CALM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALM2
Entrez Gene ID	805
Full Name	calmodulin 2
Synonyms	CAMII,LQT15,PHKD,PHKD2,caM
General protein information	Preferred Names calmodulin 2 Names calmodulin-2 LP7057 protein calmodulin 2 (phosphorylase kinase, delta) phosphorylase kinase delta phosphorylase kinase subunit delta prepro-calmodulin 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21
Summary	This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
Disorder MIM:	114182
Disorder Html:	Long QT syndrome 15, 616249 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001305625.1	NP_001292554.1	calmodulin-2 isoform 3
NM_001305626.1	NP_001292555.1	calmodulin-2 isoform 3
NM_001305624.1	NP_001292553.1	calmodulin-2 isoform 1
NM_001743.5	NP_001734.1	calmodulin-2 isoform 2
NM_001743.6	NP_001734.1	calmodulin-2 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	CALM2	NP_001734.1
Homo sapiens (human)	CALM3	NP_005175.2
	LOC717686	XP_001109440.1
Bos taurus (cattle)	CALM	NP_001159980.1
Gallus gallus (chicken)	CALM1	NP_001103834.1
Oryza sativa (rice)	Os03g0319300	NP_001049948.1
Oryza sativa (rice)	Os07g0687200	NP_001060691.1
	LOC698552	XP_001087048.2
Arabidopsis thaliana (thale cress)	CAM7	NP_189967.1
Homo sapiens (human)	CALM1	NP_008819.1
Pan troglodytes (chimpanzee)	CALM2	NP_001092028.1
	LOC716584	XP_001112374.1
Magnaporthe oryzae (rice blast fungus)	MGG_16201	XP_003709613.1
Arabidopsis thaliana (thale cress)	CAM6	NP_850860.1
Arabidopsis thaliana (thale cress)	CAM3	NP_191239.1
Oryza sativa (rice)	Os01g0267900	NP_001042688.2
Pan troglodytes (chimpanzee)	CALM3	XP_003316504.1
Arabidopsis thaliana (thale cress)	CAM5	NP_850097.1
	LOC715270	XP_001113408.2
Schizosaccharomyces pombe (fission yeast)	cam1	NP_593340.1
Neurospora crassa	NCU04120	XP_961276.2

Gene Ontology
Bibliography

Related articles in PubMed

Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation.
Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Hayano M, Nishiuchi S, Kohjitani H, Hirose S, Chen J, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Motomura H, Yoshida Y, Horie M, Makita N, Kimura T
Human molecular genetics26(9)1670-1677(2017 05)

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)

Novel calmodulin mutations associated with congenital arrhythmia susceptibility.
Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, Shigemizu D, Lichtner P, Ishikawa T, Aiba T, Homfray T, Behr ER, Klug D, Denjoy I, Mastantuono E, Theisen D, Tsunoda T, Satake W, Toda T, Nakagawa H, Tsuji Y, Tsuchiya T, Yamamoto H, Miyamoto Y, Endo N, Kimura A, Ozaki K, Motomura H, Suda K, Tanaka T, Schwartz PJ, Meitinger T, K??b S, Guicheney P, Shimizu W, Bhuiyan ZA, Watanabe H, Chazin WJ, George AL Jr
Circulation. Cardiovascular genetics7(4)466-74(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors successfully recapitulated the disease phenotypes of LQT15 and revealed that inactivation of LTCC currents was impaired in CALM2-N98S hiPSC model.
Title: Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation.

Impaired Ca(2+)-dependent inactivation in human cardiomyocytes as the plausible mechanism for Long QT Syndrome associated with 2 novel CaM mutations.
Title: Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.

the spectrum and prevalence of pathogenic CaM variants in a cohort of genetically elusive long QT syndrome, were determined.
Title: Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders.
Title: Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders.

5 novel de novo CALM2 mutations in association with long-QT syndrome and exertioninduced arrhythmias.(p.N98S, p.N98I, p.D134H, p.D132E, p.Q136P)
Title: Novel calmodulin mutations associated with congenital arrhythmia susceptibility.

