TALDO1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TALDO1
Entrez Gene ID	6888
Full Name	transaldolase 1
Synonyms	TAL,TAL-H,TALDOR,TALH
General protein information	Preferred Names transaldolase 1 Names transaldolase dihydroxyacetone transferase glycerone transferase testicular secretory protein Li 56
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.5
Summary	Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].
Disorder MIM:	602063
Disorder Html:	Transaldolase deficiency, 606003 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_006755.2	NP_006746.1	transaldolase
NM_006755.1	NP_006746.1	transaldolase

Pathways from BioSystems

Homologies

Homo sapiens (human)	TALDO1	NP_006746.1
Canis lupus familiaris (dog)	TALDO1	XP_533146.1
Danio rerio (zebrafish)	taldo1	NP_955981.1
Drosophila melanogaster (fruit fly)	Tal	NP_523835.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011800	XP_320715.3
Oryza sativa (rice)	Os08g0154300	NP_001061014.1
	LOC720828	XP_001116705.1
Caenorhabditis elegans (roundworm)	Y24D9A.8	NP_741369.1
Saccharomyces cerevisiae (baker's yeast)	TAL1	NP_013458.1
Arabidopsis thaliana (thale cress)	AT1G12230	NP_563900.1
Xenopus tropicalis (tropical clawed frog)	taldo1	NP_001017131.1
Pan troglodytes (chimpanzee)	TALDO1	XP_001148375.1
Bos taurus (cattle)	TALDO1	NP_001030360.2
Mus musculus (house mouse)	Taldo1	NP_035658.1
Kluyveromyces lactis	KLLA0A02607g	XP_451115.1
Magnaporthe oryzae (rice blast fungus)	MGG_02624	XP_003721167.1
Neurospora crassa	NCU02136	XP_964294.1
Canis lupus familiaris (dog)	LOC100855463	XP_003639736.1
Rattus norvegicus (Norway rat)	Taldo1	NP_113999.2
Eremothecium gossypii	AGOS_ACL196W	NP_983208.2
Schizosaccharomyces pombe (fission yeast)	tal1	NP_587953.1
Gallus gallus (chicken)	TALDO1	NP_001026348.1

Gene Ontology
Bibliography

Related articles in PubMed

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
Moriyama T, Tanaka S, Nakayama Y, Fukumoto M, Tsujimura K, Yamada K, Bamba T, Yoneda Y, Fukusaki E, Oka M
Scientific reports634648(2016 Oct)

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.
Li Y, Jain N, Limpanawat S, To J, Quistgaard EM, Nordlund P, Thanabalu T, Torres J
Virology482105-10(2015 Aug)

Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.
Al-Shamsi AM, Ben-Salem S, Hertecant J, Al-Jasmi F
European journal of pediatrics174(5)661-8(2015 May)

Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes.
Rajpal A, Dube S, Carvalho F, Simoes AR, Figueiredo A, Basu A, Jones J, Basu R
American journal of physiology. Endocrinology and metabolism305(4)E465-74(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The above findings support the premise that biallelic mutations in TALDO1 are responsible for transaldolase deficiency and confirm the broad phenotypic variability of this condition, even with the same genotype.
Title: Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.

This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity.
Title: Transaldolase deficiency: report of 12 new cases and further delineation of the phenotype.

Data suggest that exchange reactions during gluconeogenesis catalyzed by transaldolase and triose-phosphate isomerase do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions.
Title: Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes.

renal phenotype of patients with transaldolase deficiency
Title: Nephrological abnormalities in patients with transaldolase deficiency.

these data provide strong experimental evidence that transaldolase exchange occurs in humans, resulting in an overestimate of gluconeogenesis
Title: Transaldolase exchange and its effects on measurements of gluconeogenesis in humans.

The following TALDO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TALDO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19612	NM_006755.2 Latest version!	Homo sapiens transaldolase 1 (TALDO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu19612	NM_006755.1	Homo sapiens transaldolase 1 (TALDO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TALDO1 ( NM_006755.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_006746.1 Homo sapiens transaldolase 1 (TALDO1), mRNA.

