TAF13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TAF13
Entrez Gene ID	6884
Full Name	TATA-box binding protein associated factor 13
Synonyms	MRT60,TAF(II)18,TAF2K,TAFII-18,TAFII18
General protein information	Preferred Names TATA-box binding protein associated factor 13 Names transcription initiation factor TFIID subunit 13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa TATA box binding protein (TBP)-associated factor, RNA polymerase II, K, 18kD transcription initiation factor TFIID 18 kD subunit transcription initiation factor TFIID 18 kDa subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.3
Summary	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008].
Disorder MIM:	600774
Disorder Html:	Mental retardation, autosomal recessive 60, 617432 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005645.4	NP_005636.1	transcription initiation factor TFIID subunit 13
NM_005645.3	NP_005636.1	transcription initiation factor TFIID subunit 13

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TAF13	XP_001146772.1
Canis lupus familiaris (dog)	TAF13	NP_001238967.1
Drosophila melanogaster (fruit fly)	Taf13	NP_610024.1
Xenopus tropicalis (tropical clawed frog)	taf13	NP_001016066.1
Bos taurus (cattle)	TAF13	NP_001069065.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008045	XP_317417.3
Caenorhabditis elegans (roundworm)	taf-13	NP_496289.2
Arabidopsis thaliana (thale cress)	TAF13	NP_171768.2
Gallus gallus (chicken)	TAF13	NP_001006252.1
Mus musculus (house mouse)	Taf13	NP_079720.1
Danio rerio (zebrafish)	taf13	NP_001004665.1
Homo sapiens (human)	TAF13	NP_005636.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.
Gupta K, Watson AA, Baptista T, Scheer E, Chambers AL, Koehler C, Zou J, Obong-Ebong I, Kandiah E, Temblador A, Round A, Forest E, Man P, Bieniossek C, Laue ED, Lemke EA, Rappsilber J, Robinson CV, Devys D, Tora L, Berger I
eLife6(2017 Nov)

Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly.
Tawamie H, Martianov I, Wohlfahrt N, Buchert R, Mengus G, Uebe S, Janiri L, Hirsch FW, Schumacher J, Ferrazzi F, Sticht H, Reis A, Davidson I, Colombo R, Abou Jamra R
American journal of human genetics100(3)555-561(2017 Mar)

Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.
Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A
Experimental cell research288(1)35-50(2003 Aug)

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.
Gangloff YG, Pointud JC, Thuault S, Carr? L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I
Molecular and cellular biology21(15)5109-21(2001 Aug)

Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D
Cell94(2)239-49(1998 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

two homozygous missense are associated with autosomal-recessive intellectual disability and microcephaly
Title: Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly.

The following TAF13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TAF13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu05143	NM_005645.4 Latest version!	Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu05143	NM_005645.3	Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TAF13 ( NM_005645.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005636.1 Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.

Price & Availability↑

CloneID	OHu05143
Clone ID Related Accession (Same CDS sequence)	NM_005645.4 , NM_005645.3
Accession Version	NM_005645.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	transcription initiation factor TFIID subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX679664.7, AU280379.1, X84003.1 and AV713996.1. On May 17, 2019 this sequence version replaced NM_005645.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.374035.1, SRR1660807.313507.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142670 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000338366.6/ ENSP00000355051.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCAGATG AGGAAGAAGA CCCCACGTTT GAGGAAGAAA ATGAAGAAAT TGGAGGAGGT 
GCAGAAGGTG GACAGGGTAA AAGAAAGAGA CTTTTTTCTA AAGAATTGCG ATGTATGATG 
TATGGCTTTG GGGATGACCA GAATCCTTAT ACTGAGTCAG TGGATATTCT TGAAGATCTT 
GTCATAGAGT TTATCACTGA AATGACTCAC AAGGCAATGT CAATTGGAAG ACAAGGTCGA 
GTACAAGTTG AAGATATCGT CTTCTTGATT CGAAAGGACC CAAGGAAGTT TGCCAGGGTT 
AAAGACTTGC TTACTATGAA TGAAGAATTG AAACGAGCTA GAAAAGCATT TGATGAAGCA 
AATTATGGAT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005636.1
CDS	57..431
Translation	MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS

Target ORF information:

RefSeq Version	NM_005645.4
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005645.4

ORF Insert Sequence:

ATGGCAGATG AGGAAGAAGA CCCCACGTTT GAGGAAGAAA ATGAAGAAAT TGGAGGAGGT 
GCAGAAGGTG GACAGGGTAA AAGAAAGAGA CTTTTTTCTA AAGAATTGCG ATGTATGATG 
TATGGCTTTG GGGATGACCA GAATCCTTAT ACTGAGTCAG TGGATATTCT TGAAGATCTT 
GTCATAGAGT TTATCACTGA AATGACTCAC AAGGCAATGT CAATTGGAAG ACAAGGTCGA 
GTACAAGTTG AAGATATCGT CTTCTTGATT CGAAAGGACC CAAGGAAGTT TGCCAGGGTT 
AAAGACTTGC TTACTATGAA TGAAGAATTG AAACGAGCTA GAAAAGCATT TGATGAAGCA 
AATTATGGAT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TAF13 ( NM_005645.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005636.1 Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.

