TAL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAL2
Entrez Gene ID	6887
Full Name	TAL bHLH transcription factor 2
General protein information	Preferred Names TAL bHLH transcription factor 2 Names T-cell acute lymphocytic leukemia protein 2 T-cell acute lymphocytic leukemia 2 TAL-2 class A basic helix-loop-helix protein 19
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q31.2
Summary	This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009].
Disorder MIM:	186855
Disorder Html:	Leukemia, T-cell acute lymphocytic, somatic, 613065 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005421.3	NP_005412.1	T-cell acute lymphocytic leukemia protein 2
NM_005421.2	NP_005412.1	T-cell acute lymphocytic leukemia protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TAL2	XP_005626954.1
Mus musculus (house mouse)	Tal2	NP_033343.1
Pan troglodytes (chimpanzee)	TAL2	XP_528380.2
Bos taurus (cattle)	TAL2	XP_002689947.1
	TAL2	XP_001109420.1
Homo sapiens (human)	TAL2	NP_005412.1
Rattus norvegicus (Norway rat)	Tal2	NP_001102932.1
Danio rerio (zebrafish)	tal2	NP_958496.2

Gene Ontology
Bibliography

Related articles in PubMed

The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis.
Courtial N, M?cke C, Herkt S, Kolodziej S, Hussong H, Lausen J
PloS one8(9)e76637(2013)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, , , , Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB
PLoS genetics8(5)e1002695(2012)

Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
Guo Y, Fu P, Zhu H, Reed E, Remick SC, Petros W, Mueller MD, Yu JJ
Oncology reports27(1)286-92(2012 Jan)

Common genetic variation and performance on standardized cognitive tests.
Cirulli ET, Kasperavici?te D, Attix DK, Need AC, Ge D, Gibson G, Goldstein DB
European journal of human genetics : EJHG18(7)815-20(2010 Jul)

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM
Nature genetics41(6)648-50(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the expression control of Tal2 in hematopoietic cells
Title: The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis.

low expression of TAL2 and EGF was observed in human epithelial ovarian cancer
Title: Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.

Activation of the TAL2 gene in T-ALL.
Title: Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.

The following TAL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31740	NM_005421.3 Latest version!	Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31740	NM_005421.2	Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAL2 ( NM_005421.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005412.1 Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.

Price & Availability↑

CloneID	OHu31740
Clone ID Related Accession (Same CDS sequence)	NM_005421.3 , NM_005421.2
Accession Version	NM_005421.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	T-cell acute lymphocytic leukemia protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC126373.1, AA767775.1 and AL158070.11. On May 17, 2019 this sequence version replaced NM_005421.2. ##Evidence-Data-START## Transcript is intronless :: BC126373.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334077.6/ ENSP00000334547.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGACCAGGA AGATCTTCAC AAATACCAGG GAGCGGTGGA GGCAGCAGAA TGTCAACAGC 
GCCTTTGCCA AGCTGAGGAA GCTCATCCCC ACTCACCCTC CAGACAAAAA GCTGAGCAAA 
AATGAAACGC TTCGCCTGGC AATGAGGTAT ATCAACTTCT TGGTCAAGGT CTTGGGGGAG 
CAAAGCCTGC AACAAACGGG AGTGGCTGCT CAGGGGAACA TTCTGGGGCT CTTCCCTCAA 
GGACCCCACC TGCCAGGCCT GGAGGACAGA ACTCTGCTTG AGAACTACCA GGTTCCTTCA 
CCTGGTCCAA GCCACCACAT TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005412.1
CDS	41..367
Translation	MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGEQSLQQTGVAAQGNILGLFPQGPHLPGLEDRTLLENYQVPSPGPSHHIP

Target ORF information:

RefSeq Version	NM_005421.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005421.3

ORF Insert Sequence:

ATGACCAGGA AGATCTTCAC AAATACCAGG GAGCGGTGGA GGCAGCAGAA TGTCAACAGC 
GCCTTTGCCA AGCTGAGGAA GCTCATCCCC ACTCACCCTC CAGACAAAAA GCTGAGCAAA 
AATGAAACGC TTCGCCTGGC AATGAGGTAT ATCAACTTCT TGGTCAAGGT CTTGGGGGAG 
CAAAGCCTGC AACAAACGGG AGTGGCTGCT CAGGGGAACA TTCTGGGGCT CTTCCCTCAA 
GGACCCCACC TGCCAGGCCT GGAGGACAGA ACTCTGCTTG AGAACTACCA GGTTCCTTCA 
CCTGGTCCAA GCCACCACAT TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAL2 ( NM_005421.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005412.1 Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.

