TRPC5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRPC5
Entrez Gene ID	7224
Full Name	transient receptor potential cation channel subfamily C member 5
Synonyms	PPP1R159,TRP5
General protein information	Preferred Names transient receptor potential cation channel subfamily C member 5 Names short transient receptor potential channel 5 TRP-5 hTRP5 protein phosphatase 1, regulatory subunit 159 transient receptor potential channel 5 transient receptor protein 5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq23
Summary	This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010].
Disorder MIM:	300334

mRNA and Protein(s)

mRNA	Protein	Name
NM_012471.2	NP_036603.1	short transient receptor potential channel 5
XM_017029774.1	XP_016885263.1	short transient receptor potential channel 5 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	TRPC5	NP_001160046.1
Gallus gallus (chicken)	TRPC5	XP_420310.2
Canis lupus familiaris (dog)	TRPC5	XP_853241.1
Rattus norvegicus (Norway rat)	Trpc5	NP_543174.1
Homo sapiens (human)	TRPC5	NP_036603.1
Pan troglodytes (chimpanzee)	TRPC5	XP_003317691.1
	TRPC5	XP_001101078.1
Danio rerio (zebrafish)	LOC555897	XP_683649.2
Mus musculus (house mouse)	Trpc5	NP_033454.1
Xenopus tropicalis (tropical clawed frog)	trpc5	XP_002938829.1

Gene Ontology
Bibliography

Related articles in PubMed

Overexpression of TrpC5 promotes tumor metastasis via the HIF-1?-Twist signaling pathway in colon cancer.
Chen Z, Zhu Y, Dong Y, Zhang P, Han X, Jin J, Ma X
Clinical science (London, England : 1979)131(19)2439-2450(2017 Oct)

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKK?/AMPK?/mTOR pathway.
Zhang P, Liu X, Li H, Chen Z, Yao X, Jin J, Ma X
Scientific reports7(1)3158(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

induces the epithelial-mesenchymal transition through the HIF-1alpha-Twist signaling pathway to promote tumor metastasis in colon cancer
Title: Overexpression of TrpC5 promotes tumor metastasis via the HIF-1?-Twist signaling pathway in colon cancer.

These findings suggest identification of an important experimental tool compound, which has much higher potency for inhibiting TRPC1/4/5 channels than previously reported agents, impressive specificity, and graded subtype selectivity within the TRPC1/4/5 channel family.
Title: Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.

circulating exosome-carrying TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance.
Title: Increasing circulating exosomes-carrying TRPC5 predicts chemoresistance in metastatic breast cancer patients.

The essential role of TrpC5 in GLUT1 induction and chemoresistance in colorectal cancer.
Title: Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer.

that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5.
Title: Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) Channel.

The following TRPC5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRPC5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18312	NM_012471.2 Latest version!	Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu18312	XM_017029774.1 Latest version!	Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRPC5 ( NM_012471.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_036603.1 Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), mRNA.

