EIF4H cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF4H
Entrez Gene ID	7458
Full Name	eukaryotic translation initiation factor 4H
Synonyms	WBSCR1,WSCR1,eIF-4H
General protein information	Preferred Names eukaryotic translation initiation factor 4H Names eukaryotic translation initiation factor 4H Williams-Beuren syndrome chromosome region 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q11.23
Summary	This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
Disorder MIM:	603431

mRNA and Protein(s)

mRNA	Protein	Name
NM_022170.2	NP_071496.1	eukaryotic translation initiation factor 4H isoform 1
NM_031992.1	NP_114381.1	eukaryotic translation initiation factor 4H isoform 2
XM_011516556.1	XP_011514858.1	eukaryotic translation initiation factor 4H isoform X1
XM_011516557.1	XP_011514859.1	eukaryotic translation initiation factor 4H isoform X2
NM_031992.2	NP_114381.1	eukaryotic translation initiation factor 4H isoform 2
NM_022170.1	NP_071496.1	eukaryotic translation initiation factor 4H isoform 1

Pathways from BioSystems

Homologies

	EIF4H	XP_001082007.1
Canis lupus familiaris (dog)	EIF4H	XP_005621070.1
Bos taurus (cattle)	EIF4H	NP_001069220.1
Rattus norvegicus (Norway rat)	Eif4h	NP_001006958.1
Pan troglodytes (chimpanzee)	EIF4H	XP_003951096.1
Mus musculus (house mouse)	Eif4h	NP_291039.1
Gallus gallus (chicken)	LOC100859865	XP_003642445.1
Danio rerio (zebrafish)	eif4h	NP_991258.2
Xenopus tropicalis (tropical clawed frog)	eif4h	NP_001096677.1
Homo sapiens (human)	EIF4H	NP_071496.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.
Bai Y, Lu C, Zhang G, Hou Y, Guo Y, Zhou H, Ma X, Zhao G
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317694566(2017 Mar)

Key contribution of eIF4H-mediated translational control in tumor promotion.
Vaysse C, Philippe C, Martineau Y, Quelen C, Hieblot C, Renaud C, Nicaise Y, Desquesnes A, Pannese M, Filleron T, Escourrou G, Lawson M, Rintoul RC, Delisle MB, Pyronnet S, Brousset P, Prats H, Touriol C
Oncotarget6(37)39924-40(2015 Nov)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-?B.
Fiume G, Rossi A, de Laurentiis A, Falcone C, Pisano A, Vecchio E, Pontoriero M, Scala I, Scialdone A, Masci FF, Mimmi S, Palmieri C, Scala G, Quinto I
PloS one8(6)e66087(2013)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results from these procedures revealed eIF4H to be one of the targets of miR-519d. Downregulated eIF4H was analogous to the overexpressed miR-519d obtained from miR-519d agomir and si-eIF4H transfection. In summary, it can be concluded that miR-519d targets eIF4H in lung adenocarcinoma to inhibit cell proliferation and invasion
Title: Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.

Results demonstrate that eukaryotic translation initiation factor 4H (eIF4H) plays a crucial role in translational control.
Title: Key contribution of eIF4H-mediated translational control in tumor promotion.

Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-kappaB.
Title: Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-?B.

Studies indicate that eIF4A (DDX2), together with its accessory proteins eIF4B and eIF4H, is thought to act as a helicase that unwinds secondary structures in the mRNA 5' UTR.
Title: mRNA helicases: the tacticians of translational control.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide searching of rare genetic variants in WTCCC data.

