CLMP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CLMP
Entrez Gene ID	79827
Full Name	CXADR like membrane protein
Synonyms	ACAM,ASAM,CSBM,CSBS
General protein information	Preferred Names CXADR like membrane protein Names CXADR-like membrane protein CAR-like membrane protein adipocyte-specific adhesion molecule coxsackie- and adenovirus receptor-like membrane protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q24.1
Summary	This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015].
Disorder MIM:	611693
Disorder Html:	Congenital short bowel syndrome, 615237 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_024769.4	NP_079045.1	CXADR-like membrane protein precursor
XM_011542998.2	XP_011541300.1	CXADR-like membrane protein isoform X1
NM_024769.3	NP_079045.1	CXADR-like membrane protein precursor
NM_024769.5	NP_079045.1	CXADR-like membrane protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLMP	NP_079045.1
	CLMP	XP_001108111.1
Danio rerio (zebrafish)	LOC567179	XP_695564.4
Xenopus tropicalis (tropical clawed frog)	clmp	NP_001008177.1
Pan troglodytes (chimpanzee)	CLMP	XP_001136596.2
Gallus gallus (chicken)	CLMP	XP_417886.3
Mus musculus (house mouse)	Clmp	NP_598494.2
Danio rerio (zebrafish)	LOC100330877	XP_003200539.2
Canis lupus familiaris (dog)	CLMP	XP_005619706.1
Rattus norvegicus (Norway rat)	Clmp	NP_775177.1
Bos taurus (cattle)	CLMP	NP_001091512.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells.
Sharma A, Xu Y, Sung B, Vincent CT, Worgall T, Worgall S
Cellular microbiology19(2)(2017 Feb)

Two new mutations of the CLMP gene identified in a newborn presenting congenital short-bowel syndrome.
Gonnaud L, Alves MM, Cremillieux C, Billiemaz K, Destombe S, Varlet F, Lopez M, Trapes L, Touraine R, Hofstra RM, Patural H
Clinics and research in hepatology and gastroenterology40(6)e65-e67(2016 Dec)

Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder.
Alves MM, Halim D, Maroofian R, de Graaf BM, Rooman R, van der Werf CS, Van de Vijver E, Mehrjardi MY, Aflatoonian M, Chioza BA, Baple EL, Dehghani M, Crosby AH, Hofstra RM
European journal of human genetics : EJHG24(11)1627-1629(2016 11)

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J
Journal of cell science126(Pt 3)825-37(2013 Feb)

CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development.
van der Werf CS, Hsiao NH, Conroy S, Paredes J, Ribeiro AS, Sribudiani Y, Seruca R, Hofstra RM, Westers H, van Ijzendoorn SC
PloS one8(2)e54649(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of CFTR or histone deacetylase (HDAC) enhanced CAR expression while CFTR overexpression or restoration of the diminished HDAC activity in cystic fibrosis cells reduced CAR expression.
Title: Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells.

We describe a newborn presenting CSBS intestinal malrotation and chronic intestinal pseudo-obstruction syndrome (CIPS), compound heterozygous for two previously unreported heterozygous mutations in Coxsackie and adenovirus receptor-like membrane protein (CLMP) gene. We identified two heterozygous mutations in CLMP, one in intron 1 (c.28+1G>C) from the father, the other on exon 4 (c502C>T, p.R168X) from the mother.
Title: Two new mutations of the CLMP gene identified in a newborn presenting congenital short-bowel syndrome.

Novel inherited variants in CLMP were identified in three congenital short bowel syndrome patients derived from two unrelated families.
Title: Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder.

The key processes involved in intestinal epithelial development appear to be unaffected by wild type-CLMP or mutant-CLMP.
Title: CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development.

Coxsackievirus and adenovirus receptor gene expression is induced in esophageal cancer cells by the HDAC inhibitor trichostatin A.
Title: Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer.

