AAGAB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AAGAB
Entrez Gene ID	79719
Full Name	alpha and gamma adaptin binding protein
Synonyms	KPPP1,PPKP1,PPKP1A,p34
General protein information	Preferred Names alpha and gamma adaptin binding protein Names alpha- and gamma-adaptin-binding protein p34
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q23
Summary	The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Disorder MIM:	614888
Disorder Html:	Keratoderma, palmoplantar, punctate type IA, 148600 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024450052.1	XP_024305820.1	alpha- and gamma-adaptin-binding protein p34 isoform X2
NM_024666.5	NP_078942.3	alpha- and gamma-adaptin-binding protein p34 isoform 1
NM_024666.4	NP_078942.3	alpha- and gamma-adaptin-binding protein p34 isoform 1
XM_011522020.1	XP_011520322.1	alpha- and gamma-adaptin-binding protein p34 isoform X1
XM_024450053.1	XP_024305821.1	alpha- and gamma-adaptin-binding protein p34 isoform X3
NM_001271885.1	NP_001258814.1	alpha- and gamma-adaptin-binding protein p34 isoform 2
NM_001271886.1	NP_001258815.1	alpha- and gamma-adaptin-binding protein p34 isoform 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	AAGAB	NP_078942.3
Pan troglodytes (chimpanzee)	AAGAB	XP_001174780.1
	LOC711436	XP_001111371.2
Canis lupus familiaris (dog)	AAGAB	XP_853575.3
Bos taurus (cattle)	AAGAB	NP_001092366.1
Danio rerio (zebrafish)	aagab	NP_001002423.1
Xenopus tropicalis (tropical clawed frog)	aagab	NP_001238766.1
Mus musculus (house mouse)	Aagab	NP_080133.1
Rattus norvegicus (Norway rat)	Aagab	NP_599225.1
Gallus gallus (chicken)	AAGAB	NP_001258457.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability.
Giehl KA, Herzinger T, Wolff H, S?rdy M, von Braunm?hl T, Dekeuleneer V, Sznajer Y, Tennstedt D, Boes P, Rapprich S, Wagner N, Betz RC, Braun-Falco M, Strom T, Ruzicka T, Eckstein GN
Acta dermato-venereologica96(4)468-72(2016 May)

Low-dose etretinate shows promise in management of punctate palmoplantar keratoderma type 1: Case report and review of the published work.
Nomura T, Moriuchi R, Takeda M, Suzuki S, Kikuchi K, Ito T, Shimizu H, Shimizu S
The Journal of dermatology42(9)889-92(2015 Sep)

Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.
Akasaka E, Okawa Y, Nakano H, Takiyoshi N, Rokunohe D, Toyomaki Y, Sawamura D, Sueki H
Journal of dermatological science78(2)156-8(2015 May)

New and recurrent AAGAB mutations in punctate palmoplantar keratoderma.
Pohler E, Huber M, Boonen SE, Zamiri M, Gregersen PA, Sommerlund M, Ramsing M, Hohl D, McLean WH, Smith FJ
The British journal of dermatology171(2)433-6(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identical AAGAB genotypes presented a very broad interfamilial and intrafamilial variability of phenotypes in punctate palmoplantar keratoderma type 1 (Buschke-Fischer-Brauer syndrome).
Title: Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability.

we report two unrelated Japanese punctate palmoplantar keratoderma type 1 pedigrees harboring the novel AAGAB mutation c.191_194del-CAAA.
Title: Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.

Case Report: novel AAGAB mutation in punctate palmoplantar keratoderma type I.
Title: Punctate palmoplantar keratoderma type 1: a novel AAGAB mutation and efficacy of etretinate.

results reveal one novel and two recurrent mutations in AAGAB providing further evidence of its role in the pathogenesis of palmoplantar keratoderma.
Title: New and recurrent AAGAB mutations in punctate palmoplantar keratoderma.

families with type 1 punctate palmoplantar keratoderma have distinct mutations in AAGAB
Title: Identification of distinct mutations in AAGAB in families with type 1 punctate palmoplantar keratoderma.

