MUS81 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MUS81
Entrez Gene ID	80198
Full Name	MUS81 structure-specific endonuclease subunit
Synonyms	SLX3
General protein information	Preferred Names MUS81 structure-specific endonuclease subunit Names crossover junction endonuclease MUS81 MUS81 endonuclease homolog SLX3 structure-specific endonuclease subunit homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.1
Summary	This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017].
Disorder MIM:	606591

mRNA and Protein(s)

mRNA	Protein	Name
NM_025128.4	NP_079404.3	crossover junction endonuclease MUS81 isoform 2
NM_001350283.1	NP_001337212.1	crossover junction endonuclease MUS81 isoform 1
XM_005274307.2	XP_005274364.1	crossover junction endonuclease MUS81 isoform X1
XM_011545270.1	XP_011543572.1	crossover junction endonuclease MUS81 isoform X2
NM_001350283.2	NP_001337212.1	crossover junction endonuclease MUS81 isoform 1
NM_025128.5	NP_079404.3	crossover junction endonuclease MUS81 isoform 2
XM_011545269.1	XP_011543571.1	crossover junction endonuclease MUS81 isoform X1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008836	XP_319580.4
Pan troglodytes (chimpanzee)	MUS81	XP_522066.4
	MUS81	XP_001112824.1
Rattus norvegicus (Norway rat)	Mus81	NP_001020816.1
Eremothecium gossypii	AGOS_AFR141C	NP_985688.1
Magnaporthe oryzae (rice blast fungus)	MGG_04585	XP_003713609.1
Xenopus tropicalis (tropical clawed frog)	mus81	NP_001011004.1
Canis lupus familiaris (dog)	MUS81	XP_533230.2
Mus musculus (house mouse)	Mus81	NP_082153.3
Danio rerio (zebrafish)	mus81	NP_998683.1
Schizosaccharomyces pombe (fission yeast)	mus81	XP_001713161.1
Bos taurus (cattle)	MUS81	NP_001039756.1
Drosophila melanogaster (fruit fly)	mus81	NP_569873.1
Saccharomyces cerevisiae (baker's yeast)	MUS81	NP_010674.3
Kluyveromyces lactis	KLLA0E03015g	XP_454081.1
Neurospora crassa	NCU07457	XP_963908.1
Homo sapiens (human)	MUS81	NP_079404.3

Gene Ontology
Bibliography

Related articles in PubMed

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Rondinelli B, Gogola E, Y?cel H, Duarte AA, van de Ven M, van der Sluijs R, Konstantinopoulos PA, Jonkers J, Ceccaldi R, Rottenberg S, D'Andrea AD
Nature cell biology19(11)1371-1378(2017 Nov)

RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, H?hn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P
Molecular cell66(5)658-671.e8(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Low EZH2 or MUS81 expression levels predict chemoresistance.
Title: EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.

RECQ5 removes RAD51 filaments stabilizing stalled replication forks at common fragile sites and hence facilitates CFS cleavage by MUS81-EME1.
Title: RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.

Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81-EME1 resolving enzyme complex. (GEN1 = Holliday junction 5' flap endonuclease; SLX = structure-specific endonuclease subunit; MUS81 = MUS81 endonuclease; EME1 = essential meiotic endonuclease 1) [REVIEW]
Title: Holliday junction-resolving enzymes-structures and mechanisms.

Mus81 sumoylation is important for normal mitotic chromosome congression.
Title: Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability.

Data suggest that the ATM/Chk2 may promote the repair of DNA damage caused by cisplatin by sustaining methyl methanesulfonate and ultraviolet-sensitive gene clone 81, and the double-strand breaks generated by methyl methanesulfonate and ultraviolet-sensitive gene clone 81 may activate the ATM/Chk2 pathway.
Title: Feedback regulation of methyl methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin.

The following MUS81 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MUS81 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16482	NM_025128.5 Latest version!	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu45525	NM_001350283.2 Latest version!	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu16482	XM_011545270.1 Latest version!	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu45525	XM_005274307.2 Latest version!	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu45525	XM_011545269.1 Latest version!	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu45525	NM_001350283.1	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu16482	NM_025128.4	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MUS81 ( NM_025128.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079404.3 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16482
Clone ID Related Accession (Same CDS sequence)	NM_025128.4 , XM_011545270.1 , NM_025128.5
Accession Version	NM_025128.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA449863.1, AK223564.1, BC009999.2 and BI816797.1. This sequence is a reference standard in the RefSeqGene project. On Aug 22, 2007 this sequence version replaced NM_025128.3. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.200396.1, BC009999.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079404.3
CDS	354..2009
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	NM_025128.4
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025128.4

