SLN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLN
Entrez Gene ID	6588
Full Name	sarcolipin
General protein information	Preferred Names sarcolipin Names sarcolipin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q22.3
Summary	Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008].
Disorder MIM:	602203

mRNA and Protein(s)

mRNA	Protein	Name
NM_003063.2	NP_003054.1	sarcolipin
NM_003063.3	NP_003054.1	sarcolipin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca
Desmond PF, Labuza A, Muriel J, Markwardt ML, Mancini AE, Rizzo MA, Bloch RJ
The Journal of biological chemistry292(26)10961-10972(2017 06)

Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations.
Cao Y, Wu X, Yang R, Wang X, Sun H, Lee I
Proteins85(6)1065-1077(2017 Jun)

Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel.
Cao Y, Wu X, Wang X, Sun H, Lee I
Archives of biochemistry and biophysics604143-51(2016 Aug)

Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
Shaikh SA, Sahoo SK, Periasamy M
Journal of molecular and cellular cardiology9181-91(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity.
Title: Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca

Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations has been reported.
Title: Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations.

analysis of transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel
Title: Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel.

Phospholamban and sarcolipin are membrane proteins that differentially regulate SERCA function. (Review)
Title: Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?

Molecular dynamics simulations help to clarify and to understand better the SLN pentamer channel that had a hydrophobic gate and could switch Na(+) and Cl(-) ion permeability by hydrated and vacuum states.
Title: Molecular dynamics of water and monovalent-ions transportation mechanisms of pentameric sarcolipin.

The following SLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16033	NM_003063.3 Latest version!	Homo sapiens sarcolipin (SLN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16033	NM_003063.2	Homo sapiens sarcolipin (SLN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLN ( NM_003063.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003054.1 Homo sapiens sarcolipin (SLN), mRNA.

Price & Availability↑

CloneID	OHu16033
Clone ID Related Accession (Same CDS sequence)	NM_003063.2 , NM_003063.3
Accession Version	NM_003063.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 96bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	sarcolipin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP233121.1, BC094685.1, AP002353.4 and F30315.1. On Feb 1, 2007 this sequence version replaced NM_003063.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279849.5685.1, BC005261.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1 61	ATGGGGATAA ACACCCGGGA GCTGTTTCTC AACTTCACTA TTGTCTTGAT TACGGTTATT CTTATGTGGC TCCTTGTGAG GTCCTATCAG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003054.1
CDS	175..270
Translation	MGINTRELFLNFTIVLITVILMWLLVRSYQY

Target ORF information:

RefSeq Version	NM_003063.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sarcolipin (SLN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003063.2

ORF Insert Sequence:

1 61	ATGGGGATAA ACACCCGGGA GCTGTTTCTC AACTTCACTA TTGTCTTGAT TACGGTTATT CTTATGTGGC TCCTTGTGAG GTCCTATCAG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SLN ( NM_003063.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003054.1 Homo sapiens sarcolipin (SLN), mRNA.

Price & Availability↑

CloneID	OHu16033
Clone ID Related Accession (Same CDS sequence)	NM_003063.2 , NM_003063.3
Accession Version	NM_003063.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 96bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Homo sapiens(human)
Product	sarcolipin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP233121.1, BC094685.1 and AP002353.4. On Nov 22, 2018 this sequence version replaced NM_003063.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005261.1, SRR5189652.254065.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305991.3/ ENSP00000304707.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

1 61	ATGGGGATAA ACACCCGGGA GCTGTTTCTC AACTTCACTA TTGTCTTGAT TACGGTTATT CTTATGTGGC TCCTTGTGAG GTCCTATCAG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003054.1
CDS	170..265
Translation	MGINTRELFLNFTIVLITVILMWLLVRSYQY

Target ORF information:

RefSeq Version	NM_003063.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sarcolipin (SLN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003063.3

ORF Insert Sequence:

1 61	ATGGGGATAA ACACCCGGGA GCTGTTTCTC AACTTCACTA TTGTCTTGAT TACGGTTATT CTTATGTGGC TCCTTGTGAG GTCCTATCAG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interactions between small ankyrin 1 and sarcolipin coordinately regulate activity of the sarco(endo)plasmic reticulum Ca
The Journal of biological chemistry292(26)10961-10972(2017 06)
Desmond PF,Labuza A,Muriel J,Markwardt ML,Mancini AE,Rizzo MA,Bloch RJ

Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations.
Proteins85(6)1065-1077(2017 Jun)
Cao Y,Wu X,Yang R,Wang X,Sun H,Lee I

Transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel.
Archives of biochemistry and biophysics604143-51(2016 Aug)
Cao Y,Wu X,Wang X,Sun H,Lee I

Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
Journal of molecular and cellular cardiology9181-91(2016 Feb)
Shaikh SA,Sahoo SK,Periasamy M

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SLN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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