The following AAGAB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AAGAB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu48566	XM_024450052.1 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	Quote Price
OHu48567	XM_024450053.1 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu03992	NM_001271886.1 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu03992	NM_001271885.1 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OHu04163	NM_024666.5 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
OHu03992	XM_011522020.1 Latest version!	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
View Old Accession Versions >>
OHu04163	NM_024666.4	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AAGAB ( XM_024450052.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305820.1 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu48566
Clone ID Related Accession (Same CDS sequence)	XM_024450052.1
Accession Version	XM_024450052.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGGAAGC 
TCAAGATTTG GACTAATGAA AGGGGAGAAC GGCAAGTGGA GAAGGAAGCA TGACATAGAG 
AATAACAGTT CTATGTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305820.1
CDS	55..675
Translation	MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNGSSRFGLMKGENGKWRRKHDIENNSSMF

Target ORF information:

RefSeq Version	XM_024450052.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450052.1

ORF Insert Sequence:

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGGAAGC 
TCAAGATTTG GACTAATGAA AGGGGAGAAC GGCAAGTGGA GAAGGAAGCA TGACATAGAG 
AATAACAGTT CTATGTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( XM_024450053.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305821.1 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu48567
Clone ID Related Accession (Same CDS sequence)	XM_024450053.1
Accession Version	XM_024450053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGTTTCT 
TGGACATTGA TATTCAAAGG TCAAATATTT AATCTGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305821.1
CDS	55..639
Translation	MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNVSWTLIFKGQIFNLKI

Target ORF information:

RefSeq Version	XM_024450053.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450053.1

ORF Insert Sequence:

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGTTTCT 
TGGACATTGA TATTCAAAGG TCAAATATTT AATCTGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( NM_001271885.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258814.1 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03992
Clone ID Related Accession (Same CDS sequence)	XM_011522020.1 , NM_001271885.1 , NM_001271886.1
Accession Version	NM_001271885.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC315715.1, AK294402.1, BC047026.1, BC035852.1, AL136715.1, CB243401.1 and BQ185328.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, which causes translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.108971.1, SRR1803613.135962.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258814.1
CDS	317..937
Translation	MILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH

Target ORF information:

RefSeq Version	NM_001271885.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271885.1

ORF Insert Sequence:

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( NM_001271886.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258815.1 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu03992
Clone ID Related Accession (Same CDS sequence)	XM_011522020.1 , NM_001271885.1 , NM_001271886.1
Accession Version	NM_001271886.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA688370.1, DA160293.1, BC047026.1, BC035852.1, AL136715.1, CB243401.1 and BQ185328.1. Transcript Variant: This variant (3) contains an alternatively spliced 5' terminal exon, which causes translation initiation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.46976.1, SRR1660803.198502.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258815.1
CDS	578..1198
Translation	MILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH

Target ORF information:

RefSeq Version	NM_001271886.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271886.1

ORF Insert Sequence:

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( NM_024666.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_078942.3 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.

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CloneID	OHu04163
Clone ID Related Accession (Same CDS sequence)	NM_024666.5 , NM_024666.4
Accession Version	NM_024666.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA688370.1, BC047026.1, BC035852.1, AL136715.1, CB243401.1, BQ185328.1 and AC012568.7. On May 17, 2019 this sequence version replaced NM_024666.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.163727.1, SRR1803614.94777.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261880.10/ ENSP00000261880.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGATAGG 
AACCAAGGCT TTAGCCTTCT CAACTCATTG ACTGGAACAA ACCATAGCAT TGGGTCAGCA 
GATCCCTGTC ACCCAGAGCA ACCCCATTTG CCAGCAGCAG ATAGTACTGA ATCCCTCTCT 
GATCATCGGG GTGGTGCATC TAACACAACA GATGCCCAGG TTGATAGCAT TGTGGATCCC 
ATGTTAGATC TGGATATTCA AGAATTAGCC AGTCTTACCA CTGGAGGAGG AGATGTGGAG 
AATTTTGAAA GACTCTTTTC AAAGTTAAAG GAAATGAAAG ACAAGGCTGC GACGCTTCCT 
CATGAGCAAA GAAAAGTGCA TGCAGAAAAG GTGGCCAAAG CATTCTGGAT GGCAATCGGG 
GGAGACAGAG ATGAAATTGA AGGCCTTTCA TCTGATGAAG AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078942.3
CDS	31..978
Translation	MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH

Target ORF information:

RefSeq Version	NM_024666.5
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024666.5

ORF Insert Sequence:

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGATAGG 
AACCAAGGCT TTAGCCTTCT CAACTCATTG ACTGGAACAA ACCATAGCAT TGGGTCAGCA 
GATCCCTGTC ACCCAGAGCA ACCCCATTTG CCAGCAGCAG ATAGTACTGA ATCCCTCTCT 
GATCATCGGG GTGGTGCATC TAACACAACA GATGCCCAGG TTGATAGCAT TGTGGATCCC 
ATGTTAGATC TGGATATTCA AGAATTAGCC AGTCTTACCA CTGGAGGAGG AGATGTGGAG 
AATTTTGAAA GACTCTTTTC AAAGTTAAAG GAAATGAAAG ACAAGGCTGC GACGCTTCCT 
CATGAGCAAA GAAAAGTGCA TGCAGAAAAG GTGGCCAAAG CATTCTGGAT GGCAATCGGG 
GGAGACAGAG ATGAAATTGA AGGCCTTTCA TCTGATGAAG AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( NM_024666.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078942.3 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04163
Clone ID Related Accession (Same CDS sequence)	NM_024666.5 , NM_024666.4
Accession Version	NM_024666.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 948bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA688370.1, BC047026.1, BC035852.1, AL136715.1, CB243401.1 and BQ185328.1. On Dec 8, 2012 this sequence version replaced NM_024666.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.141514.1, SRR1803611.1575.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGATAGG 
AACCAAGGCT TTAGCCTTCT CAACTCATTG ACTGGAACAA ACCATAGCAT TGGGTCAGCA 
GATCCCTGTC ACCCAGAGCA ACCCCATTTG CCAGCAGCAG ATAGTACTGA ATCCCTCTCT 
GATCATCGGG GTGGTGCATC TAACACAACA GATGCCCAGG TTGATAGCAT TGTGGATCCC 
ATGTTAGATC TGGATATTCA AGAATTAGCC AGTCTTACCA CTGGAGGAGG AGATGTGGAG 
AATTTTGAAA GACTCTTTTC AAAGTTAAAG GAAATGAAAG ACAAGGCTGC GACGCTTCCT 
CATGAGCAAA GAAAAGTGCA TGCAGAAAAG GTGGCCAAAG CATTCTGGAT GGCAATCGGG 
GGAGACAGAG ATGAAATTGA AGGCCTTTCA TCTGATGAAG AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078942.3
CDS	106..1053
Translation	MAAGVPCALVTSCSSVFSGDQLVQHILGTEDLIVEVTSNDAVRFYPWTIDNKYYSADINLCVVPNKFLVTAEIAESVQAFVVYFDSTQKSGLDSVSSWLPLAKAWLPEVMILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH

Target ORF information:

RefSeq Version	NM_024666.4
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024666.4

ORF Insert Sequence:

ATGGCTGCTG GCGTACCCTG TGCGTTAGTC ACCAGCTGCT CCTCCGTCTT CTCAGGAGAC 
CAGCTGGTCC AACATATCCT TGGAACAGAA GATCTTATTG TGGAAGTGAC TTCCAATGAT 
GCTGTGAGAT TTTATCCCTG GACCATTGAT AATAAATACT ATTCAGCAGA CATCAATCTA 
TGTGTGGTGC CAAACAAATT TCTTGTTACT GCAGAGATTG CAGAATCTGT CCAAGCATTT 
GTGGTTTACT TTGACAGCAC ACAAAAATCG GGCCTTGATA GTGTCTCCTC ATGGCTTCCA 
CTGGCAAAAG CATGGTTACC TGAGGTGATG ATCTTGGTCT GCGATAGAGT GTCTGAAGAT 
GGTATAAACC GACAAAAAGC TCAAGAATGG TGCATCAAAC ATGGCTTTGA ATTGGTAGAA 
CTTAGTCCAG AGGAGTTGCC TGAGGAGGAT GATGACTTCC CAGAATCTAC AGGAGTAAAG 
CGAATTGTCC AAGCCCTGAA TGCCAATGTG TGGTCCAATG TAGTGATGAA GAATGATAGG 
AACCAAGGCT TTAGCCTTCT CAACTCATTG ACTGGAACAA ACCATAGCAT TGGGTCAGCA 
GATCCCTGTC ACCCAGAGCA ACCCCATTTG CCAGCAGCAG ATAGTACTGA ATCCCTCTCT 
GATCATCGGG GTGGTGCATC TAACACAACA GATGCCCAGG TTGATAGCAT TGTGGATCCC 
ATGTTAGATC TGGATATTCA AGAATTAGCC AGTCTTACCA CTGGAGGAGG AGATGTGGAG 
AATTTTGAAA GACTCTTTTC AAAGTTAAAG GAAATGAAAG ACAAGGCTGC GACGCTTCCT 
CATGAGCAAA GAAAAGTGCA TGCAGAAAAG GTGGCCAAAG CATTCTGGAT GGCAATCGGG 
GGAGACAGAG ATGAAATTGA AGGCCTTTCA TCTGATGAAG AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAGAB ( XM_011522020.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520322.1 Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu03992
Clone ID Related Accession (Same CDS sequence)	XM_011522020.1 , NM_001271885.1 , NM_001271886.1
Accession Version	XM_011522020.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	alpha- and gamma-adaptin-binding protein p34 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520322.1
CDS	683..1303
Translation	MILVCDRVSEDGINRQKAQEWCIKHGFELVELSPEELPEEDDDFPESTGVKRIVQALNANVWSNVVMKNDRNQGFSLLNSLTGTNHSIGSADPCHPEQPHLPAADSTESLSDHRGGASNTTDAQVDSIVDPMLDLDIQELASLTTGGGDVENFERLFSKLKEMKDKAATLPHEQRKVHAEKVAKAFWMAIGGDRDEIEGLSSDEEH

