F8A1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	F8A1
Entrez Gene ID	8263
Full Name	coagulation factor VIII associated 1
Synonyms	DXS522E,F8A,HAP40
General protein information	Preferred Names coagulation factor VIII associated 1 Names factor VIII intron 22 protein coagulation factor VIII-associated (intronic transcript) 1 cpG island protein factor VIII associated protein huntingtin-associated protein 40
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq28
Summary	This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008].
Disorder MIM:	305423

mRNA and Protein(s)

mRNA	Protein	Name
NM_012151.3	NP_036283.2	40-kDa huntingtin-associated protein

Pathways from BioSystems

Homologies

	F8A1	XP_001091814.1
Bos taurus (cattle)	LOC617475	XP_002699745.1
Rattus norvegicus (Norway rat)	F8a1	NP_001102793.1
Homo sapiens (human)	F8A2	NP_001007524.1
Homo sapiens (human)	F8A1	NP_036283.2
Mus musculus (house mouse)	F8a	NP_032004.2
Danio rerio (zebrafish)	zgc:101679	NP_001006078.1
Homo sapiens (human)	F8A3	NP_001007525.1
Xenopus tropicalis (tropical clawed frog)	f8a1	NP_001072171.1

Gene Ontology
Bibliography

Related articles in PubMed

The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
Huang ZN, Her LS
Molecular neurobiology(2016 Nov)

Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.
Wakabayashi H, Fay PJ
The Biochemical journal452(2)293-301(2013 Jun)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Orientations for FVIIIa are identified that bind to the membrane surface and support a new interaction between the A3 domain and the membrane, probably mediated in part by Arg(1719) and Arg(1721)
Title: Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor
Title: Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor.

analysis of the residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa
Title: Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.

The following F8A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F8A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29434	NM_012151.3 Latest version!	Homo sapiens coagulation factor VIII associated 1 (F8A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F8A1 ( NM_012151.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036283.2 Homo sapiens coagulation factor VIII associated 1 (F8A1), mRNA.

Price & Availability↑

CloneID	OHu29434
Clone ID Related Accession (Same CDS sequence)	NM_012151.3
Accession Version	NM_012151.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	40-kDa huntingtin-associated protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL556125.3 and BC039693.1. On Dec 23, 2004 this sequence version replaced NM_012151.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC039693.1, BC071963.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG CGGCTGCAGG CCTGGGCGGC GGCGGCGCCG GCCCGGGACC CGAGGCCGGG 
GACTTCCTGG CCCGCTACCG GCTGGTATCG AACAAGCTGA AGAAGCGGTT CCTGCGGAAG 
CCGAACGTGG CGGAGGCCGG CGAGCAGTTC GGACAGCTGG GCCGGGAGCT GCGCGCCCAG 
GAGTGTCTGC CCTACGCGGC CTGGTGCCAG CTGGCGGTGG CGCGCTGCCA GCAGGCGCTC 
TTCCACGGGC CCGGGGAGGC GCTGGCCCTC ACCGAGGCCG CCCGCCTCTT CCTGCGGCAG 
GAGCGCGACG CGCGCCAGCG CCTGGTCTGC CCCGCCGCCT ACGGGGAGCC GCTGCAGGCC 
GCCGCCAGCG CCCTGGGCGC CGCGGTGCGT CTGCACCTCG AGCTGGGCCA GCCGGCCGCC 
GCCGCCGCCC TCTGCCTCGA GCTGGCCGCC GCCCTGCGCG ACCTGGGCCA GCCGGCCGCC 
GCCGCCGGTC ACTTCCAGCG CGCCGCCCAG CTCCAGCTGC CCCAGCTGCC CCTGGCCGCG 
CTGCAGGCGC TTGGCGAGGC CGCCTCCTGC CAGCTGCTGG CGCGCGACTA CACCGGCGCC 
CTGGCGGTCT TCACGCGCAT GCAGCGCCTG GCGCGGGAGC ACGGCAGCCA CCCGGTGCAG 
TCACTGCCGC CGCCCCCGCC GCCGGCACCC CAGCCCGGGC CCGGGGCGAC GCCCGCCCTA 
CCGGCCGCGC TGCTTCCTCC GAACTCCGGC TCGGCGGCGC CCTCTCCCGC CGCCCTGGGC 
GCCTTCTCGG ACGTGCTGGT CCGCTGCGAG GTGTCCCGCG TGCTGCTGCT GCTCCTCCTG 
CAACCACCGC CCGCCAAGCT GCTGCCGGAG CACGCCCAGA CCCTGGAGAA GTACTCCTGG 
GAGGCTTTTG ACAGCCACGG GCAGGAGAGC AGCGGCCAGC TTCCCGAGGA GCTCTTTCTG 
CTGCTCCAGT CTTTGGTCAT GGCTACCCAC GAAAAGGACA CGGAAGCCAT CAAGTCGCTG 
CAGGTGGAGA TGTGGCCACT GTTGACTGCT GAGCAGAACC ACCTCCTTCA CCTCGTTCTG 
CAAGAAACCA TCTCCCCCTC AGGACAGGGA GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036283.2
CDS	16..1131
Translation	MAAAAAGLGGGGAGPGPEAGDFLARYRLVSNKLKKRFLRKPNVAEAGEQFGQLGRELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQERDARQRLVCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRDLGQPAAAAGHFQRAAQLQLPQLPLAALQALGEAASCQLLARDYTGALAVFTRMQRLAREHGSHPVQSLPPPPPPAPQPGPGATPALPAALLPPNSGSAAPSPAALGAFSDVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDSHGQESSGQLPEELFLLLQSLVMATHEKDTEAIKSLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV

Target ORF information:

RefSeq Version	NM_012151.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor VIII associated 1 (F8A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012151.3

ORF Insert Sequence:

ATGGCGGCAG CGGCTGCAGG CCTGGGCGGC GGCGGCGCCG GCCCGGGACC CGAGGCCGGG 
GACTTCCTGG CCCGCTACCG GCTGGTATCG AACAAGCTGA AGAAGCGGTT CCTGCGGAAG 
CCGAACGTGG CGGAGGCCGG CGAGCAGTTC GGACAGCTGG GCCGGGAGCT GCGCGCCCAG 
GAGTGTCTGC CCTACGCGGC CTGGTGCCAG CTGGCGGTGG CGCGCTGCCA GCAGGCGCTC 
TTCCACGGGC CCGGGGAGGC GCTGGCCCTC ACCGAGGCCG CCCGCCTCTT CCTGCGGCAG 
GAGCGCGACG CGCGCCAGCG CCTGGTCTGC CCCGCCGCCT ACGGGGAGCC GCTGCAGGCC 
GCCGCCAGCG CCCTGGGCGC CGCGGTGCGT CTGCACCTCG AGCTGGGCCA GCCGGCCGCC 
GCCGCCGCCC TCTGCCTCGA GCTGGCCGCC GCCCTGCGCG ACCTGGGCCA GCCGGCCGCC 
GCCGCCGGTC ACTTCCAGCG CGCCGCCCAG CTCCAGCTGC CCCAGCTGCC CCTGGCCGCG 
CTGCAGGCGC TTGGCGAGGC CGCCTCCTGC CAGCTGCTGG CGCGCGACTA CACCGGCGCC 
CTGGCGGTCT TCACGCGCAT GCAGCGCCTG GCGCGGGAGC ACGGCAGCCA CCCGGTGCAG 
TCACTGCCGC CGCCCCCGCC GCCGGCACCC CAGCCCGGGC CCGGGGCGAC GCCCGCCCTA 
CCGGCCGCGC TGCTTCCTCC GAACTCCGGC TCGGCGGCGC CCTCTCCCGC CGCCCTGGGC 
GCCTTCTCGG ACGTGCTGGT CCGCTGCGAG GTGTCCCGCG TGCTGCTGCT GCTCCTCCTG 
CAACCACCGC CCGCCAAGCT GCTGCCGGAG CACGCCCAGA CCCTGGAGAA GTACTCCTGG 
GAGGCTTTTG ACAGCCACGG GCAGGAGAGC AGCGGCCAGC TTCCCGAGGA GCTCTTTCTG 
CTGCTCCAGT CTTTGGTCAT GGCTACCCAC GAAAAGGACA CGGAAGCCAT CAAGTCGCTG 
CAGGTGGAGA TGTGGCCACT GTTGACTGCT GAGCAGAACC ACCTCCTTCA CCTCGTTCTG 
CAAGAAACCA TCTCCCCCTC AGGACAGGGA GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.
Molecular neurobiology(2016 Nov)
Huang ZN,Her LS

Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer.
The Biochemical journal452(2)293-301(2013 Jun)
Wakabayashi H,Fay PJ

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
American journal of human genetics85(5)628-42(2009 Nov)
Talmud PJ,Drenos F,Shah S,Shah T,Palmen J,Verzilli C,Gaunt TR,Pallas J,Lovering R,Li K,Casas JP,Sofat R,Kumari M,Rodriguez S,Johnson T,Newhouse SJ,Dominiczak A,Samani NJ,Caulfield M,Sever P,Stanton A,Shields DC,Padmanabhan S,Melander O,Hastie C,Delles C,Ebrahim S,Marmot MG,Smith GD,Lawlor DA,Munroe PB,Day IN,Kivimaki M,Whittaker J,Humphries SE,Hingorani AD,,,

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F8A1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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