SPANXB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPANXB1
Entrez Gene ID	728695
Full Name	SPANX family member B1
Synonyms	B1,CT11.2,SPANX-B,SPANXB,SPANXB2,SPANXF1,SPANXF2
General protein information	Preferred Names SPANX family member B1 Names sperm protein associated with the nucleus on the X chromosome B1 SPANX family member B/F SPANX family member F1 SPANX family, member B2 SPANX family, member F2 cancer/testis antigen 11.2 cancer/testis antigen family 11, member 2 nuclear-associated protein SPAN-Xb nuclear-associated protein SPAN-Xf sperm protein associated with the nucleus on the X chromosome B/F sperm protein associated with the nucleus, X chromosome, family member B1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq27.1
Summary	Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014].
Disorder MIM:	300669

mRNA and Protein(s)

mRNA	Protein	Name
NM_032461.3	NP_115850.2	sperm protein associated with the nucleus on the X chromosome B1
NM_032461.4	NP_115850.2	sperm protein associated with the nucleus on the X chromosome B1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPANXA1	NP_038481.2
Homo sapiens (human)	SPANXA2	NP_663695.1
Homo sapiens (human)	SPANXC	NP_073152.1
Homo sapiens (human)	SPANXB1	NP_115850.1
Homo sapiens (human)	SPANXD	NP_115793.1

Gene Ontology
Bibliography

Related articles in PubMed

Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.
Yilmaz-Ozcan S, Sade A, Kucukkaraduman B, Kaygusuz Y, Senses KM, Banerjee S, Gure AO
PloS one9(9)e107905(2014)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

SPANX gene variation in fertile and infertile males.
Hansen S, Eichler EE, Fullerton SM, Carrell D
Systems biology in reproductive medicine5518-26(2010 Feb)

SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.
Salemi M, Romano C, Barone C, Cal? F, Caraci F, Romano C, Scavuzzo C, Scillato F, Salluzzo MG, Piccione M, Martines M, Corsello G, Nicoletti F, Bosco P
Journal of genetics88(1)93-7(2009 Apr)

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.
Kouprina N, Pavlicek A, Noskov VN, Solomon G, Otstot J, Isaacs W, Carpten JD, Trent JM, Schleutker J, Barrett JC, Jurka J, Larionov V
Genome research15(11)1477-86(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition
Title: Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.

Copy number variation of the entire gene cluster containing all four SPANXA-E genes and with SPANXB, found exclusively in maturing sperm. Average CNV patterns did not differ between fertile and infertile men.
Title: SPANX gene variation in fertile and infertile males.

SPANX-B (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes
Title: SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.

Observational study of gene-disease association. (HuGE Navigator)
Title: SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Sicilian patients with melanoma.

Human VCX/Y, SPANX, and CSAG2 gene families together with the murine SPANX gene and the CYPT family may share a common ancestor.
Title: A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family.

The following SPANXB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPANXB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15680	NM_032461.4 Latest version!	Homo sapiens SPANX family member B1 (SPANXB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu15680	NM_032461.3	Homo sapiens SPANX family member B1 (SPANXB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPANXB1 ( NM_032461.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115850.2 Homo sapiens SPANX family member B1 (SPANXB1), mRNA.

Price & Availability↑

CloneID	OHu15680
Clone ID Related Accession (Same CDS sequence)	NM_032461.3 , NM_032461.4
Accession Version	NM_032461.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	sperm protein associated with the nucleus on the X chromosome B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ457796.1. On or before Apr 9, 2014 this sequence version replaced NM_139019.1, NM_032461.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ457796.1, BG721088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCCAAC AATCCAGTGT CCGCAGGCTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GCCAACGAGG CCAATGAGGC CAACAAGACG ATGCCGGAGA CCCCAACTGG GGACTCAGAC 
CCGCAACCTG CTCCTAAAAA AATGAAAACA TCTGAGTCCT CGACCATACT AGTGGTTCGC 
TACAGGAGGA ACGTGAAAAG AACATCTCCA GAGGAACTGC TGAATGACCA CGCCCGAGAG 
AACAGAATCA ACCCCGACCA AATGGAGGAG GAGGAATTCA TAGAAATAAC GACTGAAAGA 
CCTAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115850.2
CDS	104..415
Translation	MGQQSSVRRLKRSVPCESNEANEANEANKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRTSPEELLNDHARENRINPDQMEEEEFIEITTERPKK