The following CLMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04235	NM_024769.5 Latest version!	Homo sapiens CXADR like membrane protein (CLMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu72238	XM_011542998.2 Latest version!	Homo sapiens CXADR-like membrane protein (CLMP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu04235	NM_024769.3	Homo sapiens CXADR like membrane protein (CLMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu04235	NM_024769.4	Homo sapiens CXADR like membrane protein (CLMP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CLMP ( NM_024769.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_079045.1 Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Price & Availability↑

CloneID	OHu04235
Clone ID Related Accession (Same CDS sequence)	NM_024769.4 , NM_024769.3 , NM_024769.5
Accession Version	NM_024769.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	CXADR-like membrane protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG723094.1, AK304843.1, BC009371.2, DA394034.1 and AP000926.6. On Nov 23, 2018 this sequence version replaced NM_024769.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.85527.1, SRR1803615.73459.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079045.1
CDS	309..1430
Translation	MSLLLLLLLVSYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGSEPKKVHHANLTKAETTPSMIPSQSRAFQTV

Target ORF information:

RefSeq Version	NM_024769.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024769.4

ORF Insert Sequence:

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLMP ( NM_024769.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_079045.1 Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Price & Availability↑

CloneID	OHu04235
Clone ID Related Accession (Same CDS sequence)	NM_024769.4 , NM_024769.3 , NM_024769.5
Accession Version	NM_024769.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	CXADR-like membrane protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG723094.1, AK304843.1, BC009371.2 and DA394034.1. This sequence is a reference standard in the RefSeqGene project. On Aug 14, 2015 this sequence version replaced NM_024769.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.73459.1, SRR1803617.85527.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079045.1
CDS	366..1487
Translation	MSLLLLLLLVSYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGSEPKKVHHANLTKAETTPSMIPSQSRAFQTV

Target ORF information:

RefSeq Version	NM_024769.3
Organism	Homo sapiens(human)
Definition	Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024769.3

ORF Insert Sequence:

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLMP ( NM_024769.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_079045.1 Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Price & Availability↑

CloneID	OHu04235
Clone ID Related Accession (Same CDS sequence)	NM_024769.4 , NM_024769.3 , NM_024769.5
Accession Version	NM_024769.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	CXADR-like membrane protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP001970.3 and AP000926.6. On Aug 31, 2019 this sequence version replaced NM_024769.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.85527.1, BK001245.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000448775.4/ ENSP00000405577.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079045.1
CDS	309..1430
Translation	MSLLLLLLLVSYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQYVQSIGMVAGAVTGIVAGALLIFLLVWLLIRRKDKERYEEEERPNEIREDAEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDAAPQPGLATQAYSLVGPEVRGSEPKKVHHANLTKAETTPSMIPSQSRAFQTV

Target ORF information:

RefSeq Version	NM_024769.5
Organism	Homo sapiens(human)
Definition	Homo sapiens CXADR like membrane protein (CLMP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024769.5

ORF Insert Sequence:

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA TGTACAAAGC ATCGGCATGG TTGCAGGAGC AGTGACAGGC 
ATAGTGGCTG GAGCCCTGCT GATTTTCCTC TTGGTGTGGC TGCTAATCCG AAGGAAAGAC 
AAAGAAAGAT ATGAGGAAGA AGAGAGACCT AATGAAATTC GAGAAGATGC TGAAGCTCCA 
AAAGCCCGTC TTGTGAAACC CAGCTCCTCT TCCTCAGGCT CTCGGAGCTC ACGCTCTGGT 
TCTTCCTCCA CTCGCTCCAC AGCAAATAGT GCCTCACGCA GCCAGCGGAC ACTGTCAACT 
GACGCAGCAC CCCAGCCAGG GCTGGCCACC CAGGCATACA GCCTAGTGGG GCCAGAGGTG 
AGAGGTTCTG AACCAAAGAA AGTCCACCAT GCTAATCTGA CCAAAGCAGA AACCACACCC 
AGCATGATCC CCAGCCAGAG CAGAGCCTTC CAAACGGTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CLMP ( XM_011542998.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541300.1 Homo sapiens CXADR-like membrane protein (CLMP), transcript variant X1, mRNA.