Price & Availability↑

CloneID	OHu19612
Clone ID Related Accession (Same CDS sequence)	NM_006755.2 , NM_006755.1
Accession Version	NM_006755.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Homo sapiens(human)
Product	transaldolase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L19437.2. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_006755.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.691487.1, SRR1163658.234642.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319006.8/ ENSP00000321259.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGAGCT CACCCGTGAA GCGTCAGAGG ATGGAGTCCG CGCTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGCGAC TTCCACGCCA TCGACGAGTA CAAGCCCCAG 
GATGCTACCA CCAACCCGTC CCTGATCCTG GCCGCAGCAC AGATGCCCGC TTACCAGGAG 
CTGGTGGAGG AGGCGATTGC CTATGGCCGG AAGCTGGGCG GGTCACAAGA GGACCAGATT 
AAAAATGCTA TTGATAAACT TTTTGTGTTG TTTGGAGCAG AAATACTAAA GAAGATTCCG 
GGCCGAGTAT CCACAGAAGT AGACGCAAGG CTCTCCTTTG ATAAAGATGC GATGGTGGCC 
AGAGCCAGGC GGCTCATCGA GCTCTACAAG GAAGCTGGGA TCAGCAAGGA CCGAATTCTT 
ATAAAGCTGT CATCAACCTG GGAAGGAATT CAGGCTGGAA AGGAGCTCGA GGAGCAGCAC 
GGCATCCACT GCAACATGAC GTTACTCTTC TCCTTCGCCC AGGCTGTGGC CTGTGCCGAG 
GCGGGTGTGA CCCTCATCTC CCCATTTGTT GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACCGACAAGA AATCCTATGA GCCCCTGGAA GACCCTGGGG TAAAGAGTGT CACTAAAATC 
TACAACTACT ACAAGAAGTT TAGCTACAAA ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCCGGCTGT GACTTCCTCA CCATCTCACC CAAGCTCCTG 
GGAGAGCTGC TGCAGGACAA CGCCAAGCTG GTGCCTGTGC TCTCAGCCAA GGCGGCCCAA 
GCCAGTGACC TGGAAAAAAT CCACCTGGAT GAGAAGTCTT TCCGTTGGTT GCACAACGAG 
GACCAGATGG CTGTGGAGAA GCTCTCTGAC GGGATCCGCA AGTTTGCCGC TGATGCAGTG 
AAGCTGGAGC GGATGCTGAC AGAACGAATG TTCAATGCAG AGAATGGAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006746.1
CDS	19..1032
Translation	MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK

Target ORF information:

RefSeq Version	NM_006755.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transaldolase 1 (TALDO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006755.2

ORF Insert Sequence:

ATGTCGAGCT CACCCGTGAA GCGTCAGAGG ATGGAGTCCG CGCTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGCGAC TTCCACGCCA TCGACGAGTA CAAGCCCCAG 
GATGCTACCA CCAACCCGTC CCTGATCCTG GCCGCAGCAC AGATGCCCGC TTACCAGGAG 
CTGGTGGAGG AGGCGATTGC CTATGGCCGG AAGCTGGGCG GGTCACAAGA GGACCAGATT 
AAAAATGCTA TTGATAAACT TTTTGTGTTG TTTGGAGCAG AAATACTAAA GAAGATTCCG 
GGCCGAGTAT CCACAGAAGT AGACGCAAGG CTCTCCTTTG ATAAAGATGC GATGGTGGCC 
AGAGCCAGGC GGCTCATCGA GCTCTACAAG GAAGCTGGGA TCAGCAAGGA CCGAATTCTT 
ATAAAGCTGT CATCAACCTG GGAAGGAATT CAGGCTGGAA AGGAGCTCGA GGAGCAGCAC 
GGCATCCACT GCAACATGAC GTTACTCTTC TCCTTCGCCC AGGCTGTGGC CTGTGCCGAG 
GCGGGTGTGA CCCTCATCTC CCCATTTGTT GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACCGACAAGA AATCCTATGA GCCCCTGGAA GACCCTGGGG TAAAGAGTGT CACTAAAATC 
TACAACTACT ACAAGAAGTT TAGCTACAAA ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCCGGCTGT GACTTCCTCA CCATCTCACC CAAGCTCCTG 
GGAGAGCTGC TGCAGGACAA CGCCAAGCTG GTGCCTGTGC TCTCAGCCAA GGCGGCCCAA 
GCCAGTGACC TGGAAAAAAT CCACCTGGAT GAGAAGTCTT TCCGTTGGTT GCACAACGAG 
GACCAGATGG CTGTGGAGAA GCTCTCTGAC GGGATCCGCA AGTTTGCCGC TGATGCAGTG 
AAGCTGGAGC GGATGCTGAC AGAACGAATG TTCAATGCAG AGAATGGAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TALDO1 ( NM_006755.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_006746.1 Homo sapiens transaldolase 1 (TALDO1), mRNA.