Target ORF information:

RefSeq Version	NM_032461.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SPANX family member B1 (SPANXB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032461.3

ORF Insert Sequence:

ATGGGCCAAC AATCCAGTGT CCGCAGGCTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GCCAACGAGG CCAATGAGGC CAACAAGACG ATGCCGGAGA CCCCAACTGG GGACTCAGAC 
CCGCAACCTG CTCCTAAAAA AATGAAAACA TCTGAGTCCT CGACCATACT AGTGGTTCGC 
TACAGGAGGA ACGTGAAAAG AACATCTCCA GAGGAACTGC TGAATGACCA CGCCCGAGAG 
AACAGAATCA ACCCCGACCA AATGGAGGAG GAGGAATTCA TAGAAATAAC GACTGAAAGA 
CCTAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPANXB1 ( NM_032461.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115850.2 Homo sapiens SPANX family member B1 (SPANXB1), mRNA.

Price & Availability↑

CloneID	OHu15680
Clone ID Related Accession (Same CDS sequence)	NM_032461.3 , NM_032461.4
Accession Version	NM_032461.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	sperm protein associated with the nucleus on the X chromosome B1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ457796.1. On Nov 22, 2018 this sequence version replaced NM_032461.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF098307.1, AJ457796.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000449283.2/ ENSP00000405202.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCCAAC AATCCAGTGT CCGCAGGCTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GCCAACGAGG CCAATGAGGC CAACAAGACG ATGCCGGAGA CCCCAACTGG GGACTCAGAC 
CCGCAACCTG CTCCTAAAAA AATGAAAACA TCTGAGTCCT CGACCATACT AGTGGTTCGC 
TACAGGAGGA ACGTGAAAAG AACATCTCCA GAGGAACTGC TGAATGACCA CGCCCGAGAG 
AACAGAATCA ACCCCGACCA AATGGAGGAG GAGGAATTCA TAGAAATAAC GACTGAAAGA 
CCTAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115850.2
CDS	101..412
Translation	MGQQSSVRRLKRSVPCESNEANEANEANKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRTSPEELLNDHARENRINPDQMEEEEFIEITTERPKK

Target ORF information:

RefSeq Version	NM_032461.4
Organism	Homo sapiens(human)
Definition	Homo sapiens SPANX family member B1 (SPANXB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032461.4

ORF Insert Sequence:

ATGGGCCAAC AATCCAGTGT CCGCAGGCTG AAGAGGAGCG TCCCCTGTGA ATCCAACGAG 
GCCAACGAGG CCAATGAGGC CAACAAGACG ATGCCGGAGA CCCCAACTGG GGACTCAGAC 
CCGCAACCTG CTCCTAAAAA AATGAAAACA TCTGAGTCCT CGACCATACT AGTGGTTCGC 
TACAGGAGGA ACGTGAAAAG AACATCTCCA GAGGAACTGC TGAATGACCA CGCCCGAGAG 
AACAGAATCA ACCCCGACCA AATGGAGGAG GAGGAATTCA TAGAAATAAC GACTGAAAGA 
CCTAAAAAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition.
PloS one9(9)e107905(2014)
Yilmaz-Ozcan S,Sade A,Kucukkaraduman B,Kaygusuz Y,Senses KM,Banerjee S,Gure AO

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

SPANX gene variation in fertile and infertile males.
Systems biology in reproductive medicine5518-26(2010 Feb)
Hansen S,Eichler EE,Fullerton SM,Carrell D

SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.
Journal of genetics88(1)93-7(2009 Apr)
Salemi M,Romano C,Barone C,Cal? F,Caraci F,Romano C,Scavuzzo C,Scillato F,Salluzzo MG,Piccione M,Martines M,Corsello G,Nicoletti F,Bosco P

Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27.
Genome research15(11)1477-86(2005 Nov)
Kouprina N,Pavlicek A,Noskov VN,Solomon G,Otstot J,Isaacs W,Carpten JD,Trent JM,Schleutker J,Barrett JC,Jurka J,Larionov V

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SPANXB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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