Price & Availability↑

CloneID	OHu18312
Clone ID Related Accession (Same CDS sequence)	NM_012471.2 , XM_017029774.1
Accession Version	NM_012471.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2922bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	short transient receptor potential channel 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031388.1, AF054568.1 and AL049563.4. This sequence is a reference standard in the RefSeqGene project. On Apr 20, 2006 this sequence version replaced NM_012471.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF054568.1, SRR1660805.224298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMN03465403 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGCCCAAC TGTACTACAA AAAGGTCAAC TACTCACCGT ACAGAGACCG CATCCCCCTG 
CAAATTGTGA GGGCTGAGAC AGAGCTCTCT GCAGAGGAGA AGGCCTTCCT CAATGCTGTG 
GAGAAGGGGG ACTATGCCAC TGTGAAGCAG GCCCTTCAGG AGGCTGAGAT CTACTATAAT 
GTTAACATCA ACTGCATGGA CCCCTTGGGC CGGAGTGCCC TGCTCATTGC CATTGAGAAC 
GAGAACCTGG AGATCATGGA GCTACTGCTG AACCACAGCG TGTATGTGGG TGATGCATTG 
CTCTATGCCA TACGCAAGGA AGTGGTGGGC GCTGTGGAGC TTCTGCTCAG CTACAGGCGG 
CCCAGCGGAG AGAAGCAGGT CCCCACTCTG ATGATGGACA CGCAGTTCTC TGAATTCACA 
CCGGACATCA CTCCCATCAT GCTGGCTGCC CACACCAACA ACTACGAAAT CATCAAATTG 
CTTGTCCAAA AACGGGTCAC TATCCCACGG CCCCACCAGA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCTA GTTCAGAGGT AGACAGCCTG CGCCACTCTC GCTCCCGACT GAACATCTAT 
AAGGCTCTGG CAAGCCCCTC ACTCATTGCC TTATCAAGTG AGGACCCCAT CCTAACTGCC 
TTCCGTCTGG GCTGGGAGCT CAAGGAGCTC AGCAAGGTGG AGAATGAGTT CAAGGCCGAG 
TATGAGGAGC TCTCTCAGCA GTGCAAGCTC TTTGCCAAAG ACCTGCTGGA CCAAGCTCGG 
AGCTCCAGGG AACTGGAGAT CATCCTCAAC CATCGAGATG ACCACAGTGA AGAGCTTGAC 
CCTCAGAAGT ACCATGACCT GGCCAAGTTG AAGGTGGCAA TCAAATACCA CCAGAAAGAG 
TTTGTTGCTC AGCCCAACTG CCAACAGTTG CTTGCCACCC TGTGGTATGA TGGCTTCCCT 
GGATGGCGGC GGAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGGTTCCTG 
TTTCCCATGC TGTCTATAGC CTACCTGATC TCACCCAGGA GCAACCTTGG GCTGTTCATC 
AAGAAACCCT TTATCAAGTT TATCTGCCAC ACAGCATCCT ATTTGACCTT CCTCTTTATG 
CTTCTCCTGG CTTCTCAGCA CATTGTCAGG ACAGACCTTC ATGTACAGGG GCCTCCCCCA 
ACTGTCGTGG AATGGATGAT ATTGCCTTGG GTTCTAGGTT TCATTTGGGG TGAGATTAAG 
GAAATGTGGG ATGGTGGATT TACTGAATAC ATCCATGACT GGTGGAACCT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCCTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA GGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCAA TATCCAACAT TTTAAGTTCG TTGCGTCTCA TATCCCTGTT CACAGCCAAC 
TCCCACTTAG GACCTCTGCA GATCTCTTTG GGACGCATGC TGCTTGATAT CCTCAAATTC 
CTCTTTATCT ACTGCCTGGT ACTACTAGCT TTTGCCAATG GACTGAACCA GCTTTACTTC 
TATTATGAAA CCAGAGCTAT CGATGAGCCT AACAACTGCA AGGGGATCCG ATGTGAGAAA 
CAGAACAATG CCTTCTCCAC GCTCTTTGAG ACTCTTCAGT CACTCTTCTG GTCTGTATTT 
GGCCTTTTAA ATCTATATGT CACCAATGTG AAAGCCAGAC ACGAATTCAC CGAGTTTGTA 
GGAGCTACCA TGTTTGGAAC ATACAATGTC ATCTCCCTGG TAGTGCTGCT GAACATGCTG 
ATTGCTATGA TGAACAACTC CTATCAGCTT ATTGCCGATC ATGCTGATAT CGAGTGGAAG 
TTTGCAAGGA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT GCCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAGTCATTT CTATACCTTG GTAACTGGTT CAACAACACC 
TTCTGCCCCA AAAGAGACCC TGACGGTAGA CGGAGAAGGC GCAACTTGAG AAGTTTCACA 
GAACGCAATG CTGACAGCCT GATACAAAAT CAACATTATC AGGAAGTTAT CAGGAATTTA 
GTCAAAAGAT ATGTGGCTGC TATGATAAGA AATTCCAAAA CACATGAGGG ACTTACAGAA 
GAAAATTTTA AGGAATTAAA GCAAGACATC TCCAGCTTTC GGTATGAAGT GCTTGACCTC 
TTGGGAAATA GAAAACATCC AAGGAGCTTT TCCACTAGCA GCACTGAACT GTCTCAGAGA 
GACGATAATA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CCAAGAGTGT CTCTTTTAAT 
TTAGGCTGCA AGAAAAAGAC TTGCCATGGG CCACCTCTCA TCAGAACCAT GCCAAGGTCC 
AGTGGTGCCC AAGGAAAGTC AAAAGCTGAG TCATCAAGCA AACGCTCCTT CATGGGTCCT 
TCTCTCAAGA AACTGGGTCT CCTATTCTCC AAATTTAATG GTCATATGTC TGAACCCAGT 
TCAGAGCCAA TGTACACAAT TTCTGATGGA ATTGTTCAGC AGCACTGTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAA GCAGAGGCCT GTTCTCAAAG TGAAATTAAC 
CTCAGTGAGG TAGAATTAGG TGAAGTCCAG GGCGCTGCTC AGAGCAGTGA ATGCCCTCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC AGCATCTGCT CCTCAAATTC TAAACTTTTA 
GACTCCTCAG AGGATGTATT TGAAACTTGG GGAGAGGCTT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036603.1
CDS	920..3841
Translation	MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

