Gene Symbol | XRCC3 |
Entrez Gene ID | 7517 |
Full Name | X-ray repair cross complementing 3 |
Synonyms | CMM6 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(Human) |
Genome | |
Summary | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | {Melanoma, cutaneous malignant, 6}, 613972 (3); {Breast cancer, susceptibility to}, 114480 (3) |