LY6G5C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LY6G5C
Entrez Gene ID	80741
Full Name	lymphocyte antigen 6 family member G5C
Synonyms	C6orf20,G5C,LY6G5CA,LY6G5CB,NG33
General protein information	Preferred Names lymphocyte antigen 6 family member G5C Names lymphocyte antigen 6 complex locus protein G5c lymphocyte antigen 6 complex, locus G5C lymphocyte antigen-6 G5C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610434

mRNA and Protein(s)

mRNA	Protein	Name
NM_025262.3	NP_079538.3	lymphocyte antigen 6 complex locus protein G5c precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	LY6G5C	NP_079538.3
	LY6G5C	NP_001028062.1
Bos taurus (cattle)	LY6G5C	XP_003587751.1
Mus musculus (house mouse)	Ly6g5c	NP_683749.1
Pan troglodytes (chimpanzee)	LY6G5C	XP_001156775.2
Canis lupus familiaris (dog)	LY6G5C	NP_001003166.1
Rattus norvegicus (Norway rat)	Ly6g5c	NP_942034.3

Gene Ontology
Bibliography

Related articles in PubMed

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS genetics5(10)e1000696(2009 Oct)

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.
Harney SM, Vilari?o-G?ell C, Adamopoulos IE, Sims AM, Lawrence RW, Cardon LR, Newton JL, Meisel C, Pointon JJ, Darke C, Athanasou N, Wordsworth BP, Brown MA
Rheumatology (Oxford, England)47(12)1761-7(2008 Dec)

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Macaulay IC, Tijssen MR, Thijssen-Timmer DC, Gusnanto A, Steward M, Burns P, Langford CF, Ellis PD, Dudbridge F, Zwaginga JJ, Watkins NA, van der Schoot CE, Ouwehand WH
Blood109(8)3260-9(2007 Apr)

Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands.
Mallya M, Campbell RD, Aguado B
Protein science : a publication of the Protein Society15(10)2244-56(2006 Oct)

Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms.
Mallya M, Campbell RD, Aguado B
Genomics80(1)113-23(2002 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.

Observational study of gene-disease association. (HuGE Navigator)
Title: Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.

The following LY6G5C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LY6G5C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu21936	NM_025262.3 Latest version!	Homo sapiens lymphocyte antigen 6 family member G5C (LY6G5C), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LY6G5C ( NM_025262.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079538.3 Homo sapiens lymphocyte antigen 6 family member G5C (LY6G5C), mRNA.

Price & Availability↑

CloneID	OHu21936
Clone ID Related Accession (Same CDS sequence)	NM_025262.3
Accession Version	NM_025262.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	lymphocyte antigen 6 complex locus protein G5c precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL662899.5, AJ315542.1 and AA731226.1. On Oct 28, 2009 this sequence version replaced NM_025262.2. ##Evidence-Data-START## Transcript exon combination :: AJ315542.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGTTTTA TGGCAGGCCC TGCAGGGAGC CAGAGTCTGG GTCCCCTGTG CTTCCACAGC 
AGCCCCCAAG CCCTCTACAC GGTCCTCTTA ATAGTGCTGG TCATGATGAG CTTGGTGTTT 
GGTAAGTTTG TTCCTGTCAA TTGGGAACCC CCTCAACCAC TTCCATTCCC CAAATACCTG 
CGCTGCTACC GATGCCTCTT GGAGACCAAG GAGTTAGGGT GCCTTCTGGG ATCTGACATC 
TGCCTCACCC CAGCTGGCAG CAGCTGCATC ACTCTCCACA AAAAGAACAG CAGCGGTTCT 
GACGTCATGG TGAGTGACTG CCGAAGTAAG GAGCAGATGA GTGATTGTTC AAATACCCGA 
ACTTCTCCGG TGTCTGGCTT CTGGATATTC TCTCAATACT GCTTCCTGGA TTTCTGCAAT 
GACCCTCAAA ACAGAGGGCT CTATACTCCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079538.3
CDS	1..453
Translation	MRFMAGPAGSQSLGPLCFHSSPQALYTVLLIVLVMMSLVFGKFVPVNWEPPQPLPFPKYLRCYRCLLETKELGCLLGSDICLTPAGSSCITLHKKNSSGSDVMVSDCRSKEQMSDCSNTRTSPVSGFWIFSQYCFLDFCNDPQNRGLYTP

Target ORF information:

RefSeq Version	NM_025262.3
Organism	Homo sapiens(human)
Definition	Homo sapiens lymphocyte antigen 6 family member G5C (LY6G5C), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025262.3

ORF Insert Sequence:

ATGCGTTTTA TGGCAGGCCC TGCAGGGAGC CAGAGTCTGG GTCCCCTGTG CTTCCACAGC 
AGCCCCCAAG CCCTCTACAC GGTCCTCTTA ATAGTGCTGG TCATGATGAG CTTGGTGTTT 
GGTAAGTTTG TTCCTGTCAA TTGGGAACCC CCTCAACCAC TTCCATTCCC CAAATACCTG 
CGCTGCTACC GATGCCTCTT GGAGACCAAG GAGTTAGGGT GCCTTCTGGG ATCTGACATC 
TGCCTCACCC CAGCTGGCAG CAGCTGCATC ACTCTCCACA AAAAGAACAG CAGCGGTTCT 
GACGTCATGG TGAGTGACTG CCGAAGTAAG GAGCAGATGA GTGATTGTTC AAATACCCGA 
ACTTCTCCGG TGTCTGGCTT CTGGATATTC TCTCAATACT GCTTCCTGGA TTTCTGCAAT 
GACCCTCAAA ACAGAGGGCT CTATACTCCT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
PLoS genetics5(10)e1000696(2009 Oct)
Barcellos LF,May SL,Ramsay PP,Quach HL,Lane JA,Nititham J,Noble JA,Taylor KE,Quach DL,Chung SA,Kelly JA,Moser KL,Behrens TW,Seldin MF,Thomson G,Harley JB,Gaffney PM,Criswell LA

Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.
Rheumatology (Oxford, England)47(12)1761-7(2008 Dec)
Harney SM,Vilari?o-G?ell C,Adamopoulos IE,Sims AM,Lawrence RW,Cardon LR,Newton JL,Meisel C,Pointon JJ,Darke C,Athanasou N,Wordsworth BP,Brown MA

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins.
Blood109(8)3260-9(2007 Apr)
Macaulay IC,Tijssen MR,Thijssen-Timmer DC,Gusnanto A,Steward M,Burns P,Langford CF,Ellis PD,Dudbridge F,Zwaginga JJ,Watkins NA,van der Schoot CE,Ouwehand WH

Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands.
Protein science : a publication of the Protein Society15(10)2244-56(2006 Oct)
Mallya M,Campbell RD,Aguado B

Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms.
Genomics80(1)113-23(2002 Jul)
Mallya M,Campbell RD,Aguado B

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LY6G5C cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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