The following CALM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13807	NM_001743.6 Latest version!	Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56608	NM_001305624.1 Latest version!	Homo sapiens calmodulin 2 (CALM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu56609	NM_001305625.1 Latest version!	Homo sapiens calmodulin 2 (CALM2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu56609	NM_001305626.1 Latest version!	Homo sapiens calmodulin 2 (CALM2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu13807	NM_001743.5	Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALM2 ( NM_001743.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001734.1 Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13807
Clone ID Related Accession (Same CDS sequence)	NM_001743.5 , NM_001743.6
Accession Version	NM_001743.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	calmodulin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY022313.1, BC017385.1 and AI873701.1. On Mar 24, 2015 this sequence version replaced NM_001743.4. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1, and is the same protein encoded by other calmodulin gene family members. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.101261.1, SRR1660805.49980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGACC AACTGACTGA AGAGCAGATT GCAGAATTCA AAGAAGCTTT TTCACTATTT 
GACAAAGATG GTGATGGAAC TATAACAACA AAGGAATTGG GAACTGTAAT GAGATCTCTT 
GGGCAGAATC CCACAGAAGC AGAGTTACAG GACATGATTA ATGAAGTAGA TGCTGATGGT 
AATGGCACAA TTGACTTCCC TGAATTTCTG ACAATGATGG CAAGAAAAAT GAAAGACACA 
GACAGTGAAG AAGAAATTAG AGAAGCATTC CGTGTGTTTG ATAAGGATGG CAATGGCTAT 
ATTAGTGCTG CAGAACTTCG CCATGTGATG ACAAACCTTG GAGAGAAGTT AACAGATGAA 
GAAGTTGATG AAATGATCAG GGAAGCAGAT ATTGATGGTG ATGGTCAAGT AAACTATGAA 
GAGTTTGTAC AAATGATGAC AGCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001734.1
CDS	181..630
Translation	MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_001743.5
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001743.5

ORF Insert Sequence:

ATGGCTGACC AACTGACTGA AGAGCAGATT GCAGAATTCA AAGAAGCTTT TTCACTATTT 
GACAAAGATG GTGATGGAAC TATAACAACA AAGGAATTGG GAACTGTAAT GAGATCTCTT 
GGGCAGAATC CCACAGAAGC AGAGTTACAG GACATGATTA ATGAAGTAGA TGCTGATGGT 
AATGGCACAA TTGACTTCCC TGAATTTCTG ACAATGATGG CAAGAAAAAT GAAAGACACA 
GACAGTGAAG AAGAAATTAG AGAAGCATTC CGTGTGTTTG ATAAGGATGG CAATGGCTAT 
ATTAGTGCTG CAGAACTTCG CCATGTGATG ACAAACCTTG GAGAGAAGTT AACAGATGAA 
GAAGTTGATG AAATGATCAG GGAAGCAGAT ATTGATGGTG ATGGTCAAGT AAACTATGAA 
GAGTTTGTAC AAATGATGAC AGCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALM2 ( NM_001743.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001734.1 Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu13807
Clone ID Related Accession (Same CDS sequence)	NM_001743.5 , NM_001743.6
Accession Version	NM_001743.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calmodulin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC017385.1 and AI873701.1. On Nov 22, 2018 this sequence version replaced NM_001743.5. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, and uses an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1, and is the same protein encoded by other calmodulin gene family members. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1068523.1, SRR5189652.152363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000272298.12/ ENSP00000272298.7 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGACC AACTGACTGA AGAGCAGATT GCAGAATTCA AAGAAGCTTT TTCACTATTT 
GACAAAGATG GTGATGGAAC TATAACAACA AAGGAATTGG GAACTGTAAT GAGATCTCTT 
GGGCAGAATC CCACAGAAGC AGAGTTACAG GACATGATTA ATGAAGTAGA TGCTGATGGT 
AATGGCACAA TTGACTTCCC TGAATTTCTG ACAATGATGG CAAGAAAAAT GAAAGACACA 
GACAGTGAAG AAGAAATTAG AGAAGCATTC CGTGTGTTTG ATAAGGATGG CAATGGCTAT 
ATTAGTGCTG CAGAACTTCG CCATGTGATG ACAAACCTTG GAGAGAAGTT AACAGATGAA 
GAAGTTGATG AAATGATCAG GGAAGCAGAT ATTGATGGTG ATGGTCAAGT AAACTATGAA 
GAGTTTGTAC AAATGATGAC AGCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001734.1
CDS	69..518
Translation	MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_001743.6
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin 2 (CALM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001743.6

ORF Insert Sequence:

ATGGCTGACC AACTGACTGA AGAGCAGATT GCAGAATTCA AAGAAGCTTT TTCACTATTT 
GACAAAGATG GTGATGGAAC TATAACAACA AAGGAATTGG GAACTGTAAT GAGATCTCTT 
GGGCAGAATC CCACAGAAGC AGAGTTACAG GACATGATTA ATGAAGTAGA TGCTGATGGT 
AATGGCACAA TTGACTTCCC TGAATTTCTG ACAATGATGG CAAGAAAAAT GAAAGACACA 
GACAGTGAAG AAGAAATTAG AGAAGCATTC CGTGTGTTTG ATAAGGATGG CAATGGCTAT 
ATTAGTGCTG CAGAACTTCG CCATGTGATG ACAAACCTTG GAGAGAAGTT AACAGATGAA 
GAAGTTGATG AAATGATCAG GGAAGCAGAT ATTGATGGTG ATGGTCAAGT AAACTATGAA 
GAGTTTGTAC AAATGATGAC AGCAAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALM2 ( NM_001305624.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001292553.1 Homo sapiens calmodulin 2 (CALM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu56608
Clone ID Related Accession (Same CDS sequence)	NM_001305624.1
Accession Version	NM_001305624.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	calmodulin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY022313.1, BG563041.1, BC017385.1 and AI873701.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.385094.1, ERR279833.3178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGCGCT GGGGGCGGAG GAGGCGAATT AGTCCGAGTG GAGAGAGCGA GCTGAGTGGT 
TGTGTGGTCG CGTCTCGGAA ACCGGTAGCG CTTGCAGCAT GGTTAGCTTT GTACATAGCA 
TCTCACTTTG CACAACAACC CTGCAAGGCT GACCAACTGA CTGAAGAGCA GATTGCAGAA 
TTCAAAGAAG CTTTTTCACT ATTTGACAAA GATGGTGATG GAACTATAAC AACAAAGGAA 
TTGGGAACTG TAATGAGATC TCTTGGGCAG AATCCCACAG AAGCAGAGTT ACAGGACATG 
ATTAATGAAG TAGATGCTGA TGGTAATGGC ACAATTGACT TCCCTGAATT TCTGACAATG 
ATGGCAAGAA AAATGAAAGA CACAGACAGT GAAGAAGAAA TTAGAGAAGC ATTCCGTGTG 
TTTGATAAGG ATGGCAATGG CTATATTAGT GCTGCAGAAC TTCGCCATGT GATGACAAAC 
CTTGGAGAGA AGTTAACAGA TGAAGAAGTT GATGAAATGA TCAGGGAAGC AGATATTGAT 
GGTGATGGTC AAGTAAACTA TGAAGAGTTT GTACAAATGA TGACAGCAAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292553.1
CDS	83..676
Translation	MRRWGRRRRISPSGESELSGCVVASRKPVALAAWLALYIASHFAQQPCKADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_001305624.1
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin 2 (CALM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305624.1

ORF Insert Sequence:

ATGAGGCGCT GGGGGCGGAG GAGGCGAATT AGTCCGAGTG GAGAGAGCGA GCTGAGTGGT 
TGTGTGGTCG CGTCTCGGAA ACCGGTAGCG CTTGCAGCAT GGTTAGCTTT GTACATAGCA 
TCTCACTTTG CACAACAACC CTGCAAGGCT GACCAACTGA CTGAAGAGCA GATTGCAGAA 
TTCAAAGAAG CTTTTTCACT ATTTGACAAA GATGGTGATG GAACTATAAC AACAAAGGAA 
TTGGGAACTG TAATGAGATC TCTTGGGCAG AATCCCACAG AAGCAGAGTT ACAGGACATG 
ATTAATGAAG TAGATGCTGA TGGTAATGGC ACAATTGACT TCCCTGAATT TCTGACAATG 
ATGGCAAGAA AAATGAAAGA CACAGACAGT GAAGAAGAAA TTAGAGAAGC ATTCCGTGTG 
TTTGATAAGG ATGGCAATGG CTATATTAGT GCTGCAGAAC TTCGCCATGT GATGACAAAC 
CTTGGAGAGA AGTTAACAGA TGAAGAAGTT GATGAAATGA TCAGGGAAGC AGATATTGAT 
GGTGATGGTC AAGTAAACTA TGAAGAGTTT GTACAAATGA TGACAGCAAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALM2 ( NM_001305625.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001292554.1 Homo sapiens calmodulin 2 (CALM2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu56609
Clone ID Related Accession (Same CDS sequence)	NM_001305625.1 , NM_001305626.1
Accession Version	NM_001305625.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	calmodulin-2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY108355.1, BC017385.1 and AI873701.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.359172.1, HY108355.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGATCTC TTGGGCAGAA TCCCACAGAA GCAGAGTTAC AGGACATGAT TAATGAAGTA 
GATGCTGATG GTAATGGCAC AATTGACTTC CCTGAATTTC TGACAATGAT GGCAAGAAAA 
ATGAAAGACA CAGACAGTGA AGAAGAAATT AGAGAAGCAT TCCGTGTGTT TGATAAGGAT 
GGCAATGGCT ATATTAGTGC TGCAGAACTT CGCCATGTGA TGACAAACCT TGGAGAGAAG 
TTAACAGATG AAGAAGTTGA TGAAATGATC AGGGAAGCAG ATATTGATGG TGATGGTCAA 
GTAAACTATG AAGAGTTTGT ACAAATGATG ACAGCAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292554.1
CDS	194..535
Translation	MRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_001305625.1
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin 2 (CALM2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305625.1

ORF Insert Sequence:

ATGAGATCTC TTGGGCAGAA TCCCACAGAA GCAGAGTTAC AGGACATGAT TAATGAAGTA 
GATGCTGATG GTAATGGCAC AATTGACTTC CCTGAATTTC TGACAATGAT GGCAAGAAAA 
ATGAAAGACA CAGACAGTGA AGAAGAAATT AGAGAAGCAT TCCGTGTGTT TGATAAGGAT 
GGCAATGGCT ATATTAGTGC TGCAGAACTT CGCCATGTGA TGACAAACCT TGGAGAGAAG 
TTAACAGATG AAGAAGTTGA TGAAATGATC AGGGAAGCAG ATATTGATGG TGATGGTCAA 
GTAAACTATG AAGAGTTTGT ACAAATGATG ACAGCAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALM2 ( NM_001305626.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001292555.1 Homo sapiens calmodulin 2 (CALM2), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu56609
Clone ID Related Accession (Same CDS sequence)	NM_001305625.1 , NM_001305626.1
Accession Version	NM_001305626.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 342bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	calmodulin-2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC073283.8, BC047553.1, BC017385.1 and AI873701.1. Transcript Variant: This variant (4) differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047553.1, SRR1803615.11318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGATCTC TTGGGCAGAA TCCCACAGAA GCAGAGTTAC AGGACATGAT TAATGAAGTA 
GATGCTGATG GTAATGGCAC AATTGACTTC CCTGAATTTC TGACAATGAT GGCAAGAAAA 
ATGAAAGACA CAGACAGTGA AGAAGAAATT AGAGAAGCAT TCCGTGTGTT TGATAAGGAT 
GGCAATGGCT ATATTAGTGC TGCAGAACTT CGCCATGTGA TGACAAACCT TGGAGAGAAG 
TTAACAGATG AAGAAGTTGA TGAAATGATC AGGGAAGCAG ATATTGATGG TGATGGTCAA 
GTAAACTATG AAGAGTTTGT ACAAATGATG ACAGCAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001292555.1
CDS	3549..3890
Translation	MRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Target ORF information:

RefSeq Version	NM_001305626.1
Organism	Homo sapiens(human)
Definition	Homo sapiens calmodulin 2 (CALM2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001305626.1

ORF Insert Sequence:

ATGAGATCTC TTGGGCAGAA TCCCACAGAA GCAGAGTTAC AGGACATGAT TAATGAAGTA 
GATGCTGATG GTAATGGCAC AATTGACTTC CCTGAATTTC TGACAATGAT GGCAAGAAAA 
ATGAAAGACA CAGACAGTGA AGAAGAAATT AGAGAAGCAT TCCGTGTGTT TGATAAGGAT 
GGCAATGGCT ATATTAGTGC TGCAGAACTT CGCCATGTGA TGACAAACCT TGGAGAGAAG 
TTAACAGATG AAGAAGTTGA TGAAATGATC AGGGAAGCAG ATATTGATGG TGATGGTCAA 
GTAAACTATG AAGAGTTTGT ACAAATGATG ACAGCAAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation.
Human molecular genetics26(9)1670-1677(2017 05)
Yamamoto Y,Makiyama T,Harita T,Sasaki K,Wuriyanghai Y,Hayano M,Nishiuchi S,Kohjitani H,Hirose S,Chen J,Yokoi F,Ishikawa T,Ohno S,Chonabayashi K,Motomura H,Yoshida Y,Horie M,Makita N,Kimura T

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Circulation. Arrhythmia and electrophysiology9(8)(2016 Aug)
Gomez-Hurtado N,Boczek NJ,Kryshtal DO,Johnson CN,Sun J,Nitu FR,Cornea RL,Chazin WJ,Calvert ML,Tester DJ,Ackerman MJ,Knollmann BC

Novel calmodulin mutations associated with congenital arrhythmia susceptibility.
Circulation. Cardiovascular genetics7(4)466-74(2014 Aug)
Makita N,Yagihara N,Crotti L,Johnson CN,Beckmann BM,Roh MS,Shigemizu D,Lichtner P,Ishikawa T,Aiba T,Homfray T,Behr ER,Klug D,Denjoy I,Mastantuono E,Theisen D,Tsunoda T,Satake W,Toda T,Nakagawa H,Tsuji Y,Tsuchiya T,Yamamoto H,Miyamoto Y,Endo N,Kimura A,Ozaki K,Motomura H,Suda K,Tanaka T,Schwartz PJ,Meitinger T,K??b S,Guicheney P,Shimizu W,Bhuiyan ZA,Watanabe H,Chazin WJ,George AL Jr

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CALM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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