SLPI cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLPI
Entrez Gene ID	6590
Full Name	secretory leukocyte peptidase inhibitor
Synonyms	ALK1,ALP,BLPI,HUSI,HUSI-I,MPI,WAP4,WFDC4
General protein information	Preferred Names secretory leukocyte peptidase inhibitor Names antileukoproteinase HUSI-1 WAP four-disulfide core domain protein 4 mucus proteinase inhibitor protease inhibitor WAP4 secretory leukocyte protease inhibitor (antileukoproteinase) seminal proteinase inhibitor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.12
Summary	This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014].
Disorder MIM:	107285

mRNA and Protein(s)

mRNA	Protein	Name
NM_003064.3	NP_003055.1	antileukoproteinase precursor
NM_003064.4	NP_003055.1	antileukoproteinase precursor

Pathways from BioSystems

Homologies

	SLPI	NP_001162134.1
Canis lupus familiaris (dog)	SLPI	NP_001106642.1
Mus musculus (house mouse)	Slpi	NP_035544.1
Pan troglodytes (chimpanzee)	SLPI	NP_001129324.1
Homo sapiens (human)	SLPI	NP_003055.1
Bos taurus (cattle)	SLPI	NP_001092335.1

Gene Ontology
Bibliography

Related articles in PubMed

Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.
St?pie? T, Bro?yna M, Kuzdak K, Motylewska E, Komorowski J, St?pie? H, ?awnicka H
Disease markers20174962137(2017)

Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.
Mikami Y, Fukushima A, Komiyama Y, Iwase T, Tsuda H, Higuchi Y, Hayakawa S, Kuyama K, Komiyama K
Cancer letters379(1)84-93(2016 08)

SLPI and elafin: multifunctional antiproteases of the WFDC family.
Scott A, Weldon S, Taggart CC
Biochemical Society transactions39(5)1437-40(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results indicate that SERPINE2 and SLPI play a significant role in the development of papillary thyroid cancer and imply that the evaluation of serum concentrations of both anticoagulant molecules may be considered as additional marker for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors.
Title: Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.

we demonstrated that the oncogenic effect of SLPI may be due to protection of growth factor progranulin from enzymatic cleavage or suppression of castration-resistant prostate cancer (CRPC)cell apoptosis independent of anti-protease activity of SLPI. These findings implicate SLPI as a potential biomarker of resistance to AR inhibition and therapeutic target for CRPC treatment
Title: Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration-resistant prostate cancer.

Secretory leukocyte protease inhibitor mediates invasiveness of oral carcinoma cells.
Title: Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.

these data demonstrate increased anti-inflammatory activity of the SLPI-A16G protein compared with SLPI-WT in a murine model of pulmonary Pseudomonas infection
Title: A secretory leukocyte protease inhibitor variant with improved activity against lung infection.

Ongoing herpes simplex virus infection and resultant downregulation of local levels of SLPI may impart a greater susceptibility for keratinocytes to human papillomavirus type 16 infection through the host cell receptor annexin A2.
Title: Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection.

The following SLPI gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLPI cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21632	NM_003064.4 Latest version!	Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21632	NM_003064.3	Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLPI ( NM_003064.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003055.1 Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.

Price & Availability↑

CloneID	OHu21632
Clone ID Related Accession (Same CDS sequence)	NM_003064.3 , NM_003064.4
Accession Version	NM_003064.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	antileukoproteinase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020708.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2013 this sequence version replaced NM_003064.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020708.1, BG484664.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 16336202 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTCCA GCGGCCTCTT CCCCTTCCTG GTGCTGCTTG CCCTGGGAAC TCTGGCACCT 
TGGGCTGTGG AAGGCTCTGG AAAGTCCTTC AAAGCTGGAG TCTGTCCTCC TAAGAAATCT 
GCCCAGTGCC TTAGATACAA GAAACCTGAG TGCCAGAGTG ACTGGCAGTG TCCAGGGAAG 
AAGAGATGTT GTCCTGACAC TTGTGGCATC AAATGCCTGG ATCCTGTTGA CACCCCAAAC 
CCAACAAGGA GGAAGCCTGG GAAGTGCCCA GTGACTTATG GCCAATGTTT GATGCTTAAC 
CCCCCCAATT TCTGTGAGAT GGATGGCCAG TGCAAGCGTG ACTTGAAGTG TTGCATGGGC 
ATGTGTGGGA AATCCTGCGT TTCCCCTGTG AAAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003055.1
CDS	22..420
Translation	MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA

Target ORF information:

RefSeq Version	NM_003064.3
Organism	Homo sapiens(human)
Definition	Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003064.3

ORF Insert Sequence:

ATGAAGTCCA GCGGCCTCTT CCCCTTCCTG GTGCTGCTTG CCCTGGGAAC TCTGGCACCT 
TGGGCTGTGG AAGGCTCTGG AAAGTCCTTC AAAGCTGGAG TCTGTCCTCC TAAGAAATCT 
GCCCAGTGCC TTAGATACAA GAAACCTGAG TGCCAGAGTG ACTGGCAGTG TCCAGGGAAG 
AAGAGATGTT GTCCTGACAC TTGTGGCATC AAATGCCTGG ATCCTGTTGA CACCCCAAAC 
CCAACAAGGA GGAAGCCTGG GAAGTGCCCA GTGACTTATG GCCAATGTTT GATGCTTAAC 
CCCCCCAATT TCTGTGAGAT GGATGGCCAG TGCAAGCGTG ACTTGAAGTG TTGCATGGGC 
ATGTGTGGGA AATCCTGCGT TTCCCCTGTG AAAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLPI ( NM_003064.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003055.1 Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.

Price & Availability↑

CloneID	OHu21632
Clone ID Related Accession (Same CDS sequence)	NM_003064.3 , NM_003064.4
Accession Version	NM_003064.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-07
Organism	Homo sapiens(human)
Product	antileukoproteinase precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020708.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003064.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020708.1, BM842052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000338380.2/ ENSP00000342082.2 Protein has antimicrobial activity :: PMID: 16336202 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGTCCA GCGGCCTCTT CCCCTTCCTG GTGCTGCTTG CCCTGGGAAC TCTGGCACCT 
TGGGCTGTGG AAGGCTCTGG AAAGTCCTTC AAAGCTGGAG TCTGTCCTCC TAAGAAATCT 
GCCCAGTGCC TTAGATACAA GAAACCTGAG TGCCAGAGTG ACTGGCAGTG TCCAGGGAAG 
AAGAGATGTT GTCCTGACAC TTGTGGCATC AAATGCCTGG ATCCTGTTGA CACCCCAAAC 
CCAACAAGGA GGAAGCCTGG GAAGTGCCCA GTGACTTATG GCCAATGTTT GATGCTTAAC 
CCCCCCAATT TCTGTGAGAT GGATGGCCAG TGCAAGCGTG ACTTGAAGTG TTGCATGGGC 
ATGTGTGGGA AATCCTGCGT TTCCCCTGTG AAAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003055.1
CDS	22..420
Translation	MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA

Target ORF information:

RefSeq Version	NM_003064.4
Organism	Homo sapiens(human)
Definition	Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003064.4

ORF Insert Sequence:

ATGAAGTCCA GCGGCCTCTT CCCCTTCCTG GTGCTGCTTG CCCTGGGAAC TCTGGCACCT 
TGGGCTGTGG AAGGCTCTGG AAAGTCCTTC AAAGCTGGAG TCTGTCCTCC TAAGAAATCT 
GCCCAGTGCC TTAGATACAA GAAACCTGAG TGCCAGAGTG ACTGGCAGTG TCCAGGGAAG 
AAGAGATGTT GTCCTGACAC TTGTGGCATC AAATGCCTGG ATCCTGTTGA CACCCCAAAC 
CCAACAAGGA GGAAGCCTGG GAAGTGCCCA GTGACTTATG GCCAATGTTT GATGCTTAAC 
CCCCCCAATT TCTGTGAGAT GGATGGCCAG TGCAAGCGTG ACTTGAAGTG TTGCATGGGC 
ATGTGTGGGA AATCCTGCGT TTCCCCTGTG AAAGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.
Disease markers20174962137(2017)
St?pie? T,Bro?yna M,Kuzdak K,Motylewska E,Komorowski J,St?pie? H,?awnicka H

Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.
Cancer letters379(1)84-93(2016 08)
Mikami Y,Fukushima A,Komiyama Y,Iwase T,Tsuda H,Higuchi Y,Hayakawa S,Kuyama K,Komiyama K

SLPI and elafin: multifunctional antiproteases of the WFDC family.
Biochemical Society transactions39(5)1437-40(2011 Oct)
Scott A,Weldon S,Taggart CC

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SLPI cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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