Gene Symbol | WNK4 |
Entrez Gene ID | 65266 |
Full Name | WNK lysine deficient protein kinase 4 |
Synonyms | PHA2B,PRKWNK4 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]. |
Disorder MIM: | |
Disorder Html: | Pseudohypoaldosteronism, type IIB, 614491 (3) |