H2BC14 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	H2BC14
Entrez Gene ID	8342
Full Name	histone cluster 1 H2B family member m
Synonyms	H2B/e,H2BFE,dJ160A22.3
General protein information	Preferred Names histone cluster 1 H2B family member m Names histone H2B type 1-M H2B histone family, member E histone 1, H2bm histone H2B.e histone cluster 1, H2bm
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p22.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Disorder MIM:	602802

mRNA and Protein(s)

mRNA	Protein	Name
NM_003521.2	NP_003512.1	histone H2B type 1-M
NM_003521.3	NP_003512.1	histone H2B type 1-M

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC748505	XP_001172713.1
Mus musculus (house mouse)	Hist1h2bn	NP_835508.1
	HIST1H2BM	XP_001096102.1
Canis lupus familiaris (dog)	LOC100683643	XP_003431891.1
Homo sapiens (human)	HIST1H2BM	NP_003512.1
Bos taurus (cattle)	HIST1H2BB	XP_002697571.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S
Journal of proteome research11(4)2533-43(2012 Apr)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Pavri R, Zhu B, Li G, Trojer P, Mandal S, Shilatifard A, Reinberg D
Cell125(4)703-17(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

The following H2BC14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H2BC14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30390	NM_003521.3 Latest version!	Homo sapiens H2B clustered histone 14 (H2BC14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu30390	NM_003521.2	Homo sapiens histone cluster 1 H2B family member m (HIST1H2BM), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H2BC14 ( NM_003521.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003512.1 Homo sapiens histone cluster 1 H2B family member m (HIST1H2BM), mRNA.

Price & Availability↑

CloneID	OHu30390
Clone ID Related Accession (Same CDS sequence)	NM_003521.2 , NM_003521.3
Accession Version	NM_003521.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	histone H2B type 1-M
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z83738.1. On Sep 21, 2001 this sequence version replaced NM_003521.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BM752802.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGAAC CAGTCAAATC TGCTCCAGTC CCTAAAAAAG GCTCCAAGAA GGCCATTAAC 
AAGGCTCAGA AGAAGGATGG AAAGAAGCGC AAACGCAGCC GCAAGGAGAG CTACTCTGTG 
TATGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCTTC CAAGGCTATG 
GGAATCATGA ACTCCTTCGT CAACGACATC TTTGAGCGTA TCGCCGGAGA AGCGTCACGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCGAGGG AGATCCAGAC GGCCGTGCGC 
CTACTGCTAC CCGGGGAATT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCCGTCACC 
AAGTATACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003512.1
CDS	1..381
Translation	MPEPVKSAPVPKKGSKKAINKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003521.2
Organism	Homo sapiens(human)
Definition	Homo sapiens histone cluster 1 H2B family member m (HIST1H2BM), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003521.2

ORF Insert Sequence:

ATGCCTGAAC CAGTCAAATC TGCTCCAGTC CCTAAAAAAG GCTCCAAGAA GGCCATTAAC 
AAGGCTCAGA AGAAGGATGG AAAGAAGCGC AAACGCAGCC GCAAGGAGAG CTACTCTGTG 
TATGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCTTC CAAGGCTATG 
GGAATCATGA ACTCCTTCGT CAACGACATC TTTGAGCGTA TCGCCGGAGA AGCGTCACGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCGAGGG AGATCCAGAC GGCCGTGCGC 
CTACTGCTAC CCGGGGAATT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCCGTCACC 
AAGTATACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

H2BC14 ( NM_003521.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003512.1 Homo sapiens H2B clustered histone 14 (H2BC14), mRNA.

Price & Availability↑

CloneID	OHu30390
Clone ID Related Accession (Same CDS sequence)	NM_003521.2 , NM_003521.3
Accession Version	NM_003521.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	histone H2B type 1-M
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL049822.30. On Dec 3, 2019 this sequence version replaced NM_003521.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BM752802.1, BC067486.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTGAAC CAGTCAAATC TGCTCCAGTC CCTAAAAAAG GCTCCAAGAA GGCCATTAAC 
AAGGCTCAGA AGAAGGATGG AAAGAAGCGC AAACGCAGCC GCAAGGAGAG CTACTCTGTG 
TATGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCTTC CAAGGCTATG 
GGAATCATGA ACTCCTTCGT CAACGACATC TTTGAGCGTA TCGCCGGAGA AGCGTCACGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCGAGGG AGATCCAGAC GGCCGTGCGC 
CTACTGCTAC CCGGGGAATT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCCGTCACC 
AAGTATACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003512.1
CDS	23..403
Translation	MPEPVKSAPVPKKGSKKAINKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Target ORF information:

RefSeq Version	NM_003521.3
Organism	Homo sapiens(human)
Definition	Homo sapiens H2B clustered histone 14 (H2BC14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003521.3

ORF Insert Sequence:

ATGCCTGAAC CAGTCAAATC TGCTCCAGTC CCTAAAAAAG GCTCCAAGAA GGCCATTAAC 
AAGGCTCAGA AGAAGGATGG AAAGAAGCGC AAACGCAGCC GCAAGGAGAG CTACTCTGTG 
TATGTGTACA AGGTGCTGAA GCAGGTCCAC CCCGACACCG GCATCTCTTC CAAGGCTATG 
GGAATCATGA ACTCCTTCGT CAACGACATC TTTGAGCGTA TCGCCGGAGA AGCGTCACGC 
CTGGCGCATT ACAACAAGCG CTCGACCATC ACTTCGAGGG AGATCCAGAC GGCCGTGCGC 
CTACTGCTAC CCGGGGAATT GGCCAAGCAC GCCGTGTCCG AGGGCACCAA GGCCGTCACC 
AAGTATACCA GCTCCAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Journal of proteome research11(4)2533-43(2012 Apr)
Martins-de-Souza D,Guest PC,Mann DM,Roeber S,Rahmoune H,Bauder C,Kretzschmar H,Volk B,Baborie A,Bahn S

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.
Cell125(4)703-17(2006 May)
Pavri R,Zhu B,Li G,Trojer P,Mandal S,Shilatifard A,Reinberg D

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H2BC14 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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