Target ORF information:

RefSeq Version	XM_011522020.1
Organism	Homo sapiens(human)
Definition	Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522020.1

ORF Insert Sequence:

ATGATCTTGG TCTGCGATAG AGTGTCTGAA GATGGTATAA ACCGACAAAA AGCTCAAGAA 
TGGTGCATCA AACATGGCTT TGAATTGGTA GAACTTAGTC CAGAGGAGTT GCCTGAGGAG 
GATGATGACT TCCCAGAATC TACAGGAGTA AAGCGAATTG TCCAAGCCCT GAATGCCAAT 
GTGTGGTCCA ATGTAGTGAT GAAGAATGAT AGGAACCAAG GCTTTAGCCT TCTCAACTCA 
TTGACTGGAA CAAACCATAG CATTGGGTCA GCAGATCCCT GTCACCCAGA GCAACCCCAT 
TTGCCAGCAG CAGATAGTAC TGAATCCCTC TCTGATCATC GGGGTGGTGC ATCTAACACA 
ACAGATGCCC AGGTTGATAG CATTGTGGAT CCCATGTTAG ATCTGGATAT TCAAGAATTA 
GCCAGTCTTA CCACTGGAGG AGGAGATGTG GAGAATTTTG AAAGACTCTT TTCAAAGTTA 
AAGGAAATGA AAGACAAGGC TGCGACGCTT CCTCATGAGC AAAGAAAAGT GCATGCAGAA 
AAGGTGGCCA AAGCATTCTG GATGGCAATC GGGGGAGACA GAGATGAAAT TGAAGGCCTT 
TCATCTGATG AAGAGCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability.
Acta dermato-venereologica96(4)468-72(2016 May)
Giehl KA,Herzinger T,Wolff H,S?rdy M,von Braunm?hl T,Dekeuleneer V,Sznajer Y,Tennstedt D,Boes P,Rapprich S,Wagner N,Betz RC,Braun-Falco M,Strom T,Ruzicka T,Eckstein GN

Low-dose etretinate shows promise in management of punctate palmoplantar keratoderma type 1: Case report and review of the published work.
The Journal of dermatology42(9)889-92(2015 Sep)
Nomura T,Moriuchi R,Takeda M,Suzuki S,Kikuchi K,Ito T,Shimizu H,Shimizu S

Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.
Journal of dermatological science78(2)156-8(2015 May)
Akasaka E,Okawa Y,Nakano H,Takiyoshi N,Rokunohe D,Toyomaki Y,Sawamura D,Sueki H

New and recurrent AAGAB mutations in punctate palmoplantar keratoderma.
The British journal of dermatology171(2)433-6(2014 Aug)
Pohler E,Huber M,Boonen SE,Zamiri M,Gregersen PA,Sommerlund M,Ramsing M,Hohl D,McLean WH,Smith FJ

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AAGAB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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