PAGR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PAGR1
Entrez Gene ID	79447
Full Name	PAXIP1 associated glutamate rich protein 1
Synonyms	C16orf53,GAS,PA1
General protein information	Preferred Names PAXIP1 associated glutamate rich protein 1 Names PAXIP1-associated glutamate-rich protein 1 PAXIP1-associated protein 1 PTIP-associated 1 protein PTIP-associated protein 1 glutamate-rich coactivator associated with SRC1 glutamate-rich coactivator interacting with SRC1 glutamate-rich coactivator interacting with SRC1/NCOA1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008].
Disorder MIM:	612033

mRNA and Protein(s)

mRNA	Protein	Name
NM_024516.3	NP_078792.1	PAXIP1-associated glutamate-rich protein 1
NM_024516.4	NP_078792.1	PAXIP1-associated glutamate-rich protein 1

Pathways from BioSystems

Homologies

	PAGR1	XP_001104747.1
Canis lupus familiaris (dog)	PAGR1	XP_849156.1
Danio rerio (zebrafish)	pagr1	XP_002663938.1
Xenopus tropicalis (tropical clawed frog)	pagr1	NP_001096347.1
Mus musculus (house mouse)	Pagr1a	NP_084516.1
Homo sapiens (human)	PAGR1	NP_078792.1
Pan troglodytes (chimpanzee)	PAGR1	XP_001144010.1
Bos taurus (cattle)	PAGR1	NP_001069100.1

Gene Ontology
Bibliography

Related articles in PubMed

PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.
Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr
The Journal of biological chemistry288(1)42-58(2013 Jan)

PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
Takeshita T, Yamamoto-Ibusuki M, Yamamoto Y, Omoto Y, Honda Y, Iyama K, Zhang Z, Iwase H
PloS one8(11)e80552(2013)

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
Gong Z, Cho YW, Kim JE, Ge K, Chen J
The Journal of biological chemistry284(11)7284-93(2009 Mar)

GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function.
Liang J, Zhang H, Zhang Y, Zhang Y, Shang Y
EMBO reports10(1)51-7(2009 Jan)

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
The Journal of biological chemistry282(28)20395-406(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PA1 is a new competitive decelerator of GR transactivation and can act at more than one molecularly defined step in a manner that depends upon the specific gene
Title: PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.

PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
Title: PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.

subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.

GAS is a new transcription cofactor
Title: GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function.

PA1 (C16orf53) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

The following PAGR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAGR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13510	NM_024516.4 Latest version!	Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13510	NM_024516.3	Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PAGR1 ( NM_024516.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_078792.1 Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.

Price & Availability↑

CloneID	OHu13510
Clone ID Related Accession (Same CDS sequence)	NM_024516.3 , NM_024516.4
Accession Version	NM_024516.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	PAXIP1-associated glutamate-rich protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL549915.3, BC003640.2, AC009133.7, AC120114.2 and CA455544.1. On Aug 28, 2007 this sequence version replaced NM_024516.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.161716.1, SRR1803612.147832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCTTG CTCGGGGCCA TGGAGACACT GCGGCCAGTA CGGCGGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACCTCCGG CCTCCAGGCT CTGGCCGTGG AGGATACCGG AGGCCCCTCT 
GCCTCGGCCG GTAAGGCCGA GGACGAGGGG GAAGGAGGCC GAGAGGAGAC CGAGCGTGAG 
GGGTCCGGGG GCGAGGAGGC GCAGGGAGAA GTCCCCAGCG CTGGGGGAGA AGAGCCTGCC 
GAGGAGGACT CCGAGGACTG GTGCGTGCCC TGCAGCGACG AGGAGGTGGA GCTGCCTGCG 
GATGGGCAGC CCTGGATGCC CCCGCCCTCC GAAATCCAGC GGCTCTATGA ACTGCTGGCT 
GCCCACGGTA CTCTGGAGCT GCAAGCCGAG ATCCTGCCCC GCCGGCCTCC CACGCCGGAG 
GCCCAGAGCG AAGAGGAGAG ATCCGATGAG GAGCCGGAGG CCAAAGAAGA GGAAGAGGAA 
AAACCACACA TGCCCACGGA ATTTGATTTT GATGATGAGC CAGTGACACC AAAGGACTCC 
CTGATTGACC GGAGACGCAC CCCAGGAAGC TCAGCCCGGA GCCAGAAACG GGAGGCCCGC 
CTGGACAAGG TGCTGTCGGA CATGAAGAGA CACAAGAAGC TGGAGGAGCA GATCCTTCGT 
ACCGGGAGGG ACCTCTTCAG CCTGGACTCG GAGGACCCCA GCCCCGCCAG CCCCCCACTC 
CGATCCTCCG GGAGTAGTCT CTTCCCTCGG CAGCGGAAAT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078792.1
CDS	320..1084
Translation	MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY

Target ORF information:

RefSeq Version	NM_024516.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024516.3

ORF Insert Sequence:

ATGTCCCTTG CTCGGGGCCA TGGAGACACT GCGGCCAGTA CGGCGGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACCTCCGG CCTCCAGGCT CTGGCCGTGG AGGATACCGG AGGCCCCTCT 
GCCTCGGCCG GTAAGGCCGA GGACGAGGGG GAAGGAGGCC GAGAGGAGAC CGAGCGTGAG 
GGGTCCGGGG GCGAGGAGGC GCAGGGAGAA GTCCCCAGCG CTGGGGGAGA AGAGCCTGCC 
GAGGAGGACT CCGAGGACTG GTGCGTGCCC TGCAGCGACG AGGAGGTGGA GCTGCCTGCG 
GATGGGCAGC CCTGGATGCC CCCGCCCTCC GAAATCCAGC GGCTCTATGA ACTGCTGGCT 
GCCCACGGTA CTCTGGAGCT GCAAGCCGAG ATCCTGCCCC GCCGGCCTCC CACGCCGGAG 
GCCCAGAGCG AAGAGGAGAG ATCCGATGAG GAGCCGGAGG CCAAAGAAGA GGAAGAGGAA 
AAACCACACA TGCCCACGGA ATTTGATTTT GATGATGAGC CAGTGACACC AAAGGACTCC 
CTGATTGACC GGAGACGCAC CCCAGGAAGC TCAGCCCGGA GCCAGAAACG GGAGGCCCGC 
CTGGACAAGG TGCTGTCGGA CATGAAGAGA CACAAGAAGC TGGAGGAGCA GATCCTTCGT 
ACCGGGAGGG ACCTCTTCAG CCTGGACTCG GAGGACCCCA GCCCCGCCAG CCCCCCACTC 
CGATCCTCCG GGAGTAGTCT CTTCCCTCGG CAGCGGAAAT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PAGR1 ( NM_024516.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_078792.1 Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.

Price & Availability↑

CloneID	OHu13510
Clone ID Related Accession (Same CDS sequence)	NM_024516.3 , NM_024516.4
Accession Version	NM_024516.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	PAXIP1-associated glutamate-rich protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009133.7, AL549915.3, BC003640.2, AC120114.2 and CA455544.1. On Nov 22, 2018 this sequence version replaced NM_024516.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.161716.1, SRR1803612.147832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320330.8/ ENSP00000326519.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCTTG CTCGGGGCCA TGGAGACACT GCGGCCAGTA CGGCGGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACCTCCGG CCTCCAGGCT CTGGCCGTGG AGGATACCGG AGGCCCCTCT 
GCCTCGGCCG GTAAGGCCGA GGACGAGGGG GAAGGAGGCC GAGAGGAGAC CGAGCGTGAG 
GGGTCCGGGG GCGAGGAGGC GCAGGGAGAA GTCCCCAGCG CTGGGGGAGA AGAGCCTGCC 
GAGGAGGACT CCGAGGACTG GTGCGTGCCC TGCAGCGACG AGGAGGTGGA GCTGCCTGCG 
GATGGGCAGC CCTGGATGCC CCCGCCCTCC GAAATCCAGC GGCTCTATGA ACTGCTGGCT 
GCCCACGGTA CTCTGGAGCT GCAAGCCGAG ATCCTGCCCC GCCGGCCTCC CACGCCGGAG 
GCCCAGAGCG AAGAGGAGAG ATCCGATGAG GAGCCGGAGG CCAAAGAAGA GGAAGAGGAA 
AAACCACACA TGCCCACGGA ATTTGATTTT GATGATGAGC CAGTGACACC AAAGGACTCC 
CTGATTGACC GGAGACGCAC CCCAGGAAGC TCAGCCCGGA GCCAGAAACG GGAGGCCCGC 
CTGGACAAGG TGCTGTCGGA CATGAAGAGA CACAAGAAGC TGGAGGAGCA GATCCTTCGT 
ACCGGGAGGG ACCTCTTCAG CCTGGACTCG GAGGACCCCA GCCCCGCCAG CCCCCCACTC 
CGATCCTCCG GGAGTAGTCT CTTCCCTCGG CAGCGGAAAT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_078792.1
CDS	375..1139
Translation	MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY

Target ORF information:

RefSeq Version	NM_024516.4
Organism	Homo sapiens(human)
Definition	Homo sapiens PAXIP1 associated glutamate rich protein 1 (PAGR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024516.4

ORF Insert Sequence:

ATGTCCCTTG CTCGGGGCCA TGGAGACACT GCGGCCAGTA CGGCGGCGCC TCTGTCTGAA 
GAAGGGGAAG TGACCTCCGG CCTCCAGGCT CTGGCCGTGG AGGATACCGG AGGCCCCTCT 
GCCTCGGCCG GTAAGGCCGA GGACGAGGGG GAAGGAGGCC GAGAGGAGAC CGAGCGTGAG 
GGGTCCGGGG GCGAGGAGGC GCAGGGAGAA GTCCCCAGCG CTGGGGGAGA AGAGCCTGCC 
GAGGAGGACT CCGAGGACTG GTGCGTGCCC TGCAGCGACG AGGAGGTGGA GCTGCCTGCG 
GATGGGCAGC CCTGGATGCC CCCGCCCTCC GAAATCCAGC GGCTCTATGA ACTGCTGGCT 
GCCCACGGTA CTCTGGAGCT GCAAGCCGAG ATCCTGCCCC GCCGGCCTCC CACGCCGGAG 
GCCCAGAGCG AAGAGGAGAG ATCCGATGAG GAGCCGGAGG CCAAAGAAGA GGAAGAGGAA 
AAACCACACA TGCCCACGGA ATTTGATTTT GATGATGAGC CAGTGACACC AAAGGACTCC 
CTGATTGACC GGAGACGCAC CCCAGGAAGC TCAGCCCGGA GCCAGAAACG GGAGGCCCGC 
CTGGACAAGG TGCTGTCGGA CATGAAGAGA CACAAGAAGC TGGAGGAGCA GATCCTTCGT 
ACCGGGAGGG ACCTCTTCAG CCTGGACTCG GAGGACCCCA GCCCCGCCAG CCCCCCACTC 
CGATCCTCCG GGAGTAGTCT CTTCCCTCGG CAGCGGAAAT ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.
The Journal of biological chemistry288(1)42-58(2013 Jan)
Zhang Z,Sun Y,Cho YW,Chow CC,Simons SS Jr

PTIP associated protein 1, PA1, is an independent prognostic factor for lymphnode negative breast cancer.
PloS one8(11)e80552(2013)
Takeshita T,Yamamoto-Ibusuki M,Yamamoto Y,Omoto Y,Honda Y,Iyama K,Zhang Z,Iwase H

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
The Journal of biological chemistry284(11)7284-93(2009 Mar)
Gong Z,Cho YW,Kim JE,Ge K,Chen J

GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function.
EMBO reports10(1)51-7(2009 Jan)
Liang J,Zhang H,Zhang Y,Zhang Y,Shang Y

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
The Journal of biological chemistry282(28)20395-406(2007 Jul)
Cho YW,Hong T,Hong S,Guo H,Yu H,Kim D,Guszczynski T,Dressler GR,Copeland TD,Kalkum M,Ge K

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PAGR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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