The following EIF4H gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF4H cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29169	NM_031992.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18996	NM_022170.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OHu61320	XM_011516556.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu61321	XM_011516557.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu29169	NM_031992.1	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18996	NM_022170.1	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF4H ( NM_031992.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_114381.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29169
Clone ID Related Accession (Same CDS sequence)	NM_031992.1 , NM_031992.2
Accession Version	NM_031992.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-18
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF045555.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2 which is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D26068.1, BC010021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114381.1
CDS	9..695
Translation	MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	NM_031992.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031992.1

ORF Insert Sequence:

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4H ( NM_031992.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_114381.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29169
Clone ID Related Accession (Same CDS sequence)	NM_031992.1 , NM_031992.2
Accession Version	NM_031992.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005057.2 and AC005081.3. On Jun 2, 2019 this sequence version replaced NM_031992.1. Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This variant encodes isoform 2 which is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066928.1, SRR1803612.40829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114381.1
CDS	29..715
Translation	MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	NM_031992.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031992.2

ORF Insert Sequence:

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4H ( NM_022170.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071496.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18996
Clone ID Related Accession (Same CDS sequence)	NM_022170.2 , NM_022170.1
Accession Version	NM_022170.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC005057.2 and AC005081.3. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_022170.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.590792.1, SRR1163657.70111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG AATGGGTAGC 
TCTCGAGAAT CTAGAGGTGG ATGGGATTCC CGGGATGACT TCAATTCTGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071496.1
CDS	29..775
Translation	MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	NM_022170.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022170.2

ORF Insert Sequence:

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG AATGGGTAGC 
TCTCGAGAAT CTAGAGGTGG ATGGGATTCC CGGGATGACT TCAATTCTGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4H ( NM_022170.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_071496.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18996
Clone ID Related Accession (Same CDS sequence)	NM_022170.2 , NM_022170.1
Accession Version	NM_022170.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 747bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF045555.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.158832.1, SRR1163655.590792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG AATGGGTAGC 
TCTCGAGAAT CTAGAGGTGG ATGGGATTCC CGGGATGACT TCAATTCTGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071496.1
CDS	9..755
Translation	MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	NM_022170.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022170.1

ORF Insert Sequence:

ATGGCGGACT TCGACACCTA CGACGATCGG GCCTACAGCA GCTTCGGCGG CGGCAGAGGG 
TCCCGCGGCA GTGCTGGTGG CCATGGTTCC CGTAGCCAGA AGGAGTTGCC CACAGAGCCC 
CCCTACACAG CATACGTAGG AAATCTACCT TTCAATACGG TTCAGGGCGA CATAGATGCT 
ATCTTTAAGG ATCTCAGCAT AAGGAGTGTA CGGCTAGTCA GAGACAAAGA CACAGATAAA 
TTTAAAGGAT TCTGCTATGT AGAATTCGAT GAAGTGGATT CCCTTAAGGA AGCCTTGACA 
TACGATGGTG CACTGTTGGG CGATCGGTCA CTTCGTGTGG ACATTGCAGA AGGCAGAAAA 
CAAGATAAAG GTGGCTTTGG ATTCAGAAAA GGTGGACCAG ATGACAGAGG AATGGGTAGC 
TCTCGAGAAT CTAGAGGTGG ATGGGATTCC CGGGATGACT TCAATTCTGG CTTCAGGGAT 
GACTTCTTAG GGGGCAGGGG AGGTAGTCGC CCAGGCGACC GGCGAACAGG CCCCCCCATG 
GGCAGCCGCT TCAGAGATGG CCCTCCCCTC CGTGGATCCA ACATGGATTT CAGAGAACCC 
ACAGAAGAGG AAAGAGCACA GAGACCACGA CTCCAGCTTA AACCTCGAAC AGTCGCGACG 
CCCCTCAATC AAGTAGCCAA TCCCAACTCT GCTATCTTCG GGGGTGCCAG GCCTAGAGAG 
GAAGTCGTTC AAAAGGAGCA AGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4H ( XM_011516556.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514858.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu61320
Clone ID Related Accession (Same CDS sequence)	XM_011516556.1
Accession Version	XM_011516556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGTCTA CCTCCATGGC CCAGCCCTGC TGCCCCCTAG TGATTTCATT GAATGGGATG 
AAAAGGTCCC GCGGCAGTGC TGGTGGCCAT GGTTCCCGTA GCCAGAAGGA GTTGCCCACA 
GAGCCCCCCT ACACAGCATA CGTAGGAAAT CTACCTTTCA ATACGGTTCA GGGCGACATA 
GATGCTATCT TTAAGGATCT CAGCATAAGG AGTGTACGGC TAGTCAGAGA CAAAGACACA 
GATAAATTTA AAGGATTCTG CTATGTAGAA TTCGATGAAG TGGATTCCCT TAAGGAAGCC 
TTGACATACG ATGGTGCACT GTTGGGCGAT CGGTCACTTC GTGTGGACAT TGCAGAAGGC 
AGAAAACAAG ATAAAGGTGG CTTTGGATTC AGAAAAGGTG GACCAGATGA CAGAGGAATG 
GGTAGCTCTC GAGAATCTAG AGGTGGATGG GATTCCCGGG ATGACTTCAA TTCTGGCTTC 
AGGGATGACT TCTTAGGGGG CAGGGGAGGT AGTCGCCCAG GCGACCGGCG AACAGGCCCC 
CCCATGGGCA GCCGCTTCAG AGATGGCCCT CCCCTCCGTG GATCCAACAT GGATTTCAGA 
GAACCCACAG AAGAGGAAAG AGCACAGAGA CCACGACTCC AGCTTAAACC TCGAACAGTC 
GCGACGCCCC TCAATCAAGT AGCCAATCCC AACTCTGCTA TCTTCGGGGG TGCCAGGCCT 
AGAGAGGAAG TCGTTCAAAA GGAGCAAGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514858.1
CDS	36..788
Translation	MRSTSMAQPCCPLVISLNGMKRSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	XM_011516556.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516556.1

