TNP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNP1
Entrez Gene ID	7141
Full Name	transition protein 1
Synonyms	TP1
General protein information	Preferred Names transition protein 1 Names spermatid nuclear transition protein 1 STP-1 TP-1 transition protein 1 (during histone to protamine replacement)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q35
Summary	Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].
Disorder MIM:	190231

mRNA and Protein(s)

mRNA	Protein	Name
NM_003284.4	NP_003275.1	spermatid nuclear transition protein 1
NM_003284.3	NP_003275.1	spermatid nuclear transition protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNP1	NP_003275.1
Pan troglodytes (chimpanzee)	TNP1	NP_001233380.1
	TNP1	XP_001087783.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel Autoantigens Associated with Lupus Nephritis.
Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H
PloS one10(6)e0126564(2015)

Genome-wide association study identifies four loci associated with eruption of permanent teeth.
Geller F, Feenstra B, Zhang H, Shaffer JR, Hansen T, Esserlind AL, Boyd HA, Nohr EA, Timpson NJ, Fatemifar G, Paternoster L, Evans DM, Weyant RJ, Levy SM, Lathrop M, Smith GD, Murray JC, Olesen J, Werge T, Marazita ML, S?rensen TI, Melbye M
PLoS genetics7(9)e1002275(2011 Sep)

The TNP1 haplotype - GCG is associated with azoospermia.
Khattri A, Bhushan SS, Sireesha V, Gupta NJ, Chakravarty BN, Deendayal M, Prasad S, Singh L, Thangaraj K
International journal of andrology34(2)173-82(2011 Apr)

Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
Aston KI, Krausz C, Laface I, Ruiz-Castan? E, Carrell DT
Human reproduction (Oxford, England)25(6)1383-97(2010 Jun)

Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men.
Becker S, Soffer Y, Lewin LM, Yogev L, Shochat L, Golan R
Andrologia40(4)203-8(2008 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.
Title: Novel Autoantigens Associated with Lupus Nephritis.

frequency of the haplotype GCG (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.
Title: The TNP1 haplotype - GCG is associated with azoospermia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.

The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.
Title: Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men.

The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.
Title: Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos.

The following TNP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04116	NM_003284.4 Latest version!	Homo sapiens transition protein 1 (TNP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu04116	NM_003284.3	Homo sapiens transition protein 1 (TNP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNP1 ( NM_003284.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003275.1 Homo sapiens transition protein 1 (TNP1), mRNA.

Price & Availability↑

CloneID	OHu04116
Clone ID Related Accession (Same CDS sequence)	NM_003284.4 , NM_003284.3
Accession Version	NM_003284.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 168bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	spermatid nuclear transition protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC007557.3 and BC029516.1. On Nov 22, 2018 this sequence version replaced NM_003284.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU569792.1, BP371302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000236979.2/ ENSP00000236979.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGTCGACCA GCCGCAAATT AAAGAGTCAT GGCATGAGGA GGAGCAAGAG CCGATCTCCT 
CACAAGGGAG TCAAGAGAGG TGGCAGCAAA AGAAAATACC GTAAGGGCAA CCTGAAAAGT 
AGGAAACGGG GCGATGACGC CAATCGCAAT TACCGCTCCC ACTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003275.1
CDS	31..198
Translation	MSTSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRGDDANRNYRSHL

Target ORF information:

RefSeq Version	NM_003284.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transition protein 1 (TNP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003284.4

ORF Insert Sequence:

1
61
121

ATGTCGACCA GCCGCAAATT AAAGAGTCAT GGCATGAGGA GGAGCAAGAG CCGATCTCCT 
CACAAGGGAG TCAAGAGAGG TGGCAGCAAA AGAAAATACC GTAAGGGCAA CCTGAAAAGT 
AGGAAACGGG GCGATGACGC CAATCGCAAT TACCGCTCCC ACTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNP1 ( NM_003284.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003275.1 Homo sapiens transition protein 1 (TNP1), mRNA.

Price & Availability↑

CloneID	OHu04116
Clone ID Related Accession (Same CDS sequence)	NM_003284.4 , NM_003284.3
Accession Version	NM_003284.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 168bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	spermatid nuclear transition protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC029516.1. On Apr 5, 2007 this sequence version replaced NM_003284.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC029516.1, BI461618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGTCGACCA GCCGCAAATT AAAGAGTCAT GGCATGAGGA GGAGCAAGAG CCGATCTCCT 
CACAAGGGAG TCAAGAGAGG TGGCAGCAAA AGAAAATACC GTAAGGGCAA CCTGAAAAGT 
AGGAAACGGG GCGATGACGC CAATCGCAAT TACCGCTCCC ACTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003275.1
CDS	26..193
Translation	MSTSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRGDDANRNYRSHL

Target ORF information:

RefSeq Version	NM_003284.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transition protein 1 (TNP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003284.3

ORF Insert Sequence:

1
61
121

ATGTCGACCA GCCGCAAATT AAAGAGTCAT GGCATGAGGA GGAGCAAGAG CCGATCTCCT 
CACAAGGGAG TCAAGAGAGG TGGCAGCAAA AGAAAATACC GTAAGGGCAA CCTGAAAAGT 
AGGAAACGGG GCGATGACGC CAATCGCAAT TACCGCTCCC ACTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel Autoantigens Associated with Lupus Nephritis.
PloS one10(6)e0126564(2015)
Onishi S,Adnan E,Ishizaki J,Miyazaki T,Tanaka Y,Matsumoto T,Suemori K,Shudou M,Okura T,Takeda H,Sawasaki T,Yasukawa M,Hasegawa H

Genome-wide association study identifies four loci associated with eruption of permanent teeth.
PLoS genetics7(9)e1002275(2011 Sep)
Geller F,Feenstra B,Zhang H,Shaffer JR,Hansen T,Esserlind AL,Boyd HA,Nohr EA,Timpson NJ,Fatemifar G,Paternoster L,Evans DM,Weyant RJ,Levy SM,Lathrop M,Smith GD,Murray JC,Olesen J,Werge T,Marazita ML,S?rensen TI,Melbye M

The TNP1 haplotype - GCG is associated with azoospermia.
International journal of andrology34(2)173-82(2011 Apr)
Khattri A,Bhushan SS,Sireesha V,Gupta NJ,Chakravarty BN,Deendayal M,Prasad S,Singh L,Thangaraj K

Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
Human reproduction (Oxford, England)25(6)1383-97(2010 Jun)
Aston KI,Krausz C,Laface I,Ruiz-Castan? E,Carrell DT

Spermiogenesis defects in human: detection of transition proteins in semen from some infertile men.
Andrologia40(4)203-8(2008 Aug)
Becker S,Soffer Y,Lewin LM,Yogev L,Shochat L,Golan R

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

TNP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報