homo sapiens histone cluster 1 H4 family member c (HIST1H4C), mRNA.

Price & Availability↑

CloneID	OHu30163
Clone ID Related Accession (Same CDS sequence)	NM_003542.4 , NM_003542.3
Accession Version	NM_003542.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X60486.1. On May 22, 2002 this sequence version replaced NM_003542.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGTC GCGGCAAAGG CGGAAAAGGC TTGGGGAAGG GTGGTGCTAA GCGCCATCGT 
AAGGTGCTCC GGGATAACAT CCAGGGCATT ACAAAACCGG CTATTCGCCG TTTGGCTCGG 
CGCGGTGGCG TCAAGCGCAT TTCCGGTCTT ATCTATGAGG AGACTCGAGG TGTGCTTAAG 
GTTTTCTTAG AGAACGTTAT TCGAGACGCC GTCACCTATA CGGAGCACGC CAAGCGCAAA 
ACTGTCACAG CCATGGATGT AGTATATGCC CTAAAACGTC AGGGGCGCAC TCTGTATGGC 
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003533.1
CDS	1..312
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_003542.3
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H4 family member c (HIST1H4C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003542.3

ORF Insert Sequence:

ATGTCTGGTC GCGGCAAAGG CGGAAAAGGC TTGGGGAAGG GTGGTGCTAA GCGCCATCGT 
AAGGTGCTCC GGGATAACAT CCAGGGCATT ACAAAACCGG CTATTCGCCG TTTGGCTCGG 
CGCGGTGGCG TCAAGCGCAT TTCCGGTCTT ATCTATGAGG AGACTCGAGG TGTGCTTAAG 
GTTTTCTTAG AGAACGTTAT TCGAGACGCC GTCACCTATA CGGAGCACGC CAAGCGCAAA 
ACTGTCACAG CCATGGATGT AGTATATGCC CTAAAACGTC AGGGGCGCAC TCTGTATGGC 
TTCGGCGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control.
Nature genetics49(11)1642-1646(2017 Nov)
Tessadori F,Giltay JC,Hurst JA,Massink MP,Duran K,Vos HR,van Es RM,,Scott RH,van Gassen KLI,Bakkers J,van Haaften G

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science (New York, N.Y.)351(6278)1208-13(2016 Mar)
Mavrakis KJ,McDonald ER 3rd,Schlabach MR,Billy E,Hoffman GR,deWeck A,Ruddy DA,Venkatesan K,Yu J,McAllister G,Stump M,deBeaumont R,Ho S,Yue Y,Liu Y,Yan-Neale Y,Yang G,Lin F,Yin H,Gao H,Kipp DR,Zhao S,McNamara JT,Sprague ER,Zheng B,Lin Y,Cho YS,Gu J,Crawford K,Ciccone D,Vitari AC,Lai A,Capka V,Hurov K,Porter JA,Tallarico J,Mickanin C,Lees E,Pagliarini R,Keen N,Schmelzle T,Hofmann F,Stegmeier F,Sellers WR

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HIST1H4C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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