Price & Availability↑

CloneID	OHu19612
Clone ID Related Accession (Same CDS sequence)	NM_006755.2 , NM_006755.1
Accession Version	NM_006755.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	transaldolase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L19437.2. This sequence is a reference standard in the RefSeqGene project. On Mar 4, 2006 this sequence version replaced XM_938697.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005596.1, L19437.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGAGCT CACCCGTGAA GCGTCAGAGG ATGGAGTCCG CGCTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGCGAC TTCCACGCCA TCGACGAGTA CAAGCCCCAG 
GATGCTACCA CCAACCCGTC CCTGATCCTG GCCGCAGCAC AGATGCCCGC TTACCAGGAG 
CTGGTGGAGG AGGCGATTGC CTATGGCCGG AAGCTGGGCG GGTCACAAGA GGACCAGATT 
AAAAATGCTA TTGATAAACT TTTTGTGTTG TTTGGAGCAG AAATACTAAA GAAGATTCCG 
GGCCGAGTAT CCACAGAAGT AGACGCAAGG CTCTCCTTTG ATAAAGATGC GATGGTGGCC 
AGAGCCAGGC GGCTCATCGA GCTCTACAAG GAAGCTGGGA TCAGCAAGGA CCGAATTCTT 
ATAAAGCTGT CATCAACCTG GGAAGGAATT CAGGCTGGAA AGGAGCTCGA GGAGCAGCAC 
GGCATCCACT GCAACATGAC GTTACTCTTC TCCTTCGCCC AGGCTGTGGC CTGTGCCGAG 
GCGGGTGTGA CCCTCATCTC CCCATTTGTT GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACCGACAAGA AATCCTATGA GCCCCTGGAA GACCCTGGGG TAAAGAGTGT CACTAAAATC 
TACAACTACT ACAAGAAGTT TAGCTACAAA ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCCGGCTGT GACTTCCTCA CCATCTCACC CAAGCTCCTG 
GGAGAGCTGC TGCAGGACAA CGCCAAGCTG GTGCCTGTGC TCTCAGCCAA GGCGGCCCAA 
GCCAGTGACC TGGAAAAAAT CCACCTGGAT GAGAAGTCTT TCCGTTGGTT GCACAACGAG 
GACCAGATGG CTGTGGAGAA GCTCTCTGAC GGGATCCGCA AGTTTGCCGC TGATGCAGTG 
AAGCTGGAGC GGATGCTGAC AGAACGAATG TTCAATGCAG AGAATGGAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006746.1
CDS	51..1064
Translation	MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK

Target ORF information:

RefSeq Version	NM_006755.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transaldolase 1 (TALDO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006755.1

ORF Insert Sequence:

ATGTCGAGCT CACCCGTGAA GCGTCAGAGG ATGGAGTCCG CGCTGGACCA GCTCAAGCAG 
TTCACCACCG TGGTGGCCGA CACGGGCGAC TTCCACGCCA TCGACGAGTA CAAGCCCCAG 
GATGCTACCA CCAACCCGTC CCTGATCCTG GCCGCAGCAC AGATGCCCGC TTACCAGGAG 
CTGGTGGAGG AGGCGATTGC CTATGGCCGG AAGCTGGGCG GGTCACAAGA GGACCAGATT 
AAAAATGCTA TTGATAAACT TTTTGTGTTG TTTGGAGCAG AAATACTAAA GAAGATTCCG 
GGCCGAGTAT CCACAGAAGT AGACGCAAGG CTCTCCTTTG ATAAAGATGC GATGGTGGCC 
AGAGCCAGGC GGCTCATCGA GCTCTACAAG GAAGCTGGGA TCAGCAAGGA CCGAATTCTT 
ATAAAGCTGT CATCAACCTG GGAAGGAATT CAGGCTGGAA AGGAGCTCGA GGAGCAGCAC 
GGCATCCACT GCAACATGAC GTTACTCTTC TCCTTCGCCC AGGCTGTGGC CTGTGCCGAG 
GCGGGTGTGA CCCTCATCTC CCCATTTGTT GGGCGCATCC TTGATTGGCA TGTGGCAAAC 
ACCGACAAGA AATCCTATGA GCCCCTGGAA GACCCTGGGG TAAAGAGTGT CACTAAAATC 
TACAACTACT ACAAGAAGTT TAGCTACAAA ACCATTGTCA TGGGCGCCTC CTTCCGCAAC 
ACGGGCGAGA TCAAAGCACT GGCCGGCTGT GACTTCCTCA CCATCTCACC CAAGCTCCTG 
GGAGAGCTGC TGCAGGACAA CGCCAAGCTG GTGCCTGTGC TCTCAGCCAA GGCGGCCCAA 
GCCAGTGACC TGGAAAAAAT CCACCTGGAT GAGAAGTCTT TCCGTTGGTT GCACAACGAG 
GACCAGATGG CTGTGGAGAA GCTCTCTGAC GGGATCCGCA AGTTTGCCGC TGATGCAGTG 
AAGCTGGAGC GGATGCTGAC AGAACGAATG TTCAATGCAG AGAATGGAAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network.
Scientific reports634648(2016 Oct)
Moriyama T,Tanaka S,Nakayama Y,Fukumoto M,Tsujimura K,Yamada K,Bamba T,Yoneda Y,Fukusaki E,Oka M

Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) protein.
Virology482105-10(2015 Aug)
Li Y,Jain N,Limpanawat S,To J,Quistgaard EM,Nordlund P,Thanabalu T,Torres J

Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.
European journal of pediatrics174(5)661-8(2015 May)
Al-Shamsi AM,Ben-Salem S,Hertecant J,Al-Jasmi F

Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism305(4)E465-74(2013 Aug)
Rajpal A,Dube S,Carvalho F,Simoes AR,Figueiredo A,Basu A,Jones J,Basu R

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TALDO1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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