ORF Insert Sequence:

ATGAGGTCTA CCTCCATGGC CCAGCCCTGC TGCCCCCTAG TGATTTCATT GAATGGGATG 
AAAAGGTCCC GCGGCAGTGC TGGTGGCCAT GGTTCCCGTA GCCAGAAGGA GTTGCCCACA 
GAGCCCCCCT ACACAGCATA CGTAGGAAAT CTACCTTTCA ATACGGTTCA GGGCGACATA 
GATGCTATCT TTAAGGATCT CAGCATAAGG AGTGTACGGC TAGTCAGAGA CAAAGACACA 
GATAAATTTA AAGGATTCTG CTATGTAGAA TTCGATGAAG TGGATTCCCT TAAGGAAGCC 
TTGACATACG ATGGTGCACT GTTGGGCGAT CGGTCACTTC GTGTGGACAT TGCAGAAGGC 
AGAAAACAAG ATAAAGGTGG CTTTGGATTC AGAAAAGGTG GACCAGATGA CAGAGGAATG 
GGTAGCTCTC GAGAATCTAG AGGTGGATGG GATTCCCGGG ATGACTTCAA TTCTGGCTTC 
AGGGATGACT TCTTAGGGGG CAGGGGAGGT AGTCGCCCAG GCGACCGGCG AACAGGCCCC 
CCCATGGGCA GCCGCTTCAG AGATGGCCCT CCCCTCCGTG GATCCAACAT GGATTTCAGA 
GAACCCACAG AAGAGGAAAG AGCACAGAGA CCACGACTCC AGCTTAAACC TCGAACAGTC 
GCGACGCCCC TCAATCAAGT AGCCAATCCC AACTCTGCTA TCTTCGGGGG TGCCAGGCCT 
AGAGAGGAAG TCGTTCAAAA GGAGCAAGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4H ( XM_011516557.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514859.1 Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu61321
Clone ID Related Accession (Same CDS sequence)	XM_011516557.1
Accession Version	XM_011516557.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 693bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4H isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGTCTA CCTCCATGGC CCAGCCCTGC TGCCCCCTAG TGATTTCATT GAATGGGATG 
AAAAGGTCCC GCGGCAGTGC TGGTGGCCAT GGTTCCCGTA GCCAGAAGGA GTTGCCCACA 
GAGCCCCCCT ACACAGCATA CGTAGGAAAT CTACCTTTCA ATACGGTTCA GGGCGACATA 
GATGCTATCT TTAAGGATCT CAGCATAAGG AGTGTACGGC TAGTCAGAGA CAAAGACACA 
GATAAATTTA AAGGATTCTG CTATGTAGAA TTCGATGAAG TGGATTCCCT TAAGGAAGCC 
TTGACATACG ATGGTGCACT GTTGGGCGAT CGGTCACTTC GTGTGGACAT TGCAGAAGGC 
AGAAAACAAG ATAAAGGTGG CTTTGGATTC AGAAAAGGTG GACCAGATGA CAGAGGCTTC 
AGGGATGACT TCTTAGGGGG CAGGGGAGGT AGTCGCCCAG GCGACCGGCG AACAGGCCCC 
CCCATGGGCA GCCGCTTCAG AGATGGCCCT CCCCTCCGTG GATCCAACAT GGATTTCAGA 
GAACCCACAG AAGAGGAAAG AGCACAGAGA CCACGACTCC AGCTTAAACC TCGAACAGTC 
GCGACGCCCC TCAATCAAGT AGCCAATCCC AACTCTGCTA TCTTCGGGGG TGCCAGGCCT 
AGAGAGGAAG TCGTTCAAAA GGAGCAAGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514859.1
CDS	21..713
Translation	MRSTSMAQPCCPLVISLNGMKRSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE

Target ORF information:

RefSeq Version	XM_011516557.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4H (EIF4H), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516557.1

ORF Insert Sequence:

ATGAGGTCTA CCTCCATGGC CCAGCCCTGC TGCCCCCTAG TGATTTCATT GAATGGGATG 
AAAAGGTCCC GCGGCAGTGC TGGTGGCCAT GGTTCCCGTA GCCAGAAGGA GTTGCCCACA 
GAGCCCCCCT ACACAGCATA CGTAGGAAAT CTACCTTTCA ATACGGTTCA GGGCGACATA 
GATGCTATCT TTAAGGATCT CAGCATAAGG AGTGTACGGC TAGTCAGAGA CAAAGACACA 
GATAAATTTA AAGGATTCTG CTATGTAGAA TTCGATGAAG TGGATTCCCT TAAGGAAGCC 
TTGACATACG ATGGTGCACT GTTGGGCGAT CGGTCACTTC GTGTGGACAT TGCAGAAGGC 
AGAAAACAAG ATAAAGGTGG CTTTGGATTC AGAAAAGGTG GACCAGATGA CAGAGGCTTC 
AGGGATGACT TCTTAGGGGG CAGGGGAGGT AGTCGCCCAG GCGACCGGCG AACAGGCCCC 
CCCATGGGCA GCCGCTTCAG AGATGGCCCT CCCCTCCGTG GATCCAACAT GGATTTCAGA 
GAACCCACAG AAGAGGAAAG AGCACAGAGA CCACGACTCC AGCTTAAACC TCGAACAGTC 
GCGACGCCCC TCAATCAAGT AGCCAATCCC AACTCTGCTA TCTTCGGGGG TGCCAGGCCT 
AGAGAGGAAG TCGTTCAAAA GGAGCAAGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of miR-519d in lung adenocarcinoma inhibits cell proliferation and invasion via the association of eIF4H.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(3)1010428317694566(2017 Mar)
Bai Y,Lu C,Zhang G,Hou Y,Guo Y,Zhou H,Ma X,Zhao G

Key contribution of eIF4H-mediated translational control in tumor promotion.
Oncotarget6(37)39924-40(2015 Nov)
Vaysse C,Philippe C,Martineau Y,Quelen C,Hieblot C,Renaud C,Nicaise Y,Desquesnes A,Pannese M,Filleron T,Escourrou G,Lawson M,Rintoul RC,Delisle MB,Pyronnet S,Brousset P,Prats H,Touriol C

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-?B.
PloS one8(6)e66087(2013)
Fiume G,Rossi A,de Laurentiis A,Falcone C,Pisano A,Vecchio E,Pontoriero M,Scala I,Scialdone A,Masci FF,Mimmi S,Palmieri C,Scala G,Quinto I

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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EIF4H cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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