Price & Availability↑

CloneID	OHu05143
Clone ID Related Accession (Same CDS sequence)	NM_005645.4 , NM_005645.3
Accession Version	NM_005645.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	transcription initiation factor TFIID subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU280379.1, X84003.1 and AV713996.1. On or before May 15, 2005 this sequence version replaced XM_496381.1, NM_005645.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU280379.1, SRR1660807.302993.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142670 [ECO:0000350] ##Evidence-Data-END##

ATGGCAGATG AGGAAGAAGA CCCCACGTTT GAGGAAGAAA ATGAAGAAAT TGGAGGAGGT 
GCAGAAGGTG GACAGGGTAA AAGAAAGAGA CTTTTTTCTA AAGAATTGCG ATGTATGATG 
TATGGCTTTG GGGATGACCA GAATCCTTAT ACTGAGTCAG TGGATATTCT TGAAGATCTT 
GTCATAGAGT TTATCACTGA AATGACTCAC AAGGCAATGT CAATTGGAAG ACAAGGTCGA 
GTACAAGTTG AAGATATCGT CTTCTTGATT CGAAAGGACC CAAGGAAGTT TGCCAGGGTT 
AAAGACTTGC TTACTATGAA TGAAGAATTG AAACGAGCTA GAAAAGCATT TGATGAAGCA 
AATTATGGAT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005636.1
CDS	56..430
Translation	MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS

Target ORF information:

RefSeq Version	NM_005645.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TATA-box binding protein associated factor 13 (TAF13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005645.3

ORF Insert Sequence:

ATGGCAGATG AGGAAGAAGA CCCCACGTTT GAGGAAGAAA ATGAAGAAAT TGGAGGAGGT 
GCAGAAGGTG GACAGGGTAA AAGAAAGAGA CTTTTTTCTA AAGAATTGCG ATGTATGATG 
TATGGCTTTG GGGATGACCA GAATCCTTAT ACTGAGTCAG TGGATATTCT TGAAGATCTT 
GTCATAGAGT TTATCACTGA AATGACTCAC AAGGCAATGT CAATTGGAAG ACAAGGTCGA 
GTACAAGTTG AAGATATCGT CTTCTTGATT CGAAAGGACC CAAGGAAGTT TGCCAGGGTT 
AAAGACTTGC TTACTATGAA TGAAGAATTG AAACGAGCTA GAAAAGCATT TGATGAAGCA 
AATTATGGAT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID.
eLife6(2017 Nov)
Gupta K,Watson AA,Baptista T,Scheer E,Chambers AL,Koehler C,Zou J,Obong-Ebong I,Kandiah E,Temblador A,Round A,Forest E,Man P,Bieniossek C,Laue ED,Lemke EA,Rappsilber J,Robinson CV,Devys D,Tora L,Berger I

Hypomorphic Pathogenic Variants in TAF13 Are Associated with Autosomal-Recessive Intellectual Disability and Microcephaly.
American journal of human genetics100(3)555-561(2017 Mar)
Tawamie H,Martianov I,Wohlfahrt N,Buchert R,Mengus G,Uebe S,Janiri L,Hirsch FW,Schumacher J,Ferrazzi F,Sticht H,Reis A,Davidson I,Colombo R,Abou Jamra R

Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.
Experimental cell research288(1)35-50(2003 Aug)
Imabayashi H,Mori T,Gojo S,Kiyono T,Sugiyama T,Irie R,Isogai T,Hata J,Toyama Y,Umezawa A

The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.
Molecular and cellular biology21(15)5109-21(2001 Aug)
Gangloff YG,Pointud JC,Thuault S,Carr? L,Romier C,Muratoglu S,Brand M,Tora L,Couderc JL,Davidson I

Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Cell94(2)239-49(1998 Jul)
Birck C,Poch O,Romier C,Ruff M,Mengus G,Lavigne AC,Davidson I,Moras D

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TAF13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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