ZXDA cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZXDA
Entrez Gene ID	7789
Full Name	zinc finger, X-linked, duplicated A
Synonyms	ZNF896
General protein information	Preferred Names zinc finger, X-linked, duplicated A Names zinc finger X-linked protein ZXDA zinc finger protein 896
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.21
Summary	This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009].
Disorder MIM:	300235

mRNA and Protein(s)

mRNA	Protein	Name
NM_007156.4	NP_009087.1	zinc finger X-linked protein ZXDA

Pathways from BioSystems

Homologies

Homo sapiens (human)	ZXDA	NP_009087.1
Pan troglodytes (chimpanzee)	ZXDA	XP_529007.3
	ZXDA	XP_001097480.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Evans DM, Zhu G, Dy V, Heath AC, Madden PA, Kemp JP, McMahon G, St Pourcain B, Timpson NJ, Golding J, Lawlor DA, Steer C, Montgomery GW, Martin NG, Smith GD, Whitfield JB
Human molecular genetics22(19)3998-4006(2013 Oct)

An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.
Aleksandrova A, Galkin O, Koneni R, Fontes JD
Molecular and cellular biochemistry337(1-2)1-7(2010 Apr)

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR
Nature genetics41(5)535-43(2009 May)

Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.
Jambunathan S, Fontes JD
Biological chemistry388(9)965-72(2007 Sep)

The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.
Al-Kandari W, Koneni R, Navalgund V, Aleksandrova A, Jambunathan S, Fontes JD
Journal of molecular biology369(5)1175-87(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Role of ZXD proteins in regulating MHC II transcription.
Title: An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.

ZXDA and ZXDC form an important regulatory complex for MHC II gene transcription.
Title: The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.

The following ZXDA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZXDA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu22645	NM_007156.4 Latest version!	Homo sapiens zinc finger X-linked duplicated A (ZXDA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$404.50-$566.30 $809.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZXDA ( NM_007156.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009087.1 Homo sapiens zinc finger X-linked duplicated A (ZXDA), mRNA.

