SPRR2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SPRR2B
Entrez Gene ID	6701
Full Name	small proline rich protein 2B
General protein information	Preferred Names small proline rich protein 2B Names small proline-rich protein 2B SPR-2B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Disorder MIM:	182268

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017418.2	NP_001017418.1	small proline-rich protein 2B
XM_017002174.1	XP_016857663.1	small proline-rich protein 2B isoform X1
NM_001017418.3	NP_001017418.1	small proline-rich protein 2B

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.
Epstein TG, LeMasters GK, Bernstein DI, Ericksen MB, Martin LJ, Ryan PH, Biagini Myers JM, Butsch Kovacic MS, Lindsey MA, He H, Reponen T, Villareal MS, Lockey JE, Bernstein CK, Khurana Hershey GK
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology108(3)145-50(2012 Mar)

Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma.
Pasini FS, Maistro S, Snitcovsky I, Barbeta LP, Rotea Mangone FR, Lehn CN, Walder F, Carvalho MB, Brentani MM, Federico MH
Acta oncologica (Stockholm, Sweden)51(1)77-85(2012 Jan)

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Kainu K, Kivinen K, Zucchelli M, Suomela S, Kere J, Inerot A, Baker BS, Powles AV, Fry L, Samuelsson L, Saarialho-Kere U
Experimental dermatology18(2)109-15(2009 Feb)

Expression and regulation of cornified envelope proteins in human corneal epithelium.
Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC
Investigative ophthalmology & visual science47(5)1938-46(2006 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

An SNP in SPRR2B was predictive of asthma among white children with eczema from 2 independent populations.
Title: Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.

We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy.
Title: Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma.

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Title: Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.

SPR2B transcripts and protein were moderately increased in the human papillomaviurs 11- and 59-infected tissues.
Title: Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3.

The following SPRR2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPRR2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30528	NM_001017418.3 Latest version!	Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu30528	XM_017002174.1 Latest version!	Homo sapiens small proline rich protein 2B (SPRR2B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu30528	NM_001017418.2	Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SPRR2B ( NM_001017418.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017418.1 Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.

Price & Availability↑

CloneID	OHu30528
Clone ID Related Accession (Same CDS sequence)	NM_001017418.2 , XM_017002174.1 , NM_001017418.3
Accession Version	NM_001017418.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Homo sapiens(human)
Product	small proline-rich protein 2B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139417.9, AL356867.23, BF090370.1 and CA311074.1. On Jun 3, 2019 this sequence version replaced NM_001017418.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017418.1
CDS	67..285
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQPKYPPKSK

Target ORF information:

RefSeq Version	NM_001017418.3
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017418.3

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPRR2B ( NM_001017418.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001017418.1 Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.

Price & Availability↑

CloneID	OHu30528
Clone ID Related Accession (Same CDS sequence)	NM_001017418.2 , XM_017002174.1 , NM_001017418.3
Accession Version	NM_001017418.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-15
Organism	Homo sapiens(human)
Product	small proline-rich protein 2B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139417.9, AL356867.23, BF090370.1 and CA311074.1. On Feb 4, 2015 this sequence version replaced NM_001017418.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BF090370.1, BE716886.1 [ECO:0000331] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017418.1
CDS	64..282
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQPKYPPKSK

Target ORF information:

RefSeq Version	NM_001017418.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2B (SPRR2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017418.2

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SPRR2B ( XM_017002174.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016857663.1 Homo sapiens small proline rich protein 2B (SPRR2B), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu30528
Clone ID Related Accession (Same CDS sequence)	NM_001017418.2 , XM_017002174.1 , NM_001017418.3
Accession Version	XM_017002174.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 219bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	small proline-rich protein 2B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016857663.1
CDS	60..278
Translation	MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQPKYPPKSK

Target ORF information:

RefSeq Version	XM_017002174.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small proline rich protein 2B (SPRR2B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002174.1

ORF Insert Sequence:

ATGTCTTATC AACAGCAGCA GTGCAAGCAG CCCTGCCAGC CACCTCCTGT GTGCCCCACG 
CCAAAGTGCC CAGAGCCATG TCCACCCCCG AAGTGCCCTG AGCCCTGCCC ACCACCAAAG 
TGTCCACAGC CCTGCCCACC TCAGCAGTGC CAGCAGAAAT ATCCTCCTGT GACACCTTCC 
CCACCCTGCC AGCCAAAGTA TCCACCGAAG AGCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology108(3)145-50(2012 Mar)
Epstein TG,LeMasters GK,Bernstein DI,Ericksen MB,Martin LJ,Ryan PH,Biagini Myers JM,Butsch Kovacic MS,Lindsey MA,He H,Reponen T,Villareal MS,Lockey JE,Bernstein CK,Khurana Hershey GK

Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma.
Acta oncologica (Stockholm, Sweden)51(1)77-85(2012 Jan)
Pasini FS,Maistro S,Snitcovsky I,Barbeta LP,Rotea Mangone FR,Lehn CN,Walder F,Carvalho MB,Brentani MM,Federico MH

Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.
Experimental dermatology18(2)109-15(2009 Feb)
Kainu K,Kivinen K,Zucchelli M,Suomela S,Kere J,Inerot A,Baker BS,Powles AV,Fry L,Samuelsson L,Saarialho-Kere U

Expression and regulation of cornified envelope proteins in human corneal epithelium.
Investigative ophthalmology & visual science47(5)1938-46(2006 May)
Tong L,Corrales RM,Chen Z,Villarreal AL,De Paiva CS,Beuerman R,Li DQ,Pflugfelder SC

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SPRR2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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