NCOA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NCOA4
Entrez Gene ID	8031
Full Name	nuclear receptor coactivator 4
Synonyms	ARA70,ELE1,PTC3,RFG
General protein information	Preferred Names nuclear receptor coactivator 4 Names nuclear receptor coactivator 4 70 kDa AR-activator 70 kDa androgen receptor coactivator NCoA-4 RET-activating gene ELE1 androgen receptor-associated protein of 70 kDa ret fused
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q11.22
Summary	This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009].
Disorder MIM:	601984

mRNA and Protein(s)

mRNA	Protein	Name
NM_001145260.1	NP_001138732.1	nuclear receptor coactivator 4 isoform 1
NM_001145262.1	NP_001138734.1	nuclear receptor coactivator 4 isoform 3
NM_001145263.1	NP_001138735.1	nuclear receptor coactivator 4 isoform 3
NM_001145261.1	NP_001138733.1	nuclear receptor coactivator 4 isoform 2
NM_005437.3	NP_005428.1	nuclear receptor coactivator 4 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	NCOA4	NP_001138732.1
Pan troglodytes (chimpanzee)	NCOA4	XP_003312606.1
Bos taurus (cattle)	NCOA4	NP_001069336.1
Mus musculus (house mouse)	Ncoa4	NP_001029160.1
Canis lupus familiaris (dog)	NCOA4	XP_005637547.1
Danio rerio (zebrafish)	ncoa4	NP_957423.1
Xenopus tropicalis (tropical clawed frog)	ncoa4	XP_004919877.1
	NCOA4	XP_001106334.2
Rattus norvegicus (Norway rat)	Ncoa4	NP_001029179.1
Gallus gallus (chicken)	NCOA4	NP_001006495.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4).
Gryzik M, Srivastava A, Longhi G, Bertuzzi M, Gianoncelli A, Carmona F, Poli M, Arosio P
Biochimica et biophysica acta1861(11 Pt A)2710-2716(2017 11)

Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.
Ryu MS, Duck KA, Philpott CC
Blood cells, molecules & diseases(2017 Sep)

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF
Proceedings of the National Academy of Sciences of the United States of America114(38)10107-10112(2017 Sep)

Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.
Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA
Genomics42(2)252-9(1997 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the ATG5-ATG7-NCOA4 autophagic pathway has a role in ferroptosis
Title: Autophagy promotes ferroptosis by degradation of ferritin.

Ubiquitin-dependent NCOA4 turnover is promoted by excess iron and involves an iron-dependent interaction between NCOA4 and the HERC2 ubiquitin ligase.
Title: Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.

provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
Title: Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

RET/PTC3 gene rearrangements are the most prevalent form of rearrangements in papillary thyroid carcinomas of Chennai population.
Title: Prevalence of RET/PTC1 and RET/PTC3 gene rearrangements in Chennai population and its correlation with clinical parameters.

NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
Title: NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.

The following NCOA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NCOA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26076	NM_005437.3 Latest version!	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu26076	NM_001145263.1 Latest version!	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu26076	NM_001145262.1 Latest version!	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu26292	NM_001145260.1 Latest version!	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu26318	NM_001145261.1 Latest version!	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NCOA4 ( NM_001145262.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138734.1 Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu26076
Clone ID Related Accession (Same CDS sequence)	NM_001145262.1 , NM_001145263.1 , NM_005437.3
Accession Version	NM_001145262.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	nuclear receptor coactivator 4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292480.1 and BC012736.2. Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (3) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292480.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138734.1
CDS	230..2074
Translation	MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM

Target ORF information:

RefSeq Version	NM_001145262.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145262.1

ORF Insert Sequence:

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NCOA4 ( NM_001145263.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138735.1 Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu26076
Clone ID Related Accession (Same CDS sequence)	NM_001145262.1 , NM_001145263.1 , NM_005437.3
Accession Version	NM_001145263.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	nuclear receptor coactivator 4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB075100.1, AK312325.1, AK292480.1 and BC012736.2. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. This variant (4) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X77548.1, SRR1660803.153278.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138735.1
CDS	204..2048
Translation	MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM

Target ORF information:

RefSeq Version	NM_001145263.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145263.1

ORF Insert Sequence:

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NCOA4 ( NM_005437.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005428.1 Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 5, mRNA.

