Gene Symbol | FTO |
Entrez Gene ID | 79068 |
Full Name | FTO, alpha-ketoglutarate dependent dioxygenase |
Synonyms | ALKBH9,BMIQ14,GDFD |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]. |
Disorder MIM: | |
Disorder Html: | Growth retardation, developmental delay, facial dysmorphism, 612938 (3); {Obesity, susceptibility to, BMIQ14}, 612460 (3) |