Price & Availability↑

CloneID	OHu22645
Clone ID Related Accession (Same CDS sequence)	NM_007156.4
Accession Version	NM_007156.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2400bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	zinc finger X-linked protein ZXDA
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL034396.6. This sequence is a reference standard in the RefSeqGene project. On Nov 18, 2009 this sequence version replaced NM_007156.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAAATCC CGAAGCTGCT CCCGGCTCGC GGGACACTAC AGGGCGGCGG CGGCGGCGGT 
ATCCCCGCGG GTGGCGGCCG AGTCCACCGA GGCCCTGACT CGCCGGCTGG CCAGGTCCCC 
ACGCGCCGCC TCCTGCTGCC CCGGGGCCCC CAAGATGGCG GGCCCGGGCG GCGGCGCGAG 
GAGGCCAGCA CGGCATCACG GGGCCCTGGC CCAAGCCTGT TCGCGCCGAG GCCCCATCAA 
CCTAGCGGCG GCGGCGACGA CTTCTTCCTG GTGCTGCTTG ACCCGGTGGG TGGCGACGTG 
GAGACCGCGG GCTCCGGTCA GGCCGCAGGG CCTGTGTTGA GGGAGGAGGC CAAGGCGGGC 
CCGGGGCTCC AGGGGGACGA GAGCGGCGCG AACCCCGCGG GCTGCTCTGC GCAGGGCCCC 
CACTGCCTGT CCGCGGTTCC CACTCCGGCC CCGATCTCCG CCCCCGGCCC CGCCGCGGCC 
TTCGCGGGCA CAGTCACTAT CCACAACCAG GACCTGCTGT TGCGCTTTGA GAACGGCGTC 
CTCACCCTGG CCACGCCCCC ACCACACGCC TGGGAGCCAG GGGCCGCTCC TGCCCAGCAG 
CCCAGGTGTC TGATCGCCCC CCAAGCTGGG TTCCCGCAAG CCGCGCACCC GGGTGACTGC 
CCAGAGCTGC GGTCCGACCT CCTGCTAGCC GAGCCCGCAG AACCCGCGCC TGCTCCGGCG 
CCCCAGGAGG AGGCGGAGGG CCTGGCCGCC GCCCTGGGCC CCCGCGGACT GCTGGGCTCT 
GGTCCAGGCG TGGTGCTGTA CCTGTGCCCC GAGGCGCTGT GCGGGCAAAC CTTCGCCAAG 
AAGCACCAGC TGAAGATGCA CCTGCTGACG CACAGCAGCA GCCAGGGCCA GAGGCCCTTC 
AAATGCCCCC TGGGTGGCTG CGGCTGGACC TTCACCACCT CTTACAAGCT CAAGAGGCAC 
CTGCAGTCGC ACGATAAACT GCGGCCCTTC GGCTGCCCTG CGGAGGGCTG TGGCAAGAGC 
TTCACCACCG TGTACAACCT CAAGGCGCAC ATGAAGGGCC ATGAGCAGGA GAACTCGTTC 
AAATGTGAGG TGTGCGAGGA GAGCTTCCCC ACGCAGGCCA AACTCGGCGC CCACCAGCGC 
AGCCACTTCG AACCCGAGAG GCCTTACCAG TGCGCGTTTT CTGGCTGCAA GAAGACATTT 
ATCACAGTGA GTGCTCTGTT TTCCCATAAC CGCGCCCATT TCAGGGAACA GGAACTGTTT 
TCCTGCTCTT TCCCTGGCTG CAGCAAGCAA TATGACAAGG CTTGTAGGCT GAAAATTCAC 
CTGCGGAGTC ACACCGGCGA GAGACCTTTC CTTTGTGACT TTGATGGCTG TGGCTGGAAC 
TTCACCAGCA TGTCCAAACT CTTAAGGCAC AAAAGGAAGC ACGACGATGA CCGGAGGTTC 
ATGTGCCCTG TGGAAGGCTG TGGGAAATCT TTCACGAGGG CCGAACATCT GAAAGGCCAC 
AGCATTACCC ACCTGGGCAC AAAGCCTTTC GTGTGTCCTG TGGCAGGCTG CTGTGCCAGG 
TTCTCTGCTC GCAGTAGCCT CTACATTCAC TCCAAGAAAC ACCTGCAGGA TGTGGACACT 
TGGAAAAGCC GTTGCCCGAT CTCCTCTTGT AATAAACTCT TCACATCCAA GCACAGCATG 
AAGACGCACA TGGTTAAAAG GCATAAGGTG GGCCAGGATC TCTTAGCTCA GCTAGAAGCA 
GCAAATTCTC TTACACCCAG CAGTGAACTT ACCAGCCAGA GACAGAATGA TCTCAGTGAT 
GCAGAGATAG TGTCTCTCTT CTCTGATGTA CCTGACAGTA CTTCTGCTGC ATTGCTGGAC 
ACAGCATTGG TGAACTCTGG AATCTTGACT ATTGATGTGG CTTCTGTGAG CTCGACTCTG 
GCAGGGCACC TCCCTGCTAA TAATAATAAT TCCGTAGGGC AGGCTGTGGA CCCTCCGTCC 
TTGATGGCCA CCAGCGACCC TCCTCAAAGT CTGGATACCT CTCTCTTTTT TGGAACGGCG 
GCCACTGGTT TTCAGCAGAG CTCCTTAAAT ATGGATGAGG TCTCAAGTGT AAGTGTGGGG 
CCATTGGGAT CTCTGGACTC TTTGGCCATG AAAAACTCCA GTCCAGAGCC TCAGGCTTTG 
ACACCCAGCA GTAAGCTAAC AGTGGACACA GATACTCTGA CTCCTTCGAG CACCCTTTGT 
GAAAACAGTG TCTCAGAACT ACTGACACCA GCCAAAGCGG AGTGGAGCGT ACATCCTAAC 
TCTGACTTCT TTGGACAGGA GGGAGAAACC CAGTTTGGAT TCCCCAATGC AGCAGGAAAC 
CATGGTTCTC AGAAAGAAAG AAATCTTATC ACTGTGACTG GCAGCTCATT TTTGGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009087.1
CDS	214..2613
Translation	MEIPKLLPARGTLQGGGGGGIPAGGGRVHRGPDSPAGQVPTRRLLLPRGPQDGGPGRRREEASTASRGPGPSLFAPRPHQPSGGGDDFFLVLLDPVGGDVETAGSGQAAGPVLREEAKAGPGLQGDESGANPAGCSAQGPHCLSAVPTPAPISAPGPAAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPRCLIAPQAGFPQAAHPGDCPELRSDLLLAEPAEPAPAPAPQEEAEGLAAALGPRGLLGSGPGVVLYLCPEALCGQTFAKKHQLKMHLLTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENSFKCEVCEESFPTQAKLGAHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSVGPLGSLDSLAMKNSSPEPQALTPSSKLTVDTDTLTPSSTLCENSVSELLTPAKAEWSVHPNSDFFGQEGETQFGFPNAAGNHGSQKERNLITVTGSSFLV