Target ORF information:

RefSeq Version	NM_012471.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012471.2

ORF Insert Sequence:

ATGGCCCAAC TGTACTACAA AAAGGTCAAC TACTCACCGT ACAGAGACCG CATCCCCCTG 
CAAATTGTGA GGGCTGAGAC AGAGCTCTCT GCAGAGGAGA AGGCCTTCCT CAATGCTGTG 
GAGAAGGGGG ACTATGCCAC TGTGAAGCAG GCCCTTCAGG AGGCTGAGAT CTACTATAAT 
GTTAACATCA ACTGCATGGA CCCCTTGGGC CGGAGTGCCC TGCTCATTGC CATTGAGAAC 
GAGAACCTGG AGATCATGGA GCTACTGCTG AACCACAGCG TGTATGTGGG TGATGCATTG 
CTCTATGCCA TACGCAAGGA AGTGGTGGGC GCTGTGGAGC TTCTGCTCAG CTACAGGCGG 
CCCAGCGGAG AGAAGCAGGT CCCCACTCTG ATGATGGACA CGCAGTTCTC TGAATTCACA 
CCGGACATCA CTCCCATCAT GCTGGCTGCC CACACCAACA ACTACGAAAT CATCAAATTG 
CTTGTCCAAA AACGGGTCAC TATCCCACGG CCCCACCAGA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCTA GTTCAGAGGT AGACAGCCTG CGCCACTCTC GCTCCCGACT GAACATCTAT 
AAGGCTCTGG CAAGCCCCTC ACTCATTGCC TTATCAAGTG AGGACCCCAT CCTAACTGCC 
TTCCGTCTGG GCTGGGAGCT CAAGGAGCTC AGCAAGGTGG AGAATGAGTT CAAGGCCGAG 
TATGAGGAGC TCTCTCAGCA GTGCAAGCTC TTTGCCAAAG ACCTGCTGGA CCAAGCTCGG 
AGCTCCAGGG AACTGGAGAT CATCCTCAAC CATCGAGATG ACCACAGTGA AGAGCTTGAC 
CCTCAGAAGT ACCATGACCT GGCCAAGTTG AAGGTGGCAA TCAAATACCA CCAGAAAGAG 
TTTGTTGCTC AGCCCAACTG CCAACAGTTG CTTGCCACCC TGTGGTATGA TGGCTTCCCT 
GGATGGCGGC GGAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGGTTCCTG 
TTTCCCATGC TGTCTATAGC CTACCTGATC TCACCCAGGA GCAACCTTGG GCTGTTCATC 
AAGAAACCCT TTATCAAGTT TATCTGCCAC ACAGCATCCT ATTTGACCTT CCTCTTTATG 
CTTCTCCTGG CTTCTCAGCA CATTGTCAGG ACAGACCTTC ATGTACAGGG GCCTCCCCCA 
ACTGTCGTGG AATGGATGAT ATTGCCTTGG GTTCTAGGTT TCATTTGGGG TGAGATTAAG 
GAAATGTGGG ATGGTGGATT TACTGAATAC ATCCATGACT GGTGGAACCT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCCTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA GGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCAA TATCCAACAT TTTAAGTTCG TTGCGTCTCA TATCCCTGTT CACAGCCAAC 
TCCCACTTAG GACCTCTGCA GATCTCTTTG GGACGCATGC TGCTTGATAT CCTCAAATTC 
CTCTTTATCT ACTGCCTGGT ACTACTAGCT TTTGCCAATG GACTGAACCA GCTTTACTTC 
TATTATGAAA CCAGAGCTAT CGATGAGCCT AACAACTGCA AGGGGATCCG ATGTGAGAAA 
CAGAACAATG CCTTCTCCAC GCTCTTTGAG ACTCTTCAGT CACTCTTCTG GTCTGTATTT 
GGCCTTTTAA ATCTATATGT CACCAATGTG AAAGCCAGAC ACGAATTCAC CGAGTTTGTA 
GGAGCTACCA TGTTTGGAAC ATACAATGTC ATCTCCCTGG TAGTGCTGCT GAACATGCTG 
ATTGCTATGA TGAACAACTC CTATCAGCTT ATTGCCGATC ATGCTGATAT CGAGTGGAAG 
TTTGCAAGGA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT GCCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAGTCATTT CTATACCTTG GTAACTGGTT CAACAACACC 
TTCTGCCCCA AAAGAGACCC TGACGGTAGA CGGAGAAGGC GCAACTTGAG AAGTTTCACA 
GAACGCAATG CTGACAGCCT GATACAAAAT CAACATTATC AGGAAGTTAT CAGGAATTTA 
GTCAAAAGAT ATGTGGCTGC TATGATAAGA AATTCCAAAA CACATGAGGG ACTTACAGAA 
GAAAATTTTA AGGAATTAAA GCAAGACATC TCCAGCTTTC GGTATGAAGT GCTTGACCTC 
TTGGGAAATA GAAAACATCC AAGGAGCTTT TCCACTAGCA GCACTGAACT GTCTCAGAGA 
GACGATAATA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CCAAGAGTGT CTCTTTTAAT 
TTAGGCTGCA AGAAAAAGAC TTGCCATGGG CCACCTCTCA TCAGAACCAT GCCAAGGTCC 
AGTGGTGCCC AAGGAAAGTC AAAAGCTGAG TCATCAAGCA AACGCTCCTT CATGGGTCCT 
TCTCTCAAGA AACTGGGTCT CCTATTCTCC AAATTTAATG GTCATATGTC TGAACCCAGT 
TCAGAGCCAA TGTACACAAT TTCTGATGGA ATTGTTCAGC AGCACTGTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAA GCAGAGGCCT GTTCTCAAAG TGAAATTAAC 
CTCAGTGAGG TAGAATTAGG TGAAGTCCAG GGCGCTGCTC AGAGCAGTGA ATGCCCTCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC AGCATCTGCT CCTCAAATTC TAAACTTTTA 
GACTCCTCAG AGGATGTATT TGAAACTTGG GGAGAGGCTT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRPC5 ( XM_017029774.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885263.1 Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18312
Clone ID Related Accession (Same CDS sequence)	NM_012471.2 , XM_017029774.1
Accession Version	XM_017029774.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2922bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	short transient receptor potential channel 5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCAAC TGTACTACAA AAAGGTCAAC TACTCACCGT ACAGAGACCG CATCCCCCTG 
CAAATTGTGA GGGCTGAGAC AGAGCTCTCT GCAGAGGAGA AGGCCTTCCT CAATGCTGTG 
GAGAAGGGGG ACTATGCCAC TGTGAAGCAG GCCCTTCAGG AGGCTGAGAT CTACTATAAT 
GTTAACATCA ACTGCATGGA CCCCTTGGGC CGGAGTGCCC TGCTCATTGC CATTGAGAAC 
GAGAACCTGG AGATCATGGA GCTACTGCTG AACCACAGCG TGTATGTGGG TGATGCATTG 
CTCTATGCCA TACGCAAGGA AGTGGTGGGC GCTGTGGAGC TTCTGCTCAG CTACAGGCGG 
CCCAGCGGAG AGAAGCAGGT CCCCACTCTG ATGATGGACA CGCAGTTCTC TGAATTCACA 
CCGGACATCA CTCCCATCAT GCTGGCTGCC CACACCAACA ACTACGAAAT CATCAAATTG 
CTTGTCCAAA AACGGGTCAC TATCCCACGG CCCCACCAGA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCTA GTTCAGAGGT AGACAGCCTG CGCCACTCTC GCTCCCGACT GAACATCTAT 
AAGGCTCTGG CAAGCCCCTC ACTCATTGCC TTATCAAGTG AGGACCCCAT CCTAACTGCC 
TTCCGTCTGG GCTGGGAGCT CAAGGAGCTC AGCAAGGTGG AGAATGAGTT CAAGGCCGAG 
TATGAGGAGC TCTCTCAGCA GTGCAAGCTC TTTGCCAAAG ACCTGCTGGA CCAAGCTCGG 
AGCTCCAGGG AACTGGAGAT CATCCTCAAC CATCGAGATG ACCACAGTGA AGAGCTTGAC 
CCTCAGAAGT ACCATGACCT GGCCAAGTTG AAGGTGGCAA TCAAATACCA CCAGAAAGAG 
TTTGTTGCTC AGCCCAACTG CCAACAGTTG CTTGCCACCC TGTGGTATGA TGGCTTCCCT 
GGATGGCGGC GGAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGGTTCCTG 
TTTCCCATGC TGTCTATAGC CTACCTGATC TCACCCAGGA GCAACCTTGG GCTGTTCATC 
AAGAAACCCT TTATCAAGTT TATCTGCCAC ACAGCATCCT ATTTGACCTT CCTCTTTATG 
CTTCTCCTGG CTTCTCAGCA CATTGTCAGG ACAGACCTTC ATGTACAGGG GCCTCCCCCA 
ACTGTCGTGG AATGGATGAT ATTGCCTTGG GTTCTAGGTT TCATTTGGGG TGAGATTAAG 
GAAATGTGGG ATGGTGGATT TACTGAATAC ATCCATGACT GGTGGAACCT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCCTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA GGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCAA TATCCAACAT TTTAAGTTCG TTGCGTCTCA TATCCCTGTT CACAGCCAAC 
TCCCACTTAG GACCTCTGCA GATCTCTTTG GGACGCATGC TGCTTGATAT CCTCAAATTC 
CTCTTTATCT ACTGCCTGGT ACTACTAGCT TTTGCCAATG GACTGAACCA GCTTTACTTC 
TATTATGAAA CCAGAGCTAT CGATGAGCCT AACAACTGCA AGGGGATCCG ATGTGAGAAA 
CAGAACAATG CCTTCTCCAC GCTCTTTGAG ACTCTTCAGT CACTCTTCTG GTCTGTATTT 
GGCCTTTTAA ATCTATATGT CACCAATGTG AAAGCCAGAC ACGAATTCAC CGAGTTTGTA 
GGAGCTACCA TGTTTGGAAC ATACAATGTC ATCTCCCTGG TAGTGCTGCT GAACATGCTG 
ATTGCTATGA TGAACAACTC CTATCAGCTT ATTGCCGATC ATGCTGATAT CGAGTGGAAG 
TTTGCAAGGA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT GCCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAGTCATTT CTATACCTTG GTAACTGGTT CAACAACACC 
TTCTGCCCCA AAAGAGACCC TGACGGTAGA CGGAGAAGGC GCAACTTGAG AAGTTTCACA 
GAACGCAATG CTGACAGCCT GATACAAAAT CAACATTATC AGGAAGTTAT CAGGAATTTA 
GTCAAAAGAT ATGTGGCTGC TATGATAAGA AATTCCAAAA CACATGAGGG ACTTACAGAA 
GAAAATTTTA AGGAATTAAA GCAAGACATC TCCAGCTTTC GGTATGAAGT GCTTGACCTC 
TTGGGAAATA GAAAACATCC AAGGAGCTTT TCCACTAGCA GCACTGAACT GTCTCAGAGA 
GACGATAATA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CCAAGAGTGT CTCTTTTAAT 
TTAGGCTGCA AGAAAAAGAC TTGCCATGGG CCACCTCTCA TCAGAACCAT GCCAAGGTCC 
AGTGGTGCCC AAGGAAAGTC AAAAGCTGAG TCATCAAGCA AACGCTCCTT CATGGGTCCT 
TCTCTCAAGA AACTGGGTCT CCTATTCTCC AAATTTAATG GTCATATGTC TGAACCCAGT 
TCAGAGCCAA TGTACACAAT TTCTGATGGA ATTGTTCAGC AGCACTGTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAA GCAGAGGCCT GTTCTCAAAG TGAAATTAAC 
CTCAGTGAGG TAGAATTAGG TGAAGTCCAG GGCGCTGCTC AGAGCAGTGA ATGCCCTCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC AGCATCTGCT CCTCAAATTC TAAACTTTTA 
GACTCCTCAG AGGATGTATT TGAAACTTGG GGAGAGGCTT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885263.1
CDS	1210..4131
Translation	MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

Target ORF information:

RefSeq Version	XM_017029774.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily C member 5 (TRPC5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029774.1

ORF Insert Sequence:

ATGGCCCAAC TGTACTACAA AAAGGTCAAC TACTCACCGT ACAGAGACCG CATCCCCCTG 
CAAATTGTGA GGGCTGAGAC AGAGCTCTCT GCAGAGGAGA AGGCCTTCCT CAATGCTGTG 
GAGAAGGGGG ACTATGCCAC TGTGAAGCAG GCCCTTCAGG AGGCTGAGAT CTACTATAAT 
GTTAACATCA ACTGCATGGA CCCCTTGGGC CGGAGTGCCC TGCTCATTGC CATTGAGAAC 
GAGAACCTGG AGATCATGGA GCTACTGCTG AACCACAGCG TGTATGTGGG TGATGCATTG 
CTCTATGCCA TACGCAAGGA AGTGGTGGGC GCTGTGGAGC TTCTGCTCAG CTACAGGCGG 
CCCAGCGGAG AGAAGCAGGT CCCCACTCTG ATGATGGACA CGCAGTTCTC TGAATTCACA 
CCGGACATCA CTCCCATCAT GCTGGCTGCC CACACCAACA ACTACGAAAT CATCAAATTG 
CTTGTCCAAA AACGGGTCAC TATCCCACGG CCCCACCAGA TCCGCTGCAA CTGTGTGGAG 
TGTGTGTCTA GTTCAGAGGT AGACAGCCTG CGCCACTCTC GCTCCCGACT GAACATCTAT 
AAGGCTCTGG CAAGCCCCTC ACTCATTGCC TTATCAAGTG AGGACCCCAT CCTAACTGCC 
TTCCGTCTGG GCTGGGAGCT CAAGGAGCTC AGCAAGGTGG AGAATGAGTT CAAGGCCGAG 
TATGAGGAGC TCTCTCAGCA GTGCAAGCTC TTTGCCAAAG ACCTGCTGGA CCAAGCTCGG 
AGCTCCAGGG AACTGGAGAT CATCCTCAAC CATCGAGATG ACCACAGTGA AGAGCTTGAC 
CCTCAGAAGT ACCATGACCT GGCCAAGTTG AAGGTGGCAA TCAAATACCA CCAGAAAGAG 
TTTGTTGCTC AGCCCAACTG CCAACAGTTG CTTGCCACCC TGTGGTATGA TGGCTTCCCT 
GGATGGCGGC GGAAACACTG GGTAGTCAAG CTTCTAACCT GCATGACCAT TGGGTTCCTG 
TTTCCCATGC TGTCTATAGC CTACCTGATC TCACCCAGGA GCAACCTTGG GCTGTTCATC 
AAGAAACCCT TTATCAAGTT TATCTGCCAC ACAGCATCCT ATTTGACCTT CCTCTTTATG 
CTTCTCCTGG CTTCTCAGCA CATTGTCAGG ACAGACCTTC ATGTACAGGG GCCTCCCCCA 
ACTGTCGTGG AATGGATGAT ATTGCCTTGG GTTCTAGGTT TCATTTGGGG TGAGATTAAG 
GAAATGTGGG ATGGTGGATT TACTGAATAC ATCCATGACT GGTGGAACCT GATGGATTTT 
GCAATGAACT CCCTCTACCT GGCAACTATT TCCCTGAAGA TTGTGGCCTA TGTCAAGTAT 
AATGGTTCTC GTCCAAGGGA GGAATGGGAA ATGTGGCACC CGACTCTGAT TGCGGAAGCA 
CTCTTCGCAA TATCCAACAT TTTAAGTTCG TTGCGTCTCA TATCCCTGTT CACAGCCAAC 
TCCCACTTAG GACCTCTGCA GATCTCTTTG GGACGCATGC TGCTTGATAT CCTCAAATTC 
CTCTTTATCT ACTGCCTGGT ACTACTAGCT TTTGCCAATG GACTGAACCA GCTTTACTTC 
TATTATGAAA CCAGAGCTAT CGATGAGCCT AACAACTGCA AGGGGATCCG ATGTGAGAAA 
CAGAACAATG CCTTCTCCAC GCTCTTTGAG ACTCTTCAGT CACTCTTCTG GTCTGTATTT 
GGCCTTTTAA ATCTATATGT CACCAATGTG AAAGCCAGAC ACGAATTCAC CGAGTTTGTA 
GGAGCTACCA TGTTTGGAAC ATACAATGTC ATCTCCCTGG TAGTGCTGCT GAACATGCTG 
ATTGCTATGA TGAACAACTC CTATCAGCTT ATTGCCGATC ATGCTGATAT CGAGTGGAAG 
TTTGCAAGGA CGAAGCTCTG GATGAGTTAC TTTGATGAAG GTGGCACCTT GCCACCTCCT 
TTCAACATCA TCCCCAGCCC CAAGTCATTT CTATACCTTG GTAACTGGTT CAACAACACC 
TTCTGCCCCA AAAGAGACCC TGACGGTAGA CGGAGAAGGC GCAACTTGAG AAGTTTCACA 
GAACGCAATG CTGACAGCCT GATACAAAAT CAACATTATC AGGAAGTTAT CAGGAATTTA 
GTCAAAAGAT ATGTGGCTGC TATGATAAGA AATTCCAAAA CACATGAGGG ACTTACAGAA 
GAAAATTTTA AGGAATTAAA GCAAGACATC TCCAGCTTTC GGTATGAAGT GCTTGACCTC 
TTGGGAAATA GAAAACATCC AAGGAGCTTT TCCACTAGCA GCACTGAACT GTCTCAGAGA 
GACGATAATA ATGATGGCAG TGGTGGGGCT CGGGCCAAAT CCAAGAGTGT CTCTTTTAAT 
TTAGGCTGCA AGAAAAAGAC TTGCCATGGG CCACCTCTCA TCAGAACCAT GCCAAGGTCC 
AGTGGTGCCC AAGGAAAGTC AAAAGCTGAG TCATCAAGCA AACGCTCCTT CATGGGTCCT 
TCTCTCAAGA AACTGGGTCT CCTATTCTCC AAATTTAATG GTCATATGTC TGAACCCAGT 
TCAGAGCCAA TGTACACAAT TTCTGATGGA ATTGTTCAGC AGCACTGTAT GTGGCAGGAC 
ATCAGATATT CTCAGATGGA GAAAGGGAAA GCAGAGGCCT GTTCTCAAAG TGAAATTAAC 
CTCAGTGAGG TAGAATTAGG TGAAGTCCAG GGCGCTGCTC AGAGCAGTGA ATGCCCTCTA 
GCCTGTTCCA GCTCTCTTCA CTGTGCATCC AGCATCTGCT CCTCAAATTC TAAACTTTTA 
GACTCCTCAG AGGATGTATT TGAAACTTGG GGAGAGGCTT GTGACTTGCT CATGCACAAA 
TGGGGTGATG GACAGGAAGA ACAAGTTACA ACTCGCCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Overexpression of TrpC5 promotes tumor metastasis via the HIF-1?-Twist signaling pathway in colon cancer.
Clinical science (London, England : 1979)131(19)2439-2450(2017 Oct)
Chen Z,Zhu Y,Dong Y,Zhang P,Han X,Jin J,Ma X

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKK?/AMPK?/mTOR pathway.
Scientific reports7(1)3158(2017 Jun)
Zhang P,Liu X,Li H,Chen Z,Yao X,Jin J,Ma X

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TRPC5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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