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CloneID	OHu26076
Clone ID Related Accession (Same CDS sequence)	NM_001145262.1 , NM_001145263.1 , NM_005437.3
Accession Version	NM_005437.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	nuclear receptor coactivator 4 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA860108.1, AL162047.1 and BC012736.2. On Feb 20, 2009 this sequence version replaced NM_005437.2. Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (5) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL162047.1, SRR1660809.126303.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005428.1
CDS	144..1988
Translation	MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM

Target ORF information:

RefSeq Version	NM_005437.3
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005437.3

ORF Insert Sequence:

ATGAATACCT TCCAAGACCA GAGTGGCAGC TCCAGTAATA GAGAACCCCT TTTGAGGTGT 
AGTGATGCAC GGAGGGACTT GGAGCTTGCT ATTGGTGGAG TTCTCCGGGC TGAACAGCAA 
ATTAAAGATA ACTTGCGAGA GGTCAAAGCT CAGATTCACA GTTGCATAAG CCGTCACCTG 
GAATGTCTTA GAAGCCGTGA GGTATGGCTG TATGAACAGG TGGACCTTAT TTATCAGCTT 
AAAGAGGAGA CACTTCAACA GCAGGCTCAG CAGCTCTACT CGTTATTGGG CCAGTTCAAT 
TGTCTTACTC ATCAACTGGA GTGTACCCAA AACAAAGATC TAGCCAATCA AGTCTCTGTG 
TGCCTGGAGA GACTGGGCAG TTTGACCCTT AAGCCTGAAG ATTCAACTGT CCTGCTCTTT 
GAAGCTGACA CAATTACTCT GCGCCAGACC ATCACCACAT TTGGGTCTCT CAAAACCATT 
CAAATTCCTG AGCACTTGAT GGCTCATGCT AGTTCAGCAA ATATTGGGCC CTTCCTGGAG 
AAGAGAGGCT GTATCTCCAT GCCAGAGCAG AAGTCAGCAT CCGGTATTGT AGCTGTCCCT 
TTCAGCGAAT GGCTCCTTGG AAGCAAACCT GCCAGTGGTT ATCAAGCTCC TTACATACCC 
AGCACCGACC CCCAGGACTG GCTTACCCAA AAGCAGACCT TGGAGAACAG TCAGACTTCT 
TCCAGAGCCT GCAATTTCTT CAATAATGTC GGGGGAAACC TAAAGGGCTT AGAAAACTGG 
CTCCTCAAGA GTGAAAAATC AAGTTATCAA AAGTGTAACA GCCATTCCAC TACTAGTTCT 
TTCTCCATTG AAATGGAAAA GGTTGGAGAT CAAGAGCTTC CTGATCAAGA TGAGATGGAC 
CTATCAGATT GGCTAGTGAC TCCCCAGGAA TCCCATAAGC TGCGGAAGCC TGAGAATGGC 
AGTCGTGAAA CCAGTGAGAA GTTTAAGCTC TTATTCCAGT CCTATAATGT GAATGATTGG 
CTTGTCAAGA CTGACTCCTG TACCAACTGT CAGGGAAACC AGCCCAAAGG TGTGGAGATT 
GAAAACCTGG GCAATCTGAA GTGCCTGAAT GACCACTTGG AGGCCAAGAA ACCATTGTCC 
ACCCCCAGCA TGGTTACAGA GGATTGGCTT GTCCAGAACC ATCAGGACCC ATGTAAGGTA 
GAGGAGGTGT GCAGAGCCAA TGAGCCCTGC ACAAGCTTTG CAGAGTGTGT GTGTGATGAG 
AATTGTGAGA AGGAGGCTCT GTATAAGTGG CTTCTGAAGA AAGAAGGAAA GGATAAAAAT 
GGGATGCCTG TGGAACCCAA ACCTGAGCCT GAGAAGCATA AAGATTCCCT GAATATGTGG 
CTCTGTCCTA GAAAAGAAGT AATAGAACAA ACTAAAGCAC CAAAGGCAAT GACTCCTTCT 
AGAATTGCTG ATTCCTTCCA AGTCATAAAG AACAGCCCCT TGTCGGAGTG GCTTATCAGG 
CCCCCATACA AAGAAGGAAG TCCCAAGGAA GTGCCTGGTA CTGAAGACAG AGCTGGCAAA 
CAGAAGTTTA AAAGCCCCAT GAATACTTCC TGGTGTTCCT TTAACACAGC TGACTGGGTC 
CTGCCAGGAA AGAAGATGGG CAACCTCAGC CAGTTATCTT CTGGAGAAGA CAAGTGGCTG 
CTTCGAAAGA AGGCCCAGGA AGTATTACTT AATTCACCTC TACAGGAGGA ACATAACTTC 
CCCCCAGACC ATTATGGCCT CCCTGCAGTT TGTGATCTCT TTGCCTGTAT GCAGCTTAAA 
GTTGATAAAG AGAAGTGGTT ATATCGAACT CCTCTACAGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NCOA4 ( NM_001145260.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138732.1 Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 1, mRNA.

