TSPAN7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TSPAN7
Entrez Gene ID	7102
Full Name	tetraspanin 7
Synonyms	A15,CCG-B7,CD231,DXS1692E,MRX58,MXS1,TALLA-1,TM4SF2,TM4SF2b
General protein information	Preferred Names tetraspanin 7 Names tetraspanin-7 CD231 antigen T-cell acute lymphoblastic leukemia associated antigen 1 cell surface glycoprotein A15 membrane component chromosome X surface marker 1 membrane component, X chromosome, surface marker 1 tetraspanin protein transmembrane 4 superfamily 2b transmembrane 4 superfamily member 2 transmembrane protein A15 tspan-7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.4
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked cognitive disability and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008].
Disorder MIM:	300096
Disorder Html:	Mental retardation, X-linked 58, 300210 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004615.3	NP_004606.2	tetraspanin-7

Pathways from BioSystems

Homologies

Homo sapiens (human)	TSPAN7	NP_004606.2
Canis lupus familiaris (dog)	TSPAN7	XP_537996.1
	TSPAN7	XP_001084211.1
Bos taurus (cattle)	TSPAN7	NP_001069852.1
Danio rerio (zebrafish)	tspan7b	NP_001124290.1
Pan troglodytes (chimpanzee)	TSPAN7	NP_001009070.1
Mus musculus (house mouse)	Tspan7	NP_062608.2
Rattus norvegicus (Norway rat)	Tspan7	NP_001102285.1
Xenopus tropicalis (tropical clawed frog)	tspan7	NP_989350.1

Gene Ontology
Bibliography

Related articles in PubMed

TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.
M?nager MM
Biochemical Society transactions45(3)703-708(2017 06)

Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.
Lee SA, Suh Y, Lee S, Jeong J, Kim SJ, Kim SJ, Park SK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2301-2313(2017 06)

Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.
Cheong CM, Chow AW, Fitter S, Hewett DR, Martin SK, Williams SA, To LB, Zannettino AC, Vandyke K
Experimental cell research332(1)24-38(2015 Mar)

CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.
Wuttig D, Zastrow S, F?ssel S, Toma MI, Meinhardt M, Kalman K, Junker K, Sanjmyatav J, Boll K, Hackerm?ller J, Rolle A, Grimm MO, Wirth MP
International journal of cancer131(5)E693-704(2012 Sep)

The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
Bassani S, Cingolani LA, Valnegri P, Folci A, Zapata J, Gianfelice A, Sala C, Goda Y, Passafaro M
Neuron73(6)1143-58(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The role of TSPAN7 in immune system response to HIV-1 is reviewed. TSPAN7 appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes.
Title: TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.

These results disclosed a previously uncharacterized role of TSPAN7 in the regulation of the expression and functional activity of DRD2 by postendocytic trafficking.
Title: Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.

Elevated TSPAN7 may be associated with better outcomes for multiple myeloma patients.
Title: Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.

Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma.
Title: CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.

This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 and ampa receptor trafficking.
Title: The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.

The following TSPAN7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TSPAN7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18958	NM_004615.3 Latest version!	Homo sapiens tetraspanin 7 (TSPAN7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TSPAN7 ( NM_004615.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004606.2 Homo sapiens tetraspanin 7 (TSPAN7), mRNA.