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( NM_025128.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_079404.3 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16482
Clone ID Related Accession (Same CDS sequence)	NM_025128.4 , XM_011545270.1 , NM_025128.5
Accession Version	NM_025128.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA449863.1, AK223564.1, BC009999.2 and BI816797.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_025128.4. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.119500.1, SRR1660809.200396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308110.9/ ENSP00000307853.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079404.3
CDS	322..1977
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	NM_025128.5
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025128.5

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( NM_001350283.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001337212.1 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu45525
Clone ID Related Accession (Same CDS sequence)	NM_001350283.1 , XM_005274307.2 , NM_001350283.2 , XM_011545269.1
Accession Version	NM_001350283.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA449863.1, AK223564.1, BC009999.2, CR989527.1 and BI816797.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.116860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001337212.1
CDS	354..2012
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	NM_001350283.1
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001350283.1

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( NM_001350283.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001337212.1 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.

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CloneID	OHu45525
Clone ID Related Accession (Same CDS sequence)	NM_001350283.1 , XM_005274307.2 , NM_001350283.2 , XM_011545269.1
Accession Version	NM_001350283.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA449863.1, AK223564.1, BC009999.2, CR989527.1 and BI816797.1. On May 31, 2019 this sequence version replaced NM_001350283.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.820893.1, SRR1660805.116860.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001337212.1
CDS	322..1980
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	NM_001350283.2
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001350283.2

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( XM_011545270.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543572.1 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X2, mRNA.

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CloneID	OHu16482
Clone ID Related Accession (Same CDS sequence)	NM_025128.4 , XM_011545270.1 , NM_025128.5
Accession Version	XM_011545270.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543572.1
CDS	169..1824
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	XM_011545270.1
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545270.1

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAAACCCTG GGGAGTTGGT ACTGGATCAC ATTGTGGAGC GCAAGCGACT GGATGACCTT 
TGCAGCAGCA TCATCGACGG CCGCTTCCGG GAGCAGAAGT TCCGGCTGAA GCGCTGTGGT 
CTGGAGCGCC GGGTATACCT GGTGGAAGAG CATGGTTCCG TCCACAACCT CAGCCTTCCT 
GAGAGCACAC TGCTGCAGGC TGTCACCAAC ACTCAGGTCA TTGATGGCTT TTTTGTGAAG 
CGCACAGCAG ACATTAAGGA GTCAGCCGCC TACCTGGCCC TCTTGACGCG GGGCCTGCAG 
AGACTCTACC AGGGCCACAC CCTACGCAGC CGCCCCTGGG GAACCCCTGG GAACCCTGAA 
TCAGGGGCCA TGACCTCTCC AAACCCTCTC TGCTCACTCC TCACCTTCAG TGACTTCAAC 
GCAGGAGCCA TCAAGAATAA GGCCCAGTCG GTGCGAGAAG TGTTTGCCCG GCAGCTGATG 
CAGGTGCGCG GAGTGAGTGG GGAGAAGGCA GCAGCCCTGG TGGATCGATA CAGCACCCCT 
GCCAGCCTCC TGGCCGCCTA TGATGCCTGT GCCACCCCCA AGGAACAAGA GACACTGCTG 
AGCACCATTA AGTGTGGGCG TCTACAGAGG AATCTGGGGC CTGCTCTGAG CAGGACCTTA 
TCCCAGCTCT ACTGCAGCTA CGGCCCCTTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( XM_005274307.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005274364.1 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X3, mRNA.

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CloneID	OHu45525
Clone ID Related Accession (Same CDS sequence)	NM_001350283.1 , XM_005274307.2 , NM_001350283.2 , XM_011545269.1
Accession Version	XM_005274307.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005274307.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005274364.1
CDS	352..2010
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	XM_005274307.2
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005274307.2

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MUS81 ( XM_011545269.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011543571.1 Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu45525
Clone ID Related Accession (Same CDS sequence)	NM_001350283.1 , XM_005274307.2 , NM_001350283.2 , XM_011545269.1
Accession Version	XM_011545269.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1659bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	crossover junction endonuclease MUS81 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011543571.1
CDS	169..1827
Translation	MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPAANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Target ORF information:

RefSeq Version	XM_011545269.1
Organism	Homo sapiens(human)
Definition	Homo sapiens MUS81 structure-specific endonuclease subunit (MUS81), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011545269.1

ORF Insert Sequence:

ATGGCGGCCC CGGTCCGCCT GGGCCGGAAG CGCCCGCTGC CTGCCTGTCC CAACCCGCTC 
TTCGTTCGCT GGCTGACCGA GTGGCGGGAC GAGGCGACCC GCAGCAGGCG CCGCACGCGC 
TTCGTATTTC AGAAGGCGCT GCGTTCCCTC CGACGGTACC CACTGCCGCT GCGCAGCGGG 
AAGGAAGCTA AGATCCTACA GCACTTCGGA GACGGGCTCT GCCGGATGCT GGACGAGCGG 
CTGCAGCGGC ACCGAACATC GGGCGGTGAC CATGCCCCGG ACTCACCATC TGGAGAGAAC 
AGTCCAGCCC CGCAGGGGCG ACTTGCGGAA GTCCAGGACT CTTCCATGCC AGTTCCTGCC 
CAGCCCAAAG CGGGAGGCTC TGGCAGCTAC TGGCCAGCTC GGCACTCAGG AGCCCGAGTG 
ATACTGCTGG TGCTCTACCG GGAGCACCTG AATCCTAATG GTCACCACTT CTTAACCAAG 
GAGGAGCTGC TGCAGAGGTG TGCTCAGAAG TCCCCCAGGG TAGCCCCTGG GAGTGCTCGA 
CCCTGGCCAG CCCTCCGCTC CCTCCTTCAC AGGAACCTGG TCCTCAGGAC ACACCAGCCA 
GCCAGGTACT CATTGACCCC AGAGGGCCTG GAGCTGGCCC AGAAGTTGGC CGAGTCAGAA 
GGCCTGAGCT TGCTGAATGT GGGCATCGGG CCCAAGGAGC CCCCTGGGGA GGAGACAGCA 
GTGCCAGGAG CAGCTTCAGC AGAGCTTGCC AGTGAAGCAG GGGTCCAGCA GCAGCCACTG 
GAGCTGAGGC CTGGAGAGTA CAGGGTGCTG TTGTGTGTGG ACATTGGCGA GACCCGGGGG 
GGCGGGCACA GGCCGGAGCT GCTCCGAGAG CTACAGCGGC TGCACGTGAC CCACACGGTG 
CGCAAGCTGC ACGTTGGAGA TTTTGTGTGG GTGGCCCAGG AGACCAATCC TAGAGACCCA 
GCAGCAAACC CTGGGGAGTT GGTACTGGAT CACATTGTGG AGCGCAAGCG ACTGGATGAC 
CTTTGCAGCA GCATCATCGA CGGCCGCTTC CGGGAGCAGA AGTTCCGGCT GAAGCGCTGT 
GGTCTGGAGC GCCGGGTATA CCTGGTGGAA GAGCATGGTT CCGTCCACAA CCTCAGCCTT 
CCTGAGAGCA CACTGCTGCA GGCTGTCACC AACACTCAGG TCATTGATGG CTTTTTTGTG 
AAGCGCACAG CAGACATTAA GGAGTCAGCC GCCTACCTGG CCCTCTTGAC GCGGGGCCTG 
CAGAGACTCT ACCAGGGCCA CACCCTACGC AGCCGCCCCT GGGGAACCCC TGGGAACCCT 
GAATCAGGGG CCATGACCTC TCCAAACCCT CTCTGCTCAC TCCTCACCTT CAGTGACTTC 
AACGCAGGAG CCATCAAGAA TAAGGCCCAG TCGGTGCGAG AAGTGTTTGC CCGGCAGCTG 
ATGCAGGTGC GCGGAGTGAG TGGGGAGAAG GCAGCAGCCC TGGTGGATCG ATACAGCACC 
CCTGCCAGCC TCCTGGCCGC CTATGATGCC TGTGCCACCC CCAAGGAACA AGAGACACTG 
CTGAGCACCA TTAAGTGTGG GCGTCTACAG AGGAATCTGG GGCCTGCTCT GAGCAGGACC 
TTATCCCAGC TCTACTGCAG CTACGGCCCC TTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.
Nature cell biology19(11)1371-1378(2017 Nov)
Rondinelli B,Gogola E,Y?cel H,Duarte AA,van de Ven M,van der Sluijs R,Konstantinopoulos PA,Jonkers J,Ceccaldi R,Rottenberg S,D'Andrea AD

RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
Molecular cell66(5)658-671.e8(2017 Jun)
Di Marco S,Hasanova Z,Kanagaraj R,Chappidi N,Altmannova V,Menon S,Sedlackova H,Langhoff J,Surendranath K,H?hn D,Bhowmick R,Marini V,Ferrari S,Hickson ID,Krejci L,Janscak P

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MUS81 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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