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CloneID	OHu26292
Clone ID Related Accession (Same CDS sequence)	NM_001145260.1
Accession Version	NM_001145260.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1953bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Homo sapiens(human)
Product	nuclear receptor coactivator 4 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB075100.1, AK310849.1, DA415606.1, AL162047.1 and BC012736.2. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005270177.1, XM_005277656.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK310849.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCCC AGTTGACCAC TTTTGCTCTA GCTGGAGCAG TGAGGAGAAT GAATACCTTC 
CAAGACCAGA GTGGCAGCTC CAGTAATAGA GAACCCCTTT TGAGGTGTAG TGATGCACGG 
AGGGACTTGG AGCTTGCTAT TGGTGGAGTT CTCCGGGCTG AACAGCAAAT TAAAGATAAC 
TTGCGAGAGG TCAAAGCTCA GATTCACAGT TGCATAAGCC GTCACCTGGA ATGTCTTAGA 
AGCCGTGAGG TATGGCTGTA TGAACAGGTG GACCTTATTT ATCAGCTTAA AGAGGAGACA 
CTTCAACAGC AGGCTCAGCA GCTCTACTCG TTATTGGGCC AGTTCAATTG TCTTACTCAT 
CAACTGGAGT GTACCCAAAA CAAAGATCTA GCCAATCAAG TCTCTGTGTG CCTGGAGAGA 
CTGGGCAGTT TGACCCTTAA GCCTGAAGAT TCAACTGTCC TGCTCTTTGA AGCTGACACA 
ATTACTCTGC GCCAGACCAT CACCACATTT GGGTCTCTCA AAACCATTCA AATTCCTGAG 
CACTTGATGG CTCATGCTAG TTCAGCAAAT ATTGGGCCCT TCCTGGAGAA GAGAGGCTGT 
ATCTCCATGC CAGAGCAGAA GTCAGCATCC GGTATTGTAG CTGTCCCTTT CAGCGAATGG 
CTCCTTGGAA GCAAACCTGC CAGTGGTTAT CAAGCTCCTT ACATACCCAG CACCGACCCC 
CAGGACTGGC TTACCCAAAA GCAGACCTTG GAGAACAGTC AGACTTCTTC CAGAGCCTGC 
AATTTCTTCA ATAATGTCGG GGGAAACCTA AAGGGCTTAG AAAACTGGCT CCTCAAGAGT 
GAAAAATCAA GTTATCAAAA GTGTAACAGC CATTCCACTA CTAGTTCTTT CTCCATTGAA 
ATGGAAAAGG TTGGAGATCA AGAGCTTCCT GATCAAGATG AGATGGACCT ATCAGATTGG 
CTAGTGACTC CCCAGGAATC CCATAAGCTG CGGAAGCCTG AGAATGGCAG TCGTGAAACC 
AGTGAGAAGT TTAAGCTCTT ATTCCAGTCC TATAATGTGA ATGATTGGCT TGTCAAGACT 
GACTCCTGTA CCAACTGTCA GGGAAACCAG CCCAAAGGTG TGGAGATTGA AAACCTGGGC 
AATCTGAAGT GCCTGAATGA CCACTTGGAG GCCAAGAAAC CATTGTCCAC CCCCAGCATG 
GTTACAGAGG ATTGGCTTGT CCAGAACCAT CAGGACCCAT GTAAGGTAGA GGAGGTGTGC 
AGAGCCAATG AGCCCTGCAC AAGCTTTGCA GAGTGTGTGT GTGATGAGAA TTGTGAGAAG 
GAGGCTCTGT ATAAGTGGCT TCTGAAGAAA GAAGGAAAGG ATAAAAATGG GATGCCTGTG 
GAACCCAAAC CTGAGCCTGA GAAGCATAAA GATTCCCTGA ATATGTGGCT CTGTCCTAGA 
AAAGAAGTAA TAGAACAAAC TAAAGCACCA AAGGCAATGA CTCCTTCTAG AATTGCTGAT 
TCCTTCCAAG TCATAAAGAA CAGCCCCTTG TCGGAGTGGC TTATCAGGCC CCCATACAAA 
GAAGGAAGTC CCAAGGAAGT GCCTGGTACT GAAGACAGAG CTGGCAAACA GAAGTTTAAA 
AGCCCCATGA ATACTTCCTG GTGTTCCTTT AACACAGCTG ACTGGGTCCT GCCAGGAAAG 
AAGATGGGCA ACCTCAGCCA GTTATCTTCT GGAGAAGACA AGTGGCTGCT TCGAAAGAAG 
GCCCAGGAAG TATTACTTAA TTCACCTCTA CAGGAGGAAC ATAACTTCCC CCCAGACCAT 
TATGGCCTCC CTGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAAGAG 
AAGTGGTTAT ATCGAACTCC TCTACAGGCA TACTTCAAAA TGAACTTTCA AGATGTAACC 
GTTGGGAATT TTCAGATCCC ATGTGGATTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138732.1
CDS	253..2205
Translation	MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQAYFKMNFQDVTVGNFQIPCGF