Price & Availability↑

CloneID	OHu31740
Clone ID Related Accession (Same CDS sequence)	NM_005421.3 , NM_005421.2
Accession Version	NM_005421.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	T-cell acute lymphocytic leukemia protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC126373.1 and AA767775.1. On Mar 5, 2009 this sequence version replaced NM_005421.1.

ATGACCAGGA AGATCTTCAC AAATACCAGG GAGCGGTGGA GGCAGCAGAA TGTCAACAGC 
GCCTTTGCCA AGCTGAGGAA GCTCATCCCC ACTCACCCTC CAGACAAAAA GCTGAGCAAA 
AATGAAACGC TTCGCCTGGC AATGAGGTAT ATCAACTTCT TGGTCAAGGT CTTGGGGGAG 
CAAAGCCTGC AACAAACGGG AGTGGCTGCT CAGGGGAACA TTCTGGGGCT CTTCCCTCAA 
GGACCCCACC TGCCAGGCCT GGAGGACAGA ACTCTGCTTG AGAACTACCA GGTTCCTTCA 
CCTGGTCCAA GCCACCACAT TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005412.1
CDS	41..367
Translation	MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGEQSLQQTGVAAQGNILGLFPQGPHLPGLEDRTLLENYQVPSPGPSHHIP

Target ORF information:

RefSeq Version	NM_005421.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TAL bHLH transcription factor 2 (TAL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005421.2

ORF Insert Sequence:

ATGACCAGGA AGATCTTCAC AAATACCAGG GAGCGGTGGA GGCAGCAGAA TGTCAACAGC 
GCCTTTGCCA AGCTGAGGAA GCTCATCCCC ACTCACCCTC CAGACAAAAA GCTGAGCAAA 
AATGAAACGC TTCGCCTGGC AATGAGGTAT ATCAACTTCT TGGTCAAGGT CTTGGGGGAG 
CAAAGCCTGC AACAAACGGG AGTGGCTGCT CAGGGGAACA TTCTGGGGCT CTTCCCTCAA 
GGACCCCACC TGCCAGGCCT GGAGGACAGA ACTCTGCTTG AGAACTACCA GGTTCCTTCA 
CCTGGTCCAA GCCACCACAT TCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis.
PloS one8(9)e76637(2013)
Courtial N,M?cke C,Herkt S,Kolodziej S,Hussong H,Lausen J

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics8(5)e1002695(2012)
Fox CS,Liu Y,White CC,Feitosa M,Smith AV,Heard-Costa N,Lohman K,,,,Johnson AD,Foster MC,Greenawalt DM,Griffin P,Ding J,Newman AB,Tylavsky F,Miljkovic I,Kritchevsky SB,Launer L,Garcia M,Eiriksdottir G,Carr JJ,Gudnason V,Harris TB,Cupples LA,Borecki IB

Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
Oncology reports27(1)286-92(2012 Jan)
Guo Y,Fu P,Zhu H,Reed E,Remick SC,Petros W,Mueller MD,Yu JJ

Common genetic variation and performance on standardized cognitive tests.
European journal of human genetics : EJHG18(7)815-20(2010 Jul)
Cirulli ET,Kasperavici?te D,Attix DK,Need AC,Ge D,Gibson G,Goldstein DB

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Nature genetics41(6)648-50(2009 Jun)
Perry JR,Stolk L,Franceschini N,Lunetta KL,Zhai G,McArdle PF,Smith AV,Aspelund T,Bandinelli S,Boerwinkle E,Cherkas L,Eiriksdottir G,Estrada K,Ferrucci L,Folsom AR,Garcia M,Gudnason V,Hofman A,Karasik D,Kiel DP,Launer LJ,van Meurs J,Nalls MA,Rivadeneira F,Shuldiner AR,Singleton A,Soranzo N,Tanaka T,Visser JA,Weedon MN,Wilson SG,Zhuang V,Streeten EA,Harris TB,Murray A,Spector TD,Demerath EW,Uitterlinden AG,Murabito JM

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TAL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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