Target ORF information:

RefSeq Version	NM_007156.4
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger X-linked duplicated A (ZXDA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007156.4

ORF Insert Sequence:

ATGGAAATCC CGAAGCTGCT CCCGGCTCGC GGGACACTAC AGGGCGGCGG CGGCGGCGGT 
ATCCCCGCGG GTGGCGGCCG AGTCCACCGA GGCCCTGACT CGCCGGCTGG CCAGGTCCCC 
ACGCGCCGCC TCCTGCTGCC CCGGGGCCCC CAAGATGGCG GGCCCGGGCG GCGGCGCGAG 
GAGGCCAGCA CGGCATCACG GGGCCCTGGC CCAAGCCTGT TCGCGCCGAG GCCCCATCAA 
CCTAGCGGCG GCGGCGACGA CTTCTTCCTG GTGCTGCTTG ACCCGGTGGG TGGCGACGTG 
GAGACCGCGG GCTCCGGTCA GGCCGCAGGG CCTGTGTTGA GGGAGGAGGC CAAGGCGGGC 
CCGGGGCTCC AGGGGGACGA GAGCGGCGCG AACCCCGCGG GCTGCTCTGC GCAGGGCCCC 
CACTGCCTGT CCGCGGTTCC CACTCCGGCC CCGATCTCCG CCCCCGGCCC CGCCGCGGCC 
TTCGCGGGCA CAGTCACTAT CCACAACCAG GACCTGCTGT TGCGCTTTGA GAACGGCGTC 
CTCACCCTGG CCACGCCCCC ACCACACGCC TGGGAGCCAG GGGCCGCTCC TGCCCAGCAG 
CCCAGGTGTC TGATCGCCCC CCAAGCTGGG TTCCCGCAAG CCGCGCACCC GGGTGACTGC 
CCAGAGCTGC GGTCCGACCT CCTGCTAGCC GAGCCCGCAG AACCCGCGCC TGCTCCGGCG 
CCCCAGGAGG AGGCGGAGGG CCTGGCCGCC GCCCTGGGCC CCCGCGGACT GCTGGGCTCT 
GGTCCAGGCG TGGTGCTGTA CCTGTGCCCC GAGGCGCTGT GCGGGCAAAC CTTCGCCAAG 
AAGCACCAGC TGAAGATGCA CCTGCTGACG CACAGCAGCA GCCAGGGCCA GAGGCCCTTC 
AAATGCCCCC TGGGTGGCTG CGGCTGGACC TTCACCACCT CTTACAAGCT CAAGAGGCAC 
CTGCAGTCGC ACGATAAACT GCGGCCCTTC GGCTGCCCTG CGGAGGGCTG TGGCAAGAGC 
TTCACCACCG TGTACAACCT CAAGGCGCAC ATGAAGGGCC ATGAGCAGGA GAACTCGTTC 
AAATGTGAGG TGTGCGAGGA GAGCTTCCCC ACGCAGGCCA AACTCGGCGC CCACCAGCGC 
AGCCACTTCG AACCCGAGAG GCCTTACCAG TGCGCGTTTT CTGGCTGCAA GAAGACATTT 
ATCACAGTGA GTGCTCTGTT TTCCCATAAC CGCGCCCATT TCAGGGAACA GGAACTGTTT 
TCCTGCTCTT TCCCTGGCTG CAGCAAGCAA TATGACAAGG CTTGTAGGCT GAAAATTCAC 
CTGCGGAGTC ACACCGGCGA GAGACCTTTC CTTTGTGACT TTGATGGCTG TGGCTGGAAC 
TTCACCAGCA TGTCCAAACT CTTAAGGCAC AAAAGGAAGC ACGACGATGA CCGGAGGTTC 
ATGTGCCCTG TGGAAGGCTG TGGGAAATCT TTCACGAGGG CCGAACATCT GAAAGGCCAC 
AGCATTACCC ACCTGGGCAC AAAGCCTTTC GTGTGTCCTG TGGCAGGCTG CTGTGCCAGG 
TTCTCTGCTC GCAGTAGCCT CTACATTCAC TCCAAGAAAC ACCTGCAGGA TGTGGACACT 
TGGAAAAGCC GTTGCCCGAT CTCCTCTTGT AATAAACTCT TCACATCCAA GCACAGCATG 
AAGACGCACA TGGTTAAAAG GCATAAGGTG GGCCAGGATC TCTTAGCTCA GCTAGAAGCA 
GCAAATTCTC TTACACCCAG CAGTGAACTT ACCAGCCAGA GACAGAATGA TCTCAGTGAT 
GCAGAGATAG TGTCTCTCTT CTCTGATGTA CCTGACAGTA CTTCTGCTGC ATTGCTGGAC 
ACAGCATTGG TGAACTCTGG AATCTTGACT ATTGATGTGG CTTCTGTGAG CTCGACTCTG 
GCAGGGCACC TCCCTGCTAA TAATAATAAT TCCGTAGGGC AGGCTGTGGA CCCTCCGTCC 
TTGATGGCCA CCAGCGACCC TCCTCAAAGT CTGGATACCT CTCTCTTTTT TGGAACGGCG 
GCCACTGGTT TTCAGCAGAG CTCCTTAAAT ATGGATGAGG TCTCAAGTGT AAGTGTGGGG 
CCATTGGGAT CTCTGGACTC TTTGGCCATG AAAAACTCCA GTCCAGAGCC TCAGGCTTTG 
ACACCCAGCA GTAAGCTAAC AGTGGACACA GATACTCTGA CTCCTTCGAG CACCCTTTGT 
GAAAACAGTG TCTCAGAACT ACTGACACCA GCCAAAGCGG AGTGGAGCGT ACATCCTAAC 
TCTGACTTCT TTGGACAGGA GGGAGAAACC CAGTTTGGAT TCCCCAATGC AGCAGGAAAC 
CATGGTTCTC AGAAAGAAAG AAATCTTATC ACTGTGACTG GCAGCTCATT TTTGGTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
Human molecular genetics22(19)3998-4006(2013 Oct)
Evans DM,Zhu G,Dy V,Heath AC,Madden PA,Kemp JP,McMahon G,St Pourcain B,Timpson NJ,Golding J,Lawlor DA,Steer C,Montgomery GW,Martin NG,Smith GD,Whitfield JB

