TDRG1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TDRG1
Entrez Gene ID	732253
Full Name	testis development related 1
Synonyms	LINC00532,lincRNA-NR_024015
General protein information	Preferred Names testis development related 1 Names testis development-related protein 1 long intergenic non-protein coding RNA 532 testis development related 1 (non-protein coding) testis development related protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.2
Disorder MIM:	615676

mRNA and Protein(s)

mRNA	Protein	Name
NM_001359096.1	NP_001346025.1	testis development-related protein 1
NM_001359094.1	NP_001346023.1	testis development-related protein 1
XM_024446535.1	XP_024302303.1	testis development-related protein 1 isoform X1
NM_001359095.1	NP_001346024.1	testis development-related protein 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Chen S, Wang LL, Sun KX, Xiu YL, Zong ZH, Chen X, Zhao Y
Molecular carcinogenesis57(2)225-234(2018 Feb)

Potential lncRNA diagnostic biomarkers for early gastric cancer.
Lu Q, Yu T, Ou X, Cao D, Xie T, Chen X
Molecular medicine reports16(6)9545-9552(2017 Dec)

A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China.
Han L, Liu S, Liang J, Guo Y, Shen S, Guo X, Dong Z, Guo W
Molecular carcinogenesis56(3)960-971(2017 Mar)

TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.
Gan Y, Wang Y, Tan Z, Zhou J, Kitazawa R, Jiang X, Tang Y, Yang J
Cancer biology & therapy17(7)741-50(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrates that lincRNA-NR_024015 is up-regulated in esophageal squamous cell carcinoma (ESCC) tumor, especially in advanced stage. Furthermore, the G to A variant of rs8506 in lincRNA-NR_024015 may disrupt the binding of hsa-miR-526b to the gene, up regulate the expression level of lincRNA-NR_024015, promote cell proliferation, and associated with increased risk of ESCC.
Title: A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China.

The localization of TDRG1 in human normal spermatozoa implies its potential regulatory role in sperm motility.
Title: Expression and localization of testis developmental related gene 1 (TDRG1) in human spermatozoa.

A robust association is established between the rs8506G>A polymorphism in the lincRNA-NR_024015 exon and the risk of non-cardia gastric cancer.
Title: The has-miR-526b binding-site rs8506G>a polymorphism in the lincRNA-NR_024015 exon identified by GWASs predispose to non-cardia gastric cancer risk.

TDRG1, a newly identified testis-specific gene, may play important roles in human spermatogenesis.
Title: Characterization of a novel human testis-specific gene: testis developmental related gene 1 (TDRG1).

The significantly reduced expression of the TDRG1 protein in patients with seminoma or teratoma indicates that TDRG1 may be a candidate cancer suppressor gene.
Title: [Expression of human testis development related gene 1 in testicular cancer detected by tissue microarray].

The following TDRG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TDRG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu102805	NM_001359096.1 Latest version!	Homo sapiens testis development related 1 (TDRG1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu102805	NM_001359095.1 Latest version!	Homo sapiens testis development related 1 (TDRG1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu102805	NM_001359094.1 Latest version!	Homo sapiens testis development related 1 (TDRG1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu102805	XM_024446535.1 Latest version!	Homo sapiens testis development related 1 (TDRG1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TDRG1 ( NM_001359096.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001346025.1 Homo sapiens testis development related 1 (TDRG1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102805
Clone ID Related Accession (Same CDS sequence)	NM_001359096.1 , NM_001359094.1 , XM_024446535.1 , NM_001359095.1
Accession Version	NM_001359096.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	testis development-related protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY054410.1, AA446148.1, DQ168992.1 and BC033995.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA446148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346025.1
CDS	441..743
Translation	MKRREAVCAHRHFLGTGKPPHPLGRSIPVEPCPGLPAFAEVDLLSLLVPIKISSTPPSGSRLDPQIASSAFPGLGSLGGQDSSGSLVQRASCELESPYEL

Target ORF information:

RefSeq Version	NM_001359096.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis development related 1 (TDRG1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359096.1

ORF Insert Sequence:

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TDRG1 ( NM_001359094.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001346023.1 Homo sapiens testis development related 1 (TDRG1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102805
Clone ID Related Accession (Same CDS sequence)	NM_001359096.1 , NM_001359094.1 , XM_024446535.1 , NM_001359095.1
Accession Version	NM_001359094.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	testis development-related protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY054410.1, DQ168992.1 and BC033995.2. On Dec 20, 2017 this sequence version replaced NR_024015.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033995.2, ERR279846.6923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346023.1
CDS	591..893
Translation	MKRREAVCAHRHFLGTGKPPHPLGRSIPVEPCPGLPAFAEVDLLSLLVPIKISSTPPSGSRLDPQIASSAFPGLGSLGGQDSSGSLVQRASCELESPYEL

Target ORF information:

RefSeq Version	NM_001359094.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis development related 1 (TDRG1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359094.1

ORF Insert Sequence:

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TDRG1 ( NM_001359095.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001346024.1 Homo sapiens testis development related 1 (TDRG1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu102805
Clone ID Related Accession (Same CDS sequence)	NM_001359096.1 , NM_001359094.1 , XM_024446535.1 , NM_001359095.1
Accession Version	NM_001359095.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	testis development-related protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HY034178.1 and BC033995.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY034178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346024.1
CDS	417..719
Translation	MKRREAVCAHRHFLGTGKPPHPLGRSIPVEPCPGLPAFAEVDLLSLLVPIKISSTPPSGSRLDPQIASSAFPGLGSLGGQDSSGSLVQRASCELESPYEL

Target ORF information:

RefSeq Version	NM_001359095.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis development related 1 (TDRG1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359095.1

ORF Insert Sequence:

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TDRG1 ( XM_024446535.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302303.1 Homo sapiens testis development related 1 (TDRG1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu102805
Clone ID Related Accession (Same CDS sequence)	NM_001359096.1 , NM_001359094.1 , XM_024446535.1 , NM_001359095.1
Accession Version	XM_024446535.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-25
Organism	Homo sapiens(human)
Product	testis development-related protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Homo sapiens Annotation Release 109 Annotation Version :: 109 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302303.1
CDS	490..792
Translation	MKRREAVCAHRHFLGTGKPPHPLGRSIPVEPCPGLPAFAEVDLLSLLVPIKISSTPPSGSRLDPQIASSAFPGLGSLGGQDSSGSLVQRASCELESPYEL

Target ORF information:

RefSeq Version	XM_024446535.1
Organism	Homo sapiens(human)
Definition	Homo sapiens testis development related 1 (TDRG1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024446535.1

ORF Insert Sequence:

ATGAAGAGGA GGGAGGCAGT CTGCGCGCAC CGCCATTTTC TAGGAACTGG GAAGCCCCCC 
CACCCCTTAG GAAGATCCAT CCCTGTGGAA CCTTGCCCAG GCTTACCAGC CTTTGCTGAG 
GTTGATCTAT TGTCCCTCCT TGTCCCCATC AAAATATCCA GCACTCCACC TTCAGGGAGT 
AGACTTGACC CTCAAATAGC AAGTTCAGCC TTCCCAGGTC TAGGTTCCCT GGGAGGTCAA 
GATTCGTCTG GTTCCTTAGT ACAGAGGGCT AGCTGTGAGT TGGAATCCCC CTATGAGCTT 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Molecular carcinogenesis57(2)225-234(2018 Feb)
Chen S,Wang LL,Sun KX,Xiu YL,Zong ZH,Chen X,Zhao Y

Potential lncRNA diagnostic biomarkers for early gastric cancer.
Molecular medicine reports16(6)9545-9552(2017 Dec)
Lu Q,Yu T,Ou X,Cao D,Xie T,Chen X

A genetic polymorphism at miR-526b binding-site in the lincRNA-NR_024015 exon confers risk of esophageal squamous cell carcinoma in a population of North China.
Molecular carcinogenesis56(3)960-971(2017 Mar)
Han L,Liu S,Liang J,Guo Y,Shen S,Guo X,Dong Z,Guo W

TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway.
Cancer biology & therapy17(7)741-50(2016 Jul)
Gan Y,Wang Y,Tan Z,Zhou J,Kitazawa R,Jiang X,Tang Y,Yang J

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TDRG1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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