Target ORF information:

RefSeq Version	NM_001145260.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145260.1

ORF Insert Sequence:

ATGGGGGCCC AGTTGACCAC TTTTGCTCTA GCTGGAGCAG TGAGGAGAAT GAATACCTTC 
CAAGACCAGA GTGGCAGCTC CAGTAATAGA GAACCCCTTT TGAGGTGTAG TGATGCACGG 
AGGGACTTGG AGCTTGCTAT TGGTGGAGTT CTCCGGGCTG AACAGCAAAT TAAAGATAAC 
TTGCGAGAGG TCAAAGCTCA GATTCACAGT TGCATAAGCC GTCACCTGGA ATGTCTTAGA 
AGCCGTGAGG TATGGCTGTA TGAACAGGTG GACCTTATTT ATCAGCTTAA AGAGGAGACA 
CTTCAACAGC AGGCTCAGCA GCTCTACTCG TTATTGGGCC AGTTCAATTG TCTTACTCAT 
CAACTGGAGT GTACCCAAAA CAAAGATCTA GCCAATCAAG TCTCTGTGTG CCTGGAGAGA 
CTGGGCAGTT TGACCCTTAA GCCTGAAGAT TCAACTGTCC TGCTCTTTGA AGCTGACACA 
ATTACTCTGC GCCAGACCAT CACCACATTT GGGTCTCTCA AAACCATTCA AATTCCTGAG 
CACTTGATGG CTCATGCTAG TTCAGCAAAT ATTGGGCCCT TCCTGGAGAA GAGAGGCTGT 
ATCTCCATGC CAGAGCAGAA GTCAGCATCC GGTATTGTAG CTGTCCCTTT CAGCGAATGG 
CTCCTTGGAA GCAAACCTGC CAGTGGTTAT CAAGCTCCTT ACATACCCAG CACCGACCCC 
CAGGACTGGC TTACCCAAAA GCAGACCTTG GAGAACAGTC AGACTTCTTC CAGAGCCTGC 
AATTTCTTCA ATAATGTCGG GGGAAACCTA AAGGGCTTAG AAAACTGGCT CCTCAAGAGT 
GAAAAATCAA GTTATCAAAA GTGTAACAGC CATTCCACTA CTAGTTCTTT CTCCATTGAA 
ATGGAAAAGG TTGGAGATCA AGAGCTTCCT GATCAAGATG AGATGGACCT ATCAGATTGG 
CTAGTGACTC CCCAGGAATC CCATAAGCTG CGGAAGCCTG AGAATGGCAG TCGTGAAACC 
AGTGAGAAGT TTAAGCTCTT ATTCCAGTCC TATAATGTGA ATGATTGGCT TGTCAAGACT 
GACTCCTGTA CCAACTGTCA GGGAAACCAG CCCAAAGGTG TGGAGATTGA AAACCTGGGC 
AATCTGAAGT GCCTGAATGA CCACTTGGAG GCCAAGAAAC CATTGTCCAC CCCCAGCATG 
GTTACAGAGG ATTGGCTTGT CCAGAACCAT CAGGACCCAT GTAAGGTAGA GGAGGTGTGC 
AGAGCCAATG AGCCCTGCAC AAGCTTTGCA GAGTGTGTGT GTGATGAGAA TTGTGAGAAG 
GAGGCTCTGT ATAAGTGGCT TCTGAAGAAA GAAGGAAAGG ATAAAAATGG GATGCCTGTG 
GAACCCAAAC CTGAGCCTGA GAAGCATAAA GATTCCCTGA ATATGTGGCT CTGTCCTAGA 