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CloneID	OHu72238
Clone ID Related Accession (Same CDS sequence)	XM_011542998.2
Accession Version	XM_011542998.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	CXADR-like membrane protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011542998.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541300.1
CDS	334..1014
Translation	MSLLLLLLLVSYYVGTLGTHTEIKRVAEEKVTLPCHHQLGLPEKDTLDIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVILKVLVRPSKPKCELEGELTEGSDLTLQCESSSGTEPIVYYWQRIREKEGEDERLPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCVVRVTVQ

Target ORF information:

RefSeq Version	XM_011542998.2
Organism	Homo sapiens(human)
Definition	Homo sapiens CXADR-like membrane protein (CLMP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011542998.2

ORF Insert Sequence:

ATGTCCCTCC TCCTTCTCCT CTTGCTAGTT TCCTACTATG TTGGAACCTT GGGGACTCAC 
ACTGAGATCA AGAGAGTGGC AGAGGAAAAG GTCACTTTGC CCTGCCACCA TCAACTGGGG 
CTTCCAGAAA AAGACACTCT GGATATTGAA TGGCTGCTCA CCGATAATGA AGGGAACCAA 
AAAGTGGTGA TCACTTACTC CAGTCGTCAT GTCTACAATA ACTTGACTGA GGAACAGAAG 
GGCCGAGTGG CCTTTGCTTC CAATTTCCTG GCAGGAGATG CCTCCTTGCA GATTGAACCT 
CTGAAGCCCA GTGATGAGGG CCGGTACACC TGTAAGGTTA AGAATTCAGG GCGCTACGTG 
TGGAGCCATG TCATCTTAAA AGTCTTAGTG AGACCATCCA AGCCCAAGTG TGAGTTGGAA 
GGAGAGCTGA CAGAAGGAAG TGACCTGACT TTGCAGTGTG AGTCATCCTC TGGCACAGAG 
CCCATTGTGT ATTACTGGCA GCGAATCCGA GAGAAAGAGG GAGAGGATGA ACGTCTGCCT 
CCCAAATCTA GGATTGACTA CAACCACCCT GGACGAGTTC TGCTGCAGAA TCTTACCATG 
TCCTACTCTG GACTGTACCA GTGCACAGCA GGCAACGAAG CTGGGAAGGA AAGCTGTGTG 
GTGCGAGTAA CTGTACAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of the Coxsackie and adenovirus receptor expression is dependent on cystic fibrosis transmembrane regulator in airway epithelial cells.
Cellular microbiology19(2)(2017 Feb)
Sharma A,Xu Y,Sung B,Vincent CT,Worgall T,Worgall S

Two new mutations of the CLMP gene identified in a newborn presenting congenital short-bowel syndrome.
Clinics and research in hepatology and gastroenterology40(6)e65-e67(2016 Dec)
Gonnaud L,Alves MM,Cremillieux C,Billiemaz K,Destombe S,Varlet F,Lopez M,Trapes L,Touraine R,Hofstra RM,Patural H

Genetic screening of Congenital Short Bowel Syndrome patients confirms CLMP as the major gene involved in the recessive form of this disorder.
European journal of human genetics : EJHG24(11)1627-1629(2016 11)
Alves MM,Halim D,Maroofian R,de Graaf BM,Rooman R,van der Werf CS,Van de Vijver E,Mehrjardi MY,Aflatoonian M,Chioza BA,Baple EL,Dehghani M,Crosby AH,Hofstra RM

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Journal of cell science126(Pt 3)825-37(2013 Feb)
Fong KW,Leung JW,Li Y,Wang W,Feng L,Ma W,Liu D,Songyang Z,Chen J

CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development.
PloS one8(2)e54649(2013)
van der Werf CS,Hsiao NH,Conroy S,Paredes J,Ribeiro AS,Sribudiani Y,Seruca R,Hofstra RM,Westers H,van Ijzendoorn SC

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CLMP cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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