An N- and C-terminal truncated isoform of zinc finger X-linked duplicated C protein represses MHC class II transcription.
Molecular and cellular biochemistry337(1-2)1-7(2010 Apr)
Aleksandrova A,Galkin O,Koneni R,Fontes JD

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Nature genetics41(5)535-43(2009 May)
Tarpey PS,Smith R,Pleasance E,Whibley A,Edkins S,Hardy C,O'Meara S,Latimer C,Dicks E,Menzies A,Stephens P,Blow M,Greenman C,Xue Y,Tyler-Smith C,Thompson D,Gray K,Andrews J,Barthorpe S,Buck G,Cole J,Dunmore R,Jones D,Maddison M,Mironenko T,Turner R,Turrell K,Varian J,West S,Widaa S,Wray P,Teague J,Butler A,Jenkinson A,Jia M,Richardson D,Shepherd R,Wooster R,Tejada MI,Martinez F,Carvill G,Goliath R,de Brouwer AP,van Bokhoven H,Van Esch H,Chelly J,Raynaud M,Ropers HH,Abidi FE,Srivastava AK,Cox J,Luo Y,Mallya U,Moon J,Parnau J,Mohammed S,Tolmie JL,Shoubridge C,Corbett M,Gardner A,Haan E,Rujirabanjerd S,Shaw M,Vandeleur L,Fullston T,Easton DF,Boyle J,Partington M,Hackett A,Field M,Skinner C,Stevenson RE,Bobrow M,Turner G,Schwartz CE,Gecz J,Raymond FL,Futreal PA,Stratton MR

Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.
Biological chemistry388(9)965-72(2007 Sep)
Jambunathan S,Fontes JD

The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.
Journal of molecular biology369(5)1175-87(2007 Jun)
Al-Kandari W,Koneni R,Navalgund V,Aleksandrova A,Jambunathan S,Fontes JD

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ZXDA cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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