AAAGAAGTAA TAGAACAAAC TAAAGCACCA AAGGCAATGA CTCCTTCTAG AATTGCTGAT 
TCCTTCCAAG TCATAAAGAA CAGCCCCTTG TCGGAGTGGC TTATCAGGCC CCCATACAAA 
GAAGGAAGTC CCAAGGAAGT GCCTGGTACT GAAGACAGAG CTGGCAAACA GAAGTTTAAA 
AGCCCCATGA ATACTTCCTG GTGTTCCTTT AACACAGCTG ACTGGGTCCT GCCAGGAAAG 
AAGATGGGCA ACCTCAGCCA GTTATCTTCT GGAGAAGACA AGTGGCTGCT TCGAAAGAAG 
GCCCAGGAAG TATTACTTAA TTCACCTCTA CAGGAGGAAC ATAACTTCCC CCCAGACCAT 
TATGGCCTCC CTGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAAGAG 
AAGTGGTTAT ATCGAACTCC TCTACAGGCA TACTTCAAAA TGAACTTTCA AGATGTAACC 
GTTGGGAATT TTCAGATCCC ATGTGGATTC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NCOA4 ( NM_001145261.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001138733.1 Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26318
Clone ID Related Accession (Same CDS sequence)	NM_001145261.1
Accession Version	NM_001145261.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	nuclear receptor coactivator 4 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB075100.1, AK310849.1, DA415606.1, AK304123.1 and BC012736.2. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.250466.1, SRR1660803.134642.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGGCCC AGTTGACCAC TTTTGCTCTA GCTGGAGCAG TGAGGAGAAT GAATACCTTC 
CAAGACCAGA GTGGCAGCTC CAGTAATAGA GAACCCCTTT TGAGGTGTAG TGATGCACGG 
AGGGACTTGG AGCTTGCTAT TGGTGGAGTT CTCCGGGCTG AACAGCAAAT TAAAGATAAC 
TTGCGAGAGG TCAAAGCTCA GATTCACAGT TGCATAAGCC GTCACCTGGA ATGTCTTAGA 
AGCCGTGAGG TATGGCTGTA TGAACAGGTG GACCTTATTT ATCAGCTTAA AGAGGAGACA 
CTTCAACAGC AGGCTCAGCA GCTCTACTCG TTATTGGGCC AGTTCAATTG TCTTACTCAT 
CAACTGGAGT GTACCCAAAA CAAAGATCTA GCCAATCAAG TCTCTGTGTG CCTGGAGAGA 
CTGGGCAGTT TGACCCTTAA GCCTGAAGAT TCAACTGTCC TGCTCTTTGA AGCTGACACA 