Price & Availability↑

CloneID	OHu18958
Clone ID Related Accession (Same CDS sequence)	NM_004615.3
Accession Version	NM_004615.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Homo sapiens(human)
Product	tetraspanin-7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB475293.1, D29808.1 and AA757687.1. This sequence is a reference standard in the RefSeqGene project. On Apr 17, 2008 this sequence version replaced NM_004615.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB062057.1, SRR1803616.110072.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCATCGA GGAGAATGGA GACCAAACCT GTGATAACCT GTCTCAAAAC CCTCCTCATC 
ATCTACTCCT TCGTCTTCTG GATCACTGGG GTGATCCTGC TGGCTGTTGG AGTCTGGGGC 
AAACTTACTC TGGGCACCTA TATCTCCCTT ATTGCCGAGA ACTCCACAAA TGCTCCCTAT 
GTGCTCATCG GAACTGGCAC CACTATTGTT GTCTTTGGCC TGTTTGGATG CTTTGCTACA 
TGTCGTGGTA GCCCATGGAT GCTGAAACTG TATGCCATGT TTCTGTCCCT GGTGTTCCTG 
GCTGAGCTCG TAGCTGGCAT TTCAGGGTTT GTGTTTCGTC ATGAGATCAA GGACACCTTC 
CTGAGGACTT ACACGGACGC TATGCAGACT TACAATGGCA ATGATGAGAG GAGCCGGGCA 
GTGGACCATG TGCAGCGCAG CCTGAGCTGC TGTGGTGTGC AGAACTACAC CAACTGGAGC 
ACCAGCCCCT ACTTCCTGGA GCATGGCATC CCCCCCAGCT GCTGCATGAA CGAAACTGAT 
TGTAATCCCC AGGATCTACA CAATCTGACT GTGGCCGCCA CCAAAGTTAA CCAGAAGGGT 
TGTTATGATC TGGTAACTAG TTTCATGGAG ACTAACATGG GAATCATCGC TGGAGTGGCG 
TTTGGAATCG CATTCTCCCA GTTAATTGGC ATGCTGCTGG CCTGCTGTCT GTCCCGGTTC 
ATCACGGCCA ATCAGTATGA GATGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004606.2
CDS	70..819
Translation	MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV

Target ORF information:

RefSeq Version	NM_004615.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tetraspanin 7 (TSPAN7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004615.3

ORF Insert Sequence:

ATGGCATCGA GGAGAATGGA GACCAAACCT GTGATAACCT GTCTCAAAAC CCTCCTCATC 
ATCTACTCCT TCGTCTTCTG GATCACTGGG GTGATCCTGC TGGCTGTTGG AGTCTGGGGC 
AAACTTACTC TGGGCACCTA TATCTCCCTT ATTGCCGAGA ACTCCACAAA TGCTCCCTAT 
GTGCTCATCG GAACTGGCAC CACTATTGTT GTCTTTGGCC TGTTTGGATG CTTTGCTACA 
TGTCGTGGTA GCCCATGGAT GCTGAAACTG TATGCCATGT TTCTGTCCCT GGTGTTCCTG 
GCTGAGCTCG TAGCTGGCAT TTCAGGGTTT GTGTTTCGTC ATGAGATCAA GGACACCTTC 
CTGAGGACTT ACACGGACGC TATGCAGACT TACAATGGCA ATGATGAGAG GAGCCGGGCA 
GTGGACCATG TGCAGCGCAG CCTGAGCTGC TGTGGTGTGC AGAACTACAC CAACTGGAGC 
ACCAGCCCCT ACTTCCTGGA GCATGGCATC CCCCCCAGCT GCTGCATGAA CGAAACTGAT 
TGTAATCCCC AGGATCTACA CAATCTGACT GTGGCCGCCA CCAAAGTTAA CCAGAAGGGT 
TGTTATGATC TGGTAACTAG TTTCATGGAG ACTAACATGG GAATCATCGC TGGAGTGGCG 
TTTGGAATCG CATTCTCCCA GTTAATTGGC ATGCTGCTGG CCTGCTGTCT GTCCCGGTTC 
ATCACGGCCA ATCAGTATGA GATGGTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TSPAN7, effector of actin nucleation required for dendritic cell-mediated transfer of HIV-1 to T cells.
Biochemical Society transactions45(3)703-708(2017 06)
M?nager MM

Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(6)2301-2313(2017 06)
Lee SA,Suh Y,Lee S,Jeong J,Kim SJ,Kim SJ,Park SK

Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.
Experimental cell research332(1)24-38(2015 Mar)
Cheong CM,Chow AW,Fitter S,Hewett DR,Martin SK,Williams SA,To LB,Zannettino AC,Vandyke K

CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.
International journal of cancer131(5)E693-704(2012 Sep)
Wuttig D,Zastrow S,F?ssel S,Toma MI,Meinhardt M,Kalman K,Junker K,Sanjmyatav J,Boll K,Hackerm?ller J,Rolle A,Grimm MO,Wirth MP

The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
Neuron73(6)1143-58(2012 Mar)
Bassani S,Cingolani LA,Valnegri P,Folci A,Zapata J,Gianfelice A,Sala C,Goda Y,Passafaro M

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TSPAN7 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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