H2BC9 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2BC9
Entrez Gene ID	8345
Full Name	histone cluster 1 H2B family member h
Synonyms	H2B/j,H2BFJ
General protein information	Preferred Names histone cluster 1 H2B family member h Names histone H2B type 1-H H2B histone family, member J histone 1, H2bh histone H2B.j histone cluster 1, H2bh
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].
Disorder MIM:	602806

mRNA and Protein(s)

mRNA	Protein	Name
NM_003524.2	NP_003515.1	histone H2B type 1-H
NM_003524.3	NP_003515.1	histone H2B type 1-H

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H2BH	NP_003515.1
Schizosaccharomyces pombe (fission yeast)	htb1	NP_588181.1
Neurospora crassa	NCU02435	XP_959440.1
Arabidopsis thaliana (thale cress)	HTB4	NP_200799.1
Arabidopsis thaliana (thale cress)	AT2G37470	NP_181283.1
Arabidopsis thaliana (thale cress)	AT3G09480	NP_187559.1
Pan troglodytes (chimpanzee)	LOC463172	XP_003950797.1
	HIST1H2BH	XP_001088184.1
Saccharomyces cerevisiae (baker's yeast)	HTB2	NP_009553.1
Kluyveromyces lactis	KLLA0E17337g	XP_454731.1
Eremothecium gossypii	AGOS_AGR183C	NP_986849.1
Arabidopsis thaliana (thale cress)	AT3G53650	NP_190933.1
Arabidopsis thaliana (thale cress)	AT2G28720	NP_180440.1
Oryza sativa (rice)	Os01g0152300	NP_001042044.2
Oryza sativa (rice)	Os01g0839500	NP_001044754.1
Arabidopsis thaliana (thale cress)	HTB9	NP_190184.1
Arabidopsis thaliana (thale cress)	AT5G02570	NP_195877.1
Oryza sativa (rice)	Os01g0152900	NP_001042049.1
Oryza sativa (rice)	Os08g0490900	NP_001062114.2
Oryza sativa (rice)	Os01g0153100	NP_001042051.1
Oryza sativa (rice)	Os05g0574300	NP_001056388.2
Mus musculus (house mouse)	Hist1h2bq	NP_001091448.2
Mus musculus (house mouse)	Hist1h2br	NP_001104025.1
Saccharomyces cerevisiae (baker's yeast)	HTB1	NP_010510.3
Magnaporthe oryzae (rice blast fungus)	MGG_03578	XP_003716332.1
Oryza sativa (rice)	Os01g0149600	NP_001042026.1
Canis lupus familiaris (dog)	LOC483164	XP_005630794.1
Bos taurus (cattle)	HIST2H2BF	XP_005204026.1
Rattus norvegicus (Norway rat)	LOC100359692	XP_002728547.2
Kluyveromyces lactis	KLLA0F13310g	XP_455679.1
Arabidopsis thaliana (thale cress)	HTB1	NP_172258.1
Arabidopsis thaliana (thale cress)	HTB2	NP_197679.1
Arabidopsis thaliana (thale cress)	HTB11	NP_190189.1
Oryza sativa (rice)	Os01g0153300	NP_001042053.1

Gene Ontology
Bibliography

Related articles in PubMed

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ
Nature immunology16(12)1215-27(2015 Dec)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, Reinberg D
Cell125(4)703-17(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H2BC9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2BC9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30034	NM_003524.3 Latest version!	Homo sapiens H2B clustered histone 9 (H2BC9), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu30034	NM_003524.2	Homo sapiens histone cluster 1 H2B family member h (HIST1H2BH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2BC9 ( NM_003524.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003515.1 Homo sapiens histone cluster 1 H2B family member h (HIST1H2BH), mRNA.

Price & Availability↑

CloneID	OHu30034
Clone ID Related Accession (Same CDS sequence)	NM_003524.2 , NM_003524.3
Accession Version	NM_003524.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Homo sapiens(human)
Product	histone H2B type 1-H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z80781.1. On May 24, 2002 this sequence version replaced NM_003524.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC096116.3, DA616590.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGATC CAGCTAAGTC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCGGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGT AAACGCAGCC GCAAGGAGAG CTACTCCGTA 
TACGTTTACA AGGTGCTGAA GCAAGTCCAC CCCGACACCG GCATCTCCTC CAAAGCCATG 
GGGATCATGA ATTCCTTTGT CAACGATATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC 
CTGGCTCATT ACAACAAGCG TTCGACCATC ACCTCCAGGG AGATCCAGAC AGCCGTGCGC 
CTGCTGCTGC CTGGGGAACT GGCCAAGCAC GCCGTGTCCG AGGGCACTAA GGCCGTCACC 
AAGTACACCA GCTCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003515.1
CDS	1..381
Translation	MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003524.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2B family member h (HIST1H2BH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003524.2

ORF Insert Sequence:

ATGCCTGATC CAGCTAAGTC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCGGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGT AAACGCAGCC GCAAGGAGAG CTACTCCGTA 
TACGTTTACA AGGTGCTGAA GCAAGTCCAC CCCGACACCG GCATCTCCTC CAAAGCCATG 
GGGATCATGA ATTCCTTTGT CAACGATATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC 
CTGGCTCATT ACAACAAGCG TTCGACCATC ACCTCCAGGG AGATCCAGAC AGCCGTGCGC 
CTGCTGCTGC CTGGGGAACT GGCCAAGCAC GCCGTGTCCG AGGGCACTAA GGCCGTCACC 
AAGTACACCA GCTCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2BC9 ( NM_003524.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003515.1 Homo sapiens H2B clustered histone 9 (H2BC9), mRNA.

Price & Availability↑

CloneID	OHu30034
Clone ID Related Accession (Same CDS sequence)	NM_003524.2 , NM_003524.3
Accession Version	NM_003524.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	histone H2B type 1-H
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031777.5. On Dec 3, 2019 this sequence version replaced NM_003524.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DA374205.1, BC096116.3 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGATC CAGCTAAGTC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCGGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGT AAACGCAGCC GCAAGGAGAG CTACTCCGTA 
TACGTTTACA AGGTGCTGAA GCAAGTCCAC CCCGACACCG GCATCTCCTC CAAAGCCATG 
GGGATCATGA ATTCCTTTGT CAACGATATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC 
CTGGCTCATT ACAACAAGCG TTCGACCATC ACCTCCAGGG AGATCCAGAC AGCCGTGCGC 
CTGCTGCTGC CTGGGGAACT GGCCAAGCAC GCCGTGTCCG AGGGCACTAA GGCCGTCACC 
AAGTACACCA GCTCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003515.1
CDS	38..418
Translation	MPDPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003524.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2B clustered histone 9 (H2BC9), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003524.3

ORF Insert Sequence:

ATGCCTGATC CAGCTAAGTC CGCTCCCGCC CCGAAGAAGG GCTCCAAGAA GGCGGTGACC 
AAGGCGCAGA AGAAGGATGG CAAGAAGCGT AAACGCAGCC GCAAGGAGAG CTACTCCGTA 
TACGTTTACA AGGTGCTGAA GCAAGTCCAC CCCGACACCG GCATCTCCTC CAAAGCCATG 
GGGATCATGA ATTCCTTTGT CAACGATATC TTCGAGCGCA TCGCCGGCGA GGCTTCCCGC 
CTGGCTCATT ACAACAAGCG TTCGACCATC ACCTCCAGGG AGATCCAGAC AGCCGTGCGC 
CTGCTGCTGC CTGGGGAACT GGCCAAGCAC GCCGTGTCCG AGGGCACTAA GGCCGTCACC 
AAGTACACCA GCTCCAAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Nature immunology16(12)1215-27(2015 Dec)
Zhang Y,Mao D,Roswit WT,Jin X,Patel AC,Patel DA,Agapov E,Wang Z,Tidwell RM,Atkinson JJ,Huang G,McCarthy R,Yu J,Yun NE,Paessler S,Lawson TG,Omattage NS,Brett TJ,Holtzman MJ

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Cell125(4)703-17(2006 May)
Pavri R,Zhu B,Li G,Trojer P,Mandal S,Shilatifard A,Reinberg D

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H2BC9 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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