ATTACTCTGC GCCAGACCAT CACCACATTT GGGTCTCTCA AAACCATTCA AATTCCTGAG 
CACTTGATGG CTCATGCTAG TTCAGCAAAT ATTGGGCCCT TCCTGGAGAA GAGAGGCTGT 
ATCTCCATGC CAGAGCAGAA GTCAGCATCC GGTATTGTAG CTGTCCCTTT CAGCGAATGG 
CTCCTTGGAA GCAAACCTGC CAGTGGTTAT CAAGCTCCTT ACATACCCAG CACCGACCCC 
CAGGACTGGC TTACCCAAAA GCAGACCTTG GAGAACAGTC AGACTTCTTC CAGAGCCTGC 
AATTTCTTCA ATAATGTCGG GGGAAACCTA AAGGGCTTAG AAAACTGGCT CCTCAAGAGT 
GAAAAATCAA GTTATCAAAA GTGTAACAGC CATTCCACTA CTAGTTCTTT CTCCATTGAA 
ATGGAAAAGG TTGGAGATCA AGAGCTTCCT GATCAAGATG AGATGGACCT ATCAGATTGG 
CTAGTGACTC CCCAGGAATC CCATAAGCTG CGGAAGCCTG AGAATGGCAG TCGTGAAACC 
AGTGAGAAGT TTAAGCTCTT ATTCCAGTCC TATAATGTGA ATGATTGGCT TGTCAAGACT 
GACTCCTGTA CCAACTGTCA GGGAAACCAG CCCAAAGGTG TGGAGATTGA AAACCTGGGC 
AATCTGAAGT GCCTGAATGA CCACTTGGAG GCCAAGAAAC CATTGTCCAC CCCCAGCATG 
GTTACAGAGG ATTGGCTTGT CCAGAACCAT CAGGACCCAT GTAAGGTAGA GGAGGTGTGC 
AGAGCCAATG AGCCCTGCAC AAGCTTTGCA GAGTGTGTGT GTGATGAGAA TTGTGAGAAG 
GAGGCTCTGT ATAAGTGGCT TCTGAAGAAA GAAGGAAAGG ATAAAAATGG GATGCCTGTG 
GAACCCAAAC CTGAGCCTGA GAAGCATAAA GATTCCCTGA ATATGTGGCT CTGTCCTAGA 
AAAGAAGTAA TAGAACAAAC TAAAGCACCA AAGGCAATGA CTCCTTCTAG AATTGCTGAT 
TCCTTCCAAG TCATAAAGAA CAGCCCCTTG TCGGAGTGGC TTATCAGGCC CCCATACAAA 
GAAGGAAGTC CCAAGGAAGT GCCTGGTACT GAAGACAGAG CTGGCAAACA GAAGTTTAAA 
AGCCCCATGA ATACTTCCTG GTGTTCCTTT AACACAGCTG ACTGGGTCCT GCCAGGAAAG 
AAGATGGGCA ACCTCAGCCA GTTATCTTCT GGAGAAGACA AGTGGCTGCT TCGAAAGAAG 
GCCCAGGAAG TATTACTTAA TTCACCTCTA CAGGAGGAAC ATAACTTCCC CCCAGACCAT 
TATGGCCTCC CTGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAAGAG 
AAGTGGTTAT ATCGAACTCC TCTACAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001138733.1
CDS	253..2145
Translation	MGAQLTTFALAGAVRRMNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM

Target ORF information:

RefSeq Version	NM_001145261.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear receptor coactivator 4 (NCOA4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145261.1

ORF Insert Sequence:

ATGGGGGCCC AGTTGACCAC TTTTGCTCTA GCTGGAGCAG TGAGGAGAAT GAATACCTTC 
CAAGACCAGA GTGGCAGCTC CAGTAATAGA GAACCCCTTT TGAGGTGTAG TGATGCACGG 
AGGGACTTGG AGCTTGCTAT TGGTGGAGTT CTCCGGGCTG AACAGCAAAT TAAAGATAAC 
TTGCGAGAGG TCAAAGCTCA GATTCACAGT TGCATAAGCC GTCACCTGGA ATGTCTTAGA 
AGCCGTGAGG TATGGCTGTA TGAACAGGTG GACCTTATTT ATCAGCTTAA AGAGGAGACA 
CTTCAACAGC AGGCTCAGCA GCTCTACTCG TTATTGGGCC AGTTCAATTG TCTTACTCAT 
CAACTGGAGT GTACCCAAAA CAAAGATCTA GCCAATCAAG TCTCTGTGTG CCTGGAGAGA 
CTGGGCAGTT TGACCCTTAA GCCTGAAGAT TCAACTGTCC TGCTCTTTGA AGCTGACACA 
ATTACTCTGC GCCAGACCAT CACCACATTT GGGTCTCTCA AAACCATTCA AATTCCTGAG 
CACTTGATGG CTCATGCTAG TTCAGCAAAT ATTGGGCCCT TCCTGGAGAA GAGAGGCTGT 
ATCTCCATGC CAGAGCAGAA GTCAGCATCC GGTATTGTAG CTGTCCCTTT CAGCGAATGG 
CTCCTTGGAA GCAAACCTGC CAGTGGTTAT CAAGCTCCTT ACATACCCAG CACCGACCCC 
CAGGACTGGC TTACCCAAAA GCAGACCTTG GAGAACAGTC AGACTTCTTC CAGAGCCTGC 
AATTTCTTCA ATAATGTCGG GGGAAACCTA AAGGGCTTAG AAAACTGGCT CCTCAAGAGT 
GAAAAATCAA GTTATCAAAA GTGTAACAGC CATTCCACTA CTAGTTCTTT CTCCATTGAA 
ATGGAAAAGG TTGGAGATCA AGAGCTTCCT GATCAAGATG AGATGGACCT ATCAGATTGG 
CTAGTGACTC CCCAGGAATC CCATAAGCTG CGGAAGCCTG AGAATGGCAG TCGTGAAACC 
AGTGAGAAGT TTAAGCTCTT ATTCCAGTCC TATAATGTGA ATGATTGGCT TGTCAAGACT 
GACTCCTGTA CCAACTGTCA GGGAAACCAG CCCAAAGGTG TGGAGATTGA AAACCTGGGC 
AATCTGAAGT GCCTGAATGA CCACTTGGAG GCCAAGAAAC CATTGTCCAC CCCCAGCATG 
GTTACAGAGG ATTGGCTTGT CCAGAACCAT CAGGACCCAT GTAAGGTAGA GGAGGTGTGC 
AGAGCCAATG AGCCCTGCAC AAGCTTTGCA GAGTGTGTGT GTGATGAGAA TTGTGAGAAG 
GAGGCTCTGT ATAAGTGGCT TCTGAAGAAA GAAGGAAAGG ATAAAAATGG GATGCCTGTG 
GAACCCAAAC CTGAGCCTGA GAAGCATAAA GATTCCCTGA ATATGTGGCT CTGTCCTAGA 
AAAGAAGTAA TAGAACAAAC TAAAGCACCA AAGGCAATGA CTCCTTCTAG AATTGCTGAT 
TCCTTCCAAG TCATAAAGAA CAGCCCCTTG TCGGAGTGGC TTATCAGGCC CCCATACAAA 
GAAGGAAGTC CCAAGGAAGT GCCTGGTACT GAAGACAGAG CTGGCAAACA GAAGTTTAAA 
AGCCCCATGA ATACTTCCTG GTGTTCCTTT AACACAGCTG ACTGGGTCCT GCCAGGAAAG 
AAGATGGGCA ACCTCAGCCA GTTATCTTCT GGAGAAGACA AGTGGCTGCT TCGAAAGAAG 
GCCCAGGAAG TATTACTTAA TTCACCTCTA CAGGAGGAAC ATAACTTCCC CCCAGACCAT 
TATGGCCTCC CTGCAGTTTG TGATCTCTTT GCCTGTATGC AGCTTAAAGT TGATAAAGAG 
AAGTGGTTAT ATCGAACTCC TCTACAGATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4).
Biochimica et biophysica acta1861(11 Pt A)2710-2716(2017 11)
Gryzik M,Srivastava A,Longhi G,Bertuzzi M,Gianoncelli A,Carmona F,Poli M,Arosio P

Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells.
Blood cells, molecules & diseases(2017 Sep)
Ryu MS,Duck KA,Philpott CC

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America114(38)10107-10112(2017 Sep)
Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF

Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas.
Genomics42(2)252-9(1997 Jun)
Bongarzone I,Butti MG,Fugazzola L,Pacini F,Pinchera A,Vorontsova TV,Demidchik EP